Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590

Microenvironmental regulation of tumor progression and metastasis

Quail, D. F., & Joyce, J. A. (2013) · Nature Medicine · doi:10.1038/nm.3394 · Cited by 7,994

Role of YAP/TAZ in mechanotransduction

Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979

The biology and function of fibroblasts in cancer

Kalluri, R. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.73 · Cited by 4,366

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088

Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis

Yang, J., Mani, S. A., Donaher, J. L., Ramaswamy, S., Itzykson, R., Côme, C., Savagner, P., Gitelman, I., Richardson, A. L., & Weinberg, R. A. (2004) · Cell · doi:10.1016/j.cell.2004.06.006 · Cited by 3,917

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., & Sabatini, D. M. (2008) · Science · doi:10.1126/science.1157535 · Cited by 2,773

Understanding the Intersections between Metabolism and Cancer Biology

Heiden, M. G. V., & DeBerardinis, R. J. (2017) · Cell · doi:10.1016/j.cell.2016.12.039 · Cited by 2,369

Hippo pathway in organ size control, tissue homeostasis, and cancer

Yu, F.-X., Zhao, B., & Guan, K.-L. (2015) · Cell · doi:10.1016/j.cell.2015.10.044 · Cited by 2,206

A framework for advancing our understanding of cancer-associated fibroblasts

Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., et al. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0238-1 · Cited by 3,863

The hallmarks of cancer metabolism: still emerging

Pavlova, N. N., Zhu, J., & Thompson, C. B. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.01.007 · Cited by 1,418

Clinical and therapeutic relevance of cancer-associated fibroblasts

Chen, Y., McAndrews, K. M., & Kalluri, R. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00546-5 · Cited by 1,230

The matrix in cancer

Cox, T. R. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-020-00329-7 · Cited by 1,015

Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments

Yuan, Z., Li, Y., Zhang, S., Wang, X., Dou, H., Yu, X., Zhang, Z., Yang, S., & Xiao, M. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01744-8 · Cited by 977

Metabolites and the Tumour Microenvironment: From Cellular Mechanisms to Systemic Metabolism

Elia, I., & Haigis, M. C. (2021) · Nature Metabolism · doi:10.1038/s42255-020-00317-z · Cited by 651

Amino acid metabolism in health and disease

Ling, Z., Jiang, Y.-F., Ru, J.-N., Lu, J.-H., Ding, B., & Wu, J. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01569-3 · Cited by 590

New aspects of amino acid metabolism in cancer

Vettore, L. A., Westbrook, R. L., & Tennant, D. A. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0620-5 · Cited by 508

Fibroblasts in cancer: Unity in heterogeneity

Chhabra, Y., & Weeraratna, A. T. (2023) · Cell · doi:10.1016/j.cell.2023.03.016 · Cited by 505

Stromal cells in the tumor microenvironment: accomplices of tumor progression?

Zhao, Y. F., Shen, M., Wu, L., Yang, H., Yao, Y., Yang, Q., Du, J., Liu, L., Li, Y., & Bai, Y. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06110-6 · Cited by 487

Metabolism of Amino Acids in Cancer

Wei, Z. C., Liu, X., Cheng, C., Yu, W., & Yi, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.603837 · Cited by 456

Crosstalk between mechanotransduction and metabolism

Romani, P., Valcárcel-Jiménez, L., Frezza, C., & Dupont, S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00306-w · Cited by 418

Metabolic reprogramming of cancer-associated fibroblasts and its effect on cancer cell reprogramming

Li, Z., Sun, C., & Qin, Z. (2021) · Theranostics · doi:10.7150/thno.62378 · Cited by 404

YAP and TAZ: a signalling hub of the tumour microenvironment

Zanconato, F., Cordenonsi, M., & Piccolo, S. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0168-y · Cited by 384

The Interplay between Extracellular Matrix Remodeling and Cancer Therapeutics

Prakash, J., & Shaked, Y. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0002 · Cited by 416

Lung Myofibroblasts Promote Macrophage Profibrotic Activity through Lactate-induced Histone Lactylation

Cui, H., Xie, N., Banerjee, S., Ge, J., Jiang, D., Dey, T., Matthews, Q. L., Liu, R.-M., & Liu, G. (2020) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0360oc · Cited by 373

Mechanoresponsive metabolism in cancer cell migration and metastasis

Zanotelli, M. R., Zhang, J., & Reinhart‐King, C. A. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.04.002 · Cited by 348

