The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice
Open accessAbstract
The fundamental questions of what represents a macronutritionally balanced diet and how this maintains health and longevity remain unanswered. Here, the Geometric Framework, a state-space nutritional modeling method, was used to measure interactive effects of dietary energy, protein, fat, and carbohydrate on food intake, cardiometabolic phenotype, and longevity in mice fed one of 25 diets ad libitum. Food intake was regulated primarily by protein and carbohydrate content. Longevity and health were optimized when protein was replaced with carbohydrate to limit compensatory feeding for protein and suppress protein intake. These consequences are associated with hepatic mammalian target of rapamycin (mTOR) activation and mitochondrial function and, in turn, related to circulating branched-chain amino acids and glucose. Calorie restriction achieved by high-protein diets or dietary dilution had no beneficial effects on lifespan. The results suggest that longevity can be extended in ad libitum-fed animals by manipulating the ratio of macronutrients to inhibit mTOR activation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Although density is only a rough proxy for fitness, our results are consistent with laboratory experiments, which demonstrated that generalists pay the cost of relying on unbalanced diets, suffering either high mortality rates and disease risk52,53 or low reproductive outputs12.”
From Nutritional ecology of a prototypical generalist predator, the red fox (Vulpes vulpes) (2024) · cites this paper as [53]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Several studies have shown that restriction of protein or specific restriction of either methionine or one or more of the branched-chain amino acids (BCAAs; leucine, isoleucine, and valine) reduces mTORC1 activity and extends lifespan in preclinical species 24,150–152.”
From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [24]
Experimental — accuracy not yet measuredIn the citing paper
“For example, Solon-Biet and colleagues [30] explored the contribution of 25 different diets to the overall health and longevity of over 800 mice.”
From Multi-omics approaches to disease (2017) · cites this paper as [30]
In the citing paper
“The ratio of protein to carbohydrate in the diet was shown to have profound effects on health parameters later in life, offering mechanistic insight into how this is achieved.”
From Multi-omics approaches to disease (2017) · cites this paper as [30]
In the citing paper
“The observation that protein is prioritized and regulated to a specific target suggests that small changes in the proportion of dietary protein can induce large changes in total food and energy intake, a concept termed protein leveraging”
From FGF21 and the physiological regulation of macronutrient preference (2020) · cites this paper as [106]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Generalized Additive Models: An Introduction with R
Wood, S. N. (2017) · doi:10.1201/9781315370279 · Cited by 13,852
Data Analysis Using Regression and Multilevel/Hierarchical Models
Gelman, A., & Hill, J. (2006) · doi:10.1017/cbo9780511790942 · Cited by 13,597
Modeling Survival Data: Extending the Cox Model
Therneau, T. M., & Grambsch, P. M. (2000) · Statistics for Biology and Health · doi:10.1007/978-1-4757-3294-8 · Cited by 8,674
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
Extending Healthy Life Span—From Yeast to Humans
Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023
Wood, S. (2003) · Journal of the Royal Statistical Society Series B (Statistical Methodology) · doi:10.1111/1467-9868.00374 · Cited by 2,580
Generalized Additive Models: An Introduction With R
Anderson‐Cook, C. M. (2007) · Journal of the American Statistical Association · doi:10.1198/jasa.2007.s188 · Cited by 1,632
Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects
Larsen, S., Nielsen, J., Hansen, C. N., Nielsen, L. B., Wibrand, F., Stride, N., Schroder, H. D., Boushel, R., Helge, J. W., Dela, F., et al. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.230185 · Cited by 1,180 · cited 2×
“…Metabolism 19, 418–430, March 4, 2014 ª2014 Elsevier Inc. 423 synthase activity (which is a gold-standard marker of mitochondrial number; Larsen et al., 2012) (Figure S4) while negatively associated with state III and IVo mitochondrial respiration and hydrogen peroxide production,…”
BackgroundLifespan and reproduction in Drosophila : New insights from nutritional geometry
Lee, K. P., Simpson, S. J., Clissold, F. J., Brooks, R., Ballard, J. W. O., Taylor, P. W., Soran, N., & Raubenheimer, D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710787105 · Cited by 1,032
Self-citation
Cited by
Sorted by citations
Items 501–600 of 902
Kondo, Y., Aoki, H., Masuda, M., Nishi, H., Noda, Y., Hakuno, F., Takahashi, S., Chiba, T., & Ishigami, A. (2023) · GeroScience · doi:10.1007/s11357-023-00797-3 · Cited by 14
Quantification of healthspan in aging mice: introducing FAMY and GRAIL
Lamming, D. W. (2024) · GeroScience · doi:10.1007/s11357-024-01200-5 · Cited by 13
Lifelong dietary protein restriction induces denervation and skeletal muscle atrophy in mice
Ersoy, U., Altinpinar, A. E., Kanakis, I., Alameddine, M., Gioran, A., Chondrogianni, N., Ozanne, S. E., Peffers, M. J., Jackson, M. J., Goljanek‐Whysall, K., et al. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.09.005 · Cited by 14
Russo, L., Babboni, S., Andreassi, M. G., Daher, J., Canale, P., Turco, S. D., & Basta, G. (2025) · Antioxidants · doi:10.3390/antiox14010099 · Cited by 16
Age-associated molecular changes are deleterious and may modulate life span through diet
Lee, S., Kaya, A., Avanesov, A. S., Podolskiy, D. I., Song, E. J., Go, D., Jin, G.-D., Hwang, J. Y., Kim, E. B., Kim, D.-Y., et al. (2017) · Science Advances · doi:10.1126/sciadv.1601833 · Cited by 14
Semaniuk, U. V., Feden'ko, K. M., Yurkevych, I. S., Storey, K. B., Simpson, S. J., & Lushchak, O. V. (2018) · Entomologia Experimentalis et Applicata · doi:10.1111/eea.12643 · Cited by 15
Self-citationForbey, J. S., Liu, R., Caughlin, T. T., Matocq, M. D., Vucetich, J. A., Kohl, K. D., Dearing, M. D., & Felton, A. M. (2018) · animal · doi:10.1017/s1751731118002264 · Cited by 15
Zapata, R. C., Singh, A., Pezeshki, A., & Chelikani, P. K. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.12.006 · Cited by 14
Different duck products protein on rat physiology and gut microbiota
Wei, T., Dang, Y., Cao, J., Wu, Z. F., He, J., Sun, Y., Pan, D., & Tian, Z. (2019) · Journal of Proteomics · doi:10.1016/j.jprot.2019.103436 · Cited by 14
Fotheringham, A. K., Solon‐Biet, S. M., Bielefeldt‐Ohmann, H., McCarthy, D. A., McMahon, A. C., Ruohonen, K., Li, I., Sullivan, M. A., Whiddett, R. O., Borg, D. J., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103308 · Cited by 14
Self-citationDesai, J., Patel, B., Darji, B., Gite, A., Panchal, N., Bhosale, G., Shedage, S. A., Patel, S., Kadam, P., Patel, G., et al. (2021) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2021.128421 · Cited by 14
Effects of dietary macronutrients on the hepatic transcriptome and serum metabolome in mice
Wu, Y., Green, C. L., Wang, G., Yang, D., Li, L., Li, B., Wang, L., Li, M., Li, J., Xu, Y., et al. (2022) · Aging Cell · doi:10.1111/acel.13585 · Cited by 13
Food for healthier aging: power on your plate
Mafra, D., Ugochukwu, S. A., Borges, N. A., Cardozo, L., Stenvinkel, P., & Shiels, P. G. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2107611 · Cited by 15
Reátegui‐Zirena, E. G., & Salice, C. J. (2018) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4202 · Cited by 14
