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Cited by 296

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Transcytosis at the blood–brain barrier

Open access
Ayloo, Swathi, Gu, Chenghua·2019·Current Opinion in Neurobiology
DOI 10.1016/j.conb.2018.12.014
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Abstract

The blood-brain barrier (BBB) is a functional interface separating the brain from the circulatory system and is essential for homeostasis of the central nervous system (CNS). The BBB regulates molecular flux to maintain an optimal environment for neuronal function and protects the brain from toxins and pathogens. Endothelial cells forming the walls of CNS blood vessels constitute the BBB. CNS endothelial cells exhibit two features that underlie the restrictive properties of the BBB: specialized tight junctions that prevent paracellular passage between the blood and the brain, and unusually low levels of vesicle trafficking that limit transcellular transport or transcytosis. While the prevailing view in the field was that specialized tight junctions contributed to CNS barrier properties, recent findings have revealed the importance of maintaining low rates of transcytosis at the BBB. It is now clear that suppression of transcytosis at the BBB is an active process and that CNS-specific genetic programs inhibit this pathway to maintain a functional barrier.

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Metadata

Authors
Ayloo, S., & Gu, C.
Venue
Current Opinion in Neurobiology
Publisher
Elsevier BV
Published
2019-08
Volume
57
Pages
32-38
ISSN
0959-4388 (ISSN-L)
DOI
10.1016/j.conb.2018.12.014
OpenAlex
W2913742117
Cited by
296
References
13
FWCI
4.18
Type
journal article
Language
en
Open access
green
Licence
  • www.elsevier.com/tdm/userlicense/1.0/ (tdm)
  • www.elsevier.com/legal/tdmrep-license (tdm)
Funders
  • Mahoney postdoctoral fellowship
  • National Institutes of Health (DP1 NS092473)
  • Howard Hughes Medical Institute

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Ayloo, S., & Gu, C. (2019). Transcytosis at the blood–brain barrier. Current Opinion in Neurobiology. https://doi.org/10.1016/j.conb.2018.12.014

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