Cancer associated-fibroblast-derived exosomes in cancer progression

Li, C., Teixeira, A. F., Zhu, H., & ten Dijke, P. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01463-y · Cited by 345

Targeting the tumor stroma for cancer therapy

Xu, M., Zhang, T., Xia, R., Wei, Y., & Wei, X. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01670-1 · Cited by 334

Signaling pathways in cancer‐associated fibroblasts: recent advances and future perspectives

Fang, Z., Meng, Q., Xu, J., Wang, W., Zhang, B., Liu, J., Liang, C., Hua, J., Zhao, Y., Yu, X., et al. (2022) · 癌症：英文版 · doi:10.1002/cac2.12392 · Cited by 304

Amino Acid Depletion Therapies: Starving Cancer Cells to Death

Butler, M., van der Meer, L. T., & van Leeuwen, F. N. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.03.003 · Cited by 277

Fibroblast heterogeneity in tumor micro-environment: Role in immunosuppression and new therapies

Mhaidly, R., & Mechta‐Grigoriou, F. (2020) · Seminars in Immunology · doi:10.1016/j.smim.2020.101417 · Cited by 267

Amino acid metabolism in tumor biology and therapy

Chen, J., Cui, L., Lu, S., & Xu, S. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06435-w · Cited by 277

Mechanical regulation of chromatin and transcription

Dupont, S., & Wickström, S. A. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00493-6 · Cited by 242

Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance

Romani, P., Nirchio, N., Arboit, M., Barbieri, V., Tosi, A., Michielin, F., Shibuya, S., Benoist, T., Wu, D., Hindmarch, C. C. T., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00843-w · Cited by 235

Targeting tumor-intrinsic hexosamine biosynthesis sensitizes pancreatic cancer to anti-PD1 therapy

Sharma, N. S., Gupta, V. K., Garrido, V. T., Hadad, R., Durden, B. C., Kesh, K., Giri, B., Ferrantella, A., Dudeja, V., Saluja, A., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci127515 · Cited by 203

Matrix Stiffness Contributes to Cancer Progression by Regulating Transcription Factors

Ishihara, S., & Haga, H. (2022) · Cancers · doi:10.3390/cancers14041049 · Cited by 220

Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment

Xie, Z., Gao, Y., Ho, C., Li, L., Chen, J., Wang, X., Zou, C., Mao, Y., Wang, X., Li, Q., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-323014 · Cited by 195

Integration of Hippo-YAP Signaling with Metabolism

Ibar, C., & Irvine, K. D. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.06.025 · Cited by 190

The creatine–phosphagen system is mechanoresponsive in pancreatic adenocarcinoma and fuels invasion and metastasis

Papalazarou, V., Zhang, T., Paul, N. R., Juin, A., Cantini, M., Maddocks, O. D. K., Salmerón‐Sánchez, M., & Machesky, L. M. (2020) · Nature Metabolism · doi:10.1038/s42255-019-0159-z · Cited by 182

Metabolic heterogeneity in cancer

Demicco, M., Liu, X., Leithner, K., & Fendt, S. (2024) · Nature Metabolism · doi:10.1038/s42255-023-00963-z · Cited by 186

Roles of Proteoglycans and Glycosaminoglycans in Cancer Development and Progression

Wei, J., Hu, M., Huang, K., Lin, S., & Du, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175983 · Cited by 169

Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix

Kay, E. J., Paterson, K., Riera‐Domingo, C., Sumpton, D. P., Däbritz, J. H. M., Tardito, S., Boldrini, C., Hernandez-Fernaud, J. R., Athineos, D., Dhayade, S., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00582-0 · Cited by 197

Tumor battlefield within inflamed, excluded or desert immune phenotypes: the mechanisms and strategies

Zheng, S., Wang, W., Shen, L., Yao, Y., Xia, W., & Ni, C. (2024) · Experimental Hematology and Oncology · doi:10.1186/s40164-024-00543-1 · Cited by 200

Reprogramming the immunosuppressive tumor microenvironment through nanomedicine: an immunometabolism perspective

Liu, J., Bai, Y., Li, Y., Li, X., & Luo, K. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105301 · Cited by 170

Tissue mechanics in stem cell fate, development, and cancer

Hayward, M.-K., Muncie, J. M., & Weaver, V. M. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.05.011 · Cited by 158

Platelets, immune cells and the coagulation cascade; friend or foe of the circulating tumour cell?

