Immunology and immunotherapy of Alzheimer's disease

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works

Inflammation and Alzheimer’s disease

Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210 · see citing works

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160 · see citing works

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516 · see citing works

Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

Bard, F., Cannon, C., Barbour, R., Burke, R.-L., Games, D., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., et al. (2000) · Nature Medicine · doi:10.1038/78682 · Cited by 2,012 · see citing works

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.-H., Mistl, C., Rothacher, S., Ledermann, B., Bürki, K., Frey, P., Paganetti, P. A., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13287 · Cited by 1,507 · see citing works

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

Morgan, D., Diamond, D. M., Gottschall, P. E., Ugen, K. E., Dickey, C. A., Hardy, J., Duff, K., Jantzen, P. T., DiCarlo, G., Wilcock, D. M., et al. (2000) · Nature · doi:10.1038/35050116 · Cited by 1,488 · see citing works

Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

Janus, C., Pearson, J., McLaurin, J., Mathews, P. M., Jiang, Y., Schmidt, S. D., Chishti, M. A., Horne, P., Heslin, D., French, J., et al. (2000) · Nature · doi:10.1038/35050110 · Cited by 1,431 · see citing works

Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report

Nicoll, J. A. R., Wilkinson, D., Holmes, C., Steart, P., Markham, H., & Weller, R. O. (2003) · Nature Medicine · doi:10.1038/nm840 · Cited by 1,397 · see citing works

A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

Weggen, S., Eriksen, J. L., Das, P., Sagi, S. A., Wang, R., Pietrzik, C. U., Findlay, K. A., Smith, T. E., Murphy, M. P., Bulter, T., et al. (2001) · Nature · doi:10.1038/35102591 · Cited by 1,388 · see citing works

Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies

McGeer, P. L., Schulzer, M., & McGeer, E. G. (1996) · Neurology · doi:10.1212/wnl.47.2.425 · Cited by 1,367 · see citing works

Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization

Orgogozo, J.-M., Gilman, S., Dartigues, J.-F., Laurent, B., Puel, M., Kirby, L. C., Jouanny, P., Dubois, B., Eisner, L., Flitman, S., et al. (2003) · Neurology · doi:10.1212/01.wnl.0000073623.84147.a8 · Cited by 1,356 · see citing works

Clinical effects of Aβ immunization (AN1792) in patients with AD in an interrupted trial

Gilman, S., Koller, M., Black, R. S., Jenkins, L., Griffith, S. G., Fox, N. C., Eisner, L., Kirby, L., Rovira, M. B., Forette, F., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000159740.16984.3c · Cited by 1,329 · see citing works

Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease

DeMattos, R. B., Bales, K. R., Cummins, D. J., Dodart, J.-C., Paul, S. M., & Holtzman, D. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151261398 · Cited by 1,298 · see citing works

Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease

Simard, A. R., Soulet, D., Gowing, G., Julien, J.-P., & Rivest, S. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.022 · Cited by 1,265 · see citing works

Adult mouse astrocytes degrade amyloid-β in vitro and in situ

Wyss-Coray, T., Loike, J. D., Brionne, T. C., Lu, E., Anankov, R., Yan, F., Silverstein, S. C., & Husemann, J. (2003) · Nature Medicine · doi:10.1038/nm838 · Cited by 909 · see citing works

Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

Dodart, J.-C., Bales, K. R., Gannon, K. S., Greene, S. J., DeMattos, R. B., Mathis, C., DeLong, C. A., Wu, S., Wu, X., Holtzman, D. M., et al. (2002) · Nature Neuroscience · doi:10.1038/nn842 · Cited by 858 · see citing works

Staging of Alzheimer-Related Cortical Destruction

Braak, H., Braak, E., & Bohl, J. (2008) · European Neurology · doi:10.1159/000116984 · Cited by 836 · see citing works

Complement activation by beta-amyloid in Alzheimer disease.

Rogers, J., Cooper, N. R., Webster, S., Schultz, J., McGeer, P. L., Styren, S. D., Civin, W. H., Brachova, L., Bradt, B., & Ward, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10016 · Cited by 817 · see citing works

Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation

Qiu, W. Q., Walsh, D. M., Ye, Z., Vekrellis, K., Zhang, J., Podlisny, M. B., Rosner, M. R., Safavi, A., Hersh, L. B., & Selkoe, D. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32730 · Cited by 812 · see citing works

Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome

Oddo, S., Billings, L., Kesslak, J. P., Cribbs, D. H., & LaFerla, F. M. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.003 · Cited by 780 · see citing works

Antibodies against β-Amyloid Slow Cognitive Decline in Alzheimer's Disease

Höck, C., Konietzko, U., Streffer, J. R., Tracy, J., Signorell, A., Müller-Tillmanns, B., Lemke, U., Henke, K., Moritz, E., Garcia, E., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00294-0 · Cited by 777 · see citing works

Alzheimer's Disease: A Central Role for Amyloid

Selkoe, D. J. (1994) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199409000-00003 · Cited by 752 · see citing works

Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

Turner, P. R., O’Connor, K., Tate, W. P., & Abraham, W. C. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00089-3 · Cited by 751 · see citing works

Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils

Khoury, J. E., Hickman, S. E., Thomas, C. A., Cao, L., Silverstein, S. C., & Loike, J. D. (1996) · Nature · doi:10.1038/382716a0 · Cited by 727 · see citing works

β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis

Combs, C. K., Karlo, J. C., Kao, S.-C., & Landreth, G. E. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01179.2001 · Cited by 721 · see citing works

