Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

OWEN, M. R., DORAN, E., & HALESTRAP, A. P. (2000) · Biochemical Journal · doi:10.1042/bj3480607 · Cited by 2,157

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Shaw, R. J., Kosmatka, M., Bardeesy, N., Hurley, R. L., Witters, L. A., DePinho, R. A., & Cantley, L. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308061100 · Cited by 1,797

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

Hawley, S. A., Boudeau, J., Reid, J. L., Mustard, K. J., Udd, L., Mäkelä, T. P., Alessi, D. R., & Hardie, D. G. (2003) · Journal of Biology · doi:10.1186/1475-4924-2-28 · Cited by 1,694

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

Woods, A., Johnstone, S. R., Dickerson, K., Leiper, F. C., Fryer, L. G. D., Neumann, D., Schlattner, U., Wallimann, T., Carlson, M., & Carling, D. (2003) · Current Biology · doi:10.1016/j.cub.2003.10.031 · Cited by 1,650

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I

El-Mir, M.-Y., Nogueira, V., Fontaine, E., Avéret, N., Rigoulet, M., & Leverve, X. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.223 · Cited by 1,399

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1

Lizcano, J. M., Göransson, O., Toth, R., Deak, M., Morrice, N. A., Boudeau, J., Hawley, S. A., Udd, L., Mäkelä, T. P., Hardie, D. G., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600110 · Cited by 1,381

The specificities of protein kinase inhibitors: an update

BAIN, J., McLAUCHLAN, H., ELLIOTT, M., & COHEN, P. (2003) · Biochemical Journal · doi:10.1042/bj20021535 · Cited by 1,369

Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

Hawley, S. A., Davison, M., Woods, A., Davies, S. P., Beri, R. K., Carling, D., & Hardie, D. G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27879 · Cited by 1,264

The AMP-activated protein kinase pathway – new players upstream and downstream

Hardie, D. G. (2004) · Journal of Cell Science · doi:10.1242/jcs.01540 · Cited by 1,163

Adiponectin/adiponectin receptor in disease and aging

Iwabu, M., Okada‐Iwabu, M., Yamauchi, T., & Kadowaki, T. (2015) · npj Aging and Mechanisms of Disease · doi:10.1038/npjamd.2015.13 · Cited by 96

Selective antagonism of muscarinic receptors is neuroprotective in peripheral neuropathy

Calcutt, N. A., Smith, D. R., Frizzi, K. E., Sabbir, M. G., Chowdhury, S. R., Mixcoatl-Zecuatl, T., Saleh, A. J., Muttalib, N., der Ploeg, R. V., Ochoa, J., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88321 · Cited by 96

High intensity interval training and molecular adaptive response of skeletal muscle

Torma, F., Gombos, Z., Jokai, M., Takeda, M., Mimura, T., & Radak, Z. (2019) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2019.08.003 · Cited by 95

Regulation of rDNA transcription in response to growth factors, nutrients and energy

Kusnadi, E. P., Hannan, K. M., Hicks, R. J., Hannan, R. D., Pearson, R. B., & Kang, J. (2014) · Gene · doi:10.1016/j.gene.2014.11.010 · Cited by 105

PPARβ Is Essential for Maintaining Normal Levels of PGC-1α and Mitochondria and for the Increase in Muscle Mitochondria Induced by Exercise

Koh, J., Hancock, C. R., Terada, S., Higashida, K., Holloszy, J. O., & Han, D.-H. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.029 · Cited by 98

AMPK Function in Mammalian Spermatozoa

Martín‐Hidalgo, D., de Llera, A. H., Calle-Guisado, V., González‐Fernández, L., Garcı́a, L. J., & Bragado, M. J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113293 · Cited by 100

Blockade of MCU-Mediated Ca2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation

Tomar, D., Jaña, F., Dong, Z., Quinn, W. J., Jadiya, P., Breves, S. L., Daw, C. C., Srikantan, S., Shanmughapriya, S., Nemani, N., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.107 · Cited by 96

The distinct roles of calcium in rapid control of neuronal glycolysis and the tricarboxylic acid cycle

Díaz‐García, C. M., Meyer, D. J., Nathwani, N., Rahman, M., Martínez‐François, J. R., & Yellen, G. (2021) · eLife · doi:10.7554/elife.64821 · Cited by 98

