Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3

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Uncoupling to survive? The role of mitochondrial inefficiency in ageing

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A role for uncoupling protein‐2 as a regulator of mitochondrial hydrogen peroxide generation

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Uncoupling Protein-3 Is a Mediator of Thermogenesis Regulated by Thyroid Hormone, β3-Adrenergic Agonists, and Leptin

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UCP3: An Uncoupling Protein Homologue Expressed Preferentially and Abundantly in Skeletal Muscle and Brown Adipose Tissue

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Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

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Cloning and Characterization of an Uncoupling Protein Homolog: A Potential Molecular Mediator of Human Thermogenesis

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Uncoupling Protein 2, in Vivo Distribution, Induction upon Oxidative Stress, and Evidence for Translational Regulation

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Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane

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Reactive oxygen species, mitochondria, apoptosis and aging

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Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism.

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Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction

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Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction

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Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance

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Reactive oxygen species, mitochondria, apoptosis and aging

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Superoxide Activates Mitochondrial Uncoupling Protein 2 from the Matrix Side

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Lack of Obesity and Normal Response to Fasting and Thyroid Hormone in Mice Lacking Uncoupling Protein-3

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Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation

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Structure and function of the uncoupling protein from brown adipose tissue

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Increased Uncoupling Protein-2 Levels in β-cells Are Associated With Impaired Glucose-Stimulated Insulin Secretion

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Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic β-cells

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Physiological Role of UCP3 May Be Export of Fatty Acids from Mitochondria When Fatty Acid Oxidation Predominates: An Hypothesis

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Transport function and regulation of mitochondrial uncoupling proteins 2 and 3

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Uncoupling proteins 2 and 3 are highly active H + transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone)

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Superoxide Activates Uncoupling Proteins by Generating Carbon-centered Radicals and Initiating Lipid Peroxidation

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Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate?

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Superoxide and hydrogen peroxide production by Drosophila mitochondria

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Uncoupling Protein-3 Expression in Rodent Skeletal Muscle Is Modulated by Food Intake but Not by Changes in Environmental Temperature

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Mitochondrial uncoupling as a target for drug development for the treatment of obesity.

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Protective Role of Uncoupling Protein 2 in Atherosclerosis

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Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.

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Sodium Palmitate Induces Partial Mitochondrial Uncoupling and Reactive Oxygen Species in Rat Pancreatic Isletsin Vitro1

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The Physiological Significance of Mitochondrial Proton Leak in Animal Cells and Tissues

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A function for novel uncoupling proteins: antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet

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A plant cold-induced uncoupling protein

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The ‘Novel’‘Uncoupling’ Proteins UCP2 and UCP3: What Do They Really do? Pros and Cons for Suggested Functions

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Uncoupling Protein 2: A Possible Link Between Fatty Acid Excess and Impaired Glucose-Induced Insulin Secretion?

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UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged

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An uncoupling protein homologue putatively involved in facultative muscle thermogenesis in birds

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Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet

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Generating, Partitioning, Targeting and Functioning of Superoxide in Mitochondria

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Tissue‐dependent upregulation of rat uncoupling protein‐2 expression in response to fasting or cold

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Free Fatty Acid-induced β-Cell Defects Are Dependent on Uncoupling Protein 2 Expression

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The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3

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Mitochondrial superoxide and aging: uncoupling-protein activity and superoxide production

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Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3

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Nutrient–secretion coupling in the pancreatic islet β-cell: recent advances

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Mitochondrial ROS Metabolism: Modulation by Uncoupling Proteins

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Uncoupling proteins: the issues from a biochemist point of view

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Uncoupling proteins: their roles in adaptive thermogenesis and substrate metabolism reconsidered

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No Evidence for a Basal, Retinoic, or Superoxide-induced Uncoupling Activity of the Uncoupling Protein 2 Present in Spleen or Lung Mitochondria

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Activation of the potato plant uncoupling mitochondrial protein inhibits reactive oxygen species generation by the respiratory chain

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Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes

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Uncoupling the agony from ecstasy

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The reactions catalysed by the mitochondrial uncoupling proteins UCP2 and UCP3

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Cold‐induced mitochondrial uncoupling and expression of chicken UCP and ANT mRNA in chicken skeletal muscle

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Uncoupling Protein-2 Participates in Cellular Defense against Oxidative Stress in Clonal β-Cells

Li, L., Skorpen, F., Egeberg, K. W., Jørgensen, I. H., & Grill, V. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4577 · Cited by 140

Superoxide Stimulates a Proton Leak in Potato Mitochondria That Is Related to the Activity of Uncoupling Protein

Considine, M. J., Goodman, M., Echtay, K. S., Laloi, M., Whelan, J., Brand, M. D., & Sweetlove, L. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301075200 · Cited by 138

Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells

Duval, C., Nègre‐Salvayre, A., Doglio, A., Salvayre, R., Pénicaud, L., & Casteilla, L. (2002) · Biochemistry and Cell Biology · doi:10.1139/o02-158 · Cited by 138

Uncoupling protein and ATP/ADP carrier increase mitochondrial proton conductance after cold adaptation of king penguins

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Production of endogenous matrix superoxide from mitochondrial complex I leads to activation of uncoupling protein 3

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The role of uncoupling protein 3 in fatty acid metabolism: protection against lipotoxicity?

