The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
A role for clock genes in sleep homeostasis
Abstract
The timing and quality of both sleep and wakefulness are thought to be regulated by the interaction of two processes. One of these two processes keeps track of the prior sleep-wake history and controls the homeostatic need for sleep while the other sets the time-of-day that sleep preferably occurs. The molecular pathways underlying the latter, circadian process have been studied in detail and their key role in physiological time-keeping has been well established. Analyses of sleep in mice and flies lacking core circadian clock gene proteins have demonstrated, however, that besides disrupting circadian rhythms, also sleep homeostatic processes were affected. Subsequent studies revealed that sleep loss alters both the mRNA levels and the specific DNA-binding of the key circadian transcriptional regulators to their target sequences in the mouse brain. The fact that sleep loss impinges on the very core of the molecular circadian circuitry might explain why both inadequate sleep and disrupted circadian rhythms can similarly lead to metabolic pathology. The evidence for a role for clock genes in sleep homeostasis will be reviewed here.
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“Sleep represents an emergent set of many physiologic processes under primarily neurobiological regulation that impact many physiologic systems.”
From Sleep, Health, and Society (2017) · cites this paper as [5]
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Cites
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Borbély, A. A., Daan, S., Wirz‐Justice, A., & Deboer, T. (2016) · Journal of Sleep Research · doi:10.1111/jsr.12371 · Cited by 1,577
Molecular mechanisms and physiological importance of circadian rhythms
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Crosstalk between metabolism and circadian clocks
Reinke, H., & Asher, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0096-9 · Cited by 598
Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive
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Metadata
- Authors
- Franken, P.
- Affiliations
- University of Lausanne (CH)
- Corresponding author
- Franken, Paul
- ORCID
- Franken, Paul
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 23
- Issue
- 5
- Pages
- 864-872
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W2079320127
- Cited by
- 125
- References
- 88
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 11 · 2023: 5 · 2022: 14 · 2021: 8 · 2020: 13 · 2019: 16 · 2018: 9 · 2017: 10 · 2016: 15 · 2015: 9 · 2014: 6 · 2013: 1
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- clock genes, sleep homeostasis, circadian clock, circadian rhythm, sleep-wake regulation, sleep deprivation, DNA binding, metabolic disorders, mice, Drosophila
- MeSH terms
- Animals, Homeostasis, Humans, Sleep, Wakefulness, CLOCK Proteins, Circadian Clocks
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