Insulin‐like growth factor‐1 (IGF‐1) and leucine activate pig myogenic satellite cells through mammalian target of rapamycin (mTOR) pathway

Han, B., Tong, J., Zhu, M. J., Ma, C., & Du, ‬. (2007) · Molecular Reproduction and Development · doi:10.1002/mrd.20832 · Cited by 97

Subcellular trafficking of the substrate transporters GLUT4 and CD36 in cardiomyocytes

Steinbusch, L. K. M., Schwenk, R. W., Ouwens, D. M., Diamant, M., Glatz, J. F. C., & Luiken, J. J. F. P. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0690-x · Cited by 99

Activation of cardiac AMP-activated protein kinase by LKB1 expression or chemical hypoxia is blunted by increased Akt activity

Soltys, C.-L. M., Kovacic, S., & Dyck, J. R. B. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01206.2005 · Cited by 100

Vagal nerve stimulation improves mitochondrial dynamics via an M3 receptor/Ca MKK β/ AMPK pathway in isoproterenol‐induced myocardial ischaemia

Xue, R., Sun, L., Yu, X., Li, D., & Zang, W. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12938 · Cited by 95

Role of hypothalamic AMP-kinase in food intake regulation

Minokoshi, Y., Shiuchi, T., Lee, S. P., Suzuki, A., & Okamoto, S. (2008) · Nutrition · doi:10.1016/j.nut.2008.06.002 · Cited by 98

Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy

Laurent, A., Bisserier, M., Lucas, A., Tortosa, F., Roumieux, M., de Régibus, A., Swiader, A., Sainte–Marie, Y., Heymes, C., Vindis, C., et al. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu242 · Cited by 104

Reactive Oxygen Species–Induced Stimulation of 5′AMP-Activated Protein Kinase Mediates Sevoflurane-Induced Cardioprotection

Lamberts, R. R., Onderwater, G., Hamdani, N., Vreden, M. J. A., Steenhuisen, J., Eringa, E. C., Loer, S. A., Stienen, G. J. M., & Bouwman, R. A. (2009) · Circulation · doi:10.1161/circulationaha.108.828426 · Cited by 93

Ghrelin and lipid metabolism: key partners in energy balance

Varela, L., Vazquez, M. J., Cordido, F., Nogueiras, R., Vidal‐Puig, A., Diéguez, C., & López, M. (2010) · Journal of Molecular Endocrinology · doi:10.1677/jme-10-0068 · Cited by 95

Fyn-Dependent Regulation of Energy Expenditure and Body Weight Is Mediated by Tyrosine Phosphorylation of LKB1

Yamada, E., Pessin, J. E., Kurland, I. J., Schwartz, G. J., & Bastie, C. C. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2009.12.010 · Cited by 94

AMP-activated Kinase (AMPK) Promotes Innate Immunity and Antiviral Defense through Modulation of Stimulator of Interferon Genes (STING) Signaling

Prantner, D., Perkins, D. J., & Vogel, S. N. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.763268 · Cited by 95

Hypothalamic AMP-activated protein kinase as a mediator of whole body energy balance

de Morentin, P. B. M., González, C. R., Saha, A. K., Martins, L., Diéguez, C., Vidal‐Puig, A., Tena‐Sempere, M., & López, M. (2011) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-011-9165-5 · Cited by 96

Frontier of Epilepsy Research - mTOR signaling pathway

Cho, C. (2011) · Experimental & Molecular Medicine · doi:10.3858/emm.2011.43.5.032 · Cited by 93

Role of the α2-isoform of AMP-activated protein kinase in the metabolic response of the heart to no-flow ischemia

Zarrinpashneh, E., Carjaval, K., Beauloye, C., Ginion, A., Matéo, P., Pouleur, A., Horman, S., Vaulont, S., Hoerter, J. A., Viollet, B., et al. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01032.2005 · Cited by 96

Synaptic Activity and Bioenergy Homeostasis: Implications in Brain Trauma and Neurodegenerative Diseases

Khatri, N., & Man, H. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00199 · Cited by 96

Vanillic acid attenuates obesity via activation of the AMPK pathway and thermogenic factors in vivo and in vitro

Jung, Y., Park, J., Kim, H., Sim, J., Youn, D., Kang, J., Lim, S., Jeong, M., Yang, W. M., Lee, S., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201700231rr · Cited by 91

Increased mitochondrial respiration promotes survival from endoplasmic reticulum stress