Schrauwen, P. (2004) · Proceedings of The Nutrition Society · doi:10.1079/pns2003336 · Cited by 126

Mitochondrial functional state in clonal pancreatic β-cells exposed to free fatty acids.

Koshkin, V., Wang, X., Scherer, P. E., Chan, C. B., & Wheeler, M. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209709200 · Cited by 121

Uncoupling protein-2 deficiency promotes oxidant stress and delays liver regeneration in mice

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Reconstitution of Recombinant Uncoupling Proteins

Jabůrek, M., & Garlid, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302126200 · Cited by 114

Mitochondrial Uncoupling Proteins in Energy Expenditure

Kozak, L. P., & Harper, M. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.339 · Cited by 111

Mitochondrial uncoupling proteins – facts and fantasies

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Effects of Adenoviral Overexpression of Uncoupling Protein-2 and -3 on Mitochondrial Respiration in Insulinoma Cells**This work was supported by V.A. Medical Research Funds and NIH Grants DK-25295 and HD-29569.

Hong, Y., Fink, B. D., Dillon, J. S., & Sivitz, W. I. (2001) · Endocrinology · doi:10.1210/endo.142.1.7889 · Cited by 107

Uncoupling protein-2: evidence for its function as a metabolic regulator

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Cloning and functional characterization of an uncoupling protein homolog in hummingbirds

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Hydroperoxy Fatty Acid Cycling Mediated by Mitochondrial Uncoupling Protein UCP2

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Uncoupling protein 2 in the brain: distribution and function

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Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria

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Inhibition of Glucose-Induced Insulin Secretion by 4-Hydroxy-2-Nonenal and Other Lipid Peroxidation Products1

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The Uncoupling Protein UCP1 Does Not Increase the Proton Conductance of the Inner Mitochondrial Membrane by Functioning as a Fatty Acid Anion Transporter

González‐Barroso, M. M., Fleury, C., Bouillaud, F., Nicholls, D. G., & Rial, E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.25.15528 · Cited by 84

Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector

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Uncoupling protein 2 from carp and zebrafish, ectothermic vertebrates

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Mechanism of uncoupling protein action

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Superoxide activates a GDP-sensitive proton conductance in skeletal muscle mitochondria from king penguin (Aptenodytes patagonicus)

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Regulation of UCP3 by nucleotides is different from regulation of UCP1

Echtay, K. S., Liu, Q., Caskey, T., Winkler, E., Frischmuth, K., Bienengräber, M., & Klingenberg, M. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00460-3 · Cited by 65

Mechanism of uncoupling protein action

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Alkylsulfonates activate the uncoupling protein UCP1: implications for the transport mechanism

Rial, E., Aguirregoitia, E., Jiménez-Jiménez, J., & Ledesma, A. (2003) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2003.11.001 · Cited by 46

Alkylsulfonates as Probes of Uncoupling Protein Transport Mechanism

Jabůrek, M., Vařecha, M., Ježek, P., & Garlid, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103507200 · Cited by 42

Mitochondrial efficiency: lessons learned from transgenic mice

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UCP3 and its putative function: consistencies and controversies

Harper, M., Dent, R., Bézaire, V., Antoniou, A., Gauthier, A., Monemdjou, S., & McPherson, R. (2001) · Biochemical Society Transactions · doi:10.1042/bst0290768 · Cited by 24

Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production

Powers, S. K., & Jackson, M. J. (2008) · Physiological Reviews · doi:10.1152/physrev.00031.2007 · Cited by 2,459

Reciprocal Relationships Between Insulin Resistance and Endothelial Dysfunction: Molecular and Pathophysiological Mechanisms

Kim, J.-A., Montagnani, M., Koh, K. K., & Quon, M. J. (2006) · Circulation · doi:10.1161/circulationaha.105.563213 · Cited by 1,652

Mitochondria in innate immune responses

West, A. P., Shadel, G. S., & Ghosh, S. (2011) · Nature Reviews Immunology · doi:10.1038/nri2975 · Cited by 1,376

Mitochondrial ROS Signaling in Organismal Homeostasis

Shadel, G. S., & Horvath, T. L. (2015) · Cell · doi:10.1016/j.cell.2015.10.001 · Cited by 1,353

Mitochondrial energetics in the kidney

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Mitochondrial uncoupling proteins—What is their physiological role?

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The ‘Novel’‘Uncoupling’ Proteins UCP2 and UCP3: What Do They Really do? Pros and Cons for Suggested Functions

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Nutrition & Metabolism BioMed Central Review Uncoupling

Fisler, J. S., & Warden, C. H. (2006)

Uncoupling proteins, dietary fat and the metabolic syndrome

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UCP2 and UCP3 in muscle controlling body metabolism

Schrauwen, P., & Hesselink, M. K. C. (2002) · Journal of Experimental Biology · doi:10.1242/jeb.205.15.2275 · Cited by 210