Cited by 1,445Hydrogels: synthesis, properties, applicationsBone Tissue Engineering MaterialsTissue Engineering and Regenerative Medicine

Physical approaches to biomaterial design

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Mitragotri, Samir, Lahann, Joerg·2009·Nature Materials

Abstract

The development of biomaterials for drug delivery, tissue engineering and medical diagnostics has traditionally been based on new chemistries. However, there is growing recognition that the physical as well as the chemical properties of materials can regulate biological responses. Here, we review this transition with regard to selected physical properties including size, shape, mechanical properties, surface texture and compartmentalization. In each case, we present examples demonstrating the significance of these properties in biology. We also discuss synthesis methods and biological applications for designer biomaterials, which offer unique physical properties.

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  • Drug-eluting stents are associated with an increased risk of late-stent thrombosis owing to poor re-growth of endothelial cells lining the stents after implantation or endothelial dysfunction.

    “Another issue with the use of drug-eluting stents is the increased risk of late-stent thrombosis owing to poor re-growth of the endothelial cells lining the stents after implantation or endothelial dysfunction6.”

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  1. [31]Rehfeldt F Engler AJ Eckhardt A Ahmed F Discher DE Cell responses to the mechanochemical microenvironment- Implications for regenerative medicine and drug delivery Adv. Drug Deliv. Rev 2007 59 1329 1339 17900747 PMC4124491
  2. [42]Ingber DE Cellular mechanotransduction: putting all the pieces together again FASEB J 2006 20 811 27 16675838
  3. [73]Champion JA Walker A Mitragotri S Role of particle size in phagocytosis of polymeric microspheres Pharm. Res 2008 25 1815 1821 18373181 PMC2793372

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Authors
Mitragotri, S., & Lahann, J.
Affiliations
  • University of California, Santa Barbara (US)
  • University of Michigan (US)
Venue
Nature Materials
Published
2009-01
Volume
8
Issue
1
Pages
15-23
ISSN
  • 1476-1122 (ISSN-L)
  • 1476-4660
OpenAlex
W2070166910
Cited by
1,445
References
139
Citations by year
2026: 29 · 2025: 49 · 2024: 61 · 2023: 76 · 2022: 70 · 2021: 67 · 2020: 77 · 2019: 89 · 2018: 81 · 2017: 81 · 2016: 111 · 2015: 120 · 2014: 101 · 2013: 108 · 2012: 104
FWCI
4.19
Type
journal article
Language
en
Open access
Locations
  • Nature Materials (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart, Lung, and Blood Institute (1VO1 HL080718, U01HL080718)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
biomaterial design, physical properties of materials, drug delivery, tissue engineering, medical diagnostics, particle size, shape, mechanical properties, surface texture, compartmentalization
MeSH terms
Biocompatible Materials, Biophysics, Surface Properties, Drug Delivery Systems, Tissue Engineering, Nanostructures

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