Knupp, J., Arvan, P., & Chang, A. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0133-4 · Cited by 94

AMP-Activated Protein Kinase Restricts IFN-γ Signaling

Meares, G. P., Qin, H., Liu, Y., Holdbrooks, A. T., & Benveniste, E. N. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202390 · Cited by 91

AMPK: a master energy regulator for gonadal function

Bertoldo, M. J., Faure, M., Dupont, J., & Froment, P. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00235 · Cited by 94

AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production

Reihill, J. A., Ewart, M., Hardie, D. G., & Salt, I. P. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.110 · Cited by 91

Myostatin regulates glucose metabolism via the AMP-activated protein kinase pathway in skeletal muscle cells

Chen, Y., Ye, J., Cao, L., Zhang, Y., Xia, W., & Zhu, D. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.09.017 · Cited by 91

LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment

Peña, C. G., Nakada, Y., Saatcioglu, H. D., Aloisio, G. M., Cuevas, I., Zhang, S., Miller, D. S., Lea, J. S., Wong, K., DeBerardinis, R. J., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci82152 · Cited by 92

4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8+ T cell proliferation

Choi, B. K., Lee, D. Y., Lee, D. G., Kim, Y. H., Kim, S.-H., Oh, H. S., Han, C., & Kwon, B. S. (2016) · Cellular and Molecular Immunology · doi:10.1038/cmi.2016.02 · Cited by 93

Apelin-13 induces mitophagy in bone marrow mesenchymal stem cells to suppress intracellular oxidative stress and ameliorate osteoporosis by activation of AMPK signaling pathway

Chen, L., Shi, X., Xie, J., Weng, S., Xie, Z.-J., Tang, J., Yan, D., Wang, B.-Z., Fang, K.-H., Hong, C., et al. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.12.235 · Cited by 90

AMP-activated Protein Kinase in the Control of Cardiac Metabolism and Remodeling

Horman, S., Beauloye, C., Vanoverschelde, J., & Bertrand, L. (2012) · Current Heart Failure Reports · doi:10.1007/s11897-012-0102-z · Cited by 93

Structural Properties of AMP-activated Protein Kinase

Riek, U., Scholz, R., Konarev, P. V., Rufer, A. C., Suter, M., Nazabal, A., Ringler, P., Chami, M., Müller, S. A., Neumann, D., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708379200 · Cited by 93

AMPK activation by isorhamnetin protects hepatocytes against oxidative stress and mitochondrial dysfunction

Dong, G.-Z., Lee, J., Ki, S. H., Yang, J. H., Cho, I. J., Kang, S. H., Zhao, R., Kim, S. C., & Kim, Y. W. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.06.017 · Cited by 90

A Postsynaptic AMPK→p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons

Kong, D., Dagon, Y., Campbell, J. N., Guo, Y., Yang, Z., Yi, X., Aryal, P., Wellenstein, K., Kahn, B. B., Sabatini, B. L., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.05.025 · Cited by 91

Multiomic Analysis Reveals Disruption of Cholesterol Homeostasis by Cannabidiol in Human Cell Lines

Guard, S. E., Chapnick, D. A., Poss, Z. C., Ebmeier, C. C., Jacobsen, J. R., Nemkov, T. G., Ball, K. A., Webb, K. J., Simpson, H. L., Coleman, S. J., et al. (2022) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2022.100262 · Cited by 90

The Ca2+/Calmodulin-Dependent Protein Kinase Kinase, CaMKK2, Inhibits Preadipocyte Differentiation

Lin, F., Ribar, T. J., & Means, A. R. (2011) · Endocrinology · doi:10.1210/en.2011-1107 · Cited by 89

Rosiglitazone Stimulates Nitric Oxide Synthesis in Human Aortic Endothelial Cells via AMP-activated Protein Kinase*

Boyle, J. G., Logan, P. J., Ewart, M., Reihill, J. A., Ritchie, S. A., Connell, J., Cleland, S. J., & Salt, I. P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710048200 · Cited by 89

Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection

Li, S., Lavagnino, Z., Lemacon, D. S., Kong, L., Ustione, A., Ng, X. W., Zhang, Y., Wang, Y., Zheng, B., Piwnica-Worms, H. M., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.04.003 · Cited by 90

Resveratrol alleviates obesity-induced skeletal muscle inflammation via decreasing M1 macrophage polarization and increasing the regulatory T cell population

