Ethanol and brain damage
Abstract
It is now well established that even uncomplicated alcoholics who have no specific neurological or hepatic problems show signs of regional brain damage and cognitive dysfunction. Improvements in neuroimaging technology, magnetic resonance imaging, magnetic resonance spectroscopy and positron emission tomography have contributed significantly, revealing alcoholic-specific changes in the CNS associated with neuropsychological abnormalities. Although greater efforts are needed, a human brain bank specifically targeting alcohol cases is now able to provide fresh and frozen tissue for alcohol researchers. These tissues can be used to test hypotheses developed using animal models and/or in vitro studies. The aim is to delineate mechanisms underlying alcohol-related brain damage in humans. The development of high-throughput, non-hypothesis-driven approaches using DNA microarrays and proteomics might also provide clues to this important problem.
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Prolonged alcohol exposure produces neurotoxic effects, including structural impairments in the prefrontal cortex and hippocampus, thereby compounding the disinhibitory effects of acute intoxication.
“Prolonged alcohol exposure also produces neurotoxic effects, including structural impairments in the prefrontal cortex and hippocampus – two regions essential for behavioral inhibition and emotional reasoning - thereby compounding the disinhibitory effects of acute intoxication (Harper And Matsumoto 2005; Oscar-Berman And Marinković 2007).”
From Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework (2026) · cites this paper as Harper And Matsumoto 2005
Cites
Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia
Jack, C. R., Dickson, D. W., Parisi, J. E., Xu, Y. C., Cha, R. H., O’Brien, P. C., Edland, S. D., Smith, G. E., Boeve, B. F., Tangalos, E. G., et al. (2002) · Neurology · doi:10.1212/wnl.58.5.750 · Cited by 610 · see citing works
The cerebral cortex is damaged in chronic alcoholics
Kril, J. J., Halliday, G. M., Svoboda, M. D., & Cartwright, H. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00083-3 · Cited by 508 · see citing works
Frontal Lobe Volume Loss Observed with Magnetic Resonance Imaging in Older Chronic Alcoholics
Pfefferbaum, A., Sullivan, E. V., Mathalon, D. H., & Lim, K. O. (1997) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1997.tb03798.x · Cited by 492 · see citing works
Thomson, A. D. (2002) · Alcohol and Alcoholism · doi:10.1093/alcalc/37.6.513 · Cited by 396 · see citing works
Degeneration of anterior thalamic nuclei differentiates alcoholics with amnesia
Harding, A. (2000) · Brain · doi:10.1093/brain/123.1.141 · Cited by 395 · see citing works
Are we drinking our neurones away?
Harper, C., Kril, J. J., & Daly, J. M. (1987) · BMJ · doi:10.1136/bmj.294.6571.534 · Cited by 231 · see citing works
Self-citationBrain shrinkage in chronic alcoholics: a pathological study.
Harper, C., Kril, J. J., & HOLLOWAY, R. L. (1985) · BMJ · doi:10.1136/bmj.290.6467.501 · Cited by 214 · see citing works
Self-citationGlutamate-mediated transmission, alcohol, and alcoholism
Dodd, P. R., Beckmann, A. M., Davidson, M. S., & Wilce, P. A. (2000) · Neurochemistry International · doi:10.1016/s0197-0186(00)00061-9 · Cited by 214 · see citing works
Harper, C. G., Dixon, G., Sheedy, D. L., & Garrick, T. M. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00155-6 · Cited by 209 · see citing works
Self-citationPostmortem MR imaging of formalin-fixed human brain
Pfefferbaum, A., Sullivan, E. V., Elfar Adalsteinsson, A., Garrick, T. M., & Harper, C. G. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.024 · Cited by 199 · see citing works
Self-citationBaker, K. G., Harding, A., Halliday, G. M., Kril, J. J., & Harper, C. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)90664-9 · Cited by 194 · see citing works
Self-citationBrain atrophy in chronic alcoholic patients: a quantitative pathological study.