Cyclo-Oxygenase-2 Gene Expression in Neurons Contributes to Ischemic Brain Damage

Nogawa, S., Zhang, F., Ross, M. E., & Iadecola, C. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02746.1997 · Cited by 715 · see citing works

Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor

Paresce, D. M., Ghosh, R. N., & Maxfield, F. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80187-7 · Cited by 663 · see citing works

TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice

Wyss-Coray, T., Lin, C., Yan, F., Yu, G.-Q., Rohde, M., McConlogue, L., Masliah, E., & Mucke, L. (2001) · Nature Medicine · doi:10.1038/87945 · Cited by 587 · see citing works

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides

Koistinaho, M., Lin, S., Wu, X., Esterman, M., Koger, D., Hanson, J., Higgs, R., Liu, F., Malkani, S., Bales, K. R., et al. (2004) · Nature Medicine · doi:10.1038/nm1058 · Cited by 571 · see citing works

Neuropathology and Pathogenesis of Encephalitis following Amyloid β Immunization in Alzheimer's Disease

Ferrer, I., Boada, M., Guerra, M. L. S., Rey, M. J., & Costa‐Jussà, F. R. (2004) · Brain Pathology · doi:10.1111/j.1750-3639.2004.tb00493.x · Cited by 567 · see citing works

Effects of Aβ immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease

Fox, N. C., Black, R. S., Gilman, S., Rossor, M. N., Griffith, S. G., Jenkins, L., & Koller, M. (2005) · Neurology · doi:10.1212/01.wnl.0000159743.08996.99 · Cited by 550 · see citing works

Alzheimer's β-Amyloid Peptides Compete for Insulin Binding to the Insulin Receptor

Xie, L., Helmerhorst, E., Taddei, K., Plewright, B., van Bronswijk, W., & Martins, R. N. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-10-j0001.2002 · Cited by 542 · see citing works

The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs

Reid, G., Wielinga, P. R., Zelcer, N., van der Heijden, I., Kuil, A., de Haas, M., Wijnholds, J., & Borst, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1033060100 · Cited by 531 · see citing works

Cerebral Hemorrhage After Passive Anti-Aβ Immunotherapy

Pfeifer, M., Boncristiano, S., Bondolfi, L., Stalder, A., Deller, T., Staufenbiel, M., Mathews, P. M., & Jucker, M. (2002) · Science · doi:10.1126/science.1078259 · Cited by 511 · see citing works

A Cell Surface Receptor Complex for Fibrillar β-Amyloid Mediates Microglial Activation

Bamberger, M. E., Harris, M. E., McDonald, D. R., Husemann, J., & Landreth, G. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02665.2003 · Cited by 501 · see citing works

Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo

Klyubin, I., Walsh, D. M., Lemere, C. A., Cullen, W. K., Shankar, G. M., Betts, V., Spooner, E. T., Jiang, L., Anwyl, R., Selkoe, D. J., et al. (2005) · Nature Medicine · doi:10.1038/nm1234 · Cited by 489 · see citing works

Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases

Togo, T., Akiyama, H., Iseki, E., Kondo, H., Ikeda, K., Kato, M., Oda, T., Tsuchiya, K., & Kosaka, K. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00496-9 · Cited by 481 · see citing works

Inflammation, autotoxicity and Alzheimer disease

McGeer, P. L. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00289-5 · Cited by 474 · see citing works

Alzheimer's disease: Aβ, tau and synaptic dysfunction

LaFerla, F. M., & Oddo, S. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2005.02.009 · Cited by 461 · see citing works

Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice

Wyss-Coray, T., Yan, F., Lin, A. H.-T., Lambris, J. D., Alexander, J. J., Quigg, R. J., & Masliah, E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162350199 · Cited by 446 · see citing works

Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy

Bacskai, B. J., Kajdasz, S. T., Christie, R. H., Carter, C., Games, D., Seubert, P. A., Schenk, D., & Hyman, B. T. (2001) · Nature Medicine · doi:10.1038/85525 · Cited by 445 · see citing works

Microglial phenotype: is the commitment reversible?

Schwartz, M., Butovsky, O., Brück, W., & Hanisch, U.-K. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2005.12.005 · Cited by 434 · see citing works

Disaggregation of Alzheimer β-amyloid by site-directed mAb

Solomon, B., Koppel, R., Frankel, D., & Hanan, E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4109 · Cited by 420 · see citing works

Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4–10 and inhibit cytotoxicity and fibrillogenesis

McLaurin, J., Cecal, R., Kierstead, M. E., Tian, X., Phinney, A. L., Manea, M., French, J. E., Lambermon, M. H. L., Darabie, A. A., Brown, M. E., et al. (2002) · Nature Medicine · doi:10.1038/nm790 · Cited by 412 · see citing works

CD36, a Class B Scavenger Receptor, Is Expressed on Microglia in Alzheimer's Disease Brains and Can Mediate Production of Reactive Oxygen Species in Response to β-Amyloid Fibrils

Coraci, I. S., Husemann, J., Berman, J. W., Hulette, C., Dufour, J. H., Campanella, G. K., Luster, A. D., Silverstein, S. C., & El Khoury, J. B. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64354-4 · Cited by 398 · see citing works

Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice

Sheng, J. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00069-x · Cited by 388 · see citing works

Microglia and inflammatory mechanisms in the clearance of amyloid β peptide

Rogers, J., Strohmeyer, R., Kovelowski, C. J., & Li, R. (2002) · Glia · doi:10.1002/glia.10153 · Cited by 381 · see citing works

Activation of microglia by aggregated β-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-γ and IL-4 render them protective