Shabani, M., Sadeghi, A., Hosseini, H., Teimouri, M., Khorzoughi, R. B., Pasalar, P., & Meshkani, R. (2020) · Scientific Reports · doi:10.1038/s41598-020-60185-1 · Cited by 91

AMPK‐dependent hormonal regulation of whole‐body energy metabolism

Dzamko, N. L., & Steinberg, G. R. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01969.x · Cited by 90

Pemetrexed Indirectly Activates the Metabolic Kinase AMPK in Human Carcinomas

Rothbart, S. B., Racanelli, A. C., & Moran, R. G. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1873 · Cited by 90

Activated protein C protects against myocardial ischemic/reperfusion injury through AMP‐activated protein kinase signaling

WANG, J., YANG, L., Rezaie, A. R., & Li, J. (2011) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04331.x · Cited by 88

Radioresistant Cervical Cancers Are Sensitive to Inhibition of Glycolysis and Redox Metabolism

Rashmi, R., Huang, X., Floberg, J. M., Elhammali, A. E., McCormick, M. L., Patti, G. J., Spitz, D. R., & Schwarz, J. K. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-2367 · Cited by 87

Quercetin enhances hypoxia-mediated apoptosis via direct inhibition of AMPK activity in HCT116 colon cancer

Kim, H.-S., Wannatung, T., Lee, S., Yang, W. K., Chung, S. H., Lim, J., Choe, W., Kang, I., Kim, S. S., & Ha, J. (2012) · APOPTOSIS · doi:10.1007/s10495-012-0719-0 · Cited by 87

Promise and challenges for direct small molecule AMPK activators

Olivier, S., Foretz, M., & Viollet, B. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.01.049 · Cited by 90

AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation

Marinangeli, C., Didier, S., Ahmed, T., Caillerez, R., Domise, M., Laloux, C., Bégard, S., Carrier, S., Colin, M., Marchetti, P., et al. (2018) · iScience · doi:10.1016/j.isci.2018.10.006 · Cited by 90

Interactive Roles for AMPK and Glycogen from Cellular Energy Sensing to Exercise Metabolism

Janzen, N. R., Whitfield, J., & Hoffman, N. J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113344 · Cited by 88

Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms

Saeedi, R., Parsons, H. L., Wambolt, R. B., Paulson, K., Sharma, V. S., Dyck, J. R. B., Brownsey, R. W., & Allard, M. F. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00873.2007 · Cited by 89

LKB 1 and AMPK : central regulators of lymphocyte metabolism and function

Blagih, J., Krawczyk, C. M., & Jones, R. G. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01157.x · Cited by 91

AMPK activity is regulated by calcium-mediated protein phosphatase 2A activity

Park, S., Scheffler, T. L., Rossie, S. S., & Gerrard, D. E. (2013) · Cell Calcium · doi:10.1016/j.ceca.2012.12.001 · Cited by 86

Nitrogen Availability and TOR Regulate the Snf1 Protein Kinase in Saccharomyces cerevisiae

Orlova, M., Kanter, E., Krakovich, D., & Kuchin, S. (2006) · Eukaryotic Cell · doi:10.1128/ec.00110-06 · Cited by 86

A Kinome RNAi Screen Identified AMPK as Promoting Poxvirus Entry through the Control of Actin Dynamics

Moser, T. S., Jones, R. G., Thompson, C. B., Coyne, C. B., & Cherry, S. R. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000954 · Cited by 85

DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice

Shi, S. Y., Lu, S.-Y., Sivasubramaniyam, T., Revelo, X. S., Cai, E. P., Luk, C. T., Schroer, S. A., Patel, P., Kim, R. H., Bombardier, É., et al. (2015) · Nature Communications · doi:10.1038/ncomms8415 · Cited by 85

AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2

Fogarty, S., Ross, F. A., Vara‐Ciruelos, D., Gray, A., Gowans, G. J., & Hardie, D. G. (2016) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-15-0479 · Cited by 90

Regulation of AMP-activated protein kinase activity by G-protein coupled receptors: Potential utility in treatment of diabetes and heart disease

Hutchinson, D. S., Summers, R. J., & Bengtsson, T. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.05.008 · Cited by 88

PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27Kip1 axis

Tuo, L., Xiang, J., Pan, X., Hu, J., Tang, H., Liang, L., Xia, J., Hu, Y., Zhang, W., Huang, A., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1029-y · Cited by 84

