Cutting Edge: Memory CD8 T Cell Compartment Grows in Size with Immunological Experience but Nevertheless Can Lose Function
Abstract
The size of the adaptive immune system is considered to be kept constant by the attrition of pre-existing memory. However, recently it was shown that the CD8 memory compartment can grow in size and the number of pre-existing memory is largely preserved, predicting that pre-existing immunity should be maintained (Vezys et al.; Nature 457: 196–199). Experimental proof for this assumption is still lacking. We address this question in the Listeria monocytogenes (L.m.) infection model and confirm the growth of size of the memory compartment by subsequent vaccination with modified vaccinia virus Ankara. We also find only modest attrition of pre-existing L.m.-specific memory CD8 T cells. However, pre-existing protective immunity toward L.m. is not preserved. Pre-existing L.m.-specific effector-memory cells, in contrast to central memory cells, become altered, and this results in a significant loss of pre-existing protective immunity. Our findings are clinically relevant for vaccines introducing new CD8 memory cells in high numbers, as this might influence pre-existing immunity.
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The concept of a fixed amount of immunological space has been debated.
“Although a decline in thymic output with ageing is accepted, the concept of a fixed amount of immunological space has been debated (Huster et al. 2009; Schwanninger et al. 2007; van Leeuwen et al. 2006; Vezys et al. 2009).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Huster et al. 2009
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- Authors
- Huster, K. M., Stemberger, C., Gasteiger, G., Kastenmüller, W., Drexler, I., & Busch, D. H.
- Affiliations
- Helmholtz Munich (DE)
- Corresponding author
- Stemberger, Christian
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-12-01
- Volume
- 183
- Issue
- 11
- Pages
- 6898-6902
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1491474153
- Cited by
- 37
- References
- 28
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 6 · 2012: 3
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Site cant be reached (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- memory CD8+ T cells, central memory T cells, effector memory T cells, Listeria monocytogenes, pre-existing immunity
- MeSH terms
- Animals, Immunologic Memory, Listeriosis, Listeria monocytogenes, Mice, Inbred C57BL, Vaccination, Vaccines, Vaccinia virus, T-Lymphocyte Subsets, CD8-Positive T-Lymphocytes, Mice
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