A look inside the diabetic brain: Contributors to diabetes-induced brain aging

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

(1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291401 · Cited by 24,667 · see citing works

Prevalence of Overweight and Obesity in the United States, 1999-2004

Ogden, C. L., Carroll, M. D., Curtin, L. R., McDowell, M. A., Tabak, C. J., & Flegal, K. M. (2006) · JAMA · doi:10.1001/jama.295.13.1549 · Cited by 8,720 · see citing works

Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.

Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376 · see citing works

Hearing loss and cognitive decline in older adults

Lin, F. R., Yaffe, K., Xia, J., Xue, Q.-L., Harris, T. B., Purchase-Helzner, E., Satterfield, S., Ayonayon, H. N., Ferrucci, L., Simonsick, E. M., et al. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.1868 · Cited by 4,017 · see citing works

Alzheimer’s disease

Blennow, K., de Leon, M. J., & Zetterberg, H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69113-7 · Cited by 3,134 · see citing works

Diabetes mellitus and the risk of dementia: The Rotterdam Study

Ott, A., Stolk, R. P., van Harskamp, F., Pols, H. A. P., Hofman, A., & Breteler, M. M. B. (1999) · Neurology · doi:10.1212/wnl.53.9.1937 · Cited by 2,175 · see citing works

Clinical Correlates of White Matter Findings on Cranial Magnetic Resonance Imaging of 3301 Elderly People: The Cardiovascular Health Study

Longstreth, W. T., Manolio, T. A., Arnold, A., Burke, G. L., Bryan, N., Jungreis, C. A., Enright, P. L., O'Leary, D., & Fried, L. (1996) · Stroke · doi:10.1161/01.str.27.8.1274 · Cited by 1,464 · see citing works

Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function

Arvanitakis, Z., Wilson, R. S., Bienias, J. L., Evans, D. A., & Bennett, D. A. (2004) · Archives of Neurology · doi:10.1001/archneur.61.5.661 · Cited by 1,258 · see citing works

Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies

Peila, R., Rodriguez, B. L., & Launer, L. J. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1256 · Cited by 1,207 · see citing works

The GSK3 hypothesis of Alzheimer’s disease

Hooper, C., Killick, R., & Lovestone, S. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05194.x · Cited by 1,191 · see citing works

Signals That Regulate Food Intake and Energy Homeostasis

Woods, S. C., Seeley, R. J., Porte, D., & Schwartz, M. W. (1998) · Science · doi:10.1126/science.280.5368.1378 · Cited by 1,169 · see citing works

Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study

Whitmer, R. A., Gunderson, E. P., Barrett-Connor, E., Quesenberry, C. P., & Yaffe, K. (2005) · BMJ · doi:10.1136/bmj.38446.466238.e0 · Cited by 1,090 · see citing works

Effect of fatty acids on glucose production and utilization in man.

Ferrannini, E., Barrett, E. J., Bevilacqua, S., & DeFronzo, R. A. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111133 · Cited by 1,050 · see citing works

The Role of Advanced Glycation End Products in Progression and Complications of Diabetes

Goh, S.-Y., & Cooper, M. E. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1817 · Cited by 987 · see citing works

Type 1 diabetes

Daneman, D. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68341-4 · Cited by 917 · see citing works

Temporal structure in spatially organized neuronal ensembles: a role for interneuronal networks

Buzsáki, G., & Chrobak, J. J. (1995) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(95)80012-3 · Cited by 878 · see citing works

The Obesity Epidemic: Pathophysiology and Consequences of Obesity

Pi‐Sunyer, F. X. (2002) · Obesity Research · doi:10.1038/oby.2002.202 · Cited by 856 · see citing works

Intranasal insulin improves cognition and modulates β-amyloid in early AD

Reger, M. A., Watson, G. S., Green, P. S., Wilkinson, C. W., Baker, L. D., Cholerton, B., Fishel, M. A., Plymate, S. R., Breitner, J. C. S., DeGroodt, W., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000265401.62434.36 · Cited by 830 · see citing works

An 18-Year Follow-up of Overweight and Risk of Alzheimer Disease

Gustafson, D., Rothenberg, E., Blennow, K., Steen, B., & Skoog, I. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.13.1524 · Cited by 811 · see citing works

Cognition and synaptic plasticity in diabetes mellitus

Gispen, W. H., & Biessels, G. J. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01656-8 · Cited by 772 · see citing works

The Effects of Type 1 Diabetes on Cognitive Performance

Brands, A. M. A., Biessels, G. J., de Haan, E. H. F., Kappelle, L. J., & Kessels, R. P. C. (2005) · Diabetes Care · doi:10.2337/diacare.28.3.726 · Cited by 738 · see citing works

Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons

Passafaro, M., Piëch, V., & Sheng, M. (2001) · Nature Neuroscience · doi:10.1038/nn0901-917 · Cited by 655 · see citing works

Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons

Stranahan, A. M., Arumugam, T. V., Cutler, R. G., Lee, K. M., Egan, J. M., & Mattson, M. P. (2008) · Nature Neuroscience · doi:10.1038/nn2055 · Cited by 610 · see citing works

Preserved Cognition in Patients With Early Alzheimer Disease and Amnestic Mild Cognitive Impairment During Treatment With Rosiglitazone

Watson, G. S., Cholerton, B. A., Reger, M. A., Baker, L. D., Plymate, S. R., Asthana, S., Fishel, M. A., Kulstad, J. J., Green, P. S., Cook, D. G., et al. (2005) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.13.11.950 · Cited by 607 · see citing works

White Matter Lesions in an Unselected Cohort of the Elderly: Molecular Pathology Suggests Origin From Chronic Hypoperfusion Injury

Fernando, M. S., Simpson, J. E., Matthews, F., Brayne, C., Lewis, C. E., Barber, R., Kalaria, R. N., Forster, G., Esteves, F., Wharton, S. B., et al. (2006) · Stroke · doi:10.1161/01.str.0000221308.94473.14 · Cited by 587 · see citing works

Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI

Saykin, A. J., Wishart, H. A., Rabin, L. A., Santulli, R. B., Flashman, L. A., West, J. D., McHugh, T., & Mamourian, A. C. (2006) · Neurology · doi:10.1212/01.wnl.0000234032.77541.a2 · Cited by 584 · see citing works

Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: Relationship to severity of dementia and apolipoprotein E genotype

Craft, S., Peskind, E., Schwartz, M. W., Schellenberg, G. D., Raskind, M., & Porte, D. (1998) · Neurology · doi:10.1212/wnl.50.1.164 · Cited by 560 · see citing works

Memory improvement following induced hyperinsulinemia in Alzheimer’s disease

Craft, S., Newcomer, J., Kanne, S., Dagogo-Jack, S., Cryer, P., Sheline, Y., Luby, J., Dagogo-Jack, A., & Alderson, A. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(95)02002-0 · Cited by 538 · see citing works

The Significance of Cerebral White Matter Abnormalities 100 Years After Binswanger’s Report

Pantoni, L., & García, J. H. (1995) · Stroke · doi:10.1161/01.str.26.7.1293 · Cited by 536 · see citing works

Brain Insulin Receptors and Spatial Memory

Zhao, W., Chen, H., Xu, H., Moore, E., Meiri, N., Quon, M. J., & Alkon, D. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.34893 · Cited by 535 · see citing works

Relation between body mass index and cognitive function in healthy middle-aged men and women

Cournot, M., Marquié, J. C., Ansiau, D., Martinaud, C., Fonds, H., Ferrières, J., & Ruidavets, J. B. (2006) · Neurology · doi:10.1212/01.wnl.0000238082.13860.50 · Cited by 517 · see citing works

Glycation, Inflammation, and RAGE: A Scaffold for the Macrovascular Complications of Diabetes and Beyond

Yan, S. F., Ramasamy, R., Naka, Y., & Schmidt, A. M. (2003) · Circulation Research · doi:10.1161/01.res.0000103862.26506.3d · Cited by 513 · see citing works

Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI

den Heijer, T., Vermeer, S. E., van Dijk, E. J., Prins, N. D., Koudstaal, P. J., Albert Hofman, D., & Breteler, M. M. B. (2003) · Diabetologia · doi:10.1007/s00125-003-1235-0 · Cited by 512 · see citing works

Role of insulin and insulin receptor in learning and memory

Zhao, W., & Alkon, D. L. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00455-5 · Cited by 492 · see citing works

Brain atrophy rates predict subsequent clinical conversion in normal elderly and amnestic MCI

Jack, C. R., Shiung, M. M., Weigand, S. D., O’Brien, P. C., Gunter, J. L., Boeve, B. F., Knopman, D. S., Smith, G. E., Ivnik, R. J., Tangalos, E. G., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000180958.22678.91 · Cited by 492 · see citing works

Hippocampal damage and memory impairments as possible early brain complications of type 2 diabetes

Gold, S. M., Dziobek, I., Sweat, V., Tirsi, A., Rogers, K., Bruehl, H., Tsui, W., Richardson, S., Javier, E., & Convit, A. (2007) · Diabetologia · doi:10.1007/s00125-007-0602-7 · Cited by 489 · see citing works

Brain Magnetic Resonance Imaging Correlates of Impaired Cognition in Patients With Type 2 Diabetes

