Emerging Trends in “Smart Probiotics”: Functional Consideration for the Development of Novel Health and Industrial Applications
Open accessAbstract
The link between gut microbiota and human health is well-recognized and described. This ultimate impact on the host has contributed to explain the mutual dependence between humans and their gut bacteria. Gut microbiota can be manipulated through passive or active strategies. The former includes diet, lifestyle, and environment, while the latter comprise antibiotics, pre- and probiotics. Historically, conventional probiotic strategies included a phylogenetically limited diversity of bacteria and some yeast strains. However, biotherapeutic strategies evolved in the last years with the advent of FMT, successfully applied for treating CDI, IBD, and other diseases. Despite the positive outcomes, long-term effects resulting from the uncharacterized nature of FMT are not sufficiently studied. Thus, developing strategies to simulate the FMT, using characterized gut colonizers with identified phylogenetic diversity, may be a promising alternative. As the definition of probiotics states that the microorganism should have beneficial effects on the host, several bacterial species with proven efficacy have been considered next generation probiotics. Non-conventional candidate strains include Akkermansia muciniphila, Faecalibacterium prausnitzii, Bacteroides fragilis, and members of the Clostridia clusters IV, XIVa and XVIII. However, viable intestinal delivery is one of the current challenges, due to their stringent survival conditions. In this review, we will cover current perspectives on the development and assessment of next generation probiotics and the approaches that industry and stakeholders must consider for a successful outcome.
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Akkermansia, Bifidobacterium, Blautia, Faecalibacterium, Prevotella, Roseburia, and Ruminococcus are relevant in inducing gut metabolism changes.
“Among these, Akkermansia, Bifidobacterium, Blautia, Faecalibacterium, Prevotella, Roseburia, and Ruminococcus ASVs were considered for their high rate of variation and for their relevance in inducing gut metabolism changes [46] (Figure 7).”
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The pros, cons, and many unknowns of probiotics
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The microbiome, cancer, and cancer therapy
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A defined commensal consortium elicits CD8 T cells and anti-cancer immunity
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Interactions between probiotics and pathogenic microorganisms in hosts and foods: A review
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Probiotics in human mental health and diseases—A minireview
Sivamaruthi, B. S., Prasanth, M. I., Kesika, P., & Chaiyasut, C. (2021) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v18i4.29 · Cited by 44 · see citing works
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Dhongade, A. R., Joshi, S. S., Kulkarni, S. V., Jadhav, S. S., Nargundkar, N., Deshmukh, D., & Mehta, A. D. (2022) · Pediatric Infectious Disease · doi:10.5005/jp-journals-10081-1370 · Cited by 5 · see citing works
- Authors
- El Hage, R., Hernandez-Sanabria, E., & Van de Wiele, T.
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2017-09-29
- Volume
- 8
- Pages
- 1889-1889
- ISSN
- 1664-302X (ISSN-L)
- PMC
- PMC5626839
- OpenAlex
- W2758476865
- Cited by
- 185
- References
- 129
- Citations by year
- 2026: 5 · 2025: 18 · 2024: 12 · 2023: 23 · 2022: 34 · 2021: 31 · 2020: 18 · 2019: 27 · 2018: 14 · 2017: 1
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Microbiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- European Commission
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- next-generation probiotics, gut microbiota, fecal microbiota transplantation, Akkermansia muciniphila, Faecalibacterium prausnitzii, Bacteroides fragilis, probiotic viability, intestinal delivery, prebiotics, antibiotic-associated diarrhea, inflammatory bowel disease
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