The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.
Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling
Open accessAbstract
Dietary lipids may influence the abundance of circulating inflammatory microbial factors. Hence, inflammation in white adipose tissue (WAT) induced by dietary lipids may be partly dependent on their interaction with the gut microbiota. Here, we show that mice fed lard for 11 weeks have increased Toll-like receptor (TLR) activation and WAT inflammation and reduced insulin sensitivity compared with mice fed fish oil and that phenotypic differences between the dietary groups can be partly attributed to differences in microbiota composition. Trif(-/-) and Myd88(-/-) mice are protected against lard-induced WAT inflammation and impaired insulin sensitivity. Experiments in germ-free mice show that an interaction between gut microbiota and saturated lipids promotes WAT inflammation independent of adiposity. Finally, we demonstrate that the chemokine CCL2 contributes to microbiota-induced WAT inflammation in lard-fed mice. These results indicate that gut microbiota exacerbates metabolic inflammation through TLR signaling upon challenge with a diet rich in saturated lipids.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Saturated and unsaturated fats have profoundly different effects on the gut microbiota, and the altered microbiota that results from feeding unsaturated fats can offer protection from lard-induced weight gain44.”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [44]
In the citing paper
“germ-free mice that are fed a high-fat diet with less sucrose are only partly protected against obesity44”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [44]
In the citing paper
“A switch to a diet rich in saturated fatty acids shifts the composition of the microbiota44.”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [44]
In the citing paper
“Similarly, increased levels of Bilophila and a reduced abundance of Desulfovibrio were observed in mice that were fed lard compared with fish oil as a source of fat44.”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [44]
In the citing paper
“Latest data implied that omega-3 PUFAs modulate the intestinal microbiota composition and help normalize it after disrupting environmental stress [166,168].”
From The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders (2021) · cites this paper as [168]
In the citing paper
“In a rodent study, animals fed lard showed increases in Bacteroides and displayed signs of metabolic dysfunction.”
From The athletic gut microbiota (2020) · cites this paper as [229]
In the citing paper
“In contrast, animals fed fish oil showed increased levels of lactic acid bacteria and were protected from metabolic dysfunction [229].”
From The athletic gut microbiota (2020) · cites this paper as [229]
In the citing paper
“The gut microbiota has been shown to differ between mice fed diets that are high or low in fat and between diets that contain equal amounts of fat but from different sources [10–13] (Fig. 1).”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [10]
In the citing paper
“In another study where mice fed a high-fat diet containing lard, rich in saturated fat, were compared to mice fed a isocaloric high-fat diet containing fish oil, rich in n-3 PUFA, it was found that phylogenetic diversity and abundance of the beneficial bacteria Akkermansia muciniphila, Lactobacillus and Bifidobacterium were lower in mice on a lard diet [10].”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [10]
In the citing paper
“Transplantation of cecum microbiota into germ-free (GF) mice showed that the diet-induced differences in host phenotype were partly caused by the gut microbiota.”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [10]
In the citing paper
“The lard diet also reduced insulin sensitivity and increased inflammation in white adipose tissue (WAT) through activation of Toll-like receptor 4 (TLR4) signaling.”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [10]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638
Self-citationInduction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511
Self-citationFunctional interactions between the gut microbiota and host metabolism
Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387
Self-citationInteractions Between the Microbiota and the Immune System
Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690
Kim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061
Kanda, H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26498 · Cited by 2,682
Flagged first, then by citations
1 of the 51 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 401–500 of 960
The Effect of Enteric-Derived Lipopolysaccharides on Obesity
Wang, K., Lai, W., Min, T., Wei, J., Bai, Y., Cao, H., Guo, J., & Su, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084305 · Cited by 38
“Therefore, understanding the targets associated with LPS is essential for preventing and treating LPS-induced diseases [Figure 3, Table 1].”
Dietary Patterns, Gut Microbiota and Sports Performance in Athletes: A Narrative Review
Chen, Y., Yang, K., Xu, M., Zhang, Y., Weng, X., Luo, J., Li, Y., & Mao, Y.-H. (2024) · Nutrients · doi:10.3390/nu16111634 · Cited by 46
Strategies to increase the efficacy of using gut microbiota for the modulation of obesity
Li, J., Rajoka, M. S. R., Shao, D., Jiang, C., Jin, M., Huang, Q., Yang, H., & Shi, J. (2017) · Obesity Reviews · doi:10.1111/obr.12590 · Cited by 37
“However, the effects of fat intake are complicated, and Caesar et al. (2015) reported that saturated lipids in lard diet promoted obesity in mice, but a fish‐oil diet that contains polyunsaturated fatty acids restrained it (30).”
