FXR Acetylation Is Normally Dynamically Regulated by p300 and SIRT1 but Constitutively Elevated in Metabolic Disease States

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A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

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Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

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Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors

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Mammalian SIRT1 Represses Forkhead Transcription Factors

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Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

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Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

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Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response

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Farnesoid X receptor is essential for normal glucose homeostasis

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Tip60-Dependent Acetylation of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis

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Bile acids as regulatory molecules

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SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosisPreprint

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SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR

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Nuclear Receptor-Dependent Bile Acid Signaling Is Required for Normal Liver Regeneration

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LXRS AND FXR: The Yin and Yang of Cholesterol and Fat Metabolism

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Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

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FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction

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Metabolic adaptations through the PGC‐1α and SIRT1 pathways

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Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1

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GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1α

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Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXRPreprint

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Sirtuins in Aging and DiseasePreprint

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FXR, a multipurpose nuclear receptor

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Ligand-activated Pregnane X Receptor Interferes with HNF-4 Signaling by Targeting a Common Coactivator PGC-1α

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Functional Inhibitory Cross-talk between Constitutive Androstane Receptor and Hepatic Nuclear Factor-4 in Hepatic Lipid/Glucose Metabolism Is Mediated by Competition for Binding to the DR1 Motif and to the Common Coactivators, GRIP-1 and PGC-1α

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FXR: a promising target for the metabolic syndrome?

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Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin–proteasomal degradationPreprint

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Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin–sensitive mechanism in murine and human hepatocytes†

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Chemical genomics: Functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism

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Role of an mSin3A-Swi/Snf Chromatin Remodeling Complex in the Feedback Repression of Bile Acid Biosynthesis by SHP

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PGC-1α Activates CYP7A1 and Bile Acid Biosynthesis

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Coordinated Recruitment of Histone Methyltransferase G9a and Other Chromatin-Modifying Enzymes in SHP-Mediated Regulation of Hepatic Bile Acid Metabolism

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Phosphorylation of Farnesoid X Receptor by Protein Kinase C Promotes Its Transcriptional Activity

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The p300 Acetylase Is Critical for Ligand-activated Farnesoid X Receptor (FXR) Induction of SHP

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Life-Span Extension in Yeast

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Energy Metabolism in the Liver

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The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

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MicroRNAs in metabolism and metabolic disorders

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SIRT1 and other sirtuins in metabolism

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Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease

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Dynamic Deacetylation

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SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR

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The p300 Acetylase Is Critical for Ligand-activated Farnesoid X Receptor (FXR) Induction of SHP

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Gene selective regulation by hepatic Farnesoid x receptor (fxr) in health and disease

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Article A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity

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