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Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice
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“Moreover, stem cells from these progeroid mice are particularly sensitive to the accumulation of mtDNA mutations (Ahlqvist et al., 2012) (see also the section on Stem Cell Exhaustion).”
From The Hallmarks of Aging (2013) · cites this paper as Ahlqvist et al., 2012
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Premature ageing in mice expressing defective mitochondrial DNA polymerase
Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734
Self-citationFoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress
Tothova, Z., Kollipara, R., Huntly, B. J., Lee, B. H., Castrillon, D. H., Cullen, D. E., McDowell, E. P., Lazo-Kallanian, S., Williams, I. R., Sears, C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.01.003 · Cited by 1,562
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
Ito, K., Hirao, A., Arai, F., Matsuoka, S., Takubo, K., Hamaguchi, I., Nomiyama, K., Hosokawa, K., Sakurada, K., Nakagata, N., et al. (2004) · Nature · doi:10.1038/nature02989 · Cited by 1,175 · cited 5×
“The progressive bone marrow failure of these mice was associated with elevated reactive oxygen species (ROS), and the HSC defect could be reversed by treating the animals with n-acetyl-Lcysteine (NAC), a compound with antioxidant capacity and an effect on redox balance (Ito et al., 2004).”
BackgroundResultInfluentialDeficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
Rossi, D. J., Bryder, D., Seita, J., Nussenzweig, A., Hoeijmakers, J., & Weissman, I. L. (2007) · Nature · doi:10.1038/nature05862 · Cited by 1,115
Spelbrink, J. N., Li, F.-Y., Tiranti, V., Nikali, K., Yuan, Q.-P., Tariq, M., Wanrooij, S., Garrido, N., Comi, G., Morandi, L., et al. (2001) · Nature Genetics · doi:10.1038/90058 · Cited by 882
Unraveling the biological roles of reactive oxygen species
Murphy, M. P., Holmgren, A., Larsson, N.-G., Halliwell, B., Chang, C. J., Kalyanaraman, B., Rhee, S. G., Thornalley, P. J., Partridge, L., Gems, D., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.010 · Cited by 836
Self-citationDNA repair is limiting for haematopoietic stem cells during ageing
Nijnik, A., Woodbine, L., Marchetti, C., Dawson, S., Lambe, T., Liu, C., Rodrigues, N. P., Crockford, T. L., Cabuy, E., Vindigni, A., et al. (2007) · Nature · doi:10.1038/nature05875 · Cited by 518
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
Wong, K.-K., Maser, R. S., Bachoo, R. M., Menon, J., Carrasco, D. R., Gu, Y., Alt, F. W., & DePinho, R. A. (2003) · Nature · doi:10.1038/nature01385 · Cited by 375
Tyynismaa, H., Mjosund, K. P., Wanrooij, S., Lappalainen, I., Ylikallio, E., Jalanko, A., Spelbrink, J. N., Paetau, A., & Suomalainen, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505551102 · Cited by 342
Blackmore, D. G., Golmohammadi, M. G., Large, B., Waters, M. J., & Rietze, R. L. (2009) · Stem Cells · doi:10.1002/stem.120 · Cited by 119
Research works printed but not linked: 37
- Ameur, 2011, Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins, PLoS Genet., 7, e1002028, 10.1371/journal.pgen.1002028 · DOI · Paper page
- Arai, 2004, Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche, Cell, 118, 149, 10.1016/j.cell.2004.07.004 · DOI
- Baker, 2011, Endurance exercise training promotes medullary hematopoiesis, FASEB J., 25, 4348, 10.1096/fj.11-189043 · DOI
- Barlow, 1996, Atm-deficient mice: a paradigm of ataxia telangiectasia, Cell, 86, 159, 10.1016/S0092-8674(00)80086-0 · DOI
- Chen, 2009, Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction, Blood, 114, 4045, 10.1182/blood-2008-08-169474 · DOI
- Dai, 2010, Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria, Aging Cell, 9, 536, 10.1111/j.1474-9726.2010.00581.x · DOI · Paper page
- de Boer, 2002, Premature aging in mice deficient in DNA repair and transcription, Science, 296, 1276, 10.1126/science.1070174 · DOI · Paper page
- De Flora, 1995, Chemopreventive properties and mechanisms of N-acetylcysteine. The experimental background, J. Cell. Biochem. Suppl., 22, 33, 10.1002/jcb.240590806 · DOI
- Ema, 2000, Expansion of hematopoietic stem cells in the developing liver of a mouse embryo, Blood, 95, 2284, 10.1182/blood.V95.7.2284 · DOI
- Frappart, 2005, An essential function for NBS1 in the prevention of ataxia and cerebellar defects, Nat. Med., 11, 538, 10.1038/nm1228 · DOI
- Gu, 1997, Growth retardation and leaky SCID phenotype of Ku70-deficient mice, Immunity, 7, 653, 10.1016/S1074-7613(00)80386-6 · DOI
- Hamanaka, 2010, Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes, Trends Biochem. Sci., 35, 505, 10.1016/j.tibs.2010.04.002 · DOI · Paper page
- Korhonen, 2004, Reconstitution of a minimal mtDNA replisome in vitro, EMBO J., 23, 2423, 10.1038/sj.emboj.7600257 · DOI