Periodized low protein-high carbohydrate diet confers potent, but transient, metabolic improvements
Li, Z., Rasmussen, M. L., Li, J., Henríquez‐Olguín, C., Knudsen, J. R., Madsen, A. B., Sanchez-Quant, E., Kleinert, M., & Jensen, T. E. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.08.008 · Cited by 15
Wali, J. A., Koay, Y. C., Chami, J., Wood, C. L., Corcilius, L., Payne, R. J., Rodionov, R. N., Birkenfeld, A. L., Samocha‐Bonet, D., Simpson, S. J., et al. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00207.2020 · Cited by 14
Self-citationMorimoto, J., Conceição, P., Mirth, C. K., & Lihoreau, M. (2022) · The American Naturalist · doi:10.1086/723599 · Cited by 13
The importance of reaction norms in dietary restriction and ageing research
Simons, M. J. P., & Dobson, A. J. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101926 · Cited by 13
Dietary habits in elite soccer players
Petri, C., Mascherini, G., Pengue, L., & Galanti, G. (2016) · Sport Sciences for Health · doi:10.1007/s11332-016-0264-2 · Cited by 13
Zaini, M. A., Müller, C., Ackermann, T., Reinshagen, J., Kortman, G., Pleß, O., & Calkhoven, C. F. (2017) · Scientific Reports · doi:10.1038/srep42603 · Cited by 14
Bajracharya, R., & Ballard, J. W. O. (2018) · Fly · doi:10.1080/19336934.2018.1482139 · Cited by 13
Self-citationHuang, T., Shih, Y., Lin, S.-C., & Hsueh, Y. (2020) · iScience · doi:10.1016/j.isci.2020.101949 · Cited by 12
A “Gut Feeling” to Create a 10th Hallmark of Aging
Carter, C. S. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab191 · Cited by 15
Hawkes, M. F., Lane, S., Rapkin, J., Jensen, K., House, C. M., Sakaluk, S. K., & Hunt, J. (2021) · Functional Ecology · doi:10.1111/1365-2435.13995 · Cited by 14
Fibroblast growth factor 21 and dietary macronutrient intake in female mice
Wu, C.-T., Larson, K. R., Goodson, M. L., & Ryan, K. K. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113995 · Cited by 13
Long-Term Low Carbohydrate Diet Leads to Deleterious Metabolic Manifestations in Diabetic Mice
Handa, K., Inukai, K., Onuma, H., Kudo, A., Nakagawa, F., Tsugawa, K., Kitahara, A., Moriya, R., Takahashi, K., Sumitani, Y., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104948 · Cited by 13
Intergenerational effects of nutrition on immunity: a systematic review and meta‐analysis
Grueber, C. E., Gray, L. J., Morris, K., Simpson, S. J., & Senior, A. M. (2017) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12387 · Cited by 14
Self-citationEarly life diet conditions the molecular response to post-weaning protein restriction in the mouse
Danson, A. F., Marzi, S. J., Lowe, R., Holland, M. L., & Rakyan, V. K. (2018) · BMC Biology · doi:10.1186/s12915-018-0516-5 · Cited by 14
Modulation of frailty syndrome by diet: A review of evidence from mouse studies
Mitchell, S. J., Mitchell, G. J., & Mitchell, J. R. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.04.003 · Cited by 11
Nutritional geometry of mitochondrial genetic effects on male fertility
Camus, M., Moore, J., & Reuter, M. (2020) · Biology Letters · doi:10.1098/rsbl.2019.0891 · Cited by 13
Divergence of Drosophila species: Longevity and reproduction under different nutrient balances
Watada, M., Hayashi, Y., Watanabe, K., Mizutani, S., Mure, A., Hattori, Y., & Uemura, T. (2020) · Genes to Cells · doi:10.1111/gtc.12798 · Cited by 13
Effect of nighttime light exposure on glucose metabolism in protein-restricted mice
Borck, P. C., Rickli, S., Vettorazzi, J. F., Batista, T. M., Boschero, A. C., Vieira, E., & Carneiro, E. M. (2021) · Journal of Endocrinology · doi:10.1530/joe-21-0133 · Cited by 13
Protein Restriction in Metabolic Health: Lessons from Rodent Models
Na, K., & Park, Y. J. (2024) · Nutrients · doi:10.3390/nu16020229 · Cited by 12
Richter, M. M., Thomsen, M. N., Skytte, M. J., Kjeldsen, S. A. S., Samkani, A., Frystyk, J., Magkos, F., Holst, J. J., Madsbad, S., Krarup, T., et al. (2024) · Journal of the Endocrine Society · doi:10.1210/jendso/bvae008 · Cited by 13