Butovsky, O., Talpalar, A. E., Ben‐Yaakov, K., & Schwartz, M. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.03.005 · Cited by 368 · see citing works

Increased T cell reactivity to amyloid β protein in older humans and patients with Alzheimer disease

Monsonego, A., Zota, V., Karni, A., Krieger, J. I., Bar-Or, A., Bitan, G., Budson, A. E., Sperling, R., Selkoe, D. J., & Weiner, H. L. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318104 · Cited by 367 · see citing works

Evaluation of the safety and immunogenicity of synthetic Aβ42 (AN1792) in patients with AD

Bayer, A. J., Bullock, R., Jones, R. W., Wilkinson, D., Paterson, K. R., Jenkins, L., Millais, S. B., & Donoghue, S. (2005) · Neurology · doi:10.1212/01.wnl.0000148604.77591.67 · Cited by 356 · see citing works

Aβ vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease

Masliah, E., Hansen, L., Adame, A., Crews, L. A., Bard, F., Lee, C., Seubert, P. A., Games, D., Kirby, L., & Schenk, D. (2005) · Neurology · doi:10.1212/01.wnl.0000148590.39911.df · Cited by 355 · see citing works

Fibrillar β-Amyloid Induces Microglial Phagocytosis, Expression of Inducible Nitric Oxide Synthase, and Loss of a Select Population of Neurons in the Rat CNS<i>In Vivo</i>

Weldon, D. T., Rogers, S. D., Ghilardi, J. R., Finke, M. P., Cleary, J. P., O’Hare, E., Esler, W. P., Maggio, J. E., & Mantyh, P. W. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-06-02161.1998 · Cited by 348 · see citing works

Absence of C1q Leads to Less Neuropathology in Transgenic Mouse Models of Alzheimer's Disease

Fonseca, M. I., Zhou, J., Botto, M., & Tenner, A. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0901-04.2004 · Cited by 345 · see citing works

Intraneuronal Aβ accumulation and origin of plaques in Alzheimer's disease

Gouras, G. K., Almeida, C. G., & Takahashi, R. H. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.05.022 · Cited by 338 · see citing works

Microglial Activation and β-Amyloid Deposit Reduction Caused by a Nitric Oxide-Releasing Nonsteroidal Anti-Inflammatory Drug in Amyloid Precursor Protein Plus Presenilin-1 Transgenic Mice

Jantzen, P. T., Connor, K. E., DiCarlo, G., Wenk, G. L., Wallace, J. L., Rojiani, A. M., Coppola, D., Morgan, D., & Gordon, M. N. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02246.2002 · Cited by 337 · see citing works

The importance of inflammatory mechanisms in alzheimer disease

McGeer, E. G., & McGeer, P. L. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00013-8 · Cited by 335 · see citing works

Role of inflammation in neurodegenerative diseases

Minghetti, L. (2005) · Current Opinion in Neurology · doi:10.1097/01.wco.0000169752.54191.97 · Cited by 335 · see citing works

Microglia and Alzheimer's disease pathogenesis

Streit, W. J. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20093 · Cited by 335 · see citing works

β-Amyloid Activates the O⨪2 Forming NADPH Oxidase in Microglia, Monocytes, and Neutrophils

Della Bianca, V., Dusi, S., Bianchini, E., Dal Prà, I., & Rossi, F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.22.15493 · Cited by 324 · see citing works

Non-Fc-Mediated Mechanisms Are Involved in Clearance of Amyloid-β<i>In Vivo</i>by Immunotherapy

Bacskai, B. J., Kajdasz, S. T., McLellan, M. E., Games, D., Seubert, P., Schenk, D., & Hyman, B. T. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-18-07873.2002 · Cited by 323 · see citing works

Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide.

Solomon, B., Koppel, R., Hanan, E., & Katzav-Gozansky, T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.452 · Cited by 314 · see citing works

Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease.

Weiner, H. L., Lemere, C. A., Maron, R., Spooner, E. T., Grenfell, T. J., Mori, C., Issazadeh‐Navikas, S., Hancock, W. W., & Selkoe, D. J. (2000) · PubMed · Cited by 310 · see citing works

Amyloid β‐peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer's disease

Verdier, Y., Zarándi, M., & Penke, B. (2004) · Journal of Peptide Science · doi:10.1002/psc.573 · Cited by 261 · see citing works

Astrocytes Regulate Microglial Phagocytosis of Senile Plaque Cores of Alzheimer's Disease

DeWitt, D. A., Perry, G., Cohen, M., Doller, C., & Silver, J. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6738 · Cited by 261 · cited 1× · see citing works

Nasal administration of amyloid-? peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease

Weiner, H. L., Lemere, C. A., Maron, R., Spooner, E. T., Grenfell, T. J., Mori, C., Issazadeh‐Navikas, S., Hancock, W. W., & Selkoe, D. J. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200010)48:4 · Cited by 261 · see citing works

Immunization with a Nontoxic/Nonfibrillar Amyloid-β Homologous Peptide Reduces Alzheimer's Disease-Associated Pathology in Transgenic Mice

Sigurdsson, E. M., Scholtzova, H., Mehta, P. D., Frangione, B., & Wısnıewskı, T. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61715-4 · Cited by 258 · see citing works

Inflammation and therapeutic vaccination in CNS diseases

Weiner, H. L., & Selkoe, D. J. (2002) · Nature · doi:10.1038/nature01325 · Cited by 253 · see citing works

Targeting Amyloid-β Peptide (Aβ) Oligomers by Passive Immunization with a Conformation-selective Monoclonal Antibody Improves Learning and Memory in Aβ Precursor Protein (APP) Transgenic Mice