Ward, M. P., Kane, L. E., Norris, L., Mohamed, B. M., Kelly, T. E., Bates, M., Clarke, A., Brady, N., Martin, C. M., Brooks, R. D., et al. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01347-1 · Cited by 165

Cancer associated fibroblasts and metabolic reprogramming: unraveling the intricate crosstalk in tumor evolution

Zhang, F., Ma, Y., Li, D., Wei, J., Chen, K., Zhang, E., Liu, G., Chu, X., Liu, X., Liu, W., et al. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01600-2 · Cited by 178

Mechano-therapeutics: Targeting Mechanical Signaling in Fibrosis and Tumor Stroma

Tschumperlin, D. J., & Lagares, D. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107575 · Cited by 146

Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis

Torrino, S., Grasset, E. M., Audebert, S., Belhadj, I., Lacoux, C., Haynes, M., Pisano, S., Abélanet, S., Brau, F., Chan, S. Y., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.05.009 · Cited by 145

The transformation of cancer-associated fibroblasts: Current perspectives on the role of TGF-β in CAF mediated tumor progression and therapeutic resistance

Jena, B. C., Sarkar, S., Rout, L., & Mandal, M. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.08.002 · Cited by 143

Cancer-associated fibroblasts: The chief architect in the tumor microenvironment

Sarkar, M., Nguyen, T., Gundre, E., Ogunlusi, O., El-Sobky, M. H., Giri, B., & Sarkar, T. R. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1089068 · Cited by 145

Extracellular Matrix Stiffness: New Areas Affecting Cell Metabolism

Ge, H., Tian, M., Pei, Q., Tan, F., & Pei, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.631991 · Cited by 139

Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context

Kerk, S. A., Lin, L., Myers, A. L., Sutton, D. J., Andren, A., Sajjakulnukit, P., Zhang, L., Zhang, Y., Jiménez, J. A., Nelson, B. S., et al. (2022) · eLife · doi:10.7554/elife.73245 · Cited by 108

The significant role of amino acid metabolic reprogramming in cancer

Liu, X., Ren, B., Ren, J., Gu, M., You, L., & Zhao, Y.-P. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01760-1 · Cited by 139

Activation of Piezo1 promotes osteogenic differentiation of aortic valve interstitial cell through YAP-dependent glutaminolysis

Zhong, G., Su, S., Li, J., Zhao, H., Hu, D., Chen, J., Li, S., Lin, Y., Wen, L., Lin, X., et al. (2023) · Science Advances · doi:10.1126/sciadv.adg0478 · Cited by 127

YAP/TAZ Inhibition Induces Metabolic and Signaling Rewiring Resulting in Targetable Vulnerabilities in NF2-Deficient Tumor Cells

White, S. M., Avantaggiati, M. L., Nemazanyy, I., Poto, C. D., Yang, Y., Pende, M., Gibney, G. T., Ressom, H. W., Field, J., Atkins, M. B., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.04.014 · Cited by 121

Role of the mechanical microenvironment in cancer development and progression

Liu, Q., Luo, Q., Ju, Y., & Song, G. (2020) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2019.0437 · Cited by 123

Molecular classification of hormone receptor-positive HER2-negative breast cancer

Jin, X., Zhou, Y.-F., Ma, D., Zhao, S., Lin, C., Xiao, Y., Fu, T., Liu, C., Chen, Y., Xiao, W.-X., et al. (2023) · Nature Genetics · doi:10.1038/s41588-023-01507-7 · Cited by 118

Metabolic Reprogramming in Anticancer Drug Resistance: A Focus on Amino Acids

Pranzini, E., Pardella, E., Paoli, P., Fendt, S., & Taddei, M. L. (2021) · Trends in cancer · doi:10.1016/j.trecan.2021.02.004 · Cited by 116

Hippo signalling during development

Davis, J. R., & Tapon, N. (2019) · Development · doi:10.1242/dev.167106 · Cited by 113

Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms

Kondo, H., Ratcliffe, C. D. H., Hooper, S., Ellis, J., MacRae, J. I., Hennequart, M., Dunsby, C. W., Anderson, K. I., & Sahai, E. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108750 · Cited by 109

Metabolic reprogramming and crosstalk of cancer-related fibroblasts and immune cells in the tumor microenvironment

Zhu, Y., Li, X., Wang, L., Hong, X., & Yang, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.988295 · Cited by 116

Tumor microenvironment in head and neck squamous cell carcinoma: Functions and regulatory mechanisms

Wang, G., Zhang, M., Cheng, M., Wang, X., Li, K., Chen, J., Chen, Z., Chen, S., Chen, J., Xiong, G., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.03.009 · Cited by 113