Strilbytska, O. M., Yurkevych, I. S., Semaniuk, U. V., Gospodaryov, D. V., Simpson, S. J., & Lushchak, O. V. (2024) · The Journals of Gerontology Series A · doi:10.1093/gerona/glae057 · Cited by 15
Self-citationKim, S. Q., Spann, R. A., Khan, M. S. H., Berthoud, H., Münzberg, H., Albaugh, V. L., He, Y., McDougal, D. H., Soto, P. L., Yu, S., et al. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110010 · Cited by 10
The Geometric Framework for Nutrition and Its Application to Rodent Models
Senior, A. M., Raubenheimer, D., Couteur, D. G. L., & Simpson, S. J. (2024) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-111523-102327 · Cited by 12
Self-citationHew, J. J., Parungao, R., Tsai, K. H. ‐., Shi, H., Ma, D., Nicholls, C. M., Li, Z., Solon‐Biet, S. M., D'Souza, M. I., Couteur, D. G. L., et al. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520000276 · Cited by 12
Self-citationEffects of dietary macronutrients and body composition on glucose homeostasis in mice
Hu, S., Togo, J., Wang, L., Wu, Y., Yang, D., Xu, Y., Li, L., Li, B., Li, M., Li, J., et al. (2020) · National Science Review · doi:10.1093/nsr/nwaa177 · Cited by 12
Gall, M. L., Word, M. L., Beye, A., & Cease, A. (2020) · Current Research in Insect Science · doi:10.1016/j.cris.2020.100004 · Cited by 13
Torres, F., Khan, M. S. H., Fernandez‐Kim, S. O., Spann, R. A., Albarado, D. C., Wagner, T. J., Morrison, C. D., & Soto, P. L. (2022) · Journal of the Experimental Analysis of Behavior · doi:10.1002/jeab.745 · Cited by 13
Dietary interventions and molecular mechanisms for healthy musculoskeletal aging
Murphy, A. W., Vyavahare, S. S., Kumar, S., Lee, T. J., Sharma, A. K., Adusumilli, S., Hamrick, M. W., Isales, C. M., & Fulzele, S. (2022) · Biogerontology · doi:10.1007/s10522-022-09970-1 · Cited by 13
The effects of macronutrients metabolism on cellular and organismal aging
Nehme, J., Altulea, A., Gheorghe, T., & Demaria, M. (2023) · Biomedical Journal · doi:10.1016/j.bj.2023.02.005 · Cited by 13
Nutrition and energetics in rodent longevity research
Gibbs, V. K., & Smith, D. L. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.04.004 · Cited by 14
90th Anniversary Commentary: Caloric Restriction Effects on Aging
Couteur, D. G. L., & Simpson, S. J. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy146 · Cited by 11
Self-citationDiet composition, adherence to calorie restriction, and cardiometabolic disease risk modification
Das, S. K., Silver, R. E., Senior, A., Gilhooly, C. H., Bhapkar, M., & Le Couteur, D. (2023) · Aging Cell · doi:10.1111/acel.14018 · Cited by 11
Wu, Q., E, S., Yamamoto, K., & Tsuduki, T. (2019) · Biogerontology · doi:10.1007/s10522-018-9777-1 · Cited by 11
RetractedYin, J., Zhang, M., Jiang, W., Huang, X., & Yin, Y. (2025) · Research · doi:10.34133/research.0904 · Cited by 15
Self-citationKang, K., Cai, Y., Yue, L., & Zhang, W. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.794721 · Cited by 14
Maternal macronutrient intake effects on offspring macronutrient targets and metabolism
Freire, T., Clark, X., Pulpitel, T., Bell-Anderson, K. S., Ribeiro, R. V., Raubenheimer, D., Crean, A. J., Simpson, S. J., & Solon‐Biet, S. M. (2024) · Obesity · doi:10.1002/oby.23995 · Cited by 11
Self-citationSmith, D. L., Mitchell, S. E., Johnson, M. S., Gibbs, V. K., Dickinson, S., Henschel, B., Li, R., Kaiser, K. A., Chusyd, D. E., Brown, A. W., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01166-4 · Cited by 12
Winardi, K., Mach, J., McKay, M. J., Molloy, M. P., Mitchell, S. J., MacArthur, M. R., McKenzie, C. A., Couteur, D. G. L., & Hilmer, S. N. (2024) · Aging Cell · doi:10.1111/acel.14357 · Cited by 11
Macronutrient interactions and models of obesity: Insights from nutritional geometry
