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Type 2 Diabetes and Congenital Hyperinsulinism Cause DNA Double-Strand Breaks and p53 Activity in β Cells
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“Many studies have suggested that activated p53 induces the death of pancreatic β-cells in response to increased free fatty acid levels and oxidative stress.275–277”
From p53: from understanding its structure to advances in therapeutic targeting (2026) · cites this paper as [276]
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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
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Glucolipotoxicity: fuel excess and β-cell dysfunction
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Recovery from diabetes in mice by β cell regeneration
Nir, T., Melton, D. A., & Dor, Y. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32959 · Cited by 595
Self-citationInactivation of specific β cell transcription factors in type 2 diabetes
Guo, S., Dai, C., Guo, M., Taylor, B., Harmon, J. S., Sander, M., Robertson, R. P., Powers, A. C., & Stein, R. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65390 · Cited by 520
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Weir, G. C., Laybutt, D. R., Kaneto, H., Bonner-Weir, S., & Sharma, A. (2001) · Diabetes · doi:10.2337/diabetes.50.2007.s154 · Cited by 462
Marselli, L., Thorne, J., Dahiya, S., Sgroi, D. C., Sharma, A., Bonner-Weir, S., Marchetti, P., & Weir, G. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011499 · Cited by 313
Oxidatively generated complex DNA damage: Tandem and clustered lesions
Cadet, J., Ravanat, J.-L., TavernaPorro, M., Menoni, H., & Angelov, D. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.04.005 · Cited by 233 · cited 1×
“Oxidative stress was previously shown to cause doublestrand DNA breaks (Cadet et al., 2012).”
Backgroundβ-cell failure as a complication of diabetes
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Cited by
Lacroix, M., Riscal, R., Arena, G., Linares, L. K., & Le Cam, L. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2019.10.002 · Cited by 373
DNA damage response and metabolic disease
Shimizu, I., Yoshida, Y., Suda, M., & Minamino, T. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.10.008 · Cited by 286
The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes
Belgardt, B.-F., Ahmed, K., Spranger, M., Latreille, M., Denzler, R., Kondratiuk, N., von Meyenn, F., Villena, F. N., Herrmanns, K., Bosco, D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3862 · Cited by 278
Perspective on the Genetics and Diagnosis of Congenital Hyperinsulinism Disorders
Stanley, C. A. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3651 · Cited by 239
Self-citationβ Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance
Aguayo-Mazzucato, C., van Haaren, M., Mruk, M., Lee, T. B., Crawford, C., Hollister-Lock, J., Sullivan, B. A., Johnson, J. W., Ebrahimi, A., Dreyfuss, J. M., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.015 · Cited by 198
Metadata
- Authors
- Tornovsky-Babeay, S., Dadon, D., Ziv, O., Tzipilevich, E., Kadosh, T., Schyr-Ben Haroush, R., Hija, A., Stolovich-Rain, M., Furth-Lavi, J., Granot, Z., Porat, S., Philipson, L. H., Herold, K. C., Bhatti, T. R., Stanley, C., Ashcroft, F. M., In’t Veld, P., Saada, A., Magnuson, M. A., Glaser, B., & Dor, Y.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 19
- Issue
- 1
- Pages
- 109-121
- ISSN
- 1550-4131
- Cited by
- 141
- References
- 11
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 371 d)
- Funders
- United States Agency for International Development
- Israeli Centers for Research Excellence
- Juvenile Diabetes Research Foundation United States of America
- European Research Council
- Israel Science Foundation (41.11)
- Novo Nordisk
- Seventh Framework Programme (241883)
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- Tornovsky-Babeay, S., Dadon, D., Ziv, O., Tzipilevich, E., Kadosh, T., Schyr-Ben Haroush, R., Hija, A., Stolovich-Rain, M., Furth-Lavi, J., Granot, Z., Porat, S., Philipson, L. H., Herold, K. C., Bhatti, T. R., Stanley, C., Ashcroft, F. M., In’t Veld, P., Saada, A., Magnuson, M. A., . . . Dor, Y. (2014). Type 2 Diabetes and Congenital Hyperinsulinism Cause DNA Double-Strand Breaks and p53 Activity in β Cells. Cell Metabolism. https://doi.org/10.1016/j.cmet.2013.11.007
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