Zhuang, P., Shou, Q., Wang, W., He, L., Wang, J., Chen, J., Zhang, Y., & Jiao, J. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800448 · Cited by 35
Díaz‐Rizzolo, D. A., Kostov, B., López‐Siles, M., Serra, A., Francia, C. C., Paz, L. G., Martínez-Medina, M., Sisó‐Almirall, A., & Gomis, R. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.02.035 · Cited by 36
“In contrast, the OB-5 cluster shows a very high load of lactic acid bacteria, which has been related with a fish-oil rich diet in mice [52] and can be linked to the dietary pattern of this cluster through PUFAu3.”
HSF1 is a driver of leukemia stem cell self-renewal in acute myeloid leukemia
Dong, Q.-Z., Xiu, Y., Wang, Y., Hodgson, C., Borcherding, N., Jordan, C., Buchanan, J. L., Taylor, E., Wagner, B., Leidinger, M. R., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33861-1 · Cited by 31
Estrada, K. B., Sandoval-Cuellar, C. E., Rojas-Muñoz, Y. V., & Quintanilla‐Carvajal, M. X. (2022) · Food & Function · doi:10.1039/d2fo02723b · Cited by 36
Exercise training modifies gut microbiota with attenuated host responses to sepsis in wild‐type mice
Kim, D., & Kang, H. (2019) · The FASEB Journal · doi:10.1096/fj.201802481r · Cited by 34
“Other studies also showedthatexercise training resulted in a significant decrease in the abundance of potentially pathogenic Bacteroidetes such as Bacteroides vulgatus (28) and increases in the abundance of anti-inflammatory and antiobesityVerrucomicrobia, such as Akkermansia muciniphila (29).”
Ye, Z., Chen, C., Li, Q., Xu, Y., & Liu, Y. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109117 · Cited by 34
Yang, X., Zhang, X., Yang, W., Yu, H., He, Q., Xu, H., Li, S., Shang, Z., Gao, X., Wang, Y., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.749125 · Cited by 36
Chang, T., & Chen, J. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s343491 · Cited by 34
“A previous study found that the bacteriumassociated LPS could bind to toll-like receptor-4 and led to increased levels of proinflammatory cytokines.(31) In mice fed a high-fat diet, an enhanced abundance of the Gramnegative S24-7 family was observed, and chronic lowgrade inflammation was prevented with lower levels of…”
Qin, S., Wang, Y., Wang, S., Ning, B., Huai, J., & Yang, H. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.870422 · Cited by 34
“A highfat diet could increase the abundance of lipopolysaccharideproducing (LPS-producing) bacteria in the gut to increase fat deposition, increase body fat, induce excessive fasting blood sugar, and cause inflammation (Cani et al., 2008; Caesar et al., 2015).”
Hui, H., Wang, Z., Zhao, X., Xu, L., Yin, L., Wang, F., Qu, L., & Peng, J. (2023) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2023.08.003 · Cited by 35
Zhang, L., Andersen, D., Roager, H. M., Bahl, M. I., Hansen, C. H. F., Danneskiold‐Samsøe, N. B., Kristiansen, K., Radulescu, I. D., Sina, C., Frandsen, H. L., et al. (2017) · Scientific Reports · doi:10.1038/srep44613 · Cited by 33
“…intestinal bacteria to systemic circulation, mesenteric adipose tissue and mesenteric lymph nodes is known to increase with a high fat diet 44 , and a recent study of lard and fish oil based diets indicates that dietary lipid composition affects toll-like receptor-based activation within eWAT 45 .”
Orsso, C. E., Peng, Y., Deehan, E. C., Tan, Q., Field, C. J., Madsen, K. L., Walter, J., Prado, C. M. M., Tun, H. M., & Haqq, A. M. (2021) · Microorganisms · doi:10.3390/microorganisms9071490 · Cited by 33
“Animal experiments have established an involvement of gut microbiome in weight gain, adiposity, inflammation, and metabolic diseases through the interaction with dietary components [24,25].”
