Immune memory and aging: an infinite or finite resource?

Nikolich-Žugich, Janko; Rudd, Brian D

doi:10.1016/j.coi.2010.06.011

Cited by 58T-cell and B-cell ImmunologyImmune responses and vaccinationsImmunotherapy and Immune Responses

Immune memory and aging: an infinite or finite resource?

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Nikolich-Žugich, Janko, Rudd, Brian D·2010·Current Opinion in Immunology

DOI 10.1016/j.coi.2010.06.011PMC PMC2925022

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Abstract

Recent developments in the field of immune memory research and the accumulating literature on age-related alterations in homeostasis, primary and memory T cell responses make it pertinent to address whether and how memory responses are affected by aging with regard to their generation, maintenance, and protective function. New knowledge of T cell repertoire maintenance over long periods of time, particularly when confronted with persistent pathogen challenge, is now enriched further by studies on whether recent immunological memory can 'overfill' and/or constrict prior memory responses. Along with studies on potentiation of memory responses by dietary/metabolic interventions and the recent advances on regulation of primary responses with aging, these findings provide a platform for new approaches to vaccination of older adults.

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Immunity declines during ageing, manifest as increased susceptibility to infection by previously encountered and new emerging pathogens and decreased ability to respond to vaccination.
“Immunity declines during ageing and this is highlighted by the increased susceptibility to infection induced by previously encountered [1, 2] as well as new emerging pathogens [3-5] and also decreased ability to respond to vaccination [6].”
From Senescence of T Lymphocytes: Implications for Enhancing Human Immunity (2016) · cites this paper as [2]

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Authors: Nikolich-Žugich, J., & Rudd, B. D.
Affiliations: University of Arizona (US)
ORCID: Rudd, Brian D
Venue: Current Opinion in Immunology
Publisher: Elsevier BV
Published: 2010-08
Volume: 22
Issue: 4
Pages: 535-540
ISSN: 0952-7915 (ISSN-L)
DOI: 10.1016/j.coi.2010.06.011
PMC: PMC2925022
OpenAlex: W2042512604
Cited by: 58
References: 48
Citations by year: 2026: 3 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 5 · 2020: 2 · 2018: 3 · 2017: 2 · 2016: 7 · 2015: 3 · 2014: 2 · 2013: 8 · 2012: 9
FWCI: 0.61
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (AG03319, AG20719)
National Institute on Aging
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: immunological memory, immunosenescence, T cell homeostasis, memory T cells, primary T cell response, aging
MeSH terms: Aging, Humans, Immunologic Memory, T-Lymphocyte Subsets

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