Physical approaches to biomaterial design
Open accessAbstract
The development of biomaterials for drug delivery, tissue engineering and medical diagnostics has traditionally been based on new chemistries. However, there is growing recognition that the physical as well as the chemical properties of materials can regulate biological responses. Here, we review this transition with regard to selected physical properties including size, shape, mechanical properties, surface texture and compartmentalization. In each case, we present examples demonstrating the significance of these properties in biology. We also discuss synthesis methods and biological applications for designer biomaterials, which offer unique physical properties.
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Drug-eluting stents are associated with an increased risk of late-stent thrombosis owing to poor re-growth of endothelial cells lining the stents after implantation or endothelial dysfunction.
“Another issue with the use of drug-eluting stents is the increased risk of late-stent thrombosis owing to poor re-growth of the endothelial cells lining the stents after implantation or endothelial dysfunction6.”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [6]
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Flagged first, then by citations
Research works printed but not linked: 3
- [31]Rehfeldt F Engler AJ Eckhardt A Ahmed F Discher DE Cell responses to the mechanochemical microenvironment- Implications for regenerative medicine and drug delivery Adv. Drug Deliv. Rev 2007 59 1329 1339 17900747 PMC4124491
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- Authors
- Mitragotri, S., & Lahann, J.
- Affiliations
- University of California, Santa Barbara (US)
- University of Michigan (US)
- Venue
- Nature Materials
- Published
- 2009-01
- Volume
- 8
- Issue
- 1
- Pages
- 15-23
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- PMC
- PMC2793340
- OpenAlex
- W2070166910
- Cited by
- 1,445
- References
- 139
- Citations by year
- 2026: 29 · 2025: 49 · 2024: 61 · 2023: 76 · 2022: 70 · 2021: 67 · 2020: 77 · 2019: 89 · 2018: 81 · 2017: 81 · 2016: 111 · 2015: 120 · 2014: 101 · 2013: 108 · 2012: 104
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Materials (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (1VO1 HL080718, U01HL080718)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- biomaterial design, physical properties of materials, drug delivery, tissue engineering, medical diagnostics, particle size, shape, mechanical properties, surface texture, compartmentalization
- MeSH terms
- Biocompatible Materials, Biophysics, Surface Properties, Drug Delivery Systems, Tissue Engineering, Nanostructures
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