The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication
Open accessAbstract
Liver fibrosis is a strong predictor of long-term mortality in individuals with metabolic-associated fatty liver disease; yet, the mechanisms underlying the progression from the comparatively benign fatty liver state to advanced non-alcoholic steatohepatitis (NASH) and liver fibrosis are incompletely understood. Using cell-type-resolved genomics, we show that comprehensive alterations in hepatocyte genomic and transcriptional settings during NASH progression, led to a loss of hepatocyte identity. The hepatocyte reprogramming was under tight cooperative control of a network of fibrosis-activated transcription factors, as exemplified by the transcription factor Elf-3 (ELF3) and zinc finger protein GLIS2 (GLIS2). Indeed, ELF3- and GLIS2-controlled fibrosis-dependent hepatokine genes targeting disease-associated hepatic stellate cell gene programs. Thus, interconnected transcription factor networks not only promoted hepatocyte dysfunction but also directed the intra-hepatic crosstalk necessary for NASH and fibrosis progression, implying that molecular "hub-centered" targeting strategies are superior to existing mono-target approaches as currently used in NASH therapy.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Citations
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
Cox, J., & Mann, M. (2008) · Nature Biotechnology · doi:10.1038/nbt.1511 · Cited by 14,855
Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382
Integrating single-cell transcriptomic data across different conditions, technologies, and species
Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174
Gene ontology analysis for RNA-seq: accounting for selection bias
Young, M. D., Wakefield, M. J., Smyth, G. K., & Oshlack, A. (2010) · Genome Biology · doi:10.1186/gb-2010-11-2-r14 · Cited by 7,107
Pérez-Riverol, Y., Csordas, A., Bai, J.-W., Bernal-Llinares, M., Hewapathirana, S., Kundu, D. J., Inuganti, A., Griss, J., Mayer, G., Eisenacher, M., et al. (2018) · Nucleic Acids Res. · doi:10.1093/nar/gky1106 · Cited by 6,216
Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention
Younossi, Z., Anstee, Q. M., Marietti, M., Hardy, T., Henry, L., Eslam, M., George, J., & Bugianesi, E. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.109 · Cited by 5,249
Flagged first, then by citations
Cited by
Sorted by citations
Hepatic fibrosis 2022: Unmet needs and a blueprint for the future
Friedman, S. L., & Pinzani, M. (2022) · Hepatology · doi:10.1002/hep.32285 · Cited by 430
Molecular mechanisms in MASLD/MASH-related HCC
Wang, X., Zhang, L., & Dong, B. (2024) · Hepatology · doi:10.1097/hep.0000000000000786 · Cited by 193
Epithelial–mesenchymal transition in tissue repair and degeneration
Youssef, K. K., & Nieto, M. A. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00733-z · Cited by 165
Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)
Wang, S., & Friedman, S. L. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adi0759 · Cited by 158
Loss of liver function in chronic liver disease: An identity crisis
Berasain, C., Arechederra, M., Argemí, J., Fernández-Barrena, M. G., & Avila, M. A. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2022.09.001 · Cited by 99
A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis
Loft, A., Schmidt, S. F., Caratti, G., Stifel, U., Havelund, J., Sekar, R., Kwon, Y., Sulaj, A., Chow, K. K., Alfaro, A. J., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.01.004 · Cited by 76
Self-citationLiu, J., Liu, J., Mu, W., Ma, Q., Zhai, X., Jin, B., Liu, Y., & Zhang, N. (2024) · ACS Nano · doi:10.1021/acsnano.4c02380 · Cited by 74
Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis
Xiao, Y., Batmanov, K., Hu, W., Zhu, K., Tom, A. Y., Guan, D., Jiang, C., Cheng, L., McCright, S. J., Yang, E. C., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adc9653 · Cited by 69
Liver regeneration: Cellular origin and molecular mechanisms
Huang, R. C. C., Zhang, X., Gracia‐Sancho, J., & Xie, W. (2022) · Liver International · doi:10.1111/liv.15174 · Cited by 69
Talamantes, S., Lisjak, M., Gilglioni, E. H., Llamoza-Torres, C. J., Ramos‐Molina, B., & Gurzov, E. N. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100811 · Cited by 62
Greatorex, S., Kaur, S., Xirouchaki, C. E., Goh, P. K., Wiede, F., Genders, A. J., Tran, M., Jia, Y., Raajendiran, A., Brown, W. A., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci162533 · Cited by 61
Gong, L., Wei, F., Gonzalez, F. J., & Li, G. (2023) · Hepatology · doi:10.1097/hep.0000000000000182 · Cited by 61
Xie, W., Gan, J., Zhou, X., Tian, H., Pan, X., Liu, W., Li, X., Du, J., Xu, A., Zheng, M., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.04.020 · Cited by 55
Li, Z., Zhang, H., Li, Q., Feng, W., Jia, X., Zhou, R., Huang, Y., Li, Y., Hu, Z., Hu, X., et al. (2023) · Scientific Data · doi:10.1038/s41597-023-02257-1 · Cited by 55
The role of N-glycosylation modification in the pathogenesis of liver cancer
Hu, M., Zhang, R., Yang, J., Zhao, C., Liu, W., Huang, Y., Lyu, H., Xiao, S., Guo, D. S., Zhou, C., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05733-z · Cited by 53
Spatial genomics: mapping human steatotic liver disease
Matchett, K. P., Paris, J., Teichmann, S. A., & Henderson, N. C. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00915-2 · Cited by 53
HNF4A modulates glucocorticoid action in the liver
Hunter, A. L., Poolman, T. M., Kim, D., Gonzalez, F. J., Bechtold, D. A., Loudon, A. S. I., Iqbal, M., & Ray, D. W. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110697 · Cited by 49
Zhang, L., Deng, W., Huang, Q., Zhang, J., Wang, Y., Zhou, T., Xing, L., & Jiang, H. (2024) · Advanced Materials · doi:10.1002/adma.202311474 · Cited by 48
Liver-specific actions of GH and IGF1 that protect against MASLD
Kineman, R. D., del Río-Moreno, M., & Waxman, D. J. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01037-0 · Cited by 44
IL6 supports long-term expansion of hepatocytes in vitro
Guo, R., Jiang, M., Wang, G., Li, B., Jia, X., Ai, Y., Chen, S., Tang, P., Liu, A., Yuan, Q., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35167-8 · Cited by 36
Pellegata, N. S., Berriel Diaz, M., Rohm, M., & Herzig, S. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10058-y · Cited by 33
Self-citationWang, G., Duan, J., Pu, G., Ye, C., Li, Y., Xiu, W., Xu, J., Liu, B., Zhu, Y., & Wang, C. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166413 · Cited by 33
Aguilar‐Bravo, B., Ariño, S., Blaya, D., Pose, E., de la Torre, R. A. M. G., Latasa, M. U., Martínez–Sánchez, C., Zanatto, L., Sererols-Viñas, L., Vilà, P. C., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.04.013 · Cited by 33
Regulation of systemic metabolism by tissue-resident immune cell circuits
Li, J. H., Hepworth, M. R., & O’Sullivan, T. E. (2023) · Immunity · doi:10.1016/j.immuni.2023.05.001 · Cited by 36
Deep proteome profiling of metabolic dysfunction-associated steatotic liver disease
Pedersen, F. B., Akimov, V., Teuchler, M., Terkelsen, M. K., Wernberg, C. W., Larsen, F. T., Hallenborg, P., Lauridsen, M. M., Krag, A. A., Mandrup, S., et al. (2025) · Communications Medicine · doi:10.1038/s43856-025-00780-3 · Cited by 32
Self-citationDistinct hepatocyte identities in liver homeostasis and regeneration