Harper, C., & Kril, J. J. (1985) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.48.3.211 · Cited by 188 · see citing works
Self-citationSullivan, E. V. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000085586.91726.46 · Cited by 182 · see citing works
Distribution of ethanol-induced protein adducts in vivo: relationship to tissue injury,
Niemelä, O. J. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00744-4 · Cited by 181 · see citing works
Impairment in Cognitive Functions After Multiple Detoxifications in Alcoholic Inpatients
Duka, T., Townshend, J. M., Collier, K., & Stephens, D. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000090142.11260.d7 · Cited by 172 · see citing works
Ding, J., Eigenbrodt, M. L., Mosley, T. H., Hutchinson, R. G., Folsom, A. R., Harris, T. B., & Nieto, F. J. (2003) · Stroke · doi:10.1161/01.str.0000105929.88691.8e · Cited by 166 · see citing works
Climent, E., Pascual, M., Renau‐Piqueras, J., & Guerri, C. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10208 · Cited by 154 · see citing works
Diffusion tensor imaging in normal aging and neuropsychiatric disorders
Sullivan, E. V., & Pfefferbaum, A. (2003) · European Journal of Radiology · doi:10.1016/s0720-048x(02)00313-3 · Cited by 148 · see citing works
FDG-PET Findings in the Wernicke-Korsakoff Syndrome
Reed, L. J., Lasserson, D. S., Marsden, P. K., Stanhope, N., Stevens, T., Bello, F., Kingsley, D., Colchester, A. C. F., & Kopelman, M. D. (2003) · Cortex · doi:10.1016/s0010-9452(08)70876-1 · Cited by 144 · see citing works
Loss of vasopressin-immunoreactive neurons in alcoholics is dose-related and time-dependent
Harding, A., Halliday, G. M., Ng, J. L. F., Harper, C., & Kril, J. J. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00577-3 · Cited by 143 · see citing works
Self-citationHarper, C., & Corbett, D. (1990) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.53.10.856 · Cited by 116 · see citing works
Self-citationSchweinsburg, B. C., Taylor, M. J., Alhassoon, O. M., Videen, J. S., Brown, G. G., Patterson, T. L., Berger, F., & Igor Grant, A. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1097/00000374-200106000-00019 · Cited by 112 · see citing works
Hyperhomocysteinemia as a new risk factor for brain shrinkage in patients with alcoholism
Bleich, S., Bandelow, B., Javaheripour, K., Müller, A., Degner, D., Wilhelm, J., Havemann‐Reinecke, U., Sperling, W., Rüther, E., & Kornhuber, J. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(02)01194-1 · Cited by 107 · see citing works
Hippocampal volume deficits in alcoholic Korsakoff’s syndrome
Sullivan, E. V., & Marsh, L. (2003) · Neurology · doi:10.1212/01.wnl.0000098940.31882.bb · Cited by 106 · see citing works
Depression and cognitive functioning in alcoholism.
Uekermann, J., Daum, I., Schlebusch, P., Wiebel, B., & Trenckmann, U. (2003) · Addiction · doi:10.1046/j.1360-0443.2003.00526.x · Cited by 103 · see citing works
Proteomic mapping provides powerful insights into functional myelin biology
Taylor, C. M., Marta, C. B., Claycomb, R. J., Han, D. K., Rasband, M. N., Coetzee, T., & Pfeiffer, S. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400922101 · Cited by 102 · see citing works
Harper, C. G., Sheedy, D. L., Lara, A. I., Garrick, T. M., Hilton, J. M. N., & Raisanen, J. M. (1998) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1998.tb139081.x · Cited by 95 · see citing works
Self-citationRapid Onset of Wernicke's Encephalopathy following Gastric Restrictive Surgery
Solá, E., Morillas, C., Garzón, S., Ferrer, J. M., Martín, J. S., & Hernández‐Mijares, A. (2003) · Obesity Surgery · doi:10.1381/096089203322190934 · Cited by 92 · see citing works
SWATTON, J. E., Prabakaran, S., Karp, N. A., Lilley, K. S., & Bahn, S. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001475 · Cited by 85 · see citing works
Mortality and life‐years lost due to alcohol: a comparison of acute and chronic causes
Chikritzhs, T. N., Stockwell, T. R., Jonas, H. A., Heale, P., & Dietze, P. (2001) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2001.tb143269.x · Cited by 76 · see citing works
Jonas, H. A., Dobson, A. J., & Brown, W. J. (2000) · Australian and New Zealand Journal of Public Health · doi:10.1111/j.1467-842x.2000.tb00140.x · Cited by 72 · see citing works
Sullivan, E. V., Rosenbloom, M. J., Serventi, K. L., Deshmukh, A., & Pfefferbaum, A. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.6.1110 · Cited by 71 · see citing works
Application of DNA Microarrays to Study Human Alcoholism
Lewohl, J. M., Dodd, P. R., Mayfield, R. D., & Harris, R. A. (2001) · Journal of Biomedical Science · doi:10.1007/bf02255968 · Cited by 66 · see citing works
Miller, R. C., King, M. A., Heaton, M. B., & Walker, D. W. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03014-7 · Cited by 65 · see citing works
Brain atrophy and neuronal loss in alcoholism: a role for DNA damage?
