Cited by 785Mitochondrial Function and PathologyAdipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

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Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3

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Brand, Martin D., Esteves, Telma C.·2005·Cell Metabolism

DOI 10.1016/j.cmet.2005.06.002

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Abstract

Evidence for the physiological functions of UCP2 and UCP3 is critically reviewed. They do not mediate adaptive thermogenesis, but they may be significantly thermogenic under specific pharmacological conditions. There is strong evidence that the mild regulated uncoupling they cause attenuates mitochondrial ROS production, protects against cellular damage, and diminishes insulin secretion. Evidence that they export fatty acids physiologically is weak. UCP2 and UCP3 are important potential targets for treatment of aging, degenerative diseases, diabetes, and perhaps obesity.

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Authors: Brand, M. D., & Esteves, T. C.
Affiliations: MRC Mitochondrial Biology Unit (GB)
Corresponding author: Brand, Martin D.
ORCID: Brand, Martin D.
Esteves, Telma C.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2005-08
Volume: 2
Issue: 2
Pages: 85-93
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2005.06.002
OpenAlex: W1992678387
Cited by: 785
References: 101
Citations by year: 2026: 16 · 2025: 18 · 2024: 16 · 2023: 26 · 2022: 34 · 2021: 41 · 2020: 33 · 2019: 40 · 2018: 48 · 2017: 44 · 2016: 39 · 2015: 40 · 2014: 32 · 2013: 41 · 2012: 35
FWCI: 3.56
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2943 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: UCP2, UCP3, mitochondrial uncoupling proteins, thermogenesis, mitochondrial reactive oxygen species, insulin secretion, fatty acid export, aging, degenerative diseases, diabetes mellitus, obesity
MeSH terms: Uncoupling Protein 2, Uncoupling Protein 3, Insulin Secretion, Aging, Animals, Carrier Proteins, Fatty Acids, Insulin, Ion Channels, Mitochondria, Obesity, Oxidation-Reduction, Reactive Oxygen Species, Oxidative Stress, Protein Isoforms, Thermogenesis, Mitochondrial Proteins, Membrane Transport Proteins

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Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3

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