Wang, P., Ma, Y., Wang, D., Zhao, W., Hu, X., Chen, F., & Zhao, X. (2022) · Nutrients · doi:10.3390/nu14101994 · Cited by 33
“The gastrointestinal tract has been considered as a target tissue for the production of circulating inflammation with a HFD [8,27].”
Contribution of the microbiome for better phenotyping of people living with obesity
Ciaula, A. D., Bonfrate, L., Khalil, M., Garruti, G., & Portincasa, P. (2023) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-023-09798-1 · Cited by 40
Host–microbiota interaction induces bi-phasic inflammation and glucose intolerance in mice
Molinaro, A., Caesar, R., Mannerås-Holm, L., Tremaroli, V., Cani, P. D., & Bäckhed, F. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.08.016 · Cited by 33
“…e host interaction on adiposity and glucose metabolism during a period of 28 days after colonization using Swiss Webster mice as a model of mild obesity on chow diet in order to study the effect of microbiota on metabolism in obesity to avoid the pro-in fl ammatory effect of high fat diets [43].”
Self-citationZimmermann, P., Kurth, S., Pugin, B., & Bokulich, N. A. (2024) · npj Biofilms and Microbiomes · doi:10.1038/s41522-024-00605-6 · Cited by 38
Role of the microbiome in the normal and aberrant glycemic response
Suez, J., Shapiro, H., & Elinav, E. (2016) · Clinical Nutrition Experimental · doi:10.1016/j.yclnex.2016.01.001 · Cited by 31
Role of the Microbiome in Mediating Health Effects of Dietary Components
Gong, L., Wen, T., & Wang, J. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b08231 · Cited by 32
Microbiota and cardiovascular disease risk: A scoping review
Scarmozzino, F., Poli, A., & Visioli, F. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104952 · Cited by 32
Bai, Y., Bao, X., Mu, Q., Fang, X., Zhu, R., Liu, C., Mo, F., Zhang, D., Jiang, G., Li, P., et al. (2021) · PeerJ · doi:10.7717/peerj.10598 · Cited by 32
Fatty Acids as a Tool to Boost Cancer Immunotherapy Efficacy
Westheim, A. J. F., Stoffels, L. M., Dubois, L. J., van Bergenhenegouwen, J., van Helvoort, A., LANGEN, R. C. J., Shiri‐Sverdlov, R., & Theys, J. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.868436 · Cited by 37
“Preclinical evidence has shown that n-3 PUFAs, especially EPA and DHA, can modify the gut microbiota composition in several rodent models in a beneficial manner by increasing the intestinal population of Bifidobacteria (76, 77), Akkermansia muciniphila bacteria (77, 78) and Firmicutes bacteria (79).”
Ali, Q., Ma, S., Farooq, U., Niu, J., Li, F., Li, D., Wang, Z., Sun, H., Cui, Y., & Shi, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1041070 · Cited by 33
“These lipopolysaccharides are bacterium-associated molecular patterns, which act via TLR4/MyD88 pathway by promoting the inflammatory response (59).”
Oishi, K., Konishi, T., Hashimoto, C., Yamamoto, S., Takahashi, Y., & Shiina, Y. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.09.024 · Cited by 34
A Metabolite Perspective on the Involvement of the Gut Microbiota in Type 2 Diabetes
Fu, Y., Li, S., Xiao, Y., Liu, G., & Fang, J. Q. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914991 · Cited by 32
Obesity-related asthma and its relationship with microbiota
Huang, J., Zhou, X., Dong, B., Tan, H., Li, Q., Zhang, J., Su, H., & Sun, X. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1303899 · Cited by 34
The Microbiota and Evolution of Obesity
Saad, M. J. A., & Santos, A. (2024) · Endocrine Reviews · doi:10.1210/endrev/bnae033 · Cited by 37
Ambient temperature alters body size and gut microbiota of Xenopus tropicalis
Li, J., Rui, J., Li, Y., Tang, N., Zhan, S., Jiang, J., & Li, X. (2019) · Science China Life Sciences · doi:10.1007/s11427-019-9540-y · Cited by 30
Lopez‐Salazar, V., Sánchez‐Tapia, M., Tobón‐Cornejo, S., Díaz, D., Alemán, G., Granados‐Portillo, O., Noriega, L. G., Tovar, A. R., & Torres, N. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108751 · Cited by 34
Wang, S., Zhang, L., Wang, D., Huang, M., Zhao, J., Malik, V., Liu, X., Sun, L., Lin, X., & Chen, Y. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202001051 · Cited by 32
Larsen, I., Fritzen, A. M., Carl, C. S., Agerholm, M., Damgaard, M. V., Holm, J. B., Marette, A., Nordkild, P., Kiens, B., Kristiansen, K., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00019.2019 · Cited by 32
Evidence of adequacy of postpartum care for immigrant women.
