The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3
Open accessAbstract
Evidence for the physiological functions of UCP2 and UCP3 is critically reviewed. They do not mediate adaptive thermogenesis, but they may be significantly thermogenic under specific pharmacological conditions. There is strong evidence that the mild regulated uncoupling they cause attenuates mitochondrial ROS production, protects against cellular damage, and diminishes insulin secretion. Evidence that they export fatty acids physiologically is weak. UCP2 and UCP3 are important potential targets for treatment of aging, degenerative diseases, diabetes, and perhaps obesity.
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“UCP1 plays a role in adaptive thermogenesis in mammalian brown adipose tissue to produce heat (314), whereas the actions of UCP2 and 3 are upregulated in response to oxidant stress caused by nutrient deprivation, glucose sensing, fatty acid metabolism, or other metabolic changes in order to lessen mitochondrial ROS production (49).”
From Redox regulation of mitochondrial function (2012) · cites this paper as [49]
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Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia
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Topology of superoxide production from different sites in the mitochondrial electron transport chain
St-Pierre, J., Buckingham, J. A., Roebuck, S. J., & Brand, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207217200 · Cited by 1,545
Self-citationSuperoxide activates mitochondrial uncoupling proteins
Echtay, K. S., Roussel, D., St-Pierre, J., Jekabsons, M. B., Cadenas, S., Stuart, J. A., Harper, J. A., Roebuck, S. J., Morrison, A., Pickering, S., et al. (2002) · Nature · doi:10.1038/415096a · Cited by 1,382
Self-citationMitochondria and neuronal survival
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Metadata
- Authors
- Brand, M. D., & Esteves, T. C.
- Affiliations
- MRC Mitochondrial Biology Unit (GB)
- Corresponding author
- Brand, Martin D.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2005-08
- Volume
- 2
- Issue
- 2
- Pages
- 85-93
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1992678387
- Cited by
- 785
- References
- 101
- Citations by year
- 2026: 16 · 2025: 18 · 2024: 16 · 2023: 26 · 2022: 34 · 2021: 41 · 2020: 33 · 2019: 40 · 2018: 48 · 2017: 44 · 2016: 39 · 2015: 40 · 2014: 32 · 2013: 41 · 2012: 35
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- UCP2, UCP3, mitochondrial uncoupling proteins, thermogenesis, mitochondrial reactive oxygen species, insulin secretion, fatty acid export, aging, degenerative diseases, diabetes mellitus, obesity
- MeSH terms
- Uncoupling Protein 2, Uncoupling Protein 3, Insulin Secretion, Aging, Animals, Carrier Proteins, Fatty Acids, Insulin, Ion Channels, Mitochondria, Obesity, Oxidation-Reduction, Reactive Oxygen Species, Oxidative Stress, Protein Isoforms, Thermogenesis, Mitochondrial Proteins, Membrane Transport Proteins
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