Brooks, P. J. (2000) · Neurochemistry International · doi:10.1016/s0197-0186(00)00051-6 · Cited by 64 · see citing works
Increased TUNEL positive cells in human alcoholic brains
Ikegami, Y., Goodenough, S., Inoue, Y., Dodd, P. R., Wilce, P. A., & Matsumoto, I. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00826-7 · Cited by 60 · see citing works
Self-citationDrunkenness among young people: a cross-national comparison.
Schmid, H., ter Bogt, T., Godeau, E., Hublet, A., Dias, S., & Fotiou, A. (2003) · Journal of Studies on Alcohol · doi:10.15288/jsa.2003.64.650 · Cited by 54 · see citing works
Does a "moderate" alcohol intake damage the brain?
Harper, C., Kril, J. J., & Daly, J. M. (1988) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.51.7.909 · Cited by 53 · see citing works
Self-citationMagnetic resonance imaging in dementia: a study of brain white matter changes
Bronge, L. (2002) · Acta Radiologica · doi:10.1034/j.1600-0455.43.s.428.1.x · Cited by 49 · see citing works
Lamarche, F. (2003) · Alcohol and Alcoholism · doi:10.1093/alcalc/agg118 · Cited by 48 · see citing works
Cullen, K. M., Halliday, G. M., Caine, D., & Kril, J. J. (1997) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.63.3.315 · Cited by 44 · see citing works
Baker, K. G., Halliday, G. M., Kril, J. J., & Harper, C. (1996) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01045.x · Cited by 33 · see citing works
Self-citationThe decline in hospital autopsy rates in 2001
Ward, H. E., Clarke, B. E., Zimmerman, P. V., & Cleary, M. I. (2002) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2002.tb04307.x · Cited by 29 · see citing works
Ethanol and Gene Expression in Brain
Matsumoto, I., Wilce, P. A., Buckley, T., Dodd, P. R., Puzke, J., Spanagel, R., Zieglgansberger, W., Wolf, G. L., Leng, S., Rommelspacher, H., et al. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02379.x · Cited by 27 · see citing works
Self-citationWernicke's encephalopathy in AIDS: a preventable cause of fatal neurological deficit
Alcaide, M. L., Jayaweera, D., Espinoza, L. A., & Kolber, M. A. (2003) · International Journal of STD & AIDS · doi:10.1258/095646203322387992 · Cited by 24 · see citing works
Alcohol Consumption and Abnormalities of Brain Structure and Vasculature
Mukamal, K. J. (2004) · The American Journal of Geriatric Cardiology · doi:10.1111/j.1076-7460.2004.01334.x · Cited by 22 · see citing works
Eggspuehler, A., Bauerfeind, P., Dorn, T., & Siegel, A. M. (2003) · European Neurology · doi:10.1159/000073064 · Cited by 22 · see citing works
How Important Are Brain Banks for Alcohol Research?
Harper, C. G., Garrick, T. M., Matsumoto, I., Pfefferbaum, A., Elfar Adalsteinsson, A., Sullivan, E. V., Dodd, P. R., Lewohl, J. M., & Butterworth, R. F. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000052585.81056.ca · Cited by 18 · see citing works
Self-citationWernicke’s encephalopathy in a woman on slimming diet
Sechi, G., Serra, A., Pirastru, M. I., Sotgiu, S., & Rosati, G. (2002) · Neurology · doi:10.1212/wnl.58.11.1697 · Cited by 15 · see citing works
Baker, K. G., Halliday, G. M., Kril, J. J., & Harper, C. (1996) · Metabolic Brain Disease · doi:10.1007/bf02237959 · Cited by 15 · see citing works
Self-citationCognitive impairment and central motor conduction time in chronic alcoholics.
Ravaglia, S., Costa, A. C., Ratti, M. T., Savoldi, F., Bo, P., & Moglia, A. (2002) · PubMed · Cited by 14 · see citing works
Two models of ethanol withdrawal kindling.
Matsumoto, I., Burke, L., INOUE, Y., & Wilce, P. A. (2001) · PubMed · Cited by 13 · see citing works
Self-citationWernicke's encephalopathy: a complication of acute pancreatitis?
Lee, Y. D., Lee, S. O., & Lee, S. T. (2003) · Hospital Medicine · doi:10.12968/hosp.2003.64.6.372 · Cited by 4 · see citing works
[Wernicke's encephalopathy due to hyperemesis gravidarum].