Katz, D., & Gagnon, A. J. (2002) · PubMed · Cited by 30
Lactobacillus rhamnosus GG protects against atherosclerosis by improving ketone body synthesis
Zhai, T., Ren, W., Wang, P., & Zheng, L. (2022) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-022-12265-7 · Cited by 30
Lu, J., Liu, R., Ren, H., Wang, S., Hu, C., Shi, Z., Li, M., Liu, W., Wan, Q., Su, Q., et al. (2024) · Med · doi:10.1016/j.medj.2024.07.024 · Cited by 34
Jamar, G., Santamarina, A. B., Casagrande, B. P., Estadella, D., de Rosso, V. V., Wagner, R. C., Fagundes, M. B., & Pisani, L. P. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02208-1 · Cited by 31
McGinley, J. N., Fitzgerald, V. K., Neil, E. S., Omerigic, H., Heuberger, A. L., Weir, T. L., McGee, R. J., Vandemark, G. J., & Thompson, H. J. (2020) · Nutrients · doi:10.3390/nu12030593 · Cited by 30
Germ-Free Swiss Webster Mice on a High-Fat Diet Develop Obesity, Hyperglycemia, and Dyslipidemia
Logan, I. E., Bobe, G., Miranda, C. L., Vasquez‐Perez, S., Choi, J., Lowry, M. B., Sharpton, T. J., Morgun, A., Maier, C. S., Stevens, J. F., et al. (2020) · Microorganisms · doi:10.3390/microorganisms8040520 · Cited by 31
“In another study, GF C57BL/6J mice showed a dramatic weight increase on a lower-sucrose lard-based HFD, whereas these mice were protected from DIO on a fish oil-based HFD, suggesting both sucrose content and fat source (lard is rich in saturated lipids, fish oil in polyunsaturated lipids) affect weight gain [33].”
Modulation of the gut microbiota-adipose tissue-muscle interactions by prebiotics
Rodriguez, J., & Delzenne, N. M. (2021) · Journal of Endocrinology · doi:10.1530/joe-20-0499 · Cited by 32
Miura, K., Ishioka, M., & Iijima, K. (2017) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes.2017.26.2.86 · Cited by 35
Optimal Microbiome Networks: Macroecology and Criticality
Li, J., & Convertino, M. (2019) · Entropy · doi:10.3390/e21050506 · Cited by 28
“For instance the same level of diversity 43 can be achieved via different network topologies that may lead to different health states [12].”
How Diet and Lifestyle Can Fine-Tune Gut Microbiomes for Healthy Aging
Tamayo, M., Olivares, M., Ruas‐Madiedo, P., Margollés, A., Espı́n, J. C., Medina, I., Moreno-Arribas, M. V., Canals, S., Mirasso, C. R., Ortín, S., et al. (2024) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-072023-034458 · Cited by 33
Chronodisruption enhances inflammatory cytokine release from visceral adipose tissue in obesity
Zinna, L., Verde, L., Tolla, M. F. D., Barrea, L., Parascandolo, A., D’Alterio, F., Colao, A. A. L., Formisano, P., D’Esposito, V., & Muscogiuri, G. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06250-7 · Cited by 30
“Additionally, the gut microbiome, influenced by circadian genes, modulates adipose tissue inflammation, with disruptions linked to obesity and diabetes [20, 21].”
Dietary fatty acids and bioactive fatty acid metabolites in alcoholic liver disease
Zirnheld, K. H., Warner, D. R., Warner, J. B., Hardesty, J., McClain, C. J., & Kirpich, I. (2019) · Liver Research · doi:10.1016/j.livres.2019.10.001 · Cited by 29
Jarmakiewicz-Czaja, S., Sokal-Dembowska, A., & Filip, R. (2020) · Nutrients · doi:10.3390/nu12103073 · Cited by 29
“In addition, researchers observed that in the case of a diet containing saturated fatty acids, the expression of the C-C motif chemokine ligand 2 (CCL2) chemokine in WAT is higher than in the case of consumption of unsaturated fatty acids [96].”
