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Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway
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Abstract
Nicotinamide adenine dinucleotide (NAD), a cofactor for hundreds of metabolic reactions in all cell types, plays an essential role in metabolism, DNA repair, and aging. However, how NAD metabolism is impacted by the environment remains unclear. Here, we report an unexpected trans-kingdom cooperation between bacteria and mammalian cells wherein bacteria contribute to host NAD biosynthesis. Bacteria confer resistance to inhibitors of NAMPT, the rate-limiting enzyme in the amidated NAD salvage pathway, in cancer cells and xenograft tumors. Mechanistically, a microbial nicotinamidase (PncA) that converts nicotinamide to nicotinic acid, a precursor in the alternative deamidated NAD salvage pathway, is necessary and sufficient for this protective effect. Using stable isotope tracing and microbiota-depleted mice, we demonstrate that this bacteria-mediated deamidation contributes substantially to the NAD-boosting effect of oral nicotinamide and nicotinamide riboside supplementation in several tissues. Collectively, our findings reveal an important role of bacteria-enabled deamidated pathway in host NAD metabolism.
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“Shats et al. (2020) also reported that NAD+ enhancement by NAM and NR was mostly through microbiota-dependent deamidated pathway [44].”
From NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health (2023) · cites this paper as [44]
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“While microorganisms that inhabit the gut play a role in the metabolism of NAD+ and its metabolites [43, 44]”
From NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health (2023) · cites this paper as [44]
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“For example, the gut microbiota deamidates orally administered NAM to NA, which is then used for NAD+ synthesis via the Preiss-Handler pathway in the liver (23).”
From Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD + synthesis via enterohepatic circulation (2025) · cites this paper as [23]
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“Recent studies indicated that the gut microbiota is essentially involved in the host NAD+ metabolism network (22–24).”
From Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD + synthesis via enterohepatic circulation (2025) · cites this paper as [23]
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“However, subsequent studies and our current study demonstrated that orally administered NR was degraded into NAM and then converted to NA by gut microbiota before absorption (22–24).”
From Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD + synthesis via enterohepatic circulation (2025) · cites this paper as [23]
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Cites
KEGG: Kyoto Encyclopedia of Genes and Genomes
Kanehisa, M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.27 · Cited by 37,077
KEGG: Kyoto Encyclopedia of Genes and Genomes
Ogata, H., Goto, S., Sato, K., Fujibuchi, W., Bono, H., & Kanehisa, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.29 · Cited by 31,232
A Simple Practice Guide for Dose Conversion between Animals and Human
Nair, A., & Jacob, S. (2016) · Journal of Basic and Clinical Pharmacy · doi:10.4103/0976-0105.177703 · Cited by 6,174
Improved vectors and genome-wide libraries for CRISPR screening
Sanjana, N. E., Shalem, O., & Zhang, F. (2014) · Nature Methods · doi:10.1038/nmeth.3047 · Cited by 5,239
The Pfam protein families database in 2019
El-Gebali, S., Mistry, J., Bateman, A., Eddy, S. R., Luciani, A., Potter, S. C., Qureshi, M., Richardson, L. J., Salazar, G. A., Smart, A., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gky995 · Cited by 4,602
MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis
Chong, J., Soufan, O., Li, C., Caraus, I., Li, S., Bourque, G., Wishart, D. S., & Xia, J. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky310 · Cited by 3,637
Gut biogeography of the bacterial microbiota
Donaldson, G. P., Lee, S. M., & Mazmanian, S. K. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro3552 · Cited by 2,535
Molecular Biology and Pathogenicity of Mycoplasmas
Razin, S., Yogev, D., & Naot, Y. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.4.1094-1156.1998 · Cited by 1,930
Geller, L. T., Barzily-Rokni, M., Danino, T., Jonas, O. H., Shental, N., Nejman, D., Gavert, N., Zwang, Y., Cooper, Z. A., Shee, K., et al. (2017) · Science · doi:10.1126/science.aah5043 · Cited by 1,817
Cantó, C., Menzies, K. J., & Auwerx, J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.023 · Cited by 1,648
NAD+ and sirtuins in aging and disease
Imai, S.-I., & Guarente, L. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.04.002 · Cited by 1,481
Cantó, C., Houtkooper, R. H., Pirinen, E., Youn, D. Y., Oosterveer, M. H., Cen, Y., Fernandez-Marcos, P. J., Yamamoto, H., Andreux, P. A., Cettour-Rose, P., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.022 · Cited by 1,238
Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts
Frezza, C., Cipolat, S., & Scorrano, L. (2007) · Nature Protocols · doi:10.1038/nprot.2006.478 · Cited by 1,188
NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism
Xiao, W., Wang, R., Handy, D. E., & Loscalzo, J. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7216 · Cited by 1,062
NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR
Yoshino, J., Baur, J. A., & Imai, S.-I. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.11.002 · Cited by 1,061
Revollo, J. R., Grimm, A. A., & Imai, S.-I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408388200 · Cited by 1,010
NAD+ metabolism in health and disease
Belenky, P. A., Bogan, K. L., & Brenner, C. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.11.006 · Cited by 1,006
Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence
Rajman, L., Chwalek, K., & Sinclair, D. A. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.011 · Cited by 865
Bogan, K. L., & Brenner, C. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155443 · Cited by 707
Nicotinamide riboside is uniquely and orally bioavailable in mice and humans
Trammell, S. A. J., Schmidt, M. S., Weidemann, B. J., Redpath, P., Jaksch, F., Dellinger, R. W., Li, Z., Abel, E. D., Migaud, M. E., & Brenner, C. (2016) · Nature Communications · doi:10.1038/ncomms12948 · Cited by 697
Self-citationMartens, C. R., Denman, B. A., Mazzo, M. R., Armstrong, M. L., Reisdorph, N., McQueen, M. B., Chonchol, M., & Seals, D. R. (2018) · Nature Communications · doi:10.1038/s41467-018-03421-7 · Cited by 588
Quantitative Analysis of NAD Synthesis-Breakdown Fluxes
Liu, L., Su, X., Quinn, W. J., Hui, S., Krukenberg, K., Frederick, D. W., Redpath, P., Zhan, L., Chellappa, K., White, E., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.018 · Cited by 564
Self-citationBerger, F., Lau, C., Dahlmann, M., & Ziegler, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508660200 · Cited by 508
NAD(+) in aging: molecular mechanisms and translational implications
Fang, E. F., Lautrup, S., Hou, Y., Demarest, T. G., Croteau, D. L., Mattson, M. P., & Bohr, V. A. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.08.001 · Cited by 501
Impairment of an endothelial NAD(+)-H2S signaling network is a reversible cause of vascular aging
Das, A., Huang, G. X., Bonkowski, M. S., Longchamp, A., Li, C., Schultz, M. B., Kim, L.-J., Osborne, B., Joshi, S., Lu, Y., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.008 · Cited by 496
