Cited by 299Neuroinflammation and Neurodegeneration MechanismsTraumatic Brain Injury and Neurovascular DisturbancesInflammasome and immune disorders

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The cellular response in neuroinflammation: The role of leukocytes, microglia and astrocytes in neuronal death and survival

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Carson, Monica J., Cameron Thrash, J., Walter, Barbara·2006·Clinical Neuroscience Research

DOI 10.1016/j.cnr.2006.09.004PMC PMC2630233

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Abstract

Neuroinflammation is a complex integration of the responses of all cells present within the CNS, including the neurons, macroglia, microglia and the infiltrating leukocytes. The initiating insult, environmental factors, genetic background and age/past experiences all combine to modulate the integrated response of this complex neuroinflammatory circuit. Here, we explore how these factors interact to lead to either neuroprotective versus neurotoxic inflammatory responses. We specifically focus on microglia and astrocytic regulation of autoreactive T cell responses.

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Authors: Carson, M. J., Cameron Thrash, J., & Walter, B.
Affiliations: University of California, Riverside (US)
Corresponding author: Carson, Monica J.
ORCID: Carson, Monica J.
Walter, Barbara
Venue: Clinical Neuroscience Research
Publisher: Elsevier BV
Published: 2006-12
Volume: 6
Issue: 5
Pages: 237-245
ISSN: 1566-2772 (ISSN-L)
DOI: 10.1016/j.cnr.2006.09.004
PMC: PMC2630233
OpenAlex: W1964913218
Cited by: 299
References: 66
Citations by year: 2026: 8 · 2025: 24 · 2024: 27 · 2023: 20 · 2022: 26 · 2021: 30 · 2020: 24 · 2019: 15 · 2018: 23 · 2017: 18 · 2016: 20 · 2015: 6 · 2014: 13 · 2013: 21 · 2012: 12
FWCI: 0.88
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Clinical Neuroscience Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Academy of Sciences of Ukraine
National Institute of Neurological Disorders and Stroke (R01NS045735, R01NS039508)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: neuroinflammation, microglia, astrocytes, leukocytes, neuronal cell death, neuronal survival, neuroprotection, neurotoxicity, autoreactive T cells, macroglia

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The cellular response in neuroinflammation: The role of leukocytes, microglia and astrocytes in neuronal death and survival

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