The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
A role for clock genes in sleep homeostasis
Abstract
The timing and quality of both sleep and wakefulness are thought to be regulated by the interaction of two processes. One of these two processes keeps track of the prior sleep-wake history and controls the homeostatic need for sleep while the other sets the time-of-day that sleep preferably occurs. The molecular pathways underlying the latter, circadian process have been studied in detail and their key role in physiological time-keeping has been well established. Analyses of sleep in mice and flies lacking core circadian clock gene proteins have demonstrated, however, that besides disrupting circadian rhythms, also sleep homeostatic processes were affected. Subsequent studies revealed that sleep loss alters both the mRNA levels and the specific DNA-binding of the key circadian transcriptional regulators to their target sequences in the mouse brain. The fact that sleep loss impinges on the very core of the molecular circadian circuitry might explain why both inadequate sleep and disrupted circadian rhythms can similarly lead to metabolic pathology. The evidence for a role for clock genes in sleep homeostasis will be reviewed here.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Sleep represents an emergent set of many physiologic processes under primarily neurobiological regulation that impact many physiologic systems.”
From Sleep, Health, and Society (2017) · cites this paper as [5]
Citations
Cites
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485
Dibner, C., Schibler, U., & Albrecht, U. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135821 · Cited by 2,421
Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329
Sleep function and synaptic homeostasis
Tononi, G., & Cirelli, C. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.05.002 · Cited by 2,151
Circadian integration of metabolism and energetics
Bass, J., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195027 · Cited by 1,910
Resetting of circadian time in peripheral tissues by glucocorticoid signaling
Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U. (2000) · Science · doi:10.1126/science.289.5488.2344 · Cited by 1,859
Transplanted Suprachiasmatic Nucleus Determines Circadian Period
Ralph, M. R., Foster, R. G., Davis, F. C., & Menaker, M. (1990) · Science · doi:10.1126/science.2305266 · Cited by 1,853
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611
Transcriptional architecture and chromatin landscape of the core circadian clock in mammals
Koike, N., Yoo, S.-H., Huang, H.-C., Kumar, V., Lee, C., Kim, T.-K., & Takahashi, J. S. (2012) · Science · doi:10.1126/science.1226339 · Cited by 1,464
Nakahata, Y., Kaluzova, M., Grimaldi, B., Sahar, S., Hirayama, J., Chen, D., Guarente, L. P., & Sassone-Corsi, P. (2008) · Cell · doi:10.1016/j.cell.2008.07.002 · Cited by 1,427
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–125 of 125
Neurobiology of Sleep and Microbiomics in Aging
Larson‐Prior, L. J., Azhar, G., Davila, D., Jun, S., Kemp, A. S., Nookaew, I., Wei, J. Y., & Wassenaar, T. M. (2017) · OBM Neurobiology · doi:10.21926/obm.neurobiol.1702003 · Cited by 2
Human data at odds and in confirmation of the two-process model of sleep regulation—a perspective
Dijk, D. (2026) · npj Biological Timing and Sleep · doi:10.1038/s44323-026-00083-3 · Cited by 1
Dampak Bangun Lebih Pagi terhadap Irama Sirkadian dan Mengantuk
Tedjasukmana, R., Seleng, J. C., & Sakasasmita, S. (2022) · Jurnal Kedokteran Meditek · doi:10.36452/jkdoktmeditek.v28i2.2338 · Cited by 1
Modulation and Consequences of Sleep Duration in Child Obesity
Ferreira, M. V. N., de Moraes, A. C. F., Torres‐Leal, F. L., & Carvalho, H. B. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816658-1.00010-7 · Cited by 1
Chronobiology and Chronotherapy in Depression: Current Knowledge and Chronotherapeutic Promises
