Cited by 995Adipose Tissue and MetabolismMetabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic Diseases

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Metabolic Flexibility in Health and Disease

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Goodpaster, Bret H., Sparks, Lauren M.·2017·Cell Metabolism

DOI 10.1016/j.cmet.2017.04.015PMC PMC5513193

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Abstract

Metabolic flexibility is the ability to respond or adapt to conditional changes in metabolic demand. This broad concept has been propagated to explain insulin resistance and mechanisms governing fuel selection between glucose and fatty acids, highlighting the metabolic inflexibility of obesity and type 2 diabetes. In parallel, contemporary exercise physiology research has helped to identify potential mechanisms underlying altered fuel metabolism in obesity and diabetes. Advances in "omics" technologies have further stimulated additional basic and clinical-translational research to further interrogate mechanisms for improved metabolic flexibility in skeletal muscle and adipose tissue with the goal of preventing and treating metabolic disease.

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Authors: Goodpaster, B. H., & Sparks, L. M.
Affiliations: Sanford Burnham Prebys Medical Discovery Institute (US)
Corresponding author: Goodpaster, Bret H.
ORCID: Goodpaster, Bret H.
Sparks, Lauren M.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2017-05
Volume: 25
Issue: 5
Pages: 1027-1036
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2017.04.015
PMC: PMC5513193
OpenAlex: W2611848952
Cited by: 995
References: 129
Citations by year: 2026: 150 · 2025: 131 · 2024: 89 · 2023: 126 · 2022: 138 · 2021: 133 · 2020: 106 · 2019: 72 · 2018: 42 · 2017: 6
FWCI: 7.58
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 367 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
American Diabetes Association
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: metabolic flexibility, insulin resistance, fuel selection, glucose metabolism, fatty acid oxidation, obesity, type 2 diabetes, skeletal muscle, adipose tissue, exercise physiology, metabolic disorders
MeSH terms: Adipose Tissue, Animals, Diabetes Mellitus, Type 2, Energy Metabolism, Exercise Therapy, Fasting, Fatty Acids, Glucose, Humans, Insulin Resistance, Obesity, Rest, Exercise, Muscle, Skeletal, Caloric Restriction, Metabolic Networks and Pathways, Metabolomics, Metabolome

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