Novel opportunities for next-generation probiotics targeting metabolic syndrome
Abstract
Various studies have described the beneficial effects of specific bacteria on the characteristics of metabolic syndrome. Intestinal microbiota might therefore represent a modifiable trait for translational intervention to improve the metabolic profiles of obese and type 2 diabetic patients. However, identifying potential probiotic strains that can effectively colonize the gastrointestinal tract and significantly affect host metabolism has been challenging. This review aims to summarize the notable advances and contributions in the field that may prove useful for identifying next-generation probiotics that target metabolic syndrome and its related disorders.
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The effects of probiotic and prebiotic supplementation on metabolic health have been inconsistent due to the choice of probiotic strain, formulation, outcome of interest, and duration of intervention.
“Although the effects of probiotic and prebiotic supplementation on metabolic health have been examined in previous studies, the results are inconsistent due to the choice of probiotic strain, formulation of the probiotic, outcome of interest, and duration of the intervention [12,13,14].”
From Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study (2019) · cites this paper as [14]
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Gut microbiota in human metabolic health and disease
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Self-citationCan probiotics modulate human disease by impacting intestinal barrier function?
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“In many of these studies, diet-induced obesity models were used to induce metabolic dysfunction in the animal models to subsequently address the possible health beneficial role of probiotic supplementation((103)).”
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Rebuilding the Gut Microbiota Ecosystem
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Self-citation
- Authors
- Cani, P. D., & Van Hul, M.
- Affiliations
- Walloon Excellence in Lifesciences and Biotechnology (BE)
- ORCID
- Cani, Patrice D
- Venue
- Current Opinion in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 32
- Pages
- 21-27
- ISSN
- 0958-1669 (ISSN-L)
- OpenAlex
- W2026830654
- Cited by
- 167
- References
- 11
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 6 · 2023: 9 · 2022: 16 · 2021: 18 · 2020: 19 · 2019: 16 · 2018: 20 · 2017: 19 · 2016: 12 · 2015: 13
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (submittedVersion)
- Funders
- ERC
- ARC (336452-ENIGMO)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- probiotics, metabolic syndrome, gut microbiota, obesity, type 2 diabetes, host metabolism, intestinal colonization
- MeSH terms
- Amidohydrolases, Animals, Bifidobacterium, Humans, Intestinal Mucosa, Lactobacillus, Probiotics, Metabolic Syndrome
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