Chen, F., Schönberger, K., & Tchorz, J. S. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100779 · Cited by 30
Zhang, C., Rehman, M., Tian, X., Pei, S. L. C., Gu, J., Bell, T. A., Dong, K., Tham, M. S., Cai, Y., Wei, Z., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48025-6 · Cited by 30
Zhang, J., Shen, Y., Chen, X.-Y., Jiang, M.-L., Yuan, F.-H., Xie, S.-L., Zhang, J., & Xu, F. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1115890 · Cited by 31
EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis
Ma, F., Longo, M., Meroni, M., Bhattacharya, D., Paolini, E., Mughal, S., Hussain, S., Anand, S. K., Gupta, N., Zhu, Y., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.01.020 · Cited by 29
Pan, C., Liu, J., Gao, Y., Yang, M., Hu, H., Liu, C., Qian, M., Yuan, H.-Y., Yang, S., Zheng, M.-H., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.10.018 · Cited by 27
Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging
Occean, J. R., Yang, N., Sun, Y., Dawkins, M. S., Munk, R. B., Belair, C., Dar, S. A., Anerillas, C., Wang, L., Shi, C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50725-y · Cited by 30
Das, S. R., Finney, A. C., Anand, S. K., Rohilla, S., Liu, Y., Pandey, N. O., Ghrayeb, A., Kumar, D., Núñez, K., Liu, Z., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01134-4 · Cited by 28
Geervliet, E., Terstappen, L. W. M. M., & Bansal, R. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115612 · Cited by 26
Lactate and lactylation: novel perspectives on fibrosis pathogenesis and therapeutic directions
Liang, H., Xu, L., & Yang, Y. A. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06748-0 · Cited by 29
Banerjee, A., & Farci, P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168641 · Cited by 25
Li, Y., Xiu, W., Xu, J., Chen, X., Wang, G., Duan, J., Sun, L., Liu, B., Xie, W., Pu, G., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.162402 · Cited by 23
Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia
Kaltenecker, D., Schmidt, S. F., Weber, P., Loft, A., Morigny, P., Machado, J., Geppert, J., Saul, K. B., Benedikt, P., Molocea, C., et al. (2025) · Cell · doi:10.1016/j.cell.2025.06.039 · Cited by 28
Self-citationChemPert: mapping between chemical perturbation and transcriptional response for non-cancer cells
Zheng, M., Okawa, S., Bravo, M., Chen, F., Martínez‐Chantar, M. L., & del Sol, A. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac862 · Cited by 21
Liver receptor homolog-1 (NR5A2) orchestrates hepatic inflammation and TNF-induced cell death
Lambrecht, R., Delgado, M. E., Gloe, V., Schuetz, K., Plazzo, A. P., Franke, B., Phan, T. S., Fleming, J. R., Mayans, O. M., & Brunner, T. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113513 · Cited by 23
The Nr4a family regulates intrahepatic Treg proliferation and liver fibrosis in MASLD models
Aki, D., Hayakawa, T., Srirat, T., Shichino, S., Ito, M., Saitoh, S.-I., Mise-Omata, S., & Yoshimura, A. (2024) · Journal of Clinical Investigation · doi:10.1172/jci175305 · Cited by 22
GSNOR deficiency promotes tumor growth via FAK1 S-nitrosylation
Rizza, S., Leo, L. D., Pecorari, C., Giglio, P., Faienza, F., Montagna, C., Maiani, E., Puglia, M., Bosisio, F. M., Petersen, T. S., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.111997 · Cited by 20
Self-citationInterrogating mechanisms of liver fibrosis with omics
Oakley, F. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00567-6 · Cited by 19
Sokal-Dembowska, A., Jarmakiewicz-Czaja, S., Ferenc, K., & Filip, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105238 · Cited by 19
Wen, Y., Zou, Z.-Y., Zhao, G., Zhang, M., Zhang, Y., Wang, G., Shi, J., Wang, Y.-Y., Song, Y.-Y., Wang, H., et al. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01329-1 · Cited by 19