Rabenda-Łacka, K., Wilczyński, J., Bręborowicz, G. H., Leśniak, P., Jurga, S., & Radoch, Z. (2003) · PubMed · Cited by 4 · see citing works
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Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management
Sechi, G., & Serra, A. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70104-7 · Cited by 1,278 · see citing works
Alcohol: Effects on Neurobehavioral Functions and the Brain
Oscar-Berman, M., & Marinković, K. (2007) · Neuropsychology Review · doi:10.1007/s11065-007-9038-6 · Cited by 619 · see citing works
Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage
Alfonso-Loeches, S., Pascual-Lucas, M., Blanco, A. M., Sanchez-Vera, I., & Guerri, C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0976-10.2010 · Cited by 579 · see citing works
The Neuropathology of Alcohol-Related Brain Damage
Harper, C. (2009) · Alcohol and Alcoholism · doi:10.1093/alcalc/agn102 · Cited by 420 · see citing works
Self-citationChanraud, S., Martelli, C., Delain, F., Kostogianni, N., Douaud, G., Aubin, H., Reynaud, M., & Martinot, J. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301219 · Cited by 419 · see citing works
Pascual, M., Blanco, A. M., Cauli, O., Miñarro, J., & Guerri, C. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05298.x · Cited by 385 · see citing works
Critical role of TLR4 response in the activation of microglia induced by ethanol
Fernandez-Lizarbe, S., Pascual, M., & Guerri, C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803590 · Cited by 373 · see citing works
Alcohol-related dementia: an update of the evidence
Ridley, N. J., Draper, B., & Withall, A. (2013) · Alzheimer's Research & Therapy · doi:10.1186/alzrt157 · Cited by 335 · see citing works
Qin, L., & Crews, F. T. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-5 · Cited by 290 · see citing works
Alcohol, inflammation, and gut-liver-brain interactions in tissue damage and disease development
Wang, H. J. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i11.1304 · Cited by 282 · see citing works
Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain
Alfonso-Loeches, S., & Guerri, C. (2011) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2011.580567 · Cited by 254 · see citing works
Abuse of Amphetamines and Structural Abnormalities in the Brain
Berman, S. M., O’Neill, J., Fears, S. C., Bartzokis, G., & London, E. D. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1441.031 · Cited by 253 · see citing works
Ethanol and Cognition: Indirect Effects, Neurotoxicity and Neuroprotection: A Review
Brust, J. C. M. (2010) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph7041540 · Cited by 232 · see citing works
Pascual, M., Baliño, P., Alfonso-Loeches, S., Aragón, C. M. G., & Guerri, C. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.02.012 · Cited by 213 · see citing works
Schulte, T., & Müller‐Oehring, E. M. (2010) · Neuropsychology Review · doi:10.1007/s11065-010-9130-1 · Cited by 189 · see citing works
Ethanol induces TLR 4/ TLR 2 association, triggering an inflammatory response in microglial cells
Fernández‐Lizarbe, S., Montesinos, J., & Guerri, C. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12276 · Cited by 182 · see citing works
Cognitive control in alcohol use disorder: deficits and clinical relevance
Wilcox, C. E., Dekonenko, C. J., Mayer, A. R., Bogenschutz, M. P., & Turner, J. A. (2013) · Reviews in the Neurosciences · doi:10.1515/revneuro-2013-0054 · Cited by 162 · see citing works
Kamal, H., Tan, G. C., Ibrahim, S. F., Shaikh, M. F., Mohamed, I. N., Mohamed, R. M. P., Hamid, A. A., Ugusman, A., & Kumar, J. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00282 · Cited by 164 · see citing works
Ethanol–BDNF interactions: Still more questions than answers
Davis, M. I. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.01.003 · Cited by 159 · see citing works
Maurage, P., Grynberg, D., Noël, X., Joassin, F., Philippot, P., Hanak, C., Verbanck, P., Luminet, O., de Timary, P., & Campanella, S. (2011) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01512.x · Cited by 155 · see citing works
