Exploring cyanobacterial diversity for sustainable biotechnology
Abstract
Cyanobacteria are an evolutionarily ancient and diverse group of microorganisms. Their genetic diversity has allowed them to occupy and play vital roles in a wide range of ecological niches, from desert soil crusts to tropical oceans. Owing to bioprospecting efforts and the development of new platform technologies enabling their study and manipulation, our knowledge of cyanobacterial metabolism is rapidly expanding. This review explores our current understanding of the genetic and metabolic features of cyanobacteria, from the more established cyanobacterial model strains to the newly isolated/described species, particularly the fast-growing, highly productive, and genetically amenable strains, as promising chassis for renewable biotechnology. It also discusses emerging technologies for their study and manipulation, enabling researchers to harness the astounding diversity of the cyanobacterial genomic and metabolic treasure trove towards the establishment of a sustainable bioeconomy.
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This unified photosynthetic apparatus allows cyanobacteria to grow as photoautotrophs, using light as an energy source and CO2 as their main carbon.
“This unified photosynthetic apparatus allows cyanobacteria to grow as photoautotrophs, using light as an energy source and CO2 as their main carbon.”
From Cyanobacteria as a Photosynthetic Chassis for Metabolic Pathway Engineering with Heterologous Gene Expression (2026) · cites this paper as [38]
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Heterologous Expression of Cryptomaldamide in a Cyanobacterial Host
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Type II Toxin–Antitoxin Systems in the Unicellular Cyanobacterium Synechocystis sp. PCC 6803
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High-CO 2 Requirement as a Mechanism for the Containment of Genetically Modified Cyanobacteria
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Cyanobacterial Production of Biopharmaceutical and Biotherapeutic Proteins
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FurA influences heterocyst differentiation in Anabaena sp. PCC 7120
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Self-citationToward a genetic system in the marine cyanobacterium Prochlorococcus
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Mutations in hik26 and slr1916 lead to high-light stress tolerance in Synechocystis sp. PCC6803
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Integrating mass spectrometry and genomics for cyanobacterial metabolite discovery
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Trans-4-hydroxy-L-proline production by the cyanobacterium Synechocystis sp. PCC 6803
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Exploiting Polyploidy for Markerless and Plasmid-Free Genome Engineering in Cyanobacteria
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Transcriptional regulation of heterocyst differentiation in Anabaena sp. strain PCC 7120
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Corrosion in bioprocessing applications
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Harnessing the potential: Advances in cyanobacterial natural product research and biotechnology
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Cyanobacteria as whole-cell factories: Current status and future prospectives
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Metabolites Facilitating Adaptation of Desert Cyanobacteria to Extremely Arid Environments
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A toolbox to engineer the highly productive cyanobacterium <i>Synechococcus</i> sp. PCC 11901
Victoria, A. J., Selão, T. T., Moreno-Cabezuelo, J. Á., Mills, L. A., Gale, G. A. R., Lea-Smith, D. J., & McCormick, A. J. (2024) · Plant Physiology · doi:10.1093/plphys/kiae261 · Cited by 28 · see citing works
Self-citationGenetic variation in photosynthesis: many variants make light work
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Self-Assembly of Nanofilaments in Cyanobacteria for Protein Co-localization
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Engineering the highly productive cyanobacterium Synechococcus sp. PCC 11901Preprint
Victoria, A. J., Selão, T. T., Moreno-Cabezuelo, J. Á., Mills, L. A., Gale, G. A. R., Lea‐Smith, D. J., & McCormick, A. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.04.552009 · Cited by 3 · see citing works
Self-citationHarnessing engineered cyanobacteria for next-generation therapeutics
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New molecular tools for the next generation of solar microbial cell factories
Kirst, H. (2024) · PLANT PHYSIOLOGY · doi:10.1093/plphys/kiae412
Seiilbek, S. N., Mirza, S. S., Torekhanova, M. M., Altybaeva, N. A., Sydykbekova, R. K., Akmukhanova, N. R., & Bruce, B. D. (2026) · Frontiers in Plant Science · doi:10.3389/fpls.2026.1899035
- Authors
- Selão, T. T.
- Affiliations
- University of Nottingham (GB)
- Corresponding author
- Selão, Tiago Toscano
- ORCID
- Selão, Tiago Toscano
- Venue
- Journal of Experimental Botany
- Publisher
- Oxford University Press (OUP)
- Published
- 2022-04-25
- Volume
- 73
- Issue
- 10
- Pages
- 3057-3071
- ISSN
- 0022-0957 (ISSN-L)
- 1460-2431
- OpenAlex
- W4224866915
- Cited by
- 15
- References
- 159
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 3
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Experimental Botany (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Nottingham
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Biocrusts and Microbial Ecology
- Keywords
- cyanobacteria, cyanobacterial diversity, cyanobacterial metabolism, cyanobacterial genomics, bioprospecting, chassis organisms, bioeconomy
- MeSH terms
- Cyanobacteria, Biotechnology, Soil, Soil Microbiology, Ecosystem
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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