The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Mitochondrial Proteostasis in the Control of Aging and Longevity
Open accessAbstract
Mitochondria play a central role in the aging process. Studies in model organisms have started to integrate mitochondrial effects on aging with the maintenance of protein homeostasis. These findings center on the mitochondrial unfolded protein response (UPRmt), which has been implicated in lifespan extension in worms, flies and mice, suggesting a conserved role for in the long-term maintenance of cellular homeostasis. Here, we review current knowledge of the UPRmt and discuss its integration with cellular pathways known to regulate lifespan. We highlight how insight into the UPRmt is revolutionizing our understanding of mitochondrial lifespan extension and of the aging process.
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Cites
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Cited by
The mitochondrial basis of aging
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Metadata
- Authors
- Jensen, M. B., & Jasper, H.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 20
- Issue
- 2
- Pages
- 214-225
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2007518911
- Cited by
- 161
- References
- 23
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