Role of PNPLA3 in Hepatic Stellate Cells and Hepatic Cellular Crosstalk
Martins, M. C., Dixon, E. D., Lupo, G., Claudel, T., Trauner, M., & Rombouts, K. (2024) · Liver International · doi:10.1111/liv.16117 · Cited by 22
Cell competition in primary and metastatic colorectal cancer
van Luyk, M. E., García, A. K., Λάμπρου, Μ., & Suijkerbuijk, S. J. E. (2024) · Oncogenesis · doi:10.1038/s41389-024-00530-5 · Cited by 20
GLIS1-3: Links to Primary Cilium, Reprogramming, Stem Cell Renewal, and Disease
Jetten, A. M., Scoville, D. W., & Kang, H. S. (2022) · Cells · doi:10.3390/cells11111833 · Cited by 17
Nuclear receptors: pathophysiological mechanisms and drug targets in liver disease
Dubois, V., Lefèbvre, P., Staels, B., & Eeckhoute, J. (2024) · Gut · doi:10.1136/gutjnl-2023-331741 · Cited by 17
Xin, J., Zhou, C., Wang, Y., Chen, H., Yin, K., Gao, L., & Shao, S. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118305 · Cited by 16
Ariño, S., Ferrer‐Lorente, R., Serrano, G., Zanatto, L., de la Torre, R. A. M. G., Gratacós‐Ginès, J., Rubio, A. B., Pérez-Guasch, M., Mateos-Sánchez, C., Aguilar‐Bravo, B., et al. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.07.014 · Cited by 19
Zhang, H., Zhou, P., Xing, W., Chen, L., Zhou, Y., Yang, H., Fu, K., & Liu, Z. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.10.015 · Cited by 15
Fu, Y., Wang, Z., & Qin, H. (2024) · Metabolites · doi:10.3390/metabo14040218 · Cited by 15
Rho, H. K., Kim, S., Kim, S. U., Kim, J. W., Lee, S. H., Park, S., Escorcia, F. E., Chung, J., & Song, J. (2024) · Nature Communications · doi:10.1038/s41467-024-53002-0 · Cited by 18
Huerta, M., Franco-Serrano, L., Amela, I., Perez-Pons, J. A., Piñol, J., Mozo-Villarias, Á., Querol, E., & Cedano, J. A. (2023) · Cells · doi:10.3390/cells12020235 · Cited by 14
Karri, K., & Waxman, D. J. (2023) · RNA · doi:10.1261/rna.079580.123 · Cited by 15
López‐Alcántara, N., Oelkrug, R., Sentis, S. C., Kirchner, H., & Mittag, J. (2023) · iScience · doi:10.1016/j.isci.2023.108064 · Cited by 14
Yang, Y., Liu, X., Chen, H., Wang, P., Yao, S., Zhou, B., Yin, R., Li, C., Wu, C., Yang, X., et al. (2022) · FEBS Journal · doi:10.1111/febs.16430 · Cited by 14
Sun, Y.-D., Zhang, H., Li, Y., & Han, J. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189086 · Cited by 13
Mahmood, S., Morrice, N., Thompson, D., Milanizadeh, S., Wilson, S., Whitfield, P. D., Mcilroy, G. D., Rochford, J. J., & Mody, N. (2025) · Experimental Physiology · doi:10.1113/ep092535 · Cited by 13
Liu, T., Wang, Q., Zhou, L., Zhang, P., Mi, L., Qiu, X., Chen, Z., Kuang, H., Li, S., & Lin, J. D. (2022) · Hepatology · doi:10.1002/hep.32719 · Cited by 14
Beyoğlu, D., Huang, P., Skelton-Badlani, D., Zong, C., Popov, Y. V., & Idle, J. R. (2023) · Cells · doi:10.3390/cells12030485 · Cited by 12
Metabolism and bioenergetics in the pathophysiology of organ fibrosis
Miguel, V., Alcalde‐Estévez, E., Sirera, B., Rodríguez‐Pascual, F., & Lamas, S. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.06.001 · Cited by 13
Gonzalez‐Sanchez, E., Vaquero, J., Caballero‐Díaz, D., Grzelak, J., Fusté, N. P., Bertrán, E., Amengual, J., García‐Sáez, J., Martín‐Mur, B., Gut, M. O., et al. (2024) · The Journal of Pathology · doi:10.1002/path.6299 · Cited by 12
Chemically induced revitalization of damaged hepatocytes for regenerative liver repair
Lin, P., Bai, Y., Nian, X.-X., Chi, J., Chen, T., Zhang, J., Zhang, W., Zhou, B., Liu, Y., & Zhao, Y. (2023) · iScience · doi:10.1016/j.isci.2023.108532 · Cited by 11
Purification of GFP-tagged nuclei from frozen livers of INTACT mice for RNA- and ATAC-sequencing