Zhao, Y., Wang, F., Fan, Y., Ping, G.-F., Yang, J., & Wu, C. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.08.052 · Cited by 153 · see citing works
Alcohol-Related Dementia and Neurocognitive Impairment: A Review Study
Sachdeva, A., Chandra, M., Choudhary, M., Dayal, P., & Anand, K. S. (2016) · international journal high risk behaviors & addiction · doi:10.5812/ijhrba.27976 · Cited by 142 · see citing works
Reduction in heavy drinking as a treatment outcome in alcohol dependence
Gastfriend, D. R., Garbutt, J. C., Pettinati, H. M., & Forman, R. F. (2007) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2006.09.008 · Cited by 139 · see citing works
Alcohol and Cognition in the Elderly: A Review
Kim, J. W., Lee, D. Y., Lee, B. C., Jung, M. H., Kim, H., Choi, Y. S., & Choi, I. (2012) · Psychiatry Investigation · doi:10.4306/pi.2012.9.1.8 · Cited by 138 · see citing works
Vetreno, R. P., Hall, J. M., & Savage, L. M. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.01.003 · Cited by 136 · see citing works
Fishbein, D. H., Krupitsky, E. M., Flannery, B., Langevin, D. J., Bobashev, G., Verbitskaya, E. V., Augustine, C., Bolla, K. I., Zvartau, E. E., Schech, B., et al. (2007) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2007.02.015 · Cited by 123 · see citing works
Alfonso‐Loeches, S., Ureña‐Peralta, J. R., Morillo-Bargues, M. J., Gómez‐Pinedo, U., & Guerri, C. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1760-5 · Cited by 122 · see citing works
Toll‐like receptor 4 participates in the myelin disruptions associated with chronic alcohol abuse
Alfonso‐Loeches, S., Pascual, M., Gómez‐Pinedo, U., Pascual‐Lucas, M., Renau‐Piqueras, J., & Guerri, C. (2012) · Glia · doi:10.1002/glia.22327 · Cited by 117 · see citing works
The Association Between Alcohol Use and the Progression of Alzheimer's Disease
Heymann, D., Stern, Y., Cosentino, S., Nulman, O., Dorrejo, J., & Gu, Y. (2016) · Current Alzheimer Research · doi:10.2174/1567205013666160603005035 · Cited by 117 · see citing works
Harper, C. G. (2007) · Human & Experimental Toxicology · doi:10.1177/0960327107070499 · Cited by 112 · see citing works
Self-citationDecreased frontal white-matter volume in chronic substance abuse
Schlaepfer, T. E., Lancaster, E., Heidbreder, R., Strain, E. C., Kosel, M., Fisch, H., & Pearlson, G. D. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705005705 · Cited by 110 · see citing works
Jhala, S. S., & Hazell, A. S. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.11.019 · Cited by 107 · see citing works
Haorah, J., Schall, K. A., Ramirez, S. H., & Persidsky, Y. (2007) · Glia · doi:10.1002/glia.20596 · Cited by 106 · see citing works
Miguel-Hidalgo, J. J., Overholser, J. C., Meltzer, H. Y., Stockmeier, C. A., & Rajkowska, G. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00221.x · Cited by 103 · see citing works
Alcoholism and Diabetes Mellitus
Kim, S., & Kim, D. (2012) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2012.36.2.108 · Cited by 102 · see citing works
Alcohol consumption and transition of mild cognitive impairment to dementia
Xu, G., Liu, X., Yin, Q., Zhu, W., Zhang, R., & Fan, X. (2009) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2008.01904.x · Cited by 99 · see citing works
Nunes, P. T., Kipp, B. T., Reitz, N. L., & Savage, L. M. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.09.002 · Cited by 98 · see citing works
Blanco, A. M. A. (2006) · Frontiers in bioscience · doi:10.2741/2259 · Cited by 97 · see citing works
Green, A., Garrick, T. M., Sheedy, D. L., Blake, H., Shores, E. A., & Harper, C. G. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01108.x · Cited by 94 · see citing works
Self-citationChanraud, S., Reynaud, M., Wessa, M., Penttilä, J., Kostogianni, N., Cachia, A., Eric Artiges, A., Delain, F., Perrin, M., Aubin, H., et al. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.101 · Cited by 91 · see citing works
Alexander, K. L., James, G., Sheedy, D. L., Harper, C., & Matsumoto, I. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001741 · Cited by 93 · see citing works