GSK3β-dependent inhibition of AMPK potentiates activation of neutrophils and macrophages and enhances severity of acute lung injury

Park, D. W., Jiang, S., Liu, Y., Siegal, G. P., Inoki, K., Abraham, E. H., & Zmijewski, J. W. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00165.2014 · Cited by 84

Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance

Wang, B., & Cheng, K. K. Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113552 · Cited by 87

Control of Energy Homeostasis: Role of Enzymes and Intermediates of Fatty Acid Metabolism in the Central Nervous System

Wolfgang, M. J., & Lane, M. D. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.25.050304.092532 · Cited by 85

Regulation of AMP‐activated protein kinase by LKB1 and CaMKK in adipocytes

Gormand, A., Henriksson, E., Ström, K., Jensen, T. E., Sakamoto, K., & Göransson, O. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23053 · Cited by 85

Role of 5′-Adenosine Monophosphate-Activated Protein Kinase in Cell Survival and Death Responses in Neurons

Weisová, P., Dávila, D., Tuffy, L. P., Ward, M. W., Concannon, C. G., & Prehn, J. H. M. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3544 · Cited by 83

Energy sensing and regulation of gene expression in skeletal muscle

Freyssenet, D. G. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01126.2005 · Cited by 88

Thromboxane receptor activates the AMP-activated protein kinase in vascular smooth muscle cells via hydrogen peroxide

Zhang, M., Dong, Y., Xu, J., Xie, Z., Wu, Y., Song, P., Guzman, M., Wu, J., & Zou, M.-H. (2008) · Circulation Research · doi:10.1161/circresaha.107.163253 · Cited by 82

Metformin action on AMP‐activated protein kinase: a translational research approach to understanding a potential new therapeutic target

Boyle, J. G., Salt, I. P., & McKay, G. (2010) · Diabetic Medicine · doi:10.1111/j.1464-5491.2010.03098.x · Cited by 83

The Role of AMPK Signaling in Brown Adipose Tissue Activation

van der Vaart, J. I., Boon, M. R., & Houtkooper, R. H. (2021) · Cells · doi:10.3390/cells10051122 · Cited by 90

Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter

Schmitt, D. L., Curtis, S. D., Leung, A., Zhang, J., He, C. Y., He, C. Y., Mehta, S., Rangamani, P., Shaw, R. J., & Zhang, J. (2022) · Nature Communications · doi:10.1038/s41467-022-31190-x · Cited by 87

An evolutionary perspective of AMPK–TOR signaling in the three domains of life

Roustan, V., Jain, A., Teige, M., Ebersberger, I., & Weckwerth, W. (2016) · Journal of Experimental Botany · doi:10.1093/jxb/erw211 · Cited by 82

GSK-3β controls autophagy by modulating LKB1-AMPK pathway in prostate cancer cells

Sun, A., Li, C., Chen, R., Huang, Y., Chen, Q., Cui, X., Liu, H., Thrasher, J. B., & Li, B. (2015) · The Prostate · doi:10.1002/pros.23106 · Cited by 83

Improvement Effect of Metformin on Female and Male Reproduction in Endocrine Pathologies and Its Mechanisms

Shpakov, A. O. (2021) · Pharmaceuticals · doi:10.3390/ph14010042 · Cited by 83

Activating AMP-Activated Protein Kinase without AMP

Birnbaum, M. J. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.07.012 · Cited by 81

Compound K Induces Apoptosis via CAMK-IV/AMPK Pathways in HT-29 Colon Cancer Cells

Kim, D. Y., Park, M. W., Yuan, H. D., Lee, H., Kim, S. H., & Chung, S. H. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf902700h · Cited by 81

The role of AMP-activated protein kinase in the cardiovascular system

Nagata, D., & Hirata, Y. (2009) · Hypertension Research · doi:10.1038/hr.2009.187 · Cited by 84

Metformin, besides exhibiting strong in vivo anti-inflammatory properties, increases mptp-induced damage to the nigrostriatal dopaminergic system

Ismaiel, A. A., Espinosa‐Oliva, A. M., Santiago, M., García-Quintanilla, A., Oliva-Martín, M. J., Herrera, A. J., Venero, J. L., & de Pablos, R. M. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.03.004 · Cited by 81