Loft, A., Herzig, S., & Schmidt, S. F. (2021) · STAR Protocols · doi:10.1016/j.xpro.2021.100805 · Cited by 11
Self-citationWolff, G., Sakurai, M., Mhamane, A., Troullinaki, M., Maida, A., Deligiannis, I. K., Yin, K., Weber, P., Morgenstern, J., Wieder, A., et al. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101487 · Cited by 12
Self-citationQuitete, F. T., Teixeira, A. V. S., Peixoto, T. C., Martins, B. C., Atella, G. C., Resende, Â. C., Mucci, D. D. B., Martins, F. F., & Daleprane, J. B. (2024) · PLoS ONE · doi:10.1371/journal.pone.0308334 · Cited by 10
Skytthe, M. K., Pedersen, F. B., Wernberg, C. W., Chandran, V. I., Krag, A. A., Caterino, T. D., Mandacaru, S. C., Blagoev, B., Lauridsen, M. M., Detlefsen, S., et al. (2023) · Gastro Hep Advances · doi:10.1016/j.gastha.2023.03.006 · Cited by 9
Self-citationEmerging roles of RNA‐binding proteins in fatty liver disease
Adesanya, O. A., Das, D., & Kalsotra, A. (2024) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1840 · Cited by 9
TSC22D4 promotes TGFβ1-induced activation of hepatic stellate cells
Sakurai, M., Weber, P., Wolff, G., Wieder, A., Szendroedi, J., Herzig, S., & Üstünel, B. E. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.05.100 · Cited by 9
Self-citationCalixto-Tlacomulco, S., Luna-Reyes, I., Delgado‐Coello, B., Gutiérrez‐Vidal, R., Reyes‐Grajeda, J. P., & Mas‐Oliva, J. (2024) · Archives of Medical Research · doi:10.1016/j.arcmed.2023.102937 · Cited by 9
Lutsiv, T., McGinley, J. N., Neil, E. S., Foster, M. T., & Thompson, H. J. (2023) · Nutrients · doi:10.3390/nu15030526 · Cited by 10
Interdisciplinary advances reshape the delivery tools for effective NASH treatment
Chen, L., & Wang, Y. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101730 · Cited by 9
Sonkar, R., Ma, H., & Waxman, D. J. (2024) · Toxicological Sciences · doi:10.1093/toxsci/kfae057 · Cited by 7
Shen, T. K., Vignane, T., Gilglioni, E. H., Traini, L., Kalaitsidou, E., Conan, P., Li, A., St‐Pierre‐Wijckmans, W., Herranz, J. M., Elvira, B., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103809 · Cited by 8
Role of PDLIM1 in hepatic stellate cell activation and liver fibrosis progression
Ye, B., Yu, M., Yue, M., Yin, M., Zhang, C., Wang, Q., Ding, X., Shen, W., & Zhao, Z. (2023) · Scientific Reports · doi:10.1038/s41598-023-38144-3 · Cited by 8
Hong, W., Zhu, Y., Lin, Y., Tang, S., Chen, J., Xu, L., Jiang, J., Zong, Y., Zhang, Y., Sun, A., et al. (2024) · Life Sciences · doi:10.1016/j.lfs.2023.122320 · Cited by 9
Ntambi, J.-N., Kalyesubula, M., Cootway, D., Lewis, S. A., Phang, Y. X., Liu, Z., O’Neill, L. M., Lefers, L., Huff, H., Miller, J. R., et al. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2024.159538 · Cited by 9
Dynamic enhancer interactome promotes senescence and agingPreprint
Wang, L., Donahue, G., Zhang, C., Havas, A. P., Lei, X., Xu, C., Wang, W., Vahedi, G., Adams, P. D., & Berger, S. L. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.22.541769 · Cited by 8
Characterization of regulatory transcriptional mechanisms in hepatocyte lipotoxicity
Pérez‐Schindler, J., Vargas‐Fernández, E., Karrer‐Cardel, B., Ritz, D., Schmidt, A., & Handschin, C. (2022) · Scientific Reports · doi:10.1038/s41598-022-15731-4 · Cited by 7
An extended transcription factor regulatory network controls hepatocyte identity
Dubois‐Chevalier, J., Gheeraert, C., Berthier, A., Boulet, C., Dubois, V., Guille, L., Fourcot, M., Marot, G., Gauthier, K., Dubuquoy, L., et al. (2023) · EMBO Reports · doi:10.15252/embr.202357020 · Cited by 6
“Calling of super-enhancers (SE) and target gene assignation, essentially performed as in (Loven et al , 2013; Whyte et al , 2013), was previously described (Dubois-Chevalier et al , 2020).”