Rojas, M., Chávez-Castillo, M., Pírela, D., Ortega, Á., Salazar, J. J., Cano, C., Chacín, M., Riaño-Garzón, M., Batista, M. J., Díaz-Camargo, E. A., et al. (2020) · Current Psychiatry Research and Reviews · doi:10.2174/2666082216999201124152432 · Cited by 1
Yasugaki, S., Hayashi, Y., & Lazarus, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822963-7.00229-2 · Cited by 1
The Impact of Methylphenidate on Circadian Rhythms and Clock Gene Expression
Coogan, A. N., Thome, J., & Baird, A. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800634-4.00066-4
Chronotherapeutics in Bipolar and Major Depressive Disorders: Implications for Novel Therapeutics
Duncan, W. C. (2016) · Milestones in drug therapy · doi:10.1007/978-3-319-31689-5_7
SLEEP ALTERATIONS IN MOUSE GENETIC MODELS OF HUMAN DISEASE
Sethi, M. (2016) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2016.522
IDENTIFICATION OF NOVEL SLEEP RELATED GENES FROM LARGE SCALE PHENOTYPING EXPERIMENTS IN MICE
Joshi, S. (2017) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2017.159
Mechanisms underlying the functions of sleep in aging during starvation in Caenorhabditis elegans
Wu, Y. (2019) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7601
Exploration of neuronal ensembles responsible for sleep and body temperature regulation
Ma, Y. (2019) · Spiral (Imperial College London) · doi:10.25560/80152
Roh, H. W., Choi, S. J., Jo, H., Kim, D., Choi, J., Son, S. J., & Joo, E. Y. (2021) · Research Square · doi:10.21203/rs.3.rs-1011658/v1
An omics analysis of genetic sleep loss in C. elegans
Koutsoumparis, A. (2020) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-8314
Franken, P. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733693968.793572519
Genetics of Circadian Disorders in Humans☆
Abbott, S. M., Chang, A.-M., & Zee, P. C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.04603-1
Régulation circadienne et homéostatique du sommeil et de la veille
Taillard, J., & Gronfier, C. (2019) · Elsevier eBooks · doi:10.1016/b978-2-294-74892-9.00003-5
Hairston, I. S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816658-1.00036-3
Unbiased genetics identifies a glutamatergic signaling network as a mediator of daily sleep patternsPreprint
Grizzard, S., Lord, J. S., Ravens, A., Hao, Y., Tang, W., Lee, S. H., Sleiman, S. J., Joyce, K. K., Donohue, K. D., O’Hara, B. F., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.08.652901
Neves, C., Hor, C. N., Jimenez, S., & Franken, P. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2515047122
Mélone, M.-A. (2024) · theses.fr (ABES) · doi:10.70675/443e8c4fz712bz4232za67czb9fe970a0eeb
Miao, H., & Kim, W. J. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106778
Motor Cortex VIP Interneurons Participate in Dexmedetomidine-Associated Sleep Modulation
(17594), W. W., Zhang, H., Zhang, T., Huang, Q., Li, J., Li, N., Xi, Y., Yang, X., Wang, F., Tu, J., et al. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05994-7
Neural and genetic mechanisms regulating copulation latency in male Drosophila melanogaster
Miao, H., Zhang, T., Song, Y., Wu, Z., Huang, Y., & Kim, W. J. (2026) · Genetics · doi:10.1093/genetics/iyag161
Metadata
- Authors
- Franken, P.
- Affiliations
- University of Lausanne (CH)
- Corresponding author
- Franken, Paul
- ORCID
- Franken, Paul
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 23
- Issue
- 5
- Pages
- 864-872
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W2079320127
- Cited by
- 125
- References
- 88
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 11 · 2023: 5 · 2022: 14 · 2021: 8 · 2020: 13 · 2019: 16 · 2018: 9 · 2017: 10 · 2016: 15 · 2015: 9 · 2014: 6 · 2013: 1
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- clock genes, sleep homeostasis, circadian clock, circadian rhythm, sleep-wake regulation, sleep deprivation, DNA binding, metabolic disorders, mice, Drosophila
- MeSH terms
- Animals, Homeostasis, Humans, Sleep, Wakefulness, CLOCK Proteins, Circadian Clocks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
