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Cited by 575Diabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity

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Causes, Characteristics, and Consequences of Metabolically Unhealthy Normal Weight in Humans

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Stefan, Norbert, Schick, Fritz, Häring, Hans-Ulrich·2017·Cell Metabolism
DOI 10.1016/j.cmet.2017.07.008
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Abstract

A BMI in the normal range associates with a decreased risk of cardiometabolic disease and all-cause mortality. However, not all subjects in this BMI range have this low risk. Compared to people who are of normal weight and metabolically healthy, subjects who are of normal weight but metabolically unhealthy (∼20% of the normal weight adult population) have a greater than 3-fold higher risk of all-cause mortality and/or cardiovascular events. Here we address to what extent major risk phenotypes determine metabolic health in lean compared to overweight and obese people and provide support for the existence of a lipodystrophy-like phenotype in the general population. Furthermore, we highlight the molecular mechanisms that induce this phenotype. Finally, we propose strategies as to how this knowledge could be implemented in the prevention and treatment of cardiometabolic diseases in different stages of adiposity in routine clinical practice.

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Metadata

Authors
Stefan, N., Schick, F., & Häring, H.-U.
Affiliations
Helmholtz Munich (DE)
Corresponding author
  • Stefan, Norbert
  • Häring, Hans-Ulrich
ORCID
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2017-08
Volume
26
Issue
2
Pages
292-300
ISSN
1550-4131 (ISSN-L)
DOI
10.1016/j.cmet.2017.07.008
OpenAlex
W2741982109
Cited by
575
References
0
Citations by year
2026: 50 · 2025: 53 · 2024: 58 · 2023: 60 · 2022: 99 · 2021: 76 · 2020: 88 · 2019: 40 · 2018: 40 · 2017: 10
FWCI
7.10
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Site cant be reached (submittedVersion)
  • PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
Funders
  • Deutsche Forschungsgemeinschaft (KFO 114, STE 1096/1-3)
  • Bundesministerium für Bildung und Forschung
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
metabolically unhealthy normal weight, metabolic health, cardiometabolic disease, all-cause mortality, cardiovascular risk, adiposity, risk phenotypes, molecular mechanisms, disease prevention, treatment options
MeSH terms
Female, Heart Diseases, Humans, Male, Metabolic Diseases, Risk Factors, Body Mass Index, Adiposity

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