Wang, M., Zhou, J., Selma‐Royo, M., Simal‐Gándara, J., Collado, M. C., & Barba, F. J. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.04.017 · Cited by 29
The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium
Bermúdez, V., Durán, P., Rojas, E., Diaz, M. P., Rivas, J., Nava, M., Chacín, M., de Bravo, M. C., Carrasquero, R., Ponce, C. C., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.735070 · Cited by 31
Cao, B., Wang, S., Li, R., Wang, Z., Li, T., Zhang, Y., Dong, B., Li, Y., Lin, M., Li, X., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113081 · Cited by 29
Polyunsaturated fatty acids-rich dietary lipid prevents high fat diet-induced obesity in mice
Haneishi, Y., Furuya, Y., Hasegawa, M., Takemae, H., Tanioka, Y., Mizutani, T., Rossi, M., & Miyamoto, J. (2023) · Scientific Reports · doi:10.1038/s41598-023-32851-7 · Cited by 28
Li, Z., Lin, Z., Lu, Z., Feng, Z., Chen, Q., Deng, S.-F., Li, Z., Yan, Y., & Ying, Z. (2019) · AMB Express · doi:10.1186/s13568-019-0828-z · Cited by 29
Interplay between Microbes and the Circadian ClockPreprint
Tognini, P., Murakami, M., & Sassone‐Corsi, P. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028365 · Cited by 29
“For instance, dietary fat perturbs host immune homeostasis in various peripheral organs through change in the gut microbiome, leading to detrimental effects on the host physiology (Devkota et al. 2012; Caesar et al. 2015).”
Chain length‐dependent inulin alleviates diet‐induced obesity and metabolic disorders in mice
Li, L., Zhang, L., Zhou, L., Jin, M., & Xu, L. M. (2021) · Food Science & Nutrition · doi:10.1002/fsn3.2283 · Cited by 28
“The growing body of evidence has proposed its great potential for the prevention and treatment of obesity, insulin resistance, adipose tissue inflammation and their associated metabolic disorders in the intestinal tract for rodents (Caesar et al., 2015; Everard et al., 2013; Zhou, 2017).”
Saravi, S. S. S., Bonetti, N. R., Pugin, B., Constancias, F., Pasterk, L., Gobbato, S., Akhmedov, A. T., Liberale, L., Lüscher, T. F., Camici, G. G., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102897 · Cited by 28
“PUFA-rich diet counteracts inflammation and protects healthymetabolic state (Caesar et al., 2015; Oh et al., 2010; Calder, 2006), whereas saturated fatty acids promote inflammatory responses in diverse organs, leading to metabolic diseases (Kennedy et al., 2009).”
Al-Bulish, M. S. M., Cao, W., Yang, R., Wang, Y., Xue, C., & Tang, Q. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111373 · Cited by 29
Impact of Ethanol and Saccharin on Fecal Microbiome in Pregnant and Non-Pregnant Mice
Labrecque, M. T., Malone, D., & Allan, C. A. M. (2015) · Journal of Pregnancy and Child Health · doi:10.4172/2376-127x.1000193 · Cited by 28
“[9] consumption of artificial sweeteners was demonstrated to cause functional alteration in the gut microbiomes of mice to such a degree that metabolic abnormalities were induced.”
