Cited by 125Circadian rhythm and melatoninSleep and Wakefulness ResearchSleep and Work-Related Fatigue

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A role for clock genes in sleep homeostasis

Franken, Paul·2013·Current Opinion in Neurobiology

DOI 10.1016/j.conb.2013.05.002

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Abstract

The timing and quality of both sleep and wakefulness are thought to be regulated by the interaction of two processes. One of these two processes keeps track of the prior sleep-wake history and controls the homeostatic need for sleep while the other sets the time-of-day that sleep preferably occurs. The molecular pathways underlying the latter, circadian process have been studied in detail and their key role in physiological time-keeping has been well established. Analyses of sleep in mice and flies lacking core circadian clock gene proteins have demonstrated, however, that besides disrupting circadian rhythms, also sleep homeostatic processes were affected. Subsequent studies revealed that sleep loss alters both the mRNA levels and the specific DNA-binding of the key circadian transcriptional regulators to their target sequences in the mouse brain. The fact that sleep loss impinges on the very core of the molecular circadian circuitry might explain why both inadequate sleep and disrupted circadian rhythms can similarly lead to metabolic pathology. The evidence for a role for clock genes in sleep homeostasis will be reviewed here.

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Authors: Franken, P.
Affiliations: University of Lausanne (CH)
Corresponding author: Franken, Paul
ORCID: Franken, Paul
Venue: Current Opinion in Neurobiology
Publisher: Elsevier BV
Published: 2013-10
Volume: 23
Issue: 5
Pages: 864-872
ISSN: 0959-4388 (ISSN-L)
DOI: 10.1016/j.conb.2013.05.002
OpenAlex: W2079320127
Cited by: 125
References: 88
Citations by year: 2026: 4 · 2025: 4 · 2024: 11 · 2023: 5 · 2022: 14 · 2021: 8 · 2020: 13 · 2019: 16 · 2018: 9 · 2017: 10 · 2016: 15 · 2015: 9 · 2014: 6 · 2013: 1
FWCI: 1.23
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Neurobiology (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: clock genes, sleep homeostasis, circadian clock, circadian rhythm, sleep-wake regulation, sleep deprivation, DNA binding, metabolic disorders, mice, Drosophila
MeSH terms: Animals, Homeostasis, Humans, Sleep, Wakefulness, CLOCK Proteins, Circadian Clocks

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A role for clock genes in sleep homeostasis

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