Wali, J. A., Ni, D., Raubenheimer, D., & Simpson, S. J. (2024) · BioEssays · doi:10.1002/bies.202400071 · Cited by 11
Self-citationDNA methylation extends lifespan in the bumblebee Bombus terrestris
Renard, T., Martinet, B., Araujo, N. D. S., & Aron, S. (2023) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2023.2093 · Cited by 11
Wilder, S. M., Yuan, L., Roumilhac, C., LeGal, A., Raubenheimer, D., Simpson, S. J., & McAllan, B. M. (2016) · Journal of Mammalogy · doi:10.1093/jmammal/gyw130 · Cited by 11
Self-citationDrosophila mitotypes determine developmental time in a diet and temperature dependent manner
Towarnicki, S. G., & Ballard, J. W. O. (2017) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2017.06.002 · Cited by 12
Self-citationResponse of Liver Metabolic Pathways to Ketogenic Diet and Exercise Are Not Additive
Huang, T.-Y., Goldsmith, F., Fuller, S. E., Simon, J., Batdorf, H. M., Scott, M. C., Essajee, N. M., BROWN, J. M., Burk, D. H., Morrison, C. D., et al. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002105 · Cited by 11
The Mechanism of Programmed Aging: The Way to Create a Real Remedy for Senescence
Trubitsyn, A. G. (2019) · Current Aging Science · doi:10.2174/1874609812666191014111422 · Cited by 14
Macro-Nutritional Adaptive Strategies of Moose (Alces alces) Related to Population Density
Ma, Y., Bao, H., Bencini, R., Raubenheimer, D., Dou, H., Liu, H., Wang, S., & Jiang, G. (2019) · Animals · doi:10.3390/ani10010073 · Cited by 11
Self-citationPaik, J. K., Park, M., Shin, J. E., Jang, S., & Shin, J.-Y. (2020) · Nutrients · doi:10.3390/nu12113274 · Cited by 13
Goldsmith, J. A., Holman, M. E., Puri, P., Khalil, R. E., Ennasr, A. N., & Gorgey, A. S. (2022) · British Journal Of Nutrition · doi:10.1017/s0007114522001830 · Cited by 11
Feeding on frozen live yeast has some deleterious effects in Drosophila melanogaster
Bourg, É. L., Gauthier, T., & Colinet, H. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.06.019 · Cited by 11
Hennig, M., Ewering, L., Pyschny, S., Shimoyama, S., Olecka, M., Ewald, D., Magarin, M., Uebing, A. S., Thierfelder, L., Jux, C., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-51654-3 · Cited by 11
Diet and Cancer MetabolismPreprint
Locasale, J. W., Goncalves, M. D., Tano, M. D., & Burgos-Barragan, G. (2024) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041549 · Cited by 12
Circadian clock and temporal meal pattern
Li, X., & Sun, Z. (2022) · Medical Review · doi:10.1515/mr-2022-0021 · Cited by 10
Janoschek, R., Handwerk, M., Hucklenbruch‐Rother, E., Schmitz, L., Bae‐Gartz, I., Kasper, P., Lackmann, J., Kretschmer, T., Vohlen, C., Mesaros, A., et al. (2023) · Nutrition & Metabolism · doi:10.1186/s12986-023-00729-0 · Cited by 10
Nguyen, V. T. T., Taheri, N., Choi, E. L., Kellogg, T. A., Linden, D. R., & Hayashi, Y. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.06.002 · Cited by 10
Abghari, M., Vu, J. T. C. M., Eckberg, N., Aldana, B. I., & Kohlmeier, K. A. (2023) · Biomolecules · doi:10.3390/biom13101461 · Cited by 12
Chun, D.-W., Kwon, Y., Heo, S., & Lee, J. (2024) · Nutrition · doi:10.1016/j.nut.2024.112360 · Cited by 10
Effects of calorie, protein, and branched chain amino acid restriction on ovarian aging in mice
Veiga, G. B., Zanini, B. M., Garcia, D. N., Hense, J. D., Barreto, M. M., Isola, J. V. V., Mondadori, R. G., Masternak, M. M., Stout, M. B., & Schneider, A. (2024) · Reproductive Biology · doi:10.1016/j.repbio.2024.100856 · Cited by 10
Short-term hypercaloric carbohydrate loading increases surgical stress resilience by inducing FGF21
Agius, T., Emsley, R., Lyon, A., MacArthur, M. R., Kiesworo, K., Faivre, A., Stavart, L., Lambelet, M., Legouis, D., de Seigneux, S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-44866-3 · Cited by 10