Formulated diet alters gut microbiota compositions in marine fishNibea coiborandNibea diacanthus
Li, Z., Zhang, X., Aweya, J. J., Wang, S., Hu, Z., Li, S., & Wen, X. (2018) · Aquaculture Research · doi:10.1111/are.13874 · Cited by 27
Gosens, R., Hiemstra, P. S., Adcock, I. M., Bracke, K. R., Dickson, R. P., Hansbro, P. M., Krauss‐Etschmann, S., Smits, H. H., Stassen, F. R. M., & Bartel, S. (2020) · European Respiratory Journal · doi:10.1183/13993003.02320-2019 · Cited by 28
Ke, W., Bonilla‐Rosso, G., Engel, P., Wang, P., Chen, F., & Hu, X. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa159 · Cited by 27
Huang, J., Xiao, N., Sun, Y., Wu, S., Tian, W., Lai, Y., Li, P., & Du, B. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10977-2 · Cited by 27
Zhao, Z., Fan, X., Gu, Y., Han, J., Jia, Y., Ye, K., & Zhang, Y. Q. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101149 · Cited by 27
Effects of hawthorn seed oil on plasma cholesterol and gut microbiota
Kwek, E., Yan, C., Ding, H., Hao, W., He, Z., Liu, J., Ma, K. Y., Zhu, H., & Chen, Z. (2022) · Nutrition & Metabolism · doi:10.1186/s12986-022-00690-4 · Cited by 28
Peng, F., Ren, X., Du, B., Niu, K., Yu, Z., & Yang, Y. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105354 · Cited by 27
Bailey, M. A., Thompson, S. V., Mysonhimer, A. R., Bennett, J. N., Vanhie, J. J., Lisio, M. D., Burd, N. A., Khan, N. A., & Holscher, H. D. (2023) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00176.2021 · Cited by 30
Jiang, S., & Miao, Z. (2023) · PubMed Central · Cited by 29
Bartsch, M., Hahn, A., & Berkemeyer, S. (2023) · Metabolites · doi:10.3390/metabo13121182 · Cited by 28
Fachi, J. L., Pral, L. P., de Assis, H. C., de Oliveira, S., Rodovalho, V. D. R., dos Santos, J. A. C., Fernandes, M. F., Matheus, V. A., Sesti‐Costa, R., Basso, P. J., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2023.2297872 · Cited by 27
“62–66 Furthermore, a recent study demonstrated that A. muciniphila exerts significant effects on the microbiota community and function, protecting mice from Clostridioides difficile infection (CDI).”
The Gut Microbiota Profile in Children with Prader–Willi Syndrome
Peng, Y., Tan, Q., Afhami, S., Deehan, E. C., Liang, S., Gantz, M. G., Triador, L., Madsen, K. L., Walter, J., Tun, H. M., et al. (2020) · Genes · doi:10.3390/genes11080904 · Cited by 27
Orange Pectin with Compact Conformation Effectively Alleviates Acute Colitis in Mice
Cui, J., Wang, F., Zhao, C., Zhou, S., & Zheng, J. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c07951 · Cited by 26
Reconsidering Meat Intake and Human Health: A Review of Current Research
Xie, Y., Ma, Y., Cai, L., Jiang, S., & Li, C. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202101066 · Cited by 26
Boisseau, N., Barnich, N., & Koechlin‐Ramonatxo, C. (2022) · Nutrients · doi:10.3390/nu14050924 · Cited by 32
“It is known that n-3 PUFAs from natural sources or dietary supplements exert a beneficial effect on body composition and inflammation status [188,189], improve the intestinal barrier function [63] and integrity, and increase healthy bacterial communities [62,190].”
Li, Y., Yang, S., Jin, X., Li, D. X., Lu, J., Wang, X., & Wu, M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1082817 · Cited by 26
“LPS subsequently stimulates the TLR 4 and TLR4/MyD88/TRIF signaling pathways to trigger macrophages and systemic inflammation (Caesar et al., 2015).”
Neyrinck, A. M., Schüppel, V. L., Lockett, T. J., Haller, D., & Delzenne, N. M. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.08.012 · Cited by 26
Chronodisruption, Metabolic Homeostasis, and the Regulation of Inflammation in Adipose Tissues.
Kolbe, I., & Oster, H. (2019) · PubMed Central · Cited by 27
High-altitude-induced alterations in intestinal microbiota
Liu, D., Chen, D., Xiao, J., Wang, W., Zhang, L., Peng, H., Han, C., & Yao, H. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1369627 · Cited by 28
Inflammation-related miRNAs in obesity, CVD, and NAFLD
Aghaei, S. M., & Hosseini, S. M. (2024) · Cytokine · doi:10.1016/j.cyto.2024.156724 · Cited by 26
Schipke, J., Vital, M., Schnapper, A., Pieper, D. H., & Mühlfeld, C. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy272 · Cited by 26
Oh, J. K., Amoranto, M. B. C., Oh, N. S., Kim, S., Lee, J. Y., Oh, Y. N., Shin, Y. K., Yoon, Y., & Kang, D. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10634-8 · Cited by 25
“Desulfovibrio is generally known to be associated with leanness in mice and humans (Caesar et al. 2015).”
Gut microbiome: A possible common therapeutic target for treatment of atherosclerosis and cancer
Wu, W., Ivanova, E. A., & Orekhov, A. N. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.06.017 · Cited by 26
A Novel Insight at Atherogenesis: The Role of Microbiome
Kirichenko, T. V., Markina, Y. V., Sukhorukov, V. N., Khotina, V. A., Wu, W., & Orekhov, A. N. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.586189 · Cited by 25
“In addition, the full suppression of gut microbiota may enhance macrophage-to-feces reverse cholesterol transport (Canyelles et al., 2018).”