Cross-Talk Between the Tumor Microenvironment, Extracellular Matrix, and Cell Metabolism in Cancer

Nazemi, M., & Rainero, E. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00239 · Cited by 110

Reciprocal regulation of cellular mechanics and metabolism

Evers, T. M. J., Holt, L. J., Alberti, S., & Mashaghi, A. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00384-w · Cited by 104

Immunometabolic Endothelial Phenotypes: Integrating Inflammation and Glucose Metabolism

Xiao, W., Oldham, W. M., Priolo, C., Pandey, A. K., & Loscalzo, J. (2021) · Circulation Research · doi:10.1161/circresaha.120.318805 · Cited by 109

TSPAN8 + myofibroblastic cancer–associated fibroblasts promote chemoresistance in patients with breast cancer

Fan, G., Yu, B., Tang, L., Zhu, R., Chen, J., Zhu, Y., Huang, H., Zhou, L., Liu, J., Wang, W., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adj5705 · Cited by 116

Starve Cancer Cells of Glutamine: Break the Spell or Make a Hungry Monster?

Jiang, J., Srivastava, S., & Zhang, J. (2019) · Cancers · doi:10.3390/cancers11060804 · Cited by 108

Cancer-Associated Fibroblast Mediated Inhibition of CD8+ Cytotoxic T Cell Accumulation in Tumours: Mechanisms and Therapeutic Opportunities

Freeman, P., & Mielgo, A. (2020) · Cancers · doi:10.3390/cancers12092687 · Cited by 106

Microenvironment-driven intratumoral heterogeneity in head and neck cancers: clinical challenges and opportunities for precision medicine

den Bossche, V. V., Zaryouh, H., Vara-Messler, M., Vignau, J., Machiels, J., Wouters, A., Schmitz, S., & Corbet, C. (2022) · Drug Resistance Updates · doi:10.1016/j.drup.2022.100806 · Cited by 105

An SCD1-dependent mechanoresponsive pathway promotes HCC invasion and metastasis through lipid metabolic reprogramming

Liu, H., Xu, Y., Li, C.-J., Hsu, S.-J., Lin, X., Zhang, R., Chen, J., Chen, J., Gao, D., Cui, J., et al. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.03.015 · Cited by 101

The Roles of YAP/TAZ and the Hippo Pathway in Healthy and Diseased Skin

Rognoni, E., & Walko, G. (2019) · Cells · doi:10.3390/cells8050411 · Cited by 106

A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic Alterations

Yamaguchi, H., & Taouk, G. M. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00928 · Cited by 106

Regulation of Extracellular Matrix Production in Activated Fibroblasts: Roles of Amino Acid Metabolism in Collagen Synthesis

Kay, E. J., Koulouras, G., & Zanivan, S. R. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.719922 · Cited by 105

Fibroblast heterogeneity in solid tumors: From single cell analysis to whole-body imaging

Peltier, A., Seban, R., Buvat, I., Bidard, F., & Mechta‐Grigoriou, F. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.04.008 · Cited by 96

Glutamine Metabolism in Brain Tumors

Natarajan, S. K., & Venneti, S. (2019) · Cancers · doi:10.3390/cancers11111628 · Cited by 99

Collagen Remodeling along Cancer Progression Providing a Novel Opportunity for Cancer Diagnosis and Treatment

Song, K., Yu, Z., Zu, X., Li, G., Hu, Z., & Xue, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810509 · Cited by 97

Landscape of cancer-associated fibroblasts identifies the secreted biglycan as a protumor and immunosuppressive factor in triple-negative breast cancer

Zheng, S., Zou, Y., Tang, Y., Yang, A., Liang, J.-Y., Wu, L., Tian, W., Xiao, W., Xie, X., Yang, L., et al. (2022) · OncoImmunology · doi:10.1080/2162402x.2021.2020984 · Cited by 92

Oncofetal reprogramming in tumour development and progression

Sharma, A., Blériot, C., Currenti, J., & Ginhoux, F. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00497-8 · Cited by 104

Glycolysis reprogramming in cancer-associated fibroblasts promotes the growth of oral cancer through the lncRNA H19/miR-675-5p/PFKFB3 signaling pathway

Yang, J., Shi, X., Yang, M., Luo, J., Gao, Q., Wang, X., Wu, Y., Tian, Y., Wu, F., & Zhou, H. (2021) · International Journal of Oral Science · doi:10.1038/s41368-021-00115-7 · Cited by 89

Extracellular matrix-mediated regulation of cancer stem cells and chemoresistance