Lee, E. B., Leng, L. Z., Zhang, B., Kwong, L. K., Trojanowski, J. Q., Abel, T. G., & Lee, V. M. ‐. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m511018200 · Cited by 252 · see citing works

Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs

Yasojima, K., Schwab, C., McGeer, E. G., & McGeer, P. L. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01389-x · Cited by 250 · see citing works

Comparative Analysis of Amyloid-β Chemical Structure and Amyloid Plaque Morphology of Transgenic Mouse and Alzheimer's Disease Brains

Kuo, Y., Kokjohn, T. A., Beach, T. G., Sue, L. I., Brune, D. C., Lopez, J. C., Kalback, W. M., Abramowski, D., Sturchler, C., Staufenbiel, M., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007859200 · Cited by 245 · see citing works

Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation

Wilcock, D. M., DiCarlo, G., Henderson, D., Jackson, J., Clarke, K., Ugen, K. E., Gordon, M. N., & Morgan, D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03745.2003 · Cited by 232 · see citing works

Integrins take partners: cross-talk between integrins and other membrane receptors

Porter, J. C., & Hogg, N. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01344-0 · Cited by 228 · see citing works

Intrahippocampal LPS injections reduce Aβ load in APP+PS1 transgenic mice

DiCarlo, G. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00292-5 · Cited by 223 · see citing works

Glial activation in Alzheimer's disease: the role of Aβ and its associated proteins

Meda, L. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00307-4 · Cited by 222 · see citing works

Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice

Tan, J., Town, T., Crawford, F., Mori, T., DelleDonne, A., Crescentini, R., Obregon, D., Flavell, R. A., & Mullan, M. J. (2002) · Nature Neuroscience · doi:10.1038/nn968 · Cited by 217 · see citing works

Immunotherapeutic Approaches to Alzheimer's Disease

Monsonego, A., & Weiner, H. L. (2003) · Science · doi:10.1126/science.1088469 · Cited by 217 · see citing works

Amyloid-β Immunization Effectively Reduces Amyloid Deposition in FcRγ-/-Knock-Out Mice

Das, P., HOWARD, V. G., Loosbrock, N., Dickson, D. W., Murphy, M. P., & Golde, T. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-24-08532.2003 · Cited by 212 · see citing works

Anti-A 42- and anti-A 40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model

Levites, Y. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25410 · Cited by 207 · see citing works

Microglial activation facilitates Aβ plaque removal following intracranial anti-Aβ antibody administration

Wilcock, D. M., Munireddy, S. K., Rosenthal, A., Ugen, K. E., Gordon, M. N., & Morgan, D. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.09.015 · Cited by 202 · see citing works

Induction of Nitric Oxide Synthase and Nitric Oxide‐Mediated Apoptosis in Neuronal PC12 Cells After Stimulation with Tumor Necrosis FActor‐α/Lipopolysaccharide

Heneka, M. T., Löschmann, P., Gleichmann, M., Weller, M., Schulz, J. B., Wüllner, U., & Klockgether, T. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71010088.x · Cited by 199 · see citing works

Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears β-amyloid in a mouse model of Alzheimer disease

Frenkel, D., Maron, R., Burt, D. S., & Weiner, H. L. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23241 · Cited by 186 · see citing works

Sulindac Sulfide Is a Noncompetitive γ-Secretase Inhibitor That Preferentially Reduces Aβ42 Generation

Takahashi, Y., Hayashi, I., Tominari, Y., Rikimaru, K., Morohashi, Y., Kan, T., Natsugari, H., Fukuyama, T., Tomita, T., & Iwatsubo, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301619200 · Cited by 179 · see citing works

Microglia as a Potential Bridge between the Amyloid β‐Peptide and Tau

Kitazawa, M., Yamasaki, T. R., & LaFerla, F. M. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1332.006 · Cited by 177 · see citing works

Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer’s disease

Sly, L. M., KRZESICKI, R. F., Brashler, J. R., Buhl, A.-L., McKinley, D. D., Carter, D. B., & Chin, J. E. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00730-4 · Cited by 174 · see citing works

Immunization against Alzheimer's β-amyloid plaques via EFRH phage administration

Frenkel, D., Katz, O., & Solomon, B. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11455 · Cited by 166 · see citing works

Time-dependent reduction in Aβ levels after intracranial LPS administration in APP transgenic mice

Herber, D., Roth, L. M., Wilson, D., Wilson, N., Mason, J. E., Morgan, D., & Gordon, M. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.07.007 · Cited by 164 · see citing works

The HHQK Domain of β-Amyloid Provides a Structural Basis for the Immunopathology of Alzheimer's Disease

Giulian, D., Haverkamp, L. J., Yu, J., Karshin, W. L., Tom, D., Li, J., Kazanskaia, A., Kirkpatrick, J. B., & Roher, A. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29719 · Cited by 164 · see citing works

Immune hyporesponsiveness to amyloid β-peptide in amyloid precursor protein transgenic mice: Implications for the pathogenesis and treatment of Alzheimer's disease

Monsonego, A., Maron, R., Zota, V. E., Selkoe, D. J., & Weiner, H. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191118298 · Cited by 162 · see citing works

Aβ-induced meningoencephalitis is IFN-γ-dependent and is associated with T cell-dependent clearance of Aβ in a mouse model of Alzheimer's disease

Monsonego, A., Imitola, J., Petrovic, S., Zota, V. E., Nemirovsky, A., Baron, R., Fisher, Y., Owens, T., & Weiner, H. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506209103 · Cited by 159 · see citing works

