Cited by 138Memory and Neural MechanismsEpigenetics and DNA MethylationGenomics and Chromatin Dynamics

Regulation of chromatin structure in memory formation

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Roth, Tania L, Sweatt, J David·2009·Current Opinion in Neurobiology

Abstract

This brief review focuses on the role of epigenetic mechanisms in plasticity and memory formation, and their identification as targets of activity-dependent regulation in neurons. Epigenetic modifications of chromatin, namely post-translational modifications of nuclear proteins and covalent modification of DNA, result in potent regulation of gene readout. Recent data have demonstrated that epigenetic mechanisms play a significant role in regulating synaptic plasticity and memory. In this review, we focus on this theme, describing some basic background concerning epigenetic molecular mechanisms, and describing recent results concerning plasticity and memory formation. As an understanding of these novel mechanisms of transcriptional regulation promises to invigorate many areas of investigation, we end by speculating upon some of the open questions ripe for discovery.

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Crossref · 10.1016/j.conb.2009.05.011

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Authors
Roth, T. L., & Sweatt, J. D.
Affiliations
University of Alabama at Birmingham (US)
Corresponding author
Sweatt, J David
Venue
Current Opinion in Neurobiology
Publisher
Elsevier BV
Published
2009-06
Volume
19
Issue
3
Pages
336-342
ISSN
0959-4388 (ISSN-L)
OpenAlex
W2001351912
Cited by
138
References
51
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 8 · 2019: 2 · 2018: 8 · 2017: 3 · 2016: 6 · 2015: 14 · 2014: 14 · 2013: 11 · 2012: 11
FWCI
1.51
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • McKnight Foundation
  • Coins for Alzheimer's Research Trust
  • National Institutes of Health
  • National Institute on Aging (R01AG031722)
  • National Institute of Mental Health (R01MH057014)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
chromatin structure, epigenetic regulation, memory formation, synaptic plasticity, activity-dependent regulation, post-translational modification, DNA methylation, histone modifications, transcriptional regulation, neurons
MeSH terms
Animals, Chromatin, DNA, Histones, Memory, Methylation, Models, Neurological, Nucleic Acid Conformation, DNA Methylation

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