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Transcription factors drive B cell development

Hagman, James, Lukin, Kara·2006·Current Opinion in Immunology
DOI 10.1016/j.coi.2006.01.007
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Abstract

Transcription factors including PU.1, E2A and early B cell factor (EBF) are essential for the earliest stages of B lymphocyte development. Recent advances suggest that, although PU.1 initiates events leading to B lymphopoiesis, it might be dispensable at later stages of development. E2A proteins are also crucial for B cell lineage determination, as shown by the pluripotency of E2A-deficient progenitors. Both PU.1 and E2A are required for expression of EBF. EBF activates the early program of genes unique to B cells, including the lineage commitment factor Pax5. EBF also facilitates the function of Pax5 by mediating epigenetic changes necessary for the function of Pax5 at gene targets. Together, these proteins function in a hierarchy of factors that orchestrates B cell development.

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Research works printed but not linked: 60

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Metadata

Authors
Hagman, J., & Lukin, K.
Venue
Current Opinion in Immunology
Publisher
Elsevier BV
Published
2006-04
Volume
18
Issue
2
Pages
127-134
ISSN
0952-7915
DOI
10.1016/j.coi.2006.01.007
Cited by
82
References
7
Language
en
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