Evidence for peripheral clearance of cerebral Aβ protein following chronic, active Aβ immunization in PSAPP mice

Lemere, C. A. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00044-5 · Cited by 138 · see citing works

Overexpression of Monocyte Chemotactic Protein-1/CCL2 in β-Amyloid Precursor Protein Transgenic Mice Show Accelerated Diffuse β-Amyloid Deposition

Yamamoto, M., Horiba, M., Buescher, J. L., Huang, D., Gendelman, H. E., Ransohoff, R. M., & Ikezu, T. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62364-4 · Cited by 137 · see citing works

Cyclooxygenase-2 Promotes Amyloid Plaque Deposition in a Mouse Model of Alzheimer's Disease Neuropathology

Xiang, Z., Ho, L., Yemul, S., Zhao, Z., Pompl, P. N., Kelley, K. A., Dang, A., Qing, W., Teplow, D. B., & Pasinetti, G. M. (2002) · Gene Expression · doi:10.3727/000000002783992352 · Cited by 135 · see citing works

Current progress in beta-amyloid immunotherapy

Schenk, D., Hagen, M., & Seubert, P. A. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.07.012 · Cited by 134 · see citing works

Neuroinflammation‐induced acceleration of amyloid deposition in the APP^V717F transgenic mouse

Qiao, X., Cummins, D. J., & Paul, S. M. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01666.x · Cited by 119 · see citing works

Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis in C57/BL6 mice

Furlan, R. (2003) · Brain · doi:10.1093/brain/awg031 · Cited by 116 · see citing works

Lipopolysaccharide-induced IL-12 expression in the central nervous system and cultured astrocytes and microglia

Stalder, A. K., Pagenstecher, A., Yu, N., Kincaid, C., Chiang, C., Hobbs, M. V., Bloom, F. E., & Campbell, I. L. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.3.1344 · Cited by 111 · see citing works

Antibody-Mediated Phagocytosis of the Amyloid β-Peptide in Microglia Is Differentially Modulated by C1q

Webster, S. D., Galvan, M. D., Ferran, E., Garzon-Rodriguez, W., Glabe, C. G., & Tenner, A. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7496 · Cited by 104 · see citing works

Role of Formyl Peptide Receptor–Like 1 (FPRL1/FPR2) in Mononuclear Phagocyte Responses in Alzheimer Disease

Iribarren, P., Zhou, Y., Hu, J., Le, Y., & Wang, J. M. (2005) · Immunologic Research · doi:10.1385/ir:31:3:165 · Cited by 104 · see citing works

A nontransgenic mouse model shows inducible amyloid-β (Aβ) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade

Dolev, I., & Michaelson, D. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404458101 · Cited by 102 · see citing works

A novel recombinant adeno-associated virus vaccine reduces behavioral impairment and β-amyloid plaques in a mouse model of Alzheimer's disease

Zhang, J., Wu, X., Qin, C., Jin, Q., Ma, S., Zhang, H., Kong, Q., Chen, D., Ba, D., & He, W. (2003) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.07.005 · Cited by 102 · see citing works

Inflammation and cerebral amyloidosis are disconnected in an animal model of Alzheimer's disease

Quinn, J. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00037-7 · Cited by 102 · see citing works

LPS-induced neuroinflammatory effects do not recover with time

Hauss‐Wegrzyniak, B., Vraniak, P., & Wenk, G. L. (2000) · Neuroreport · doi:10.1097/00001756-200006050-00032 · Cited by 99 · see citing works

Brain Trauma in Aged Transgenic Mice Induces Regression of Established Aβ Deposits

Nakagawa, Y., Reed, L., Nakamura, M., McIntosh, T. K., Smith, D. H., Saatman, K. E., Raghupathi, R., Clemens, J., Saido, T. C., Lee, V. M.-Y., et al. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7375 · Cited by 91 · cited 1× · see citing works

N-terminal EFRH sequence of Alzheimer's β-amyloid peptide represents the epitope of its anti-aggregating antibodies

Frenkel, D., Balass, M., & Solomon, B. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00098-8 · Cited by 91 · see citing works

Development of a safe oral Aβ vaccine using recombinant adeno-associated virus vector for Alzheimer's disease

Hara, H., Monsonego, A., Yuasa, K., Adachi, K., Xiao, X., Takeda, S., Takahashi, K., Weiner, H. L., & Tabira, T. (2004) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6504 · Cited by 90 · see citing works

The Serpin-Enzyme Complex Receptor Recognizes Soluble, Nontoxic Amyloid-β Peptide but Not Aggregated, Cytotoxic Amyloid-β Peptide

Boland, K., Behrens, M. I., Choi, D. W., Manias, K., & Perlmutter, D. H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.18032 · Cited by 89 · see citing works

Acetylcholinesterase-Positive Fiber Deafferentation and Cell Shrinkage in the Septohippocampal Pathway of Aged Amyloid Precursor Protein London Mutant Transgenic Mice

Bronfman, F. C., Moechars, D., & LEUVEN, F. V. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0283 · Cited by 85 · see citing works

Reduction of β-amyloid plaques in brain of transgenic mouse model of Alzheimer’s disease by EFRH-phage immunization

Frenkel, D., Dewachter, I., LEUVEN, F. V., & Solomon, B. (2003) · Vaccine · doi:10.1016/s0264-410x(02)00609-6 · Cited by 85 · see citing works

Metabolism of Alzheimer beta-amyloid precursor protein: regulation by protein kinase A in intact cells and in a cell-free system.