Xie, M., Kaiser, M., Gershtein, Y., Schnyder, D., Deviatiiarov, R. M., Gazizova, G. R., Shagimardanova, E. I., Zikmund, T., Kerckhofs, G., Ivashkin, E. G., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46030-3 · Cited by 10
Dargenio, V. N., Sgarro, N., Grasta, G. L., Begucci, M., Castellaneta, S. P., Dargenio, C., Paulucci, L., Francavilla, R., & Cristofori, F. (2025) · Nutrients · doi:10.3390/nu17223601 · Cited by 15
Zandveld, J., van den Heuvel, J., Mulder, M., Brakefield, P. M., Kirkwood, T. B. L., Shanley, D. P., & Zwaan, B. J. (2017) · Evolution · doi:10.1111/evo.13327 · Cited by 10
Evolution, mechanism and limits of dietary restriction induced health benefits & longevity
Becker, F. R., Behrends, M., & Rudolph, K. L. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102725 · Cited by 12
Nutrient intake and its possible drivers in free‐ranging European brown bears (Ursus arctos arctos)
Cuyper, A. D., Strubbe, D., Clauß, M., Lens, L., Zedrosser, A., Steyaert, S. M. J. G., Verbist, L., & Janssens, G. (2023) · Ecology and Evolution · doi:10.1002/ece3.10156 · Cited by 9
Practical prospects for boosting hepatic production of the “pro-longevity” hormone FGF21
McCarty, M. F. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0057 · Cited by 10
Zandveld, J., van den Heuvel, J., Zwaan, B. J., & Piper, M. D. W. (2017) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-017-0004-0 · Cited by 10
Cheng, H. L., Raubenheimer, D., Steinbeck, K. S., Baur, L. A., & Garnett, S. P. (2019) · British Journal Of Nutrition · doi:10.1017/s0007114519001326 · Cited by 11
Self-citationProportions of macronutrients, including specific dietary fats, in prospective anti-Alzheimer’s diet
Studnıckı, M., Dębski, K. J., & Stępkowski, D. (2019) · Scientific Reports · doi:10.1038/s41598-019-56687-2 · Cited by 10
A glucose-supplemented diet enhances gut barrier integrity in Drosophila
Galenza, A., & Foley, E. (2021) · Biology Open · doi:10.1242/bio.056515 · Cited by 15
Responsible biology, aging populations and the 50th anniversary of the “War on Cancer”
Farrelly, C. (2021) · Biogerontology · doi:10.1007/s10522-021-09925-y · Cited by 10
Obesity in C57BL/6J mice fed diets differing in carbohydrate and fat but not energy content
Tordoff, M. G., & Ellis, H. T. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113644 · Cited by 10
Yan, J., Ren, C., Dong, Y., Wali, J. A., Song, H., Zhang, Y., Zhang, H., Kou, G., Raubenheimer, D., & Cui, Z. (2023) · Nutrients · doi:10.3390/nu15010251 · Cited by 12
Self-citationOpen Data for Open Questions in Comparative Nutrition
Morimoto, J., & Lihoreau, M. (2020) · Insects · doi:10.3390/insects11040236 · Cited by 10
Encoding of hunger by the neuronal epigenome slows aging in DrosophilaPreprint
Weaver, K. J., Holt, R., Henry, E., & Pletcher, S. D. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.21.501022 · Cited by 10
Zhou, X., Hao, R., Zhu, X., Tan, X., & Li, D. (2024) · Food Frontiers · doi:10.1002/fft2.379 · Cited by 9
Yin, X., Dai, F., Ran, D., Zhang, Y., Qu, Z., & Zheng, S. (2024) · Aging Cell · doi:10.1111/acel.14286 · Cited by 9
Koemel, N., Senior, A. M., Laouali, N., Celermajer, D., Grech, A., Parker, H. M., Simpson, S., Raubenheimer, D., Gill, T., & Skilton, M. R. (2024) · European Journal of Nutrition · doi:10.1007/s00394-024-03523-7 · Cited by 8
Self-citationDietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice
Trautman, M. E., Green, C. L., MacArthur, M. R., Chaiyakul, K., Alam, Y. H., Yeh, C., Babygirija, R., James, I., Gilpin, M., Zelenovskiy, E., et al. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102248 · Cited by 10
Wernicke, C., Apostolopoulou, K., Hornemann, S., Efthymiou, A., Machann, J., Schmidt, S. H., Primeßnig, U., Bergmann, M. M., Grune, T., Gerbracht, C., et al. (2020) · Medicine · doi:10.1097/md.0000000000022381 · Cited by 11
Hatle, J. D., Awan, A., Nicholas, J., Koch, R. G., Vokrri, J. R., McCue, M. D., Williams, C. M., Davidowitz, G., & Hahn, D. A. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.06.019 · Cited by 9
