Immunosenescence: influenza vaccination and the elderly
Abstract
Aging is associated with a decline in the normal function of the immune system, both cellular and humoral, which often leads to a state of 'immunosenescence'. It is necessary that we understand the fundamental cellular and molecular basis of immune senescence and immune responsiveness to prevent age-related diseases, such as viral and bacterial infections, in order to develop appropriate preventative and novel therapeutic measures. Vaccination has been a highly effective prophylactic in protecting vulnerable populations worldwide from many pathogens. Novel vaccine research to enhance protection against these diseases remains a global area of innovation and improvement. This review discusses the impact of immune senescence on the response to influenza vaccines, and the recent progress in translating the knowledge into developing effective influenza vaccines for the elderly to promote healthy aging.
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Despite inconsistent results over the effects of CMV on antibody responses to vaccination, studies consistently show that elderly individuals exhibiting other established hallmarks of an ageing immune system respond poorly to vaccines.
“Despite inconsistent results over the effects of CMV on antibody responses to vaccination, studies consistently show that elderly individuals, exhibiting other established hallmarks of an ageing immune system, respond poorly to vaccines (Haq and McElhaney 2014; Strindhall et al. 2016).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Haq and McElhaney 2014
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- Authors
- Haq, K., & McElhaney, J. E.
- Corresponding author
- McElhaney, Janet E
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 29
- Pages
- 38-42
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W2060654063
- Cited by
- 256
- References
- 39
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 18 · 2023: 28 · 2022: 12 · 2021: 35 · 2020: 24 · 2019: 28 · 2018: 21 · 2017: 19 · 2016: 31 · 2015: 15 · 2014: 10 · 2013: 2
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- immunosenescence, influenza vaccination, older adults, aging, immune response, age-related infection, vaccine development, healthy aging, humoral and cellular immune response
- MeSH terms
- Adjuvants, Immunologic, Aged, Animals, Humans, Inflammation, Influenza, Human, Influenza Vaccines, Cellular Senescence
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