De novo NAD+ synthesis enhances mitochondrial function and improves health
Katsyuba, E., Mottis, A., Ziętak, M., Franco, F., van der Velpen, V., Gariani, K., Ryu, D., Cialabrini, L., Matilainen, O., Liscio, P., et al. (2018) · Nature · doi:10.1038/s41586-018-0645-6 · Cited by 447
Poly(2-oxazoline)s based biomaterials: a comprehensive and critical update
Lorson, T., Lübtow, M. M., Wegener, E., Haider, M. S., Borova, S., Nahm, D., Jordan, R., Sokolski-Papkov, M., Kabanov, A. V., & Luxenhofer, R. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.05.022 · Cited by 391
Self-citationTarragó, M. G., Chini, C. C. S., Kanamori, K. S., Warner, G. M., Caride, A., de Oliveira, G. C., Rud, M., Samani, A., Hein, K. Z., Huang, R., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.016 · Cited by 384
NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells
Ratajczak, J., Joffraud, M., Trammell, S. A. J., Ras, R., Canela, N., Boutant, M., Kulkarni, S. S., Rodrigues, M., Redpath, P., Migaud, M. E., et al. (2016) · Nature Communications · doi:10.1038/ncomms13103 · Cited by 378
Self-citationGariani, K., Menzies, K. J., Ryu, D., Wegner, C. J., Wang, X., Ropelle, E. R., Moullan, N., Zhang, H., Perino, A., Lemos, V., et al. (2016) · Hepatology · doi:10.1002/hep.28245 · Cited by 368
Slc12a8 is a nicotinamide mononucleotide transporter
Grozio, A., Mills, K. F., Yoshino, J., Bruzzone, S., Sociali, G., Tokizane, K., Lei, H. C., Cunningham, R., Sasaki, Y., Migaud, M. E., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0009-4 · Cited by 287
Self-citationBaumann, L., Cina, M., Egli-Gany, D., Goutaki, M., Halbeisen, F. S., Lohrer, G.-R., Ali, H., Scott, P., & Low, N. N. (2018) · Sexually Transmitted Infections · doi:10.1136/sextrans-2017-053384 · Cited by 253
Evolution, human-microbe interactions, and life history plasticity
Rook, G., Bäckhed, F., Levin, B. R., McFall-Ngai, M. J., & McLean, A. R. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30566-4 · Cited by 246
NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling
Chowdhry, S., Zanca, C., Rajkumar, U., Koga, T., Diao, Y., Raviram, R., Liu, F., Turner, K. M., Yang, H., Brunk, E., et al. (2019) · Nature · doi:10.1038/s41586-019-1150-2 · Cited by 239
Modulating NAD+ metabolism, from bench to bedside
Katsyuba, E., & Auwerx, J. H. (2017) · The EMBO Journal · doi:10.15252/embj.201797135 · Cited by 231
Microbial NAD Metabolism: Lessons from Comparative Genomics
Gazzaniga, F., Stebbins, R., Chang, S. Z., McPeek, M. A., & Brenner, C. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00042-08 · Cited by 230
NAD Metabolism in Cancer Therapeutics
Yaku, K., Okabe, K., Hikosaka, K., & Nakagawa, T. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00622 · Cited by 229
Hara, N., Yamada, K., Shibata, T., Osago, H., Hashimoto, T., & Tsuchiya, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610357200 · Cited by 205
He, Z., Wan, X., Schulz, A., Bludau, H., Dobrovolskaia, M. A., Stern, S. T., Montgomery, S. A., Yuan, H., Li, Z., Alakhova, D., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.06.002 · Cited by 197
Self-citationTARGETED, LCMS-BASED METABOLOMICS FOR QUANTITATIVE MEASUREMENT OF NAD + METABOLITES
Trammell, S. A. J., & Brenner, C. (2013) · Computational and Structural Biotechnology Journal · doi:10.5936/csbj.201301012 · Cited by 193
Mycoplasmas and oncogenesis: persistent infection and multistage malignant transformation.
Tsai, S., Wear, D. J., Shih, J. W., & Lo, S. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.22.10197 · Cited by 192
Tan, B., Young, D. A., Lu, Z.-H., Wang, T., Meier, T. I., Shepard, R. L., Roth, K. D. W., Zhai, Y. W., Huss, K., Kuo, M., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.394510 · Cited by 181
Development and Quantitative Evaluation of a High-Resolution Metabolomics Technology
