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Cited by 84Axon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity

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de Winter, F., Kwok, J. C. F., Fawcett, J. W., Vo, T. T., Carulli, D., Verhaagen, J.·2016·Neural Plasticity
DOI 10.1155/2016/3679545PMC PMC4738953
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Abstract

During postnatal development, closure of critical periods coincides with the appearance of extracellular matrix structures, called perineuronal nets (PNN), around various neuronal populations throughout the brain. The absence or presence of PNN strongly correlates with neuronal plasticity. It is not clear how PNN regulate plasticity. The repulsive axon guidance proteins Semaphorin (Sema) 3A and Sema3B are also prominently expressed in the postnatal and adult brain. In the neocortex, Sema3A accumulates in the PNN that form around parvalbumin positive inhibitory interneurons during the closure of critical periods. Sema3A interacts with high-affinity with chondroitin sulfate E, a component of PNN. The localization of Sema3A in PNN and its inhibitory effects on developing neurites are intriguing features and may clarify how PNN mediate structural neural plasticity. In the cerebellum, enhanced neuronal plasticity as a result of an enriched environment correlates with reduced Sema3A expression in PNN. Here, we first review the distribution of Sema3A and Sema3B expression in the rat brain and the biochemical interaction of Sema3A with PNN. Subsequently, we review what is known so far about functional correlates of changes in Sema3A expression in PNN. Finally, we propose a model of how Semaphorins in the PNN may influence local connectivity.

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Cited by

Sorted by citations

Authors
de Winter, F., Kwok, J. C. F., Fawcett, J. W., Vo, T. T., Carulli, D., & Verhaagen, J.
Affiliations
  • Netherlands Institute for Neuroscience, Royal Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, Netherlands
  • University of Cambridge (GB)
  • Netherlands Institute for Neuroscience (NL)
  • Neuroscience Institute Cavalieri Ottolenghi (IT)
Corresponding author
Verhaagen, J.
ORCID
Venue
Neural Plasticity
Publisher
Hindawi Limited
Published
2016
Volume
2016
Pages
1-14
ISSN
  • 1687-5443 (ISSN-L)
  • 2090-5904
DOI
10.1155/2016/3679545
PMC
PMC4738953
OpenAlex
W2239707532
Cited by
84
References
17
Citations by year
2026: 2 · 2025: 5 · 2024: 6 · 2023: 11 · 2022: 6 · 2021: 15 · 2020: 16 · 2019: 6 · 2018: 6 · 2017: 10 · 2016: 1
FWCI
0.84
Type
journal article
Language
en
Open access
Licence
Locations
  • Neural Plasticity (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (publishedVersion, other-oa)
  • White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion, other-oa)
  • Apollo (University of Cambridge) (submittedVersion, cc-by)
  • Apollo
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
semaphorin 3A, SEMA3B, perineuronal nets, axon guidance, chemorepulsion, neuroplasticity, chondroitin sulfate E, parvalbumin interneurons, cerebellum, environmental enrichment, local connectivity, extracellular matrix
MeSH terms
Animals, Extracellular Matrix, Neuronal Plasticity, Neurons, Extracellular Matrix Proteins, Semaphorin-3A, Rats

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