- Kujoth, 2005, Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging, Science, 309, 481, 10.1126/science.1112125 · DOI · Paper page
- Le Belle, 2011, Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner, Cell Stem Cell, 8, 59, 10.1016/j.stem.2010.11.028 · DOI · Paper page
- Miller, 2009, Home at last: neural stem cell niches defined, Cell Stem Cell, 4, 507, 10.1016/j.stem.2009.05.008 · DOI
- Narasimhaiah, 2005, Oxidative damage and defective DNA repair is linked to apoptosis of migrating neurons and progenitors during cerebral cortex development in Ku70-deficient mice, Cereb. Cortex, 15, 696, 10.1093/cercor/bhh171 · DOI
- Norddahl, 2011, Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging, Cell Stem Cell, 8, 499, 10.1016/j.stem.2011.03.009 · DOI · Paper page
- Piltti, 2006, E6/E7 oncogenes increase and tumor suppressors decrease the proportion of self-renewing neural progenitor cells, Oncogene, 25, 4880, 10.1038/sj.onc.1209492 · DOI
- Ross, 2010, High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio, Proc. Natl. Acad. Sci. USA, 107, 20087, 10.1073/pnas.1008189107 · DOI · Paper page
- Safdar, 2011, Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice, Proc. Natl. Acad. Sci. USA, 108, 4135, 10.1073/pnas.1019581108 · DOI · Paper page
- Schlessinger, 2001, Does functional depletion of stem cells drive aging?, Mech. Ageing Dev., 122, 1537, 10.1016/S0047-6374(01)00299-8 · DOI
- Shao, 2011, Reactive oxygen species and hematopoietic stem cell senescence, Int. J. Hematol., 94, 24, 10.1007/s12185-011-0872-1 · DOI
- Sharpless, 2007, How stem cells age and why this makes us grow old, Nat. Rev. Mol. Cell Biol., 8, 703, 10.1038/nrm2241 · DOI · Paper page
- Shefer, 2010, Reduced satellite cell numbers and myogenic capacity in aging can be alleviated by endurance exercise, PLoS ONE, 5, e13307, 10.1371/journal.pone.0013307 · DOI
- Sorensen, 2001, Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice, J. Neurosci., 21, 8082, 10.1523/JNEUROSCI.21-20-08082.2001 · DOI · Paper page
- Suh, 2009, Signaling in adult neurogenesis, Annu. Rev. Cell Dev. Biol., 25, 253, 10.1146/annurev.cellbio.042308.113256 · DOI
- Suomalainen, 2010, Mitochondrial DNA depletion syndromes—many genes, common mechanisms, Neuromuscul. Disord., 20, 429, 10.1016/j.nmd.2010.03.017 · DOI
- Suomalainen, 1992, Multiple deletions of mitochondrial DNA in several tissues of a patient with severe retarded depression and familial progressive external ophthalmoplegia, J. Clin. Invest., 90, 61, 10.1172/JCI115856 · DOI
- Trifunovic, 2005, Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production, Proc. Natl. Acad. Sci. USA, 102, 17993, 10.1073/pnas.0508886102 · DOI · Paper page
- Tyynismaa, 2010, Mitochondrial myopathy induces a starvation-like response, Hum. Mol. Genet., 19, 3948, 10.1093/hmg/ddq310 · DOI · Paper page
- Vermulst, 2008, DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice, Nat. Genet., 40, 392, 10.1038/ng.95 · DOI · Paper page
- Weissman, 2007, DNA repair, mitochondria, and neurodegeneration, Neuroscience, 145, 1318, 10.1016/j.neuroscience.2006.08.061 · DOI
- Williams, 2010, The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers, Cell Metab., 12, 675, 10.1016/j.cmet.2010.11.012 · DOI · Paper page
- Wu, 2008, Exercise enhances the proliferation of neural stem cells and neurite growth and survival of neuronal progenitor cells in dentate gyrus of middle-aged mice, J. Appl. Physiol., 105, 1585, 10.1152/japplphysiol.90775.2008 · DOI
- Ylikallio, 2010, High mitochondrial DNA copy number has detrimental effects in mice, Hum. Mol. Genet., 19, 2695, 10.1093/hmg/ddq163 · DOI
- Yoneyama, 2010, Endogenous reactive oxygen species are essential for proliferation of neural stem/progenitor cells, Neurochem. Int., 56, 740, 10.1016/j.neuint.2009.11.018 · DOI
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Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931
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Metadata
- Authors
- Ahlqvist, K. J., Hämäläinen, R. H., Yatsuga, S., Uutela, M., Terzioglu, M., Götz, A., Forsström, S., Salven, P., Angers-Loustau, A., Kopra, O. H., Tyynismaa, H., Larsson, N.-G., Wartiovaara, K., Prolla, T., Trifunovic, A., & Suomalainen, A.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 15
- Issue
- 1
- Pages
- 100-109
- ISSN
- 1550-4131
- Cited by
- 221
- References
- 10
- Language
- en
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- The paper
- Ahlqvist, K. J., Hämäläinen, R. H., Yatsuga, S., Uutela, M., Terzioglu, M., Götz, A., Forsström, S., Salven, P., Angers-Loustau, A., Kopra, O. H., Tyynismaa, H., Larsson, N.-G., Wartiovaara, K., Prolla, T., Trifunovic, A., & Suomalainen, A. (2012). Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice. Cell Metabolism. https://doi.org/10.1016/j.cmet.2011.11.012