Liu, X., Ser, Z., & Locasale, J. W. (2014) · Analytical Chemistry · doi:10.1021/ac403845u · Cited by 177
Self-citationWang, S., Wan, T., Ye, M., Qiu, Y., Pei, L., Jiang, R., Pang, N., Huang, Y., Liang, B., Ling, W., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2018.04.006 · Cited by 174
Boosting NAD+ with a small molecule that activates NAMPT
Gardell, S. J., Hopf, M., Khan, A., Dispagna, M., Hampton Sessions, E., Falter, R., Kapoor, N., Brooks, J., Culver, J., Petucci, C., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11078-z · Cited by 169
Chini, C. C. S., Guerrico, A. M. G., Nin, V., Camacho-Pereira, J., Escande, C., Barbosa, M. T., & Chini, E. N. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0150 · Cited by 147
Association of Mycoplasma hominis infection with prostate cancer
Barykova, Y. A., Logunov, D. Y., Шмаров, М. М., Винаров, А. З., Fiev, D., Винаров, А. З., Rakovskaya, I. V., Baker, P. S., Shyshynova, I., Stephenson, A. J., et al. (2011) · Oncotarget · doi:10.18632/oncotarget.256 · Cited by 123
Dihydronicotinamide riboside is a potent NAD+ concentration enhancer in vitro and in vivo
Yang, Y. J., Mohammed, N. A. K., Zhang, N., & Sauve, A. A. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005772 · Cited by 113
Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration
Mukherjee, S., Chellappa, K., Moffitt, A. B., Ndungu, J., Dellinger, R. W., Davis, J. G., Agarwal, B., & Baur, J. A. (2016) · Hepatology · doi:10.1002/hep.28912 · Cited by 108
The Impact of Intratumoral and Gastrointestinal Microbiota on Systemic Cancer Therapy
Cogdill, A. P., Gaudreau, P. O., Arora, R., Gopalakrishnan, V., & Wargo, J. A. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.09.007 · Cited by 98
Ahdesmaki, M. J., Gray, S. R., Johnson, J. H., & Lai, Z. (2016) · F1000Research · doi:10.12688/f1000research.10082.1 · Cited by 86
Generation, Release, and Uptake of the NAD Precursor Nicotinic Acid Riboside by Human Cells
Kulikova, V., Shabalin, K., Nerinovski, K., Dölle, C., Niere, M., Yakimov, A., Redpath, P., Khodorkovskiy, M., Migaud, M. E., Ziegler, M., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.664458 · Cited by 84
Self-citationUddin, G. M., Youngson, N. A., Doyle, B. M., Sinclair, D. A., & Morris, M. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-14866-z · Cited by 82
Matheny, C., Wei, M. C., Bassik, M. C., Donnelly, A. J., Kampmann, M., 岩崎, 正., Piloto, O., Solow-Cordero, D. E., Bouley, D. M., Rau, R. E., et al. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.09.014 · Cited by 76
Nicotinamide phosphoribosyltransferase (Nampt) in carcinogenesis: new clinical opportunities
Chen, H., Wang, S., Zhang, H., Nice, E. C., & Huang, C. (2016) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2016.1190649 · Cited by 64
Hong, S. M., Hwang, S. W., Wang, T., Park, C. W., Ryu, Y., Jung, J., Shin, J. H., Kim, S., Lee, J. L., Kim, C. W., et al. (2018) · Cancer Science · doi:10.1111/cas.13886 · Cited by 62
French, J. B., Cen, Y., Vrablik, T. L., Xu, P., Allen, E. K. H., Hanna‐Rose, W., & Sauve, A. A. (2010) · Biochemistry · doi:10.1021/bi1012518 · Cited by 59
Mycoplasma Hyorhinis Infection Promotes NF- κ B–Dependent Migration of Gastric Cancer Cells
Duan, H., Chen, L., Qu, L., Yang, H., Song, S. W., Han, Y. K., Ye, M., Chen, W., He, X., & Shou, C. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0650 · Cited by 56
Expression level is a key determinant of E2F1-mediated cell fate
Shats, I., Deng, M., Davidovich, A., Zhang, C., Kwon, J. S., Manandhar, D., Gordân, R., Yao, G., & You, L. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.12 · Cited by 55
Self-citationNew strategies to maximize therapeutic opportunities for NAMPT inhibitors in oncology
Roulston, A., & Shore, G. C. (2015) · Molecular & Cellular Oncology · doi:10.1080/23723556.2015.1052180 · Cited by 54