Brown, Y., Hua, S., & Tanwar, P. S. (2019) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2019.02.002 · Cited by 90

Cellular senescence and metabolic reprogramming: Unraveling the intricate crosstalk in the immunosuppressive tumor microenvironment

Zhang, F., Guo, J., Yu, S., Zheng, Y., Duan, M., Zhao, L., Wang, Y., Yang, Z., & Jiang, X. (2024) · 癌症：英文版 · doi:10.1002/cac2.12591 · Cited by 100

Cell Response to Mechanical Microenvironment Cues Via Rho Signaling: From Mechanobiology to Mechanomedicine

Xie, N., Xiao, C., Shu, Q., Cheng, B., Wang, Z., Xue, R., Zhang, W., Wang, J., Shi, H., Fan, D., et al. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.01.039 · Cited by 90

Niche stiffness sustains cancer stemness via TAZ and NANOG phase separation

Liu, X., Ye, Y., Zhu, L., Xiao, X., Zhou, B., Gu, Y., Si, H., Liang, H., Liu, M., Li, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-35856-y · Cited by 93

Stiffness Increases with Myofibroblast Content and Collagen Density in Mesenchymal High Grade Serous Ovarian Cancer

Mieulet, V., Garnier, C., Kieffer, Y., Guilbert, T., Nemati, F., Marangoni, E., Renault, G., Chamming’s, F., Vincent-Salomon, A., & Mechta-Grigoriou, F. (2021) · Scientific Reports · doi:10.1038/s41598-021-83685-0 · Cited by 79

Cell death in head and neck cancer pathogenesis and treatment

Raudenská, M., Balvan, J., & Masařík, M. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03474-5 · Cited by 82

The fibrotic and immune microenvironments as targetable drivers of metastasis

Boulter, L., Bullock, E., Mabruk, Z., & Brunton, V. G. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01172-1 · Cited by 78

Biomaterial-based platforms for tumour tissue engineering

Curvello, R., Kast, V., Ordóñez‐Morán, P., Mata, Á., & Loessner, D. (2023) · Nature Reviews Materials · doi:10.1038/s41578-023-00535-3 · Cited by 82

Extracellular matrix stiffness as an energy metabolism regulator drives osteogenic differentiation in mesenchymal stem cells

Na, J., Yang, Z., Shi, Q., Li, C., Liu, Y., Song, Y., Li, X., Zheng, L., & Fan, Y. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.02.003 · Cited by 85

Fibroblasts as Modulators of Local and Systemic Cancer Metabolism

Sanford-Crane, H., Abrego, J., & Sherman, M. H. (2019) · Cancers · doi:10.3390/cancers11050619 · Cited by 77

DNA Damage and Activation of cGAS/STING Pathway Induce Tumor Microenvironment Remodeling

Shen, R., Liu, D., Wang, X., Guo, Z., Sun, H., Song, Y., & Wang, D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.828657 · Cited by 77

Stromal reprogramming: A target for tumor therapy

Najafi, M., Mortezaee, K., & Majidpoor, J. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.117049 · Cited by 74

Stromal architecture and fibroblast subpopulations with opposing effects on outcomes in hepatocellular carcinoma

Cheng, Y., Chen, X., Li, F., Yang, Z., Xiao, L., Xiang, B., Wang, X., Liu, D., Lin, P., Shi, J.-Y., et al. (2025) · Cell Discovery · doi:10.1038/s41421-024-00747-z · Cited by 80

LOXL1 Is Regulated by Integrin α11 and Promotes Non-Small Cell Lung Cancer Tumorigenicity

Zeltz, C., Pasko, E., Cox, T. R., Navab, R., & Tsao, M. (2019) · Cancers · doi:10.3390/cancers11050705 · Cited by 72

SLC1A3 contributes to L‐asparaginase resistance in solid tumors

Sun, J., Nagel, R., Zaal, E. A., Ugalde, A. P., Han, R., Proost, N., Song, J., Pataskar, A., Burylo, A. M., Fu, H., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2019102147 · Cited by 69

Revisiting the role of cancer-associated fibroblasts in tumor microenvironment

Lan, X., Li, W., Zhao, K., Wang, J., Li, S., & Hai, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1582532 · Cited by 75

Regulation of Ferroptosis by Amino Acid Metabolism in Cancer

Yang, J., Dai, X., Xu, H., Tang, Q., & Bi, F. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.64982 · Cited by 70

Metabolic heterogeneity in cancer: An overview and therapeutic implications

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