Xu, H., Sweeney, D. A., Greengard, P., & Gandy, S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.4081 · Cited by 84 · see citing works

Modulation of Alzheimer’s β-amyloid neurotoxicity by site-directed single-chain antibody

Frenkel, D., Solomon, B., & Benhar, I. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00232-5 · Cited by 82 · see citing works

Hormonal Regulation of Growth Plate Cartilage

Savendahl, L. S. (2005) · Hormone Research in Paediatrics · doi:10.1159/000087764 · Cited by 82 · see citing works

Non-steroidal Anti-inflammatory Drugs and Cyclooxygenase in Alzheimer s Disease

Hoozemans, J. J. M., Veerhuis, R., Rozemüller, A. J. M., & Eikelenboom, P. (2003) · Current Drug Targets · doi:10.2174/1389450033490902 · Cited by 81 · see citing works

Evidence of a trimolecular complex involving LPS, LPS binding protein and soluble CD14 as an effector of LPS response

Thomas, C. J., Kapoor, M., Sharma, S., Bausinger, H., Ziylan, U., Lipsker, D. M., Hanau, D., & Surolia, A. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03499-3 · Cited by 80 · see citing works

Structure-function studies of the receptors for complement C1q

McGreal, E. P., & Gasque, P. (2002) · Biochemical Society Transactions · doi:10.1042/bst0301010 · Cited by 80 · see citing works

Innate immunity in Alzheimer's disease: a model for local inflammatory reactions.

McGeer, E. G., & McGeer, P. L. (2001) · PubMed · Cited by 75 · see citing works

Modeling Alzheimer's disease in transgenic mice: effect of age and of Presenilin1 on amyloid biochemistry and pathology in APP/London mice

Dewachter, I., Dorpe, J. V., Spittaels, K., Tesseur, I. C., den Haute, C. V., Moechars, D., & LEUVEN, F. V. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00149-2 · Cited by 74 · see citing works

CpG‐containing oligodeoxynucleotide promotes microglial cell uptake of amyloid β 1–42 peptide by up‐regulating the expression of the G‐protein‐coupled receptor mFPR2

Iribarren, P., Chen, K., Hu, J., Gong, W., Cho, E. H., Lockert, S., Uranchimeg, B., & Wang, J. M. (2005) · The FASEB Journal · doi:10.1096/fj.05-4578fje · Cited by 73 · see citing works

Microglial interaction with β‐amyloid: Implications for the pathogenesis of Alzheimer's disease

Bamberger, M. E., & Landreth, G. E. (2001) · Microscopy Research and Technique · doi:10.1002/jemt.1121 · Cited by 71 · see citing works

Subacute NO generation induced by Alzheimer's beta-amyloid in the living brain: reversal by inhibition of the inducible NO synthase

Ishii, K., Muelhauser, F., Liebl, U., Picard, M. A., Kühl, S., Penke, B., Bayer, T. A., Wießler, M., Hennerici, M. G., Beyreuther, K. T., et al. (2000) · The FASEB Journal · doi:10.1096/fj.99-0786com · Cited by 68 · see citing works

High affinity binding of monoclonal antibodies to the sequential epitope EFRH of β-amyloid peptide is essential for modulation of fibrillar aggregation

Frenkel, D., Balass, M., Katchalski‐Katzir, E., & Solomon, B. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00003-x · Cited by 64 · see citing works

EFRH–Phage Immunization of Alzheimer's Disease Animal Model Improves Behavioral Performance in Morris Water Maze Trials

Lavie, V., Becker, M., Cohen-Kupiec, R., Yacoby, I., Koppel, R., Wedenig, M., Hutter‐Paier, B., & Solomon, B. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:24:1:105 · Cited by 62 · see citing works

Proteasome inhibitors prevent the degradation of familial Alzheimer's disease-linked presenilin 1 and potentiate A beta 42 recovery from human cells.

Marambaud, P., Ancolio, K., Lopez‐Perez, E., & Checler, F. (1998) · PubMed Central · Cited by 60 · see citing works

The amino-terminus of the amyloid-β protein is critical for the cellular binding and consequent activation of the respiratory burst of human macrophages

Muiswinkel, F. L. V., Raupp, S. F. A., Vos, N., Smits, H. A., Verhoef, J., Eikelenboom, P., & Nottet, H. S. L. M. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00019-3 · Cited by 57 · see citing works

Protollin™: a novel adjuvant for intranasal vaccines

Jones, T., Cyr, S. L., Allard, F., Bellerose, N., Lowell, G. H., & Burt, D. S. (2004) · Vaccine · doi:10.1016/j.vaccine.2004.03.035 · Cited by 52 · see citing works

Specificity of mechanisms for plaque removal after Aβ immunotherapy for Alzheimer disease

Akiyama, H., & McGeer, P. L. (2004) · Nature Medicine · doi:10.1038/nm0204-117 · Cited by 51 · see citing works

Overcoming antigen masking of anti-amyloidbeta antibodies reveals breaking of B cell tolerance by virus-like particles in amyloidbeta immunized amyloid precursor protein transgenic mice

Li, Q., Cao, C., Chackerian, B., Schiller, J. T., Gordon, M. N., Ugen, K. E., & Morgan, D. (2004) · BMC Neuroscience · doi:10.1186/1471-2202-5-21 · Cited by 50 · see citing works

Microglial overexpression of the M-CSF receptor augments phagocytosis of opsonized Aβ

Mitrasinovic, O. M. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00237-3 · Cited by 46 · see citing works

Selective localization of gelatinase A, an enzyme degrading ?-amyloid protein, in white matter microglia and in Schwann cells