Self-citationCrowe, S. F., Cammisuli, D. M., & Stranks, E. K. (2018) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acy106 · Cited by 90 · see citing works
Alcohol-induced oxidative/nitrosative stress alters brain mitochondrial membrane properties
Reddy, V. D., Padmavathi, P., Kavitha, G., Bulle, S., & Nallanchakravarthula, V. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1526-1 · Cited by 86 · see citing works
Guo, L., Wang, L. H., Sun, B., Yang, J., Zhao, Y. Q., Dong, Y. X., Spranger, M. I., & Wu, C. F. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf070440a · Cited by 86 · see citing works
Chronic Neurologic Effects of Alcohol
Hammoud, N., & Shahed, J. J. (2018) · Clinics in Liver Disease · doi:10.1016/j.cld.2018.09.010 · Cited by 85 · see citing works
Neurobiological and neurocognitive effects of chronic cigarette smoking and alcoholism
Durazzo, T. C. (2007) · Frontiers in bioscience · doi:10.2741/2373 · Cited by 83 · see citing works
Function and Dysfunction of Prefrontal Brain Circuitry in Alcoholic Korsakoff’s Syndrome
Oscar‐Berman, M. (2012) · Neuropsychology Review · doi:10.1007/s11065-012-9198-x · Cited by 82 · see citing works
Taki, Y., Kinomura, S., Sato, K., Goto, R., Inoue, K., Okada, K., Ono, S., Kawashima, R., & Fukuda, H. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00118.x · Cited by 79 · see citing works
Zhong, Y., Dong, G., Luo, H., Cao, J., Wang, C., Wu, J., Feng, Y.-Q., & Yue, J. (2012) · Toxicology · doi:10.1016/j.tox.2012.08.009 · Cited by 77 · see citing works
Myths and truths about the cellular composition of the human brain: A review of influential concepts
von Bartheld, C. S. (2017) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2017.08.004 · Cited by 77 · see citing works
The Relationships between Early Trauma, Dissociation, and Alexithymia in Alcohol Addiction
Craparo, G., Ardino, V., Gori, A., & Caretti, V. (2014) · Psychiatry Investigation · doi:10.4306/pi.2014.11.3.330 · Cited by 77 · see citing works
Hashimoto, J. G., & Wiren, K. M. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301494 · Cited by 76 · see citing works
Widespread Effects of Alcohol on White Matter Microstructure
Fortier, C. B., Leritz, E. C., Salat, D. H., Lindemer, E., Maksimovskiy, A. L., Shepel, J., Williams, V. J., Venne, J. R., Milberg, W., & McGlinchey, R. E. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12568 · Cited by 72 · see citing works
Neural Circuitry Associated with Risk for Alcohol Use Disorders
Tessner, K. D., & Hill, S. Y. (2009) · Neuropsychology Review · doi:10.1007/s11065-009-9111-4 · Cited by 71 · see citing works
Alhassoon, O. M., Sorg, S. F., Taylor, M. J., Stephan, R. A., Schweinsburg, B. C., Stricker, N. H., Gongvatana, A., & Grant, I. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01808.x · Cited by 70 · see citing works
Yang, J., Xue, X., Tian, H., Wang, X., Dong, Y., Wang, F., Zhao, Y., Yao, X., Cui, W., & Wu, C. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.07.002 · Cited by 72 · see citing works
Anstey, K. J., Jorm, A. F., Réglade‐Meslin, C., Maller, J. J., Kumar, R., von Sanden, C., Windsor, T. D., Rodgers, B., Wen, W. X., & Sachdev, P. S. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000237779.56500.af · Cited by 70 · see citing works
Alcohol-related Cognitive Impairment: Current Trends and Future Perspectives
Hayes, V., Demirkol, A., Ridley, N. J., Withall, A., & Draper, B. (2016) · Neurodegenerative Disease Management · doi:10.2217/nmt-2016-0030 · Cited by 68 · see citing works
The Impact of Excessive Alcohol Use on Prospective Memory: A Brief Review
Heffernan, T. (2008) · Current Drug Abuse Reviews · doi:10.2174/1874473710801010036 · Cited by 64 · see citing works
Modulatory action of taurine on ethanol-induced aggressive behavior in zebrafish
Fontana, B. D., Meinerz, D. L., Rosa, L. V., Mezzomo, N. J., Silveira, A., Giuliani, G. S., de Quadros, V. A., Filho, G. L. B., Blaser, R. E., & Rosemberg, D. B. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.11.011 · Cited by 64 · see citing works
