Cited by 342Alcoholism and Thiamine DeficiencyAlcohol Consumption and Health EffectsSubstance Abuse Treatment and Outcomes

Ethanol and brain damage

Harper, Clive, Matsumoto, Izuru·2005·Current Opinion in Pharmacology

Abstract

It is now well established that even uncomplicated alcoholics who have no specific neurological or hepatic problems show signs of regional brain damage and cognitive dysfunction. Improvements in neuroimaging technology, magnetic resonance imaging, magnetic resonance spectroscopy and positron emission tomography have contributed significantly, revealing alcoholic-specific changes in the CNS associated with neuropsychological abnormalities. Although greater efforts are needed, a human brain bank specifically targeting alcohol cases is now able to provide fresh and frozen tissue for alcohol researchers. These tissues can be used to test hypotheses developed using animal models and/or in vitro studies. The aim is to delineate mechanisms underlying alcohol-related brain damage in humans. The development of high-throughput, non-hypothesis-driven approaches using DNA microarrays and proteomics might also provide clues to this important problem.

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Crossref · 10.1016/j.coph.2004.06.011

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  • Prolonged alcohol exposure produces neurotoxic effects, including structural impairments in the prefrontal cortex and hippocampus, thereby compounding the disinhibitory effects of acute intoxication.

    “Prolonged alcohol exposure also produces neurotoxic effects, including structural impairments in the prefrontal cortex and hippocampus – two regions essential for behavioral inhibition and emotional reasoning - thereby compounding the disinhibitory effects of acute intoxication (Harper And Matsumoto 2005; Oscar-Berman And Marinković 2007).”

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Authors
Harper, C., & Matsumoto, I.
Affiliations
The University of Sydney (AU)
Corresponding author
  • Harper, Clive
  • Matsumoto, Izuru
Venue
Current Opinion in Pharmacology
Publisher
Elsevier BV
Published
2005-02
Volume
5
Issue
1
Pages
73-78
ISSN
1471-4892 (ISSN-L)
OpenAlex
W2149927155
Cited by
342
References
55
Citations by year
2026: 2 · 2025: 7 · 2024: 8 · 2023: 9 · 2022: 12 · 2021: 10 · 2020: 9 · 2019: 12 · 2018: 12 · 2017: 10 · 2016: 17 · 2015: 28 · 2014: 26 · 2013: 22 · 2012: 24
FWCI
11.22
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Alcohol Abuse and Alcoholism (R01AA012725)
Topics
  • Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords
ethanol, alcohol-related brain damage, alcoholic brain damage, cognitive impairment, brain banks, human brain tissue, neuroimaging, magnetic resonance spectroscopy, positron emission tomography, animal models of alcoholism, DNA microarrays, proteomics, neuropsychological abnormalities
MeSH terms
Aged, Ethanol, Alcoholism, Brain, Central Nervous System Depressants, Cognition Disorders, Female, Humans, Male

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