AMP-Activated Protein Kinase and Host Defense against Infection

Silwal, P., Kim, J. K., Yuk, J., & Jo, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113495 · Cited by 82

Dysregulation of Glucose Metabolism by Oncogenes and Tumor Suppressors in Cancer Cells

Marbaniang, C., & Kma, L. (2018) · Europe PMC (PubMed Central) · doi:10.22034/apjcp.2018.19.9.2377 · Cited by 82

MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer

Casciano, J. C., Perry, C. E., Cohen-Nowak, A. J., Miller, K. D., Voorde, J. V., Zhang, Q., Chalmers, S., Sandison, M. E., Liu, Q., Hedley, A., et al. (2020) · British Journal of Cancer · doi:10.1038/s41416-019-0711-3 · Cited by 80

Perivascular fat, AMP ‐activated protein kinase and vascular diseases

Almabrouk, T. A. M., Ewart, M., Salt, I. P., & Kennedy, S. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12479 · Cited by 84

Cross-phosphorylation between Arabidopsis thaliana Sucrose Nonfermenting 1-related Protein Kinase 1 (AtSnRK1) and Its Activating Kinase (AtSnAK) Determines Their Catalytic Activities

Crozet, P., Jammes, F., Valot, B., Ambard‐Bretteville, F., Nessler, S., Hodges, M., Vidal, J., & Thomas, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.079194 · Cited by 80

Activation of NAD(P)H:Quinone Oxidoreductase 1 Prevents Arterial Restenosis by Suppressing Vascular Smooth Muscle Cell Proliferation

Kim, S.-Y., Jeoung, N. H., Oh, C. J., Choi, Y., Lee, H., Kim, H., Kim, J., Hwang, J. H., Tadi, S., Yim, Y., et al. (2009) · Circulation Research · doi:10.1161/circresaha.108.189837 · Cited by 80

Role of Hypothalamic Adenosine 5′-Monophosphate-Activated Protein Kinase in the Impaired Counterregulatory Response Induced by Repetitive Neuroglucopenia

Alquier, T., Kawashima, J., Tsuji, Y., & Kahn, B. B. (2006) · Endocrinology · doi:10.1210/en.2006-1039 · Cited by 80

Characterization of the role of γ2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome

Davies, J. K., Wells, D. J., Liu, K., Whitrow, H. R., Daniel, T. D., Grignani, R., Lygate, C. A., Schneider, J. E., Noël, G., Watkins, H. C., et al. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01020.2005 · Cited by 83

Ablation of CD44 induces glycolysis-to-oxidative phosphorylation transition via modulation of the c-Src–Akt–LKB1–AMPKα pathway

Nam, K., Oh, S., & Shin, I. (2016) · Biochemical Journal · doi:10.1042/bcj20160613 · Cited by 80

FCS ‐like zinc finger 6 and 10 repress Sn RK 1 signalling in Arabidopsis

Muhammed Jamsheer, K., Sharma, M., Singh, D., Mannully, C. T., Jindal, S., Shukla, B. N., & Laxmi, A. (2018) · The Plant Journal · doi:10.1111/tpj.13854 · Cited by 80

Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate liver steatosis by promoting fatty acid oxidation and reducing fatty acid synthesis

Yang, F., Wu, Y., Chen, Y., Xi, J., Chu, Y., Jin, J., & Yan, Y. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100746 · Cited by 79

Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain

Handa, N., Takagi, T., Saijo, S., Kishishita, S., Takaya, D., Toyama, M., Terada, T., Shirouzu, M., Suzuki, A., Lee, S., et al. (2011) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444911010201 · Cited by 80

AMPK Activators Suppress Cervical Cancer Cell Growth through Inhibition of DVL3 Mediated Wnt/β-Catenin Signaling Activity

Kwan, H., Chan, D. W., Cai, P. C. H., Mak, C. S. L., Yung, M. M. H., Leung, T. H. Y., Wong, O. G., Cheung, A., & Ngan, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053597 · Cited by 81

Muscle cell depolarization induces a gain in surface GLUT4 via reduced endocytosis independently of AMPK

Wijesekara, N., Tung, A., Thong, F. S. L., & Klip, A. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00573.2005 · Cited by 79

AMP-Activated Protein Kinase Activation by Adrenoceptors in L6 Skeletal Muscle Cells

Hutchinson, D. S., & Bengtsson, T. (2006) · Diabetes · doi:10.2337/diabetes.55.03.06.db05-0901 · Cited by 79