Oliveira‐da‐Silva, A., Vieira, F. B., Cristina‐Rodrigues, F., Filgueiras, C. C., Manhães, A. C., & Abreu‐Villaça, Y. (2009) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2009.06.009 · Cited by 60 · see citing works
Oxidative stress is the primary event: Effects of ethanol consumption in brain
Das, S. K., Hiran, K. R., Mukherjee, S., & Vasudevan, D. M. (2007) · Indian Journal of Clinical Biochemistry · doi:10.1007/bf02912890 · Cited by 60 · see citing works
Floreani, N. A., Rump, T. J., Muneer, P. M. A., Alikunju, S., Morsey, B., Brodie, M. R., Persidsky, Y., & Haorah, J. (2010) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-010-9213-z · Cited by 60 · see citing works
Prevalence and characteristics of addictive behaviors in a community sample: A latent class analysis
Deleuze, J., Rochat, L., Romo, L., der Linden, M. V., Achab, S., Thorens, G., Khazaal, Y., ZULLINO, D. F., Maurage, P., Rothen, S., et al. (2015) · Addictive Behaviors Reports · doi:10.1016/j.abrep.2015.04.001 · Cited by 59 · see citing works
Shirpoor, A., Salami, S., Ansari, M. H. K., Minassian, S., & Yegiazarian, M. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.00941.x · Cited by 59 · see citing works
Grodin, E. N., Lin, H., Durkee, C. A., Hommer, D. W., & Momenan, R. (2013) · NeuroImage Clinical · doi:10.1016/j.nicl.2013.03.013 · Cited by 59 · see citing works
Kameda, S. R., Frussa‐Filho, R., Carvalho, R. C., Takatsu-Coleman, A. L., Ricardo, V. P., Patti, C. L., Calzavara, M. B., Lopez, G. B., de Araujo, N. P., Abílio, V. C., et al. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0684-9 · Cited by 58 · see citing works
Johansson, S., Fuchs, A., Ökvist, A., Karimi, M., Harper, C. G., Garrick, T. M., Sheedy, D. L., Hurd, Y. L., Bakalkin, G. Y., & Ekström, T. J. (2007) · Brain Research · doi:10.1016/j.brainres.2006.11.026 · Cited by 58 · see citing works
Self-citationDNA damage and neurotoxicity of chronic alcohol abuse
Kruman, I. I., Henderson, G. I., & Bergeson, S. E. (2012) · Experimental Biology and Medicine · doi:10.1258/ebm.2012.011421 · Cited by 54 · see citing works
Inflammation: good or bad for ADHD?
Donev, R., & Thome, J. (2010) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-010-0038-7 · Cited by 54 · see citing works
Autophagy in Alcohol-Induced Multiorgan Injury: Mechanisms and Potential Therapeutic Targets
Li, Y., Wang, S., Ni, H., Huang, H., & Ding, W. (2014) · BioMed Research International · doi:10.1155/2014/498491 · Cited by 54 · see citing works
Cold-Inducible RNA-Binding Protein Is an Important Mediator of Alcohol-Induced Brain Inflammation
Rajayer, S. R., Jacob, A., Yang, W.-L., Zhou, M., Chaung, W. W., & Wang, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079430 · Cited by 53 · see citing works
Relationship of Wine Consumption with Alzheimer’s Disease
Reale, M., Costantini, E., Jagarlapoodi, S., Khan, H. Z., Belwal, T., & Cichelli, A. (2020) · Nutrients · doi:10.3390/nu12010206 · Cited by 53 · see citing works
Preclinical and clinical pharmacology of alcohol dependence
Tambour, S., & Quertemont, É. (2006) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2006.00459.x · Cited by 53 · see citing works
Cognitive Performance in Long‐Term Abstinent Elderly Alcoholics
Fein, G., & McGillivray, S. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00481.x · Cited by 53 · see citing works
Verbaten, M. N. (2009) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.1022 · Cited by 52 · see citing works
Zhang, X., Kusumo, H., Sakharkar, A. J., Pandey, S. C., & Guizzetti, M. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12465 · Cited by 51 · see citing works
Maurage, P., de Timary, P., Billieux, J., Collignon, M., & Heeren, A. (2014) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.12444 · Cited by 51 · see citing works
Wang, J. J., Durazzo, T. C., Gazdzinski, S. P., Yeh, P., Mon, A., & Meyerhoff, D. J. (2009) · NMR in Biomedicine · doi:10.1002/nbm.1363 · Cited by 50 · see citing works
Alcohol-related neurodegeneration and recovery: mechanisms from animal models.