Low- and high-protein diets do not alter ex vivo insulin action in skeletal muscle
Li, Z., Rasmussen, M. L., Li, J., Henríquez‐Olguín, C., Knudsen, J. R., Søgaard, O. S., Madsen, A. B., & Jensen, T. E. (2018) · Physiological Reports · doi:10.14814/phy2.13798 · Cited by 8
Diet and Nutrition: Implications to Cardiometabolic Health
Johnson, M. (2019) · Journal of Cardiology and Cardiovascular Sciences · doi:10.29245/2578-3025/2019/2.1168 · Cited by 9
The Effects of Cloudberry Fruit Extract on Drosophila melanogaster Lifespan and Stress Resistance
Lashmanova, E., Kuzivanova, O., Васильевна, Д. О., & Moskalev, A. (2019) · Advances in Gerontology · doi:10.1134/s2079057019020127 · Cited by 9
França, L. M., dos Santos, P. C., Barroso, W. A., Gondim, R. S. D., Coêlho, C. F. F., Flister, K. F. T., & Paes, A. M. D. A. (2020) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174420000598 · Cited by 9
Zone-specific damage of the olfactory epithelium under protein restriction
Tuerdi, A., Kikuta, S., Kinoshita, M., Kamogashira, T., Kondo, K., & Yamasoba, T. (2020) · Scientific Reports · doi:10.1038/s41598-020-79249-3 · Cited by 10
Minderis, P., Fokin, A., Dirmontas, M., Kvedaras, M., & Ratkevičius, A. (2021) · Nutrients · doi:10.3390/nu13093004 · Cited by 9
Effects of dietary interventions on telomere dynamics
Ng, G. Y.-Q., Hande, V., Ong, M. H., Wong, B. W.-X., Loh, Z. W.-L., Ho, W. D., Handison, L. B., Tan, I. M.-S. P., Fann, D. Y., Arumugam, T. V., et al. (2022) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2022.503472 · Cited by 11
Wabo, T. M. C., Wang, Y., Nyamao, R. M., Wang, W., & Zhu, S. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.1043035 · Cited by 10
Metadata
- Authors
- Solon-Biet, S. M., McMahon, A. C., Ballard, J. W. O., Ruohonen, K., Wu, L. E., Cogger, V. C., Warren, A., Huang, X., Pichaud, N., Melvin, R. G., Gokarn, R., Khalil, M., Turner, N., Cooney, G. J., Sinclair, D. A., Raubenheimer, D., Le Couteur, D. G., & Simpson, S. J.
- Affiliations
- The University of Sydney (AU)
- UNSW Sydney (AU)
- Ewos Innovation (Norway) (NO)
- University of Helsinki (FI)
- Garvan Institute of Medical Research (AU)
- Harvard University (US)
- Corresponding author
- Simpson, Stephen J.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 19
- Issue
- 3
- Pages
- 418-430
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC5087279
- OpenAlex
- W2042438674
- Cited by
- 904
- References
- 39
- Citations by year
- 2026: 37 · 2025: 47 · 2024: 71 · 2023: 75 · 2022: 82 · 2021: 86 · 2020: 101 · 2019: 86 · 2018: 76 · 2017: 74 · 2016: 68 · 2015: 68 · 2014: 31
- FWCI
- 27.47
- Type
- journal article
- Language
- en
- Update notices
- erratum (2020-03-03)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Research Centre
- Cancer Institute NSW
- Australian Research Council
- National Health and Medical Research Council
- National Medical Research Council
- National Institute on Aging (DP1AG058605, R37AG028730, R01AG028730, R01AG019719)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK100263)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- macronutrient ratio, dietary protein, dietary carbohydrates, dietary fat, ad libitum feeding, longevity, cardiometabolic health, aging, compensatory feeding, mTOR signaling, mitochondrial function, branched-chain amino acids, glucose, food intake regulation, caloric restriction, dietary dilution, geometric framework, mice
- MeSH terms
- Aging, Amino Acids, Branched-Chain, Animals, Blood Pressure, Body Composition, Energy Intake, Cardiovascular Physiological Phenomena, Diet, Glucose, Insulin, Liver, Longevity, Male, Mice, Inbred C57BL, Phosphorylation, Glucose Intolerance, Leptin, Mice, Kaplan-Meier Estimate, TOR Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