Plissonneau, C., Capel, F., Chassaing, B., Dupuit, M., Maillard, F., Wawrzyniak, I., Combaret, L., Dutheil, F., Etienne, M., Mairesse, G., et al. (2021) · Nutrients · doi:10.3390/nu13030788 · Cited by 26
“Similarly, n-3 PUFAs improve intestinal barrier function and integrity [31] and increase healthy bacterial communities [17,18,32].”
Shima, H., Masuda, S., Date, Y., Shino, A., Tsuboi, Y., Kajikawa, M., Inoue, Y. H., Kanamoto, T., & Kikuchi, J. (2017) · Nutrients · doi:10.3390/nu9121307 · Cited by 27
“In addition, the genus Akkermansia, which is known to affect metabolism and reduce obesity and inflammation [55,56], responded to M.”
Dupuit, M., Chavanelle, V., Chassaing, B., Pérrière, F., Etienne, M., Plissonneau, C., Boscaro, A., Barnich, N., Pialoux, V., Maugard, T., et al. (2021) · Nutrients · doi:10.3390/nu13051569 · Cited by 26
Microbiota and metabolism: what's new in 2018?
Bretin, A., Gewirtz, A. T., & Chassaing, B. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00014.2018 · Cited by 24
Martín, M. Á., Robles‐Vera, I., Sánchez-Roncero, A., Escrivá, F., Pérez‐Vizcaíno, F., Duarte, J., Álvarez, C., & Fernández‐Millán, E. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108383 · Cited by 24
Rubio, C., Lizárraga-Mollinedo, E., Álvarez‐Cilleros, D., Perez‐Pardo, P., Sanmartín-Salinas, P., Toledo-Lobo, M. V., Álvarez, C., Escrivá, F., Fernández‐Lobato, M., Guijarro, L. G., et al. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa313 · Cited by 25
The Role of Dietary Lipids in Cognitive Health: Implications for Neurodegenerative Disease
Hans, S., Karadimou, A., Mulvihill, J. J., Grabrucker, A. M., & Zabetakis, I. (2022) · Biomedicines · doi:10.3390/biomedicines10123250 · Cited by 23
“The diversity of beneficial bacteria is also reduced in mice fed a diet enriched with lard or sunflower oils compared to those fed a diet supplemented with fish oil [63,64].”
Interactions between dietary cholesterol and intestinal flora and their effects on host health
Liu, Y., Xiao, H., Wang, Z., Pan, Q., Zhao, X., & Lu, B. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2276883 · Cited by 26
“Lipids are one of the major nutrients of the human diet that can decisively alter the gut microbiome (Caesar et al. 2015; Wan et al. 2019).”
Microbial contributions to chronic inflammation and metabolic disease
Shanahan, F., & Sheehan, D. (2016) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000282 · Cited by 24
“The microbiota also influence the composition of adipose tissue or fat quality, and interactions between gut microbiota and saturated lipids promote white adipocyte tissue (WAT) inflammation independent of adiposity [27].”
Zhou, Z., Zeng, C., Nie, L., Huang, S., Guo, C., Xiao, D., Han, Y., Ye, X., Ou, M., Huang, C., et al. (2017) · Gene · doi:10.1016/j.gene.2017.05.011 · Cited by 24
“TRIF-mutant mice were deficient in TLR3-mediated responses, and TRIF-deficient mice were protected against lard-induce white adipose tissue inflammation and impaired insulin sensitivity (Caesar et al., 2015).”