Mesenchymal drift: A convergent framework for the hallmarks of aging
Lu, J. Y., Tu, W. B., Ma, S., Ma, Z., Imaz-Rosshandler, I., Weng, M., Qu, J., Esteban, C. R., Reddy, P., Liu, G.-H., et al. (2026) · Cell · doi:10.1016/j.cell.2026.04.020 · Cited by 10
Alterations in the hepatocyte epigenetic landscape in steatosis
Maji, R. K., Czepukojc, B., Scherer, M., Tierling, S., Cadenas, C., Gianmoena, K., Gasparoni, N., Nordström, K. J. V., Gasparoni, G., Laggai, S., et al. (2023) · Epigenetics & Chromatin · doi:10.1186/s13072-023-00504-8 · Cited by 7
NHE1 regulation in NAFLD in vitro contributes to hepatocyte injury and HSC crosstalk
Sjøgaard-Frich, L. M., Henriksen, M. S., Lam, S., Birkbak, F. J., Czaplińska, D., Flinck, M., & Pedersen, S. F. (2024) · Journal of Endocrinology · doi:10.1530/joe-24-0099 · Cited by 6
Altered hepatic metabolic landscape and insulin sensitivity in response to pulmonary tuberculosis
Das, M., Savidge, B. O., Pearl, J. E., Yates, T. E., Miles, G. J., Pareek, M., Haldar, P., & Cooper, A. M. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012565 · Cited by 6
Cell-Type Resolved Insights into the Cis-Regulatory Genome of NAFLD
Dam, T. V., Toft, N. I., & Grøntved, L. (2022) · Cells · doi:10.3390/cells11050870 · Cited by 6
Modelling the Sorafenib-resistant Liver Cancer Microenvironment by Using 3-D Spheroids
Sarıyar, E., & Karagonlar, Z. F. (2023) · Alternatives to Laboratory Animals · doi:10.1177/02611929231193421 · Cited by 6
Taguchi, D., Shirakami, Y., Sakai, H., Maeda, T., Miwa, T., Kubota, M., Imai, K., Ibuka, T., & Shimizu, M. (2024) · Nutrients · doi:10.3390/nu16152506 · Cited by 5
Wang, G., Garcia, V., Lee, J., Yanum, J. A., Lin, J., Jiang, H., & Dai, G. (2022) · PLoS ONE · doi:10.1371/journal.pone.0269383 · Cited by 5
Ma, M., Wang, X., Liu, X., Han, Y., Chu, Y., Guan, Y., & Liu, H. (2023) · Archives of Pharmacal Research · doi:10.1007/s12272-023-01435-4 · Cited by 5
Sun, J., Shen, Y., Wang, X., Men, R., Xing, X., Lv, L., Yang, F., Shen, M., Zheng, Y., Fan, X., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03940-8 · Cited by 4
Lipid-induced granules in hepatocytes alleviate liver fibrosis
Li, Y., Lei, T., Nie, W., Ma, M., Zhao, W., Zhou, Y., Liu, Y., Wang, M., Jia, K., Liu, S., et al. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2025.12.015 · Cited by 7
Hung, Y.-H., Sritharan, R., Vohl, M., Ilkayeva, O., Biertho, L. D., Tchernof, A., White, P. J., & Sethupathy, P. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.20.457162 · Cited by 4
Indirubin alleviates CCl4-induced liver fibrosis by regulation of TGF-β-mediated signaling pathways.