Mycoplasma and cancer: in search of the link
Rogers, M. B. (2011) · Oncotarget · doi:10.18632/oncotarget.264 · Cited by 50
Yaku, K., Okabe, K., & Nakagawa, T. (2018) · Biomedical Chromatography · doi:10.1002/bmc.4205 · Cited by 49
Demarest, T. G., Truong, G. T. D., Lovett, J., Mohanty, J. G., Mattison, J. A., Mattson, M. P., Ferrucci, L., Bohr, V. A., & Moaddel, R. (2019) · Analytical Biochemistry · doi:10.1016/j.ab.2019.02.019 · Cited by 48
Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer
Espíndola‐Netto, J. M., Chini, C. C. S., Tarragó, M. G., Wang, E., Dutta, S. K., Pal, K., Mukhopadhyay, D., Sola‐Penna, M., & Chini, E. N. (2017) · Oncotarget · doi:10.18632/oncotarget.18841 · Cited by 44
Harasawa, R., Mizusawa, H., Fujii, M., Yamamoto, J., Mukai, H., Uemori, T., Asada, K., & Kato, I. (2005) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2005.tb03675.x · Cited by 41
Shi, W., Hegeman, M. A., Doncheva, A. I., Bekkenkamp‐Grovenstein, M., de Boer, V. C. J., & Keijer, J. (2019) · Nutrients · doi:10.3390/nu11102439 · Cited by 37
Sanchez-Garcia, E. K., Contreras‐Paredes, A., Abundis, E. M., Garcia-Chan, D., Lizano, M., & la Cruz-Hernández, E. N. D. (2019) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001044 · Cited by 31
Voorde, J. V., Vervaeke, P., Liekens, S., & Balzarini, J. M. (2015) · FEBS Open Bio · doi:10.1016/j.fob.2015.07.007 · Cited by 27
Hara, N., Osago, H., Hiyoshi, M., Kobayashi‐Miura, M., & Tsuchiya, M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214000 · Cited by 21
Pajk, M., Cselkó, A., Varga, C., Pósa, A., Tokodi, M., Boldogh, I. R., Goto, S., & Radak, Z. O. (2017) · Biogerontology · doi:10.1007/s10522-017-9705-9 · Cited by 20
Fraterrigo, G., Fabbrini, E., Mittendorfer, B., O’Rahilly, S., Scherer, P. E., Patterson, B. W., & Klein, S. (2012) · Cardiorenal Medicine · doi:10.1159/000340037 · Cited by 16
Voorde, J. V., Liekens, S., & Balzarini, J. M. (2013) · Molecular Pharmacology · doi:10.1124/mol.113.088625 · Cited by 14
Increased risk of ankylosing spondylitis after Mycoplasma pneumonia
Chu, K., Chen, W., Hung, Y., & Wei, J. C. (2019) · Medicine · doi:10.1097/md.0000000000015596 · Cited by 12
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Metadata
- Authors
- Shats, I., Williams, J. G., Liu, J., Makarov, M. V., Wu, X., Lih, F. B., Deterding, L. J., Lim, C., Xu, X., Randall, T. A., Lee, E., Li, W., Fan, W., Li, J.-L., Sokolsky, M., Kabanov, A. V., Li, L., Migaud, M. E., Locasale, J. W., & Li, X.
- Affiliations
- National Institutes of Health (US)
- Duke University (US)
- University of South Alabama (US)
- National Institute of Environmental Health Sciences (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Shats, Igor
- Li, Xiaoling
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 31
- Issue
- 3
- Pages
- 564-579.e7
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC7194078
- OpenAlex
- W3010636379
- Cited by
- 242
- References
- 73
- Citations by year
- 2026: 31 · 2025: 52 · 2024: 37 · 2023: 37 · 2022: 42 · 2021: 28 · 2020: 14
- FWCI
- 15.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institute of Environmental Health Sciences
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- NAD+ metabolism, NAD biosynthesis, NAMPT inhibitors, nicotinamide, nicotinamide riboside, gut microbiota, host-microbe interactions, cancer cells, tumor xenografts
- MeSH terms
- Gastrointestinal Microbiome, Administration, Oral, Amides, Animals, Energy Metabolism, Female, Humans, Male, Mammals, Mice, Inbred C57BL, Mycoplasma, NAD, Nicotinamidase, Niacinamide, Nicotinamide Mononucleotide, Pyridinium Compounds, Cytokines, Cell Line, Tumor, Biosynthetic Pathways, Nicotinamide Phosphoribosyltransferase, Metabolome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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