Cited by 293Protein Hydrolysis and Bioactive PeptidesSeaweed-derived Bioactive CompoundsProteins in Food Systems

Bioactive Peptides Derived from Seaweed Protein and Their Health Benefits: Antihypertensive, Antioxidant, and Antidiabetic Properties

Admassu, Habtamu, Gasmalla, Mohammed Abdalbasit. A., Yang, Ruijin, Zhao, Wei·2018·Journal of Food Science

Abstract

Cardiovascular diseases and diabetes are the biggest causes of death globally. Therefore, prevention of these diseases is a focus of pharmaceuticals and functional food manufacturers. This review summarizes recent research trends and scientific knowledge in seaweed protein‐derived peptides with particular emphasis on production, isolation and potential health impacts in prevention of hypertension, diabetes and oxidative stress. The current status and future prospects of bioactive peptides are also discussed. Bioactive peptides have strong potential for use in therapeutic drug and functional food formulation in health management strategy, especially cardiovascular disease and diabetes. Seaweeds can be used as sustainable protein sources in the production of these peptide‐based drugs and functional foods for preventing such diseases. Many studies have reported that peptides showing angiotensin converting enzyme inhibition, antihypertensive, antioxidative and antidiabetics activities, have been successfully isolated from seaweed. However, further research is needed in large‐scale production of these peptides, efficient isolation methods, interactions with functional foods and other pharmaceuticals, and their ease to digestion in in vivo studies and safety to validate the health benefits of these peptides.

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Crossref · 10.1111/1750-3841.14011

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98 of 98 references verified0 citation errors · 0 not checkable

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  • A novel peptide GIVAGDVTPI derived from Limnospira platensis promotes endothelial nitric oxide production via activation of the PI3K/AKT pathway, leading to vasorelaxation and improved serum nitrite levels in vivo.

    “For instance, a novel peptide (GIVAGDVTPI) derived from Limnospira platensis was shown to promote endothelial nitric oxide (NO) production via activation of the PI3K/AKT pathway, leading to vasorelaxation and improved serum nitrite levels in vivo [68].”

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Authors
Admassu, H., Gasmalla, M. A. A., Yang, R., & Zhao, W.
Affiliations
Jiangnan University (CN)
Corresponding author
  • Yang, Ruijin
  • Zhao, Wei
Venue
Journal of Food Science
Publisher
Wiley
Published
2017-12-11
Volume
83
Issue
1
Pages
6-16
ISSN
  • 0022-1147 (ISSN-L)
  • 1750-3841
OpenAlex
W2774714865
Cited by
293
References
98
Citations by year
2026: 25 · 2025: 27 · 2024: 45 · 2023: 46 · 2022: 52 · 2021: 42 · 2020: 31 · 2019: 17 · 2018: 8
FWCI
1.43
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Food Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (31522044)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
Keywords
bioactive peptides, seaweed proteins, antihypertensive peptides, antioxidant peptides, antidiabetic peptides, angiotensin-converting enzyme inhibition, hypertension, diabetes mellitus, oxidative stress, cardiovascular disease prevention, functional foods, peptide isolation, sustainable protein sources
MeSH terms
Amino Acid Sequence, Angiotensin-Converting Enzyme Inhibitors, Animals, Antihypertensive Agents, Antioxidants, Cardiovascular Diseases, Diabetes Mellitus, Humans, Hypertension, Hypoglycemic Agents, Peptides, Seaweed, Functional Food

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