Li, X., Yao, Y., & Lin, W. (2023) · PubMed Central · doi:10.22038/ijbms.2023.70476.15319 · Cited by 3
Wada, T., Takeda, Y., Okekawa, A., Komatsu, G., Iwasa, Y., Onogi, Y., Takasaki, I., Hamashima, T., Sasahara, M., Tsuneki, H., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-75713-6 · Cited by 6
Grandt, J., Johansen, C. D., Jensen, A. H., Werge, M. P., Rashu, E. B., Møller, A., Junker, A. E., Hobolth, L., Mortensen, C., Vyberg, M., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0307345 · Cited by 3
Komiya, Y., Sugiyama, M., Koyama, C., Kameshima, S., Ochiai, M., Adachi, Y., Yokoyama, I., Fukasawa, H., Yoshioka, K., & Arihara, K. (2023) · Nutrition Research · doi:10.1016/j.nutres.2023.02.001 · Cited by 3
Wang, Y., Yu, H., Cen, Z., Zhu, Y., & Wu, W. (2023) · Metabolism Open · doi:10.1016/j.metop.2023.100267 · Cited by 3
In Silico Treatment: a computational framework for animal model selection and drug assessmentPreprint
Picart‐Armada, S., Becker, K., Kästle, M., Krenkel, O., Simon, E. S., Tenbaum, S. P., Strobel, B., Geillinger‐Kästle, K. E., Fundel‐Clemens, K., Matera, D., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.17.599264 · Cited by 3
Transcriptional factor RUNX1: A potential therapeutic target for fibrotic pulmonary disease
LIU, J., WANG, F., YUAN, B., & Luo, F. (2023) · Biocell · doi:10.32604/biocell.2023.026148 · Cited by 3
Metadata
- Authors
- Loft, A., Alfaro, A. J., Schmidt, S. F., Pedersen, F. B., Terkelsen, M. K., Puglia, M., Chow, K. K., Feuchtinger, A., Troullinaki, M., Maida, A., Wolff, G., Sakurai, M., Berutti, R., Ekim Üstünel, B., Nawroth, P., Ravnskjaer, K., Diaz, M. B., Blagoev, B., & Herzig, S.
- Affiliations
- University of Southern Denmark (DK)
- Heidelberg University (DE)
- Helmholtz Munich (DE)
- University Hospital Heidelberg (DE)
- Corresponding author
- Loft, Anne
- Herzig, Stephan
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2021-08
- Volume
- 33
- Issue
- 8
- Pages
- 1685-1700.e9
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W3180909105
- Cited by
- 129
- References
- 80
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 38 · 2023: 36 · 2022: 22 · 2021: 4
- FWCI
- 18.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 367 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Site cant be reached (submittedVersion, other-oa)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- Funders
- International Design Centre
- Deutsche Forschungsgemeinschaft (CRC) 1118)
- Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences (DFF-6110-00265)
- Danmarks Grundforskningsfond (DNRF141)
- Shanxi Datong University
- Danmarks Frie Forskningsfond
- Novo Nordisk Fonden (NNF16OC0020742, NNF18OC0052768, NNFOC150019050)
- European Molecular Biology Organization (ALTF 897-2015)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Keywords
- liver fibrosis, nonalcoholic steatohepatitis, metabolic-associated fatty liver disease, hepatocyte reprogramming, ELF3, GLIS2, transcriptional regulatory networks, hepatokines, hepatic stellate cells
- MeSH terms
- Communication, Humans, Liver, Liver Cirrhosis, Hepatocytes, Gene Regulatory Networks, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review