Cited by 211Epigenetics and DNA MethylationStress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Epigenetics and the regulation of stress vulnerability and resilience

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Zannas, A.S., West, A.E.·2014·Neuroscience

Abstract

The human brain has a remarkable capacity to adapt to and learn from a wide range of variations in the environment. However, environmental challenges can also precipitate psychiatric disorders in susceptible individuals. Why any given experience should induce one brain to adapt while another is edged toward psychopathology remains poorly understood. Like all aspects of psychological function, both nature (genetics) and nurture (life experience) sculpt the brain's response to stressful stimuli. Here we review how these two influences intersect at the epigenetic regulation of neuronal gene transcription, and we discuss how the regulation of genomic DNA methylation near key stress-response genes may influence psychological susceptibility or resilience to environmental stressors. Our goal is to offer a perspective on the epigenetics of stress responses that works to bridge the gap between the study of this molecular process in animal models and its potential usefulness for understanding stress vulnerabilities in humans.

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  • Genes related to HPA axis regulation, especially NR3C1, are among the most promising epigenetic biomarkers for identifying individuals susceptible to maladaptive responses to psychological stressors and could serve as surrogate markers of HPA axis activity when comparing different treatment modalities.

    “genes related to HPA axis regulation, especially NR3C1, are among the most promising epigenetic biomarkers, which are currently explored regarding their predictive potential at identifying individuals susceptible to maladaptive responses to psychological stressors, and could also serve as surrogate markers of HPA axis activity, when comparing different treatment modalities (Zannas & West, 2014)”

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Authors
Zannas, A. S., & West, A. E.
Affiliations
Duke University (US)
Corresponding author
West, A.E.
Venue
Neuroscience
Publisher
Elsevier BV
Published
2014-04
Volume
264
Pages
157-170
ISSN
0306-4522 (ISSN-L)
OpenAlex
W2115418898
Cited by
211
References
106
Citations by year
2026: 16 · 2025: 20 · 2024: 7 · 2023: 9 · 2022: 17 · 2021: 17 · 2020: 23 · 2019: 14 · 2018: 21 · 2017: 20 · 2016: 19 · 2015: 18 · 2014: 10
FWCI
1.47
Type
journal article
Language
en
Open access
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (R21MH096310)
  • National Institute on Drug Abuse (R01DA033610)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
epigenetics, stress vulnerability, resilience, DNA methylation, stress response, mental illness, environmental stressors, gene-environment interaction, brain adaptation
MeSH terms
Animals, Brain, Humans, Stress, Psychological, Epigenesis, Genetic, Mice, Rats, Resilience, Psychological

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