Crews, F. T. (2008) · Europe PMC (PubMed Central) · Cited by 49 · see citing works
Kashem, M. A., James, G., Harper, C. G., Wilce, P. A., & Matsumoto, I. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.10.009 · Cited by 49 · see citing works
Self-citationDifferential protein expression profiles in the hippocampus of human alcoholics
Matsuda-Matsumoto, H., Iwazaki, T., Kashem, M. A., Harper, C., & Matsumoto, I. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.04.001 · Cited by 49 · see citing works
Self-citationBagga, D., Sharma, A., Kumari, A., Kaur, P., Bhattacharya, D., Garg, M. L., Khushu, S., & Singh, N. (2013) · Alcohol · doi:10.1016/j.alcohol.2013.10.009 · Cited by 48 · see citing works
Zois, E., Kortlang, N., Vollstädt‐Klein, S., Leménager, T., Beutel, M., Mann, K. F., & Fauth‐Bühler, M. (2014) · Brain and Behavior · doi:10.1002/brb3.231 · Cited by 49 · see citing works
Cheon, Y.-H., Park, J.-W., Joe, K., & Kim, D. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708008663 · Cited by 47 · see citing works
Oyenihi, O. R., Afolabi, B. A., Oyenihi, A. B., Ogunmokun, O. J., & Oguntibeju, O. O. (2016) · Toxicology Reports · doi:10.1016/j.toxrep.2016.01.003 · Cited by 49 · see citing works
Maurage, P., Joassin, F., Pesenti, M., Grandin, C. B. G., Heeren, A., Philippot, P., & de Timary, P. (2012) · Cortex · doi:10.1016/j.cortex.2012.04.012 · Cited by 46 · see citing works
Dupuy, M., & Chanraud, S. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.04.003 · Cited by 46 · see citing works
Berre, A. L., Pitel, A., Chanraud, S., Beaunieux, H., Eustache, F., Martinot, J., Reynaud, M., Martelli, C., Torsten Rohlfing, B., Sullivan, E. V., et al. (2014) · Human Brain Mapping · doi:10.1002/hbm.22500 · Cited by 45 · see citing works
Acute Ethanol Alters Multiple Histone Modifications at Model Gene Promoters in the Cerebral Cortex
Finegersh, A., & Homanics, G. E. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12465 · Cited by 45 · see citing works
Liu, I., Chiu, C., Chen, C.-J., Kuo, L., Lo, Y., & Tseng, W. I. (2010) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2010.07.002 · Cited by 45 · see citing works
Cruz, C., Meireles, M., & Silva, S. M. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.04.005 · Cited by 43 · see citing works
Diffusion Tensor Imaging of the Corpus Callosum in Addiction
Arnone, D., Abou‐Saleh, M. T., & Barrick, T. R. (2006) · Neuropsychobiology · doi:10.1159/000096992 · Cited by 43 · see citing works
Magnetic Resonance Imaging Findings in Substance Abuse
Spampinato, M. V., Castillo, M., Rojas, R., Palacios, E., Verzelli, L. F., & Descartes, F. (2005) · Topics in Magnetic Resonance Imaging · doi:10.1097/01.rmr.0000192175.26243.a7 · Cited by 42 · see citing works
Miller, M. W., & SPEAR, L. P. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00177.x · Cited by 43 · see citing works
Ren, J. T., Babcock, S. A., Li, Q., Huff, A. F., Li, S., & Doser, T. A. (2009) · Toxicology Letters · doi:10.1016/j.toxlet.2009.02.019 · Cited by 40 · see citing works
The relationship between alcohol and cognitive functioning following traumatic brain injury
Ponsford, J. L., Tweedly, L., & Taffe, J. R. (2013) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2012.752437 · Cited by 40 · see citing works
Biological Studies on Alcohol-Induced Neuronal Damage
Tateno, M., & Saito, T. (2008) · Psychiatry Investigation · doi:10.4306/pi.2008.5.1.21 · Cited by 39 · see citing works
Fontana, B. D., Stefanello, F. V., Mezzomo, N. J., Müller, T. E., de Quadros, V. A., Parker, M. O., Rico, E. P., & Rosemberg, D. B. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.08.008 · Cited by 39 · see citing works
Le « bien vieillir » : concepts et modèles
Gangbè, M., & Ducharme, F. (2006) · médecine/sciences · doi:10.1051/medsci/2006223297 · Cited by 38 · see citing works
- Authors
- Harper, C., & Matsumoto, I.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Harper, Clive
- Matsumoto, Izuru
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2005-02
- Volume
- 5
- Issue
- 1
- Pages
- 73-78
- ISSN
- 1471-4892 (ISSN-L)
- OpenAlex
- W2149927155
- Cited by
- 342
- References
- 55
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 8 · 2023: 9 · 2022: 12 · 2021: 10 · 2020: 9 · 2019: 12 · 2018: 12 · 2017: 10 · 2016: 17 · 2015: 28 · 2014: 26 · 2013: 22 · 2012: 24
- FWCI
- 11.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA012725)
- Topics
- Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- ethanol, alcohol-related brain damage, alcoholic brain damage, cognitive impairment, brain banks, human brain tissue, neuroimaging, magnetic resonance spectroscopy, positron emission tomography, animal models of alcoholism, DNA microarrays, proteomics, neuropsychological abnormalities
- MeSH terms
- Aged, Ethanol, Alcoholism, Brain, Central Nervous System Depressants, Cognition Disorders, Female, Humans, Male
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