Yamada, T., Miyazaki, K., Koshikawa, N., Takahashi, M., Akatsu, H., & Yamamoto, T. (1995) · Acta Neuropathologica · doi:10.1007/bf00309334 · Cited by 45 · see citing works

β -Amyloid Peptide Vaccination Results in Marked Changes in Serum and Brain A β Levels in APPswe/PS1ΔE9 Mice, as Detected by SELDI-TOF-Based ProteinChip ® Technology

Vehmas, A. K., Borchelt, D., Price, D. L., McCarthy, D. B., Wills-Karp, M. A., Peper, M. J., Rudow, G. L., Luyinbazi, J., Siew, L. T., & Troncoso, J. C. (2001) · DNA and Cell Biology · doi:10.1089/10445490152717578 · Cited by 43 · see citing works

Proteasome Inhibitors Prevent the Degradation of Familial Alzheimer’s Disease-Linked Presenilin 1 and Potentiate Aβ42 Recovery from Human Cells

Marambaud, P., Ancolio, K., Lopez‐Perez, E., & Checler, F. (1998) · Molecular Medicine · doi:10.1007/bf03401912 · Cited by 40 · see citing works

High Performance Computing in Chemistry

Lewerenz, M., & Harms, U. (1998) · Journal of Molecular Modeling · doi:10.1007/s0089480040147 · Cited by 35 · see citing works

Risk Factors Associated With β-Amyloid(1-42) Immunotherapy in Preimmunization Gene Expression Patterns of Blood Cells

O’Toole, M. (2005) · Archives of Neurology · doi:10.1001/archneur.62.10.1531 · Cited by 29 · see citing works

Measuring Memory in a Mouse Model of Alzheimer's Disease

Routtenberg, A. (1997) · Science · doi:10.1126/science.277.5327.839 · Cited by 28 · see citing works

Complement activation in acquired and hereditary amyloid neuropathy

Hafer‐Macko, C. E., Dyck, P. J. B., & Koski, C. L. (2000) · Journal of the Peripheral Nervous System · doi:10.1046/j.1529-8027.2000.00018.x · Cited by 28 · see citing works

Evidence supporting a role for anti-Aβ antibodies in the treatment of Alzheimer’s disease

Morgan, D., & Gitter, B. D. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.02.005 · Cited by 27 · see citing works

Antibodies from a DNA peptide vaccination decrease the brain amyloid burden in a mouse model of Alzheimer?s disease

Schultz, J. G., Salzer, U., Mohajeri, M. H., Franke, D., Heinrich, J., Pavlovic, J., Wollmer, M. A., Nitsch, R. M., & Moelling, K. (2004) · Journal of Molecular Medicine · doi:10.1007/s00109-004-0570-z · Cited by 27 · see citing works

Nonsteroidal antiinflammatory drugs inhibiting prostanoid efflux: As easy as ABC?

Warner, T. D., & Mitchell, J. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1733826100 · Cited by 16 · see citing works

Treating brain swelling

Paczynski, R. P., & Diringer, M. N. (1996) · Neurology · doi:10.1212/wnl.46.4.1186 · Cited by 13 · see citing works

AD neuropathology

Jellinger, K. A., & Bancher, C. (1996) · Neurology · doi:10.1212/wnl.46.4.1186-b · Cited by 12 · see citing works

Effects of Rofecoxib or Naproxen vs Placebo on Alzheimer Disease Progression: A Randomized Controlled Trial

Aisen, P. S., Schafer, K. A., Grundman, M., Pfeiffer, E., Sano, M., Davis, K. L., Farlow, M. R., Jin, S., Thomas, R. G., Thal, L. J., et al. (2003) · JAMA · doi:10.1001/jama.289.21.2819 · Cited by 5 · see citing works

Untitled work

Webster (1996) · doi:10.1002/(sici)1097-4547(19961001)46:1

Sterile inflammation: sensing and reacting to damage

Chen, G. Y., & Nuñez, G. (2010) · Nature Reviews Immunology · doi:10.1038/nri2873 · Cited by 3,051 · see citing works

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., Fitzgerald, K. A., Latz, E., Moore, K. J., & Golenbock, D. T. (2008) · Nature Immunology · doi:10.1038/ni.1636 · Cited by 2,441 · see citing works

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

Holmes, C., Boche, D., Wilkinson, D., Yadegarfar, G., Hopkins, V., Bayer, A., Jones, R. W., Bullock, R., Love, S., Neal, J. W., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61075-2 · Cited by 1,416 · see citing works

The Sterile Inflammatory Response

Rock, K. L., Latz, E., Ontiveros, F., & Kono, H. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101311 · Cited by 865 · see citing works

Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab

Ostrowitzki, S. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.1538 · Cited by 431 · see citing works

U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer’s disease

Bai, B., Hales, C. M., Chen, P.-C., Gozal, Y., Dammer, E. B., Fritz, J. J., Wang, X., Xia, Q., Duong, D. M., Street, C., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310249110 · Cited by 335 · see citing works

Comprehensive review of mechanisms of pathogenesis involved in Alzheimer’s disease and potential therapeutic strategies

Sharma, P., Srivastava, P., Seth, A., Tripathi, P. N., Banerjee, A. G., & Shrivastava, S. K. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.12.006 · Cited by 331 · see citing works

The cellular response in neuroinflammation: The role of leukocytes, microglia and astrocytes in neuronal death and survival

Carson, M. J., Cameron Thrash, J., & Walter, B. (2006) · Clinical Neuroscience Research · doi:10.1016/j.cnr.2006.09.004 · Cited by 299 · see citing works

