Cited by 154Genetics, Aging, and Longevity in Model OrganismsNeuroscience and Neuropharmacology ResearchNeurobiology and Insect Physiology Research

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Functional Aging in the Nervous System Contributes to Age-Dependent Motor Activity Decline in C. elegans

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Liu, Jie, Zhang, Bi, Lei, Haoyun, Feng, Zhaoyang, Liu, Jianfeng, Hsu, Ao-Lin, Xu, X.Z. Shawn·2013·Cell Metabolism

DOI 10.1016/j.cmet.2013.08.007PMC PMC3811915

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Abstract

Aging is characterized by a progressive decline in multiple physiological functions (i.e., functional aging). As animals age, they exhibit a gradual loss in motor activity, but the underlying mechanisms remain unclear. Here we approach this question in C. elegans by functionally characterizing its aging nervous system and muscles. We find that motor neurons exhibit a progressive functional decline, beginning in early life. Surprisingly, body-wall muscles, which were previously thought to undergo functional aging, do not manifest such a decline until mid-late life. Notably, motor neurons first develop a deficit in synaptic vesicle fusion followed by that in quantal size and vesicle docking/priming, revealing specific functional deteriorations in synaptic transmission. Pharmacological stimulation of synaptic transmission can improve motor activity in aged animals. These results uncover a critical role for the nervous system in age-dependent motor activity decline in C. elegans and provide insights into how functional aging occurs in this organism.

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Authors: Liu, J., Zhang, B., Lei, H., Feng, Z., Liu, J., Hsu, A.-L., & Xu, X. Z. S.
Affiliations: University of Michigan (US)
Case Western Reserve University (US)
Corresponding author: Xu, X.Z. Shawn
ORCID: Liu, Jie
Zhang, Bi
Lei, Haoyun
Feng, Zhaoyang
Liu, Jianfeng
Hsu, Ao-Lin
Xu, X.Z. Shawn
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2013-09
Volume: 18
Issue: 3
Pages: 392-402
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2013.08.007
PMC: PMC3811915
OpenAlex: W2056724437
Cited by: 154
References: 30
Citations by year: 2026: 7 · 2025: 16 · 2024: 20 · 2023: 8 · 2022: 11 · 2021: 10 · 2020: 15 · 2019: 13 · 2018: 10 · 2017: 7 · 2016: 14 · 2015: 12 · 2014: 7 · 2013: 3
FWCI: 4.26
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 367 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences
National Natural Science Foundation of China (31130028, 31225011)
Ministry of Education of the People's Republic of China (B08029)
Ministry of Science and Technology of the People's Republic of China (2012CB51800)
National Institute on Aging
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords: functional aging, motor neurons, body wall muscle, synaptic vesicle fusion, quantal size, synaptic transmission, Caenorhabditis elegans
MeSH terms: Acetylcholine, Aging, Animals, gamma-Aminobutyric Acid, Motor Activity, Mutation, Nervous System, Synaptic Transmission, Neurons, Receptor, Insulin, Caenorhabditis elegans, Caenorhabditis elegans Proteins

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Functional Aging in the Nervous System Contributes to Age-Dependent Motor Activity Decline in C. elegans

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