Regulation of chromatin structure in memory formation
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This brief review focuses on the role of epigenetic mechanisms in plasticity and memory formation, and their identification as targets of activity-dependent regulation in neurons. Epigenetic modifications of chromatin, namely post-translational modifications of nuclear proteins and covalent modification of DNA, result in potent regulation of gene readout. Recent data have demonstrated that epigenetic mechanisms play a significant role in regulating synaptic plasticity and memory. In this review, we focus on this theme, describing some basic background concerning epigenetic molecular mechanisms, and describing recent results concerning plasticity and memory formation. As an understanding of these novel mechanisms of transcriptional regulation promises to invigorate many areas of investigation, we end by speculating upon some of the open questions ripe for discovery.
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- Authors
- Roth, T. L., & Sweatt, J. D.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Sweatt, J David
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 19
- Issue
- 3
- Pages
- 336-342
- ISSN
- 0959-4388 (ISSN-L)
- PMC
- PMC2744442
- OpenAlex
- W2001351912
- Cited by
- 138
- References
- 51
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 8 · 2019: 2 · 2018: 8 · 2017: 3 · 2016: 6 · 2015: 14 · 2014: 14 · 2013: 11 · 2012: 11
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- McKnight Foundation
- Coins for Alzheimer's Research Trust
- National Institutes of Health
- National Institute on Aging (R01AG031722)
- National Institute of Mental Health (R01MH057014)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- chromatin structure, epigenetic regulation, memory formation, synaptic plasticity, activity-dependent regulation, post-translational modification, DNA methylation, histone modifications, transcriptional regulation, neurons
- MeSH terms
- Animals, Chromatin, DNA, Histones, Memory, Methylation, Models, Neurological, Nucleic Acid Conformation, DNA Methylation
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