Cited by 173Circadian rhythm and melatoninGenetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

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Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila

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Katewa, Subhash D., Akagi, Kazutaka, Bose, Neelanjan, Rakshit, Kuntol, Camarella, Timothy, Zheng, Xiangzhong, Hall, David, Davis, Sonnet, Nelson, Christopher S., Brem, Rachel B., Ramanathan, Arvind, Sehgal, Amita, Giebultowicz, Jadwiga M., Kapahi, Pankaj·2016·Cell Metabolism

DOI 10.1016/j.cmet.2015.10.014PMC PMC4715572

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Abstract

Endogenous circadian clocks orchestrate several metabolic and signaling pathways that are known to modulate lifespan, suggesting clocks as potential targets for manipulation of metabolism and lifespan. We report here that the core circadian clock genes, timeless (tim) and period (per), are required for the metabolic and lifespan responses to DR in Drosophila. Consistent with the involvement of a circadian mechanism, DR enhances the amplitude of cycling of most circadian clock genes, including tim, in peripheral tissues. Mass-spectrometry-based lipidomic analysis suggests a role of tim in cycling of specific medium chain triglycerides under DR. Furthermore, overexpression of tim in peripheral tissues improves its oscillatory amplitude and extends lifespan under ad libitum conditions. Importantly, effects of tim on lifespan appear to be mediated through enhanced fat turnover. These findings identify a critical role for specific clock genes in modulating the effects of nutrient manipulation on fat metabolism and aging.

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Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,310
Clock Mutants of Drosophila melanogaster
Konopka, R. J., & Benzer, S. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.9.2112 · Cited by 2,287
High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice
Kohsaka, A., Laposky, A. D., Ramsey, K. M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F. W., & Bass, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.006 · Cited by 1,528
LMSD: LIPID MAPS structure database
Sud, M., Fahy, E., Cotter, D., Brown, A., Dennis, E. A., Glass, C. K., Merrill, A. H., Murphy, R. C., Raetz, C. R. H., Russell, D. W., et al. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl838 · Cited by 1,388
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V., & Benzer, S. (2004) · Current Biology · doi:10.1016/j.cub.2004.03.059 · Cited by 1,293
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Bordone, L., & Guarente, L. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1616 · Cited by 1,038
Lifespan and reproduction in Drosophila : New insights from nutritional geometry
Lee, K. P., Simpson, S. J., Clissold, F. J., Brooks, R., Ballard, J. W. O., Taylor, P. W., Soran, N., & Raubenheimer, D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710787105 · Cited by 1,032
LIPID MAPS online tools for lipid research
Fahy, E., Sud, M., Cotter, D., & Subramaniam, S. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm324 · Cited by 916

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Campisi, J., Kapahi, P., Lithgow, G. J., Melov, S., Newman, J. C., & Verdin, E. (2019) · Nature · doi:10.1038/s41586-019-1365-2 · Cited by 1,389
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Hood, S., & Amir, S. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90328 · Cited by 645
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Li, S., Yu, X., & Feng, Q. (2018) · Annual Review of Entomology · doi:10.1146/annurev-ento-011118-112007 · Cited by 338
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Authors: Katewa, S. D., Akagi, K., Bose, N., Rakshit, K., Camarella, T., Zheng, X., Hall, D., Davis, S., Nelson, C. S., Brem, R. B., Ramanathan, A., Sehgal, A., Giebultowicz, J. M., & Kapahi, P.
Affiliations: Buck Institute for Research on Aging (US)
Oregon State University (US)
University of Pennsylvania (US)
Corresponding author: Katewa, Subhash D.
Kapahi, Pankaj
ORCID: Katewa, Subhash D.
Akagi, Kazutaka
Bose, Neelanjan
Zheng, Xiangzhong
Hall, David
Davis, Sonnet
Nelson, Christopher S.
Brem, Rachel B.
Ramanathan, Arvind
Sehgal, Amita
Giebultowicz, Jadwiga M.
Kapahi, Pankaj
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2016-01
Volume: 23
Issue: 1
Pages: 143-154
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2015.10.014
PMC: PMC4715572
OpenAlex: W2175005753
Cited by: 173
References: 78
Citations by year: 2026: 10 · 2025: 14 · 2024: 14 · 2023: 20 · 2022: 12 · 2021: 18 · 2020: 17 · 2019: 14 · 2018: 18 · 2017: 23 · 2016: 13
FWCI: 9.85
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 377 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Ellison Medical Foundation
American Federation for Aging Research
Larry L. Hillblom Foundation
National Institutes of Health (AG038012, AG045835, R01 AG045830, R01AG038688)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Keywords: circadian clock, dietary restriction, lifespan extension, TIMELESS, period, peripheral tissues, fat metabolism, lipid metabolism, medium-chain triglycerides, aging, Drosophila
MeSH terms: Animals, Drosophila melanogaster, Female, Gene Expression Regulation, Longevity, Male, Signal Transduction, Gene Expression, Drosophila Proteins, Caloric Restriction, Lipid Metabolism, CLOCK Proteins, Circadian Clocks

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Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila

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