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Cited by 284Regulation of Appetite and ObesityAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Leptin and brain–adipose crosstalks

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Caron, Alexandre, Lee, Syann, Elmquist, Joel K., Gautron, Laurent·2018·Nature Reviews Neuroscience
DOI 10.1038/nrn.2018.7PMC PMC5962962
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Abstract

Interactions between the brain and distinct adipose depots have a key role in maintaining energy balance, thereby promoting survival in response to metabolic challenges such as cold exposure and starvation. Recently, there has been renewed interest in the specific central neuronal circuits that regulate adipose depots. Here, we review anatomical, genetic and pharmacological studies on the neural regulation of adipose function, including lipolysis, non-shivering thermogenesis, browning and leptin secretion. In particular, we emphasize the role of leptin-sensitive neurons and the sympathetic nervous system in modulating the activity of brown, white and beige adipose tissues. We provide an overview of advances in the understanding of the heterogeneity of the brain regulation of adipose tissues and offer a perspective on the challenges and paradoxes that the community is facing regarding the actions of leptin on this system.

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Cited by

Sorted by citations

Authors
Caron, A., Lee, S., Elmquist, J. K., & Gautron, L.
Affiliations
The University of Texas Southwestern Medical Center (US)
Corresponding author
  • Elmquist, Joel K.
  • Gautron, Laurent
ORCID
Venue
Nature Reviews Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2018-02-16
Volume
19
Issue
3
Pages
153-165
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
DOI
10.1038/nrn.2018.7
PMC
PMC5962962
OpenAlex
W2788781113
Cited by
284
References
17
Citations by year
2026: 31 · 2025: 30 · 2024: 34 · 2023: 47 · 2022: 40 · 2021: 35 · 2020: 36 · 2019: 25 · 2018: 6
FWCI
3.60
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Canadian Diabetes Association
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK053301, R37DK053301, R01DK088423, R01DK100659)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
leptin, energy balance, sympathetic nervous system, brown adipose tissue, white adipose tissue, beige adipose tissue, lipolysis, non-shivering thermogenesis, adipose tissue browning, leptin secretion, cold exposure, starvation
MeSH terms
Adipose Tissue, Animals, Brain, Energy Metabolism, Humans, Lipolysis, Neurons, Sympathetic Nervous System, Leptin, Thermogenesis

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