Rosmarinic Acid, a Rosemary Extract Polyphenol, Increases Skeletal Muscle Cell Glucose Uptake and Activates AMPK

Vlavcheski, F., Naimi, M., Murphy, B. A., Hudlický, T., & Tsiani, E. (2017) · Molecules · doi:10.3390/molecules22101669 · Cited by 80

CAMKK2 Promotes Prostate Cancer Independently of AMPK via Increased Lipogenesis

Penfold, L., Woods, A., Muckett, P. J., Nikitin, A. Y., Kent, T. R., Zhang, S., Graham, R., Pollard, A., & Carling, D. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0585 · Cited by 81

LKB1 and AMPK and the regulation of skeletal muscle metabolism

Koh, H.-J., Brandauer, J., & Goodyear, L. J. (2008) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e3282fb7b76 · Cited by 78

Citrus Tangeretin Improves Skeletal Muscle Mitochondrial Biogenesis via Activating the AMPK-PGC1-α Pathway In Vitro and In Vivo: A Possible Mechanism for Its Beneficial Effect on Physical Performance

Kou, G., Li, Z., Wu, C., Liu, Y., Hu, Y., Guo, L., Xu, X., & Zhou, Z. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b04124 · Cited by 78

The AMPK Agonist AICAR Inhibits TGF-β1 Induced Activation of Kidney Myofibroblasts

Chen, K., Hsu, H., Lee, C., Yen, T.-H., Ko, Y.-C., Yang, C., & Hung, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106554 · Cited by 79

Increased oxidative stress and anaerobic energy release, but blunted Thr172-AMPKα phosphorylation, in response to sprint exercise in severe acute hypoxia in humans

Morales‐Álamo, D., Ponce‐González, J. G., Guadalupe‐Grau, A., Rodríguez‐García, L., Santana, A., Cussó, M. R., Guerrero, M., Guerra, B., Dorado, C., & Calbet, J. A. L. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00415.2012 · Cited by 83

Androgen-regulated metabolism and biosynthesis in prostate cancer

Barfeld, S. J., Itkonen, H. M., Urbanucci, A., & Mills, I. G. (2014) · Endocrine Related Cancer · doi:10.1530/erc-13-0515 · Cited by 78

Insulin resistance and fuel homeostasis: the role of AMP‐activated protein kinase

Hegarty, B. D., Turner, N. A., Cooney, G. J., & Kraegen, E. W. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01968.x · Cited by 78

EJE PRIZE 2017: Hypothalamic AMPK: a golden target against obesity?

López, M. (2017) · European Journal of Endocrinology · doi:10.1530/eje-16-0927 · Cited by 78

Adenosine Monophosphate–Activated Kinase and Its Key Role in Catabolism: Structure, Regulation, Biological Activity, and Pharmacological Activation

Krishan, S., Richardson, D. R., & Sahni, S. (2014) · Molecular Pharmacology · doi:10.1124/mol.114.095810 · Cited by 80

Ca2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells

Woods, A., Dickerson, K., Heath, R. B., Hong, S. P., Momcilovic, M., Johnstone, S. R., Carlson, M., & Carling, D. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.06.005 · Cited by 1,418

Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP

Fogarty, S., Hawley, S. A., Green, K. A., Saner, N., Mustard, K. J., & Hardie, D. G. (2009) · Biochemical Journal · doi:10.1042/bj20091372 · Cited by 146

The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases

Hurley, R. L., Anderson, K. A., Franzone, J. M., Kemp, B. E., Means, A. R., & Witters, L. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503824200 · Cited by 1,004

5′-AMP Activates the AMP-activated Protein Kinase Cascade, and Ca2+/Calmodulin Activates the Calmodulin-dependent Protein Kinase I Cascade, via Three Independent Mechanisms

Hawley, S. A., Selbert, M. A., Goldstein, E. G., Edelman, A. M., Carling, D., & Hardie, D. G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.27186 · Cited by 441

AMP-activated protein kinase–mediated feedback phosphorylation controls the Ca2+/calmodulin (CaM) dependence of Ca2+/CaM-dependent protein kinase kinase β

Nakanishi, A., Hatano, N., Fujiwara, Y., Sha’ri, A., Takabatake, S., Akano, H., Kanayama, N., Magari, M., Nozaki, N., & Tokumitsu, H. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.805085 · Cited by 56