Yin, X., Liao, W., Li, Q., Zhang, H., Liu, Z., Zheng, X., Lin, Z., & Feng, X. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103883 · Cited by 25
Fisiopatología y alteraciones clínicas de la diabetes mellitus tipo 2
Fernández, C. I. J., Pereira, Y. A. M., Chang, A. S. O., Olmedo, S. I. G., & Gaete, M. C. A. (2022) · Nova · doi:10.22490/24629448.6184 · Cited by 24
Öneş, E., Zavotçu, M., Nisan, N., Baş, M., & Sağlam, D. (2025) · Nutrients · doi:10.3390/nu17030512 · Cited by 23
Araújo, F. D. O., Moreira, M. E. D. C., Lima, C. F., Toledo, R. C. L., de Sousa, A. R., Veloso, M. P., de Freitas, P. G., dos Santos, M. H., de Souza, E. C. G., Mantovani, H. C., et al. (2019) · Food Research International · doi:10.1016/j.foodres.2019.04.012 · Cited by 23
Djurić, Z., Bassis, C. M., Plegue, M. A., Sen, A., Turgeon, D. K., Herman, K., Young, V. B., Brenner, D. E., & Ruffin, M. T. (2019) · Journal of Nutrition · doi:10.1093/jn/nxy255 · Cited by 25
“For example, fish oil in the diet counteracts the effects of a high-saturated-fat diet on increased proinflammatory Toll-like receptor signaling, increased intestinal permeability, and the nature of the intestinal microbiome (29, 30).”
Perruzza, L., Strati, F., Gargari, G., D’Erchia, A. M., Fosso, B., Pesole, G., Guglielmetti, S., & Grassi, F. (2019) · Scientific Reports · doi:10.1038/s41598-019-45724-9 · Cited by 25
Yan, C., Zhang, C., Cao, X., Feng, B., & Li, X. (2020) · Molecules · doi:10.3390/molecules25245857 · Cited by 24
“Bilophila has been previously identified to aggravate inflammatory colitis through white adipose tissue WAT inflammation via the toll-like receptor (TLR) signaling pathway [94,95] in genetically susceptible hosts [96].”
Lu, X., Zhong, R., Hu, L., Huang, L., Chen, L., Cheng, W., Zheng, B., & Liang, P. (2021) · Food & Function · doi:10.1039/d1fo00747e · Cited by 23
Role of gut microbe-derived metabolites in cardiometabolic diseases: Systems based approach
Cao, Y., Aquino-Martínez, R., Hutchison, E. R., Allayee, H., Lusis, A. J., & Rey, F. E. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101557 · Cited by 26
Patil, R. S., & Tupe, R. S. (2023) · Medicinal Research Reviews · doi:10.1002/med.21987 · Cited by 23
“It is noted that diet modulations modulate the composition of microbes and, therefore, their function in rodents 326 and humans.”
Metadata
- Authors
- Caesar, R., Tremaroli, V., Kovatcheva-Datchary, P., Cani, P. D., & Bäckhed, F.
- Affiliations
- University of Gothenburg (SE)
- Walloon Excellence in Lifesciences and Biotechnology (BE)
- University of Copenhagen (DK)
- Corresponding author
- Caesar, Robert
- Bäckhed, Fredrik
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 22
- Issue
- 4
- Pages
- 658-668
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC4598654
- OpenAlex
- W2096736123
- Cited by
- 960
- References
- 51
- Citations by year
- 2026: 43 · 2025: 52 · 2024: 76 · 2023: 89 · 2022: 124 · 2021: 109 · 2020: 114 · 2019: 105 · 2018: 88 · 2017: 85 · 2016: 59 · 2015: 12
- FWCI
- 35.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by-nc-nd)
- Digital Access to Libraries (submittedVersion, other-oa)
- Funders
- Stiftelsen för Strategisk Forskning
- Fonds De La Recherche Scientifique - FNRS (WELBIO-CR-2012S-02R)
- Knut och Alice Wallenbergs Stiftelse
- Novo Nordisk
- Vetenskapsrådet
- Göteborgs Universitet
- Novo Nordisk Fonden (NNF13OC0008163)
- Walloon excellence in life sciences and biotechnology
- Wageningen University and Research
- Uppsala Multidisciplinary Center for Advanced Computational Science
- FP7 Food, Agriculture and Fisheries, Biotechnology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- gut microbiota, dietary fat, white adipose tissue inflammation, Toll-like receptor signaling, lard, fish oil, saturated fatty acids, insulin sensitivity, metabolic inflammation, CCL2 chemokine, MyD88, TRIF, germ-free mice
- MeSH terms
- Gastrointestinal Microbiome, Animals, Bacteria, Body Weight, DNA, Bacterial, Fish Oils, Inflammation, Male, Mice, Inbred C57BL, Phylogeny, Signal Transduction, Mice, Knockout, Chemokine CCL2, Adaptor Proteins, Vesicular Transport, Gastrointestinal Tract, Toll-Like Receptors, Mice, Adipose Tissue, White, Myeloid Differentiation Factor 88, Diet, High-Fat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