Amyloid-β Contributes to Blood–Brain Barrier Leakage in Transgenic Human Amyloid Precursor Protein Mice and in Humans With Cerebral Amyloid Angiopathy

Hartz, A. M. S., Bauer, B., Soldner, E. L. B., Wolf, A., Boy, S., Backhaus, R., Mihaljevic, I., Bogdahn, U., Klünemann, H. H., Schuierer, G., et al. (2012) · Stroke · doi:10.1161/strokeaha.111.627562 · Cited by 248 · see citing works

Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease

Farfara, D., Lifshitz, V., & Frenkel, D. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00314.x · Cited by 216 · see citing works

CNS expression of anti‐inflammatory cytokine interleukin‐4 attenuates Alzheimer's disease‐like pathogenesis in APP+PS1 bigenic mice

Kiyota, T., Okuyama, S., Swan, R. J., Jacobsen, M. T., Gendelman, H. E., & Ikezu, T. (2010) · The FASEB Journal · doi:10.1096/fj.10-155317 · Cited by 212 · see citing works

IL-4-Induced Selective Clearance of Oligomeric β-Amyloid Peptide1–42 by Rat Primary Type 2 Microglia

Shimizu, E., Kawahara, K., Kajizono, M., Sawada, M., & Nakayama, H. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.6503 · Cited by 143 · see citing works

Internalized Antibodies to the Aβ Domain of APP Reduce Neuronal Aβ and Protect against Synaptic Alterations

Tampellini, D., Magrané, J., Takahashi, R. H., Li, F., Lin, M. T., Almeida, C. G., & Gouras, G. K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700373200 · Cited by 118 · see citing works

Disease modifying therapy for AD?¹

Golde, T. E. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04211.x · Cited by 117 · see citing works

Safety, tolerability and immunogenicity of an active anti-Aβ40 vaccine (ABvac40) in patients with Alzheimer’s disease: a randomised, double-blind, placebo-controlled, phase I trial

Lacosta, A.-M., Pascual-Lucas, M., Pesini, P., Casabona, D., Pérez-Grijalba, V., Marcos-Campos, I., Sarasa, L., Canudas, J., Badi, H., Monleón, I., et al. (2018) · Alzheimer's Research &amp; Therapy · doi:10.1186/s13195-018-0340-8 · Cited by 111 · see citing works

Cytokine-Mediated Inhibition of Fibrillar Amyloid-β Peptide Degradation by Human Mononuclear Phagocytes

Yamamoto, M., Kiyota, T., Walsh, S. M., Liu, J., Kipnis, J., & Ikezu, T. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.3877 · Cited by 100 · see citing works

Heat Shock Protein Inspired Nanochaperones Restore Amyloid-β Homeostasis for Preventative Therapy of Alzheimer’s Disease

Yang, H., Li, X., Zhu, L., Wu, X., Zhang, S., Huang, F., Feng, X., & Shi, L. (2019) · Advanced Science · doi:10.1002/advs.201901844 · Cited by 98 · see citing works

Towards Retinoid Therapy for Alzheimers Disease

Shudo, K., Fukasawa, H., Nakagomi, M., & Yamagata, N. (2009) · Current Alzheimer Research · doi:10.2174/156720509788486581 · Cited by 91 · see citing works

Complementing the inflammasome

Triantafilou, M., Hughes, T. R., Morgan, B. P., & Triantafilou, K. (2016) · Immunology · doi:10.1111/imm.12556 · Cited by 76 · see citing works

Microglial TNF-α-Dependent Elevation of MHC Class I Expression on Brain Endothelium Induced by Amyloid-Beta Promotes T Cell Transendothelial Migration

Yang, Y.-M., Shang, D.-S., Zhao, W.-D., Fang, W.-G., & Chen, Y.-H. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1138-5 · Cited by 57 · see citing works

MHC class I limits hippocampal synapse density by inhibiting neuronal insulin receptor signaling

Dixon-Salazar, T. J., Fourgeaud, L., Tyler, C. M., Poole, J. R., Park, J. J., & Boulanger, L. M. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4642-12.2014 · Cited by 51 · see citing works

Real-Time Analysis of Binding Events between Different Aβ_1–42 Species and Human Lilrb2 by Dual Polarization Interferometry

Hu, T., Wang, S., Chen, C., Sun, J., & Yang, X. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.6b04950 · Cited by 28 · see citing works

Deep Profiling of the Aggregated Proteome in Alzheimer’s Disease: From Pathology to Disease Mechanisms

Lutz, B. M., & Peng, J. (2018) · Proteomes · doi:10.3390/proteomes6040046 · Cited by 27 · see citing works

Clinical immunologic approaches for the treatment of Alzheimer's disease

Solomon, B. (2007) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.16.6.819 · Cited by 22 · see citing works

Types Research of Discontinuation of a Crime

Ping, Z. (2007) · Journal of Tongji University

Current and future applications of SPECT in clinical psychiatry.

Ballenger, J. C., Pecknold, J., Rickels, K., & Sellers, E. M. (1992) · PubMed · Cited by 39 · see citing works

Accurate collection of reasons for treatment discontinuation to better define estimands in clinical trialsPreprint

Qu, Y., White, R. D., & Ruberg, S. J. (2022) · arXiv (Cornell University) · doi:10.48550/arxiv.2206.01659

[Discontinuation of chronic treatment with lithium salts].

Tondo, L., & Rudas, N. (1992) · PubMed · Cited by 1 · see citing works

Contraceptive discontinuation and switching in urban Istanbul region in Turkey

Kurutas, S., Sato, R., Huber‐Krum, S., et al. (2021) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.13577 · Cited by 7 · see citing works