Manschot, S., Brands, A. M. A., van der Grond, J., Kessels, R. P. C., Algra, A., Kappelle, L. J., Biessels, G. J., & on behalf of the Utrecht Diabetic Encephalopathy Study Group (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-1323 · Cited by 482 · see citing works

Ageing and diabetes: implications for brain function

Biessels, G. J., van der Heide, L. P., Kamal, A., Bleys, R. L. A. W., & Gispen, W. H. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01486-3 · Cited by 458 · see citing works

Localization of insulin receptor mRNA in rat brain by in situ hybridization

MARKS, J. L., PORTE, D., STAHL, W. L., & BASKIN, D. G. (1990) · Endocrinology · doi:10.1210/endo-127-6-3234 · Cited by 448 · see citing works

Insulin signaling in the central nervous system: Learning to survive

van der Heide, L. P., Ramakers, G. M. J., & Smidt, M. P. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.06.003 · Cited by 444 · see citing works

Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents

Li, X.-L., Aou, S., Oomura, Y., Hori, N., Fukunaga, K., & Hori, T. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00162-8 · Cited by 440 · see citing works

Association between features of the insulin resistance syndrome and alzheimer's disease independently of apolipoprotein e4 phenotype: cross sectional population based study

Kuusisto, J., Koivisto, K. J., Mykkänen, L. M., Helkala, E.-L., Vanhanen, M., Hänninen, T., Kervinen, K., Kesäniemi, Y. A., Riekkinen, P. J., & Laakso, M. (1997) · BMJ · doi:10.1136/bmj.315.7115.1045 · Cited by 426 · see citing works

Cognitive Deficits in Adolescents Who Developed Diabetes Early in Life

Ryan, C. M., Vega, A., & DRASH, A. L. (1985) · PEDIATRICS · doi:10.1542/peds.75.5.921 · Cited by 418 · see citing works

Leptin Enhances NMDA Receptor Function and Modulates Hippocampal Synaptic Plasticity

Shanley, L. J., Irving, A. J., & Harvey, J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-24-j0001.2001 · Cited by 416 · see citing works

Aging: Overview

Harman, D. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05631.x · Cited by 416 · see citing works

Circuit-Specific Alterations in Hippocampal Synaptophysin Immunoreactivity Predict Spatial Learning Impairment in Aged Rats

Smith, T. D., Adams, M., Gallagher, M., Morrison, J., & Rapp, P. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06587.2000 · Cited by 404 · see citing works

Risk factors for progression of brain atrophy in aging

Enzinger, C., Fazekas, F., Matthews, P. M., Ropele, S., Schmidt, H., Smith, S. M., & Schmidt, R. (2005) · Neurology · doi:10.1212/01.wnl.0000161871.83614.bb · Cited by 397 · see citing works

Microtubule-associated protein tau in development, degeneration and protection of neurons

Wang, J., & Liu, F. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.03.002 · Cited by 395 · see citing works

Obesity, diabetes and cognitive deficit: The Framingham Heart Study

Elias, M. F., Elias, P. K., Sullivan, L. M., Wolf, P. A., & D’Agostino, R. B. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.08.019 · Cited by 395 · see citing works

The role of cerebral amyloid accumulation in common forms of Alzheimer disease

Gandy, S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25100 · Cited by 394 · see citing works

Decreases in rat extracellular hippocampal glucose concentration associated with cognitive demand during a spatial task

McNay, E. C., Fries, T. M., & Gold, P. E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050583697 · Cited by 386 · see citing works

Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment

Biessels, G. J., Kamal, A., Urban, I. J. A., Spruijt, B. M., Erkelens, D. W., & Gispen, W. H. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00510-1 · Cited by 379 · see citing works

Glucose transporter expression in the central nervous system: relationship to synaptic function

McEwen, B. S., & Reagan, L. P. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.041 · Cited by 378 · see citing works

Oxidative Stress at Onset and in Early Stages of Type 1 Diabetes in Children and Adolescents

Domı́nguez, C., Ruíz, E., Gussinyé, M., & Carrascosa, A. (1998) · Diabetes Care · doi:10.2337/diacare.21.10.1736 · Cited by 377 · see citing works

What is the best predictor of future type 2 diabetes

Abdul-Ghani, M. A., Williams, K., DeFronzo, R. A., & Stern, M. (2007) · Diabetes Care · doi:10.2337/dc06-1331 · Cited by 355 · see citing works

Brain Imaging in Patients With Diabetes

van Harten, B., de Leeuw, F., Weinstein, H. C., Scheltens, P., & Biessels, G. J. (2006) · Diabetes Care · doi:10.2337/dc06-1637 · Cited by 349 · see citing works

Neurocognitive aging: prior memories hinder new hippocampal encoding

Wilson, I. A., Gallagher, M., Eichenbaum, H., & Tanila, H. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.10.002 · Cited by 343 · see citing works

Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice

Pedersen, W. A., McMillan, P. J., Kulstad, J. J., Leverenz, J. B., Craft, S., & Haynatzki, G. R. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.01.018 · Cited by 321 · see citing works

Effects of Type 1 Diabetes on Gray Matter Density as Measured by Voxel-Based Morphometry

Musen, G., Lyoo, I. K., Sparks, C. R., Weinger, K., Hwang, J., Ryan, C. M., Jimerson, D. C., Hennen, J. A., Renshaw, P. F., & Jacobson, A. M. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-0520 · Cited by 319 · see citing works

Effects of leptin on memory processing

Farr, S. A., Banks, W. A., & Morley, J. E. (2005) · Peptides · doi:10.1016/j.peptides.2005.10.006 · Cited by 314 · see citing works

Enhancement of Memory in Alzheimer Disease With Insulin and Somatostatin, but Not Glucose

Craft, S., Asthana, S., Newcomer, J. W., Wilkinson, C. W., Matos, I. T., Baker, L. D., Cherrier, M., Lofgreen, C., Latendresse, S., Petrova, A., et al. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.12.1135 · Cited by 312 · see citing works

Insulin promotes rapid delivery of N -methyl- d - aspartate receptors to the cell surface by exocytosis

Skeberdis, V. A., Lan, J.-Y., Zheng, X., Zukin, R. S., & Bennett, M. V. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051634698 · Cited by 303 · see citing works

Intranasal Insulin Improves Memory in Humans: Superiority of Insulin Aspart

Benedict, C., Hallschmid, M., Schmitz, K., Schultes, B., Ratter, F., Fehm, H. L., Born, J., & Kern, W. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301193 · Cited by 302 · see citing works

Relationships Between Hyperglycemia and Cognitive Performance Among Adults With Type 1 and Type 2 Diabetes

Cox, D. J., Kovatchev, B. P., Gonder-Frederick, L. A., Summers, K. H., McCall, A. L., Grimm, K. J., & Clarke, W. L. (2005) · Diabetes Care · doi:10.2337/diacare.28.1.71 · Cited by 299 · see citing works

Cognitive Ability and Brain Structure in Type 1 Diabetes

Ferguson, S. C., Blane, A., Perros, P., McCrimmon, R. J., Best, J. J. K., Wardlaw, J. M., Deary, I. J., & Frier, B. M. (2003) · Diabetes · doi:10.2337/diabetes.52.1.149 · Cited by 286 · see citing works

Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats

Oomura, Y., Hori, N., Shiraishi, T., Fukunaga, K., Takeda, H., Tsuji, M., Matsumiya, T., Ishibashi, M., Aou, S., Li, X. L., et al. (2006) · Peptides · doi:10.1016/j.peptides.2006.07.001 · Cited by 284 · see citing works

Memory impairment in obese Zucker rats: An investigation of cognitive function in an animal model of insulin resistance and obesity.

Winocur, G., Greenwood, C. E., Piroli, G. G., Grillo, C. A., Reznikov, L. R., Reagan, L. P., & McEwen, B. S. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.5.1389 · Cited by 281 · see citing works

Regional Brain Atrophy Rate Predicts Future Cognitive Decline: 6-year Longitudinal MR Imaging Study of Normal Aging

Rusinek, H., De Santi, S., Frid, D., Tsui, W.-H., Tarshish, C. Y., Convit, A., & de Leon, M. J. (2003) · Radiology · doi:10.1148/radiol.2293021299 · Cited by 281 · see citing works

Diabetes is related to cerebral infarction but not to AD pathology in older persons

Arvanitakis, Z., Schneider, J. A., Wilson, R. S., Li, Y., Arnold, S. E., Wang, Z., & Bennett, D. A. (2006) · Neurology · doi:10.1212/01.wnl.0000247053.45483.4e · Cited by 280 · see citing works

Impairment of Learning and Memory in Rats Caused by Oxidative Stress and Aging, and Changes in Antioxidative Defense Systems

Fukui, K., Onodera, K., Shinkai, T., Suzuki, S., & Urano, S. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05646.x · Cited by 279 · see citing works

Insulin modulates hippocampal activity‐dependent synaptic plasticity in a <i>N</i>‐methyl‐<scp>d</scp>‐aspartate receptor and phosphatidyl‐inositol‐3‐kinase‐dependent manner

Van Der Heide, L. P., Kamal, A., Artola, A., Gispen, W. H., & Ramakers, G. M. J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03269.x · Cited by 278 · see citing works

Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?

Biessels, G. J., & Kappelle, L. J. (2005) · Biochemical Society Transactions · doi:10.1042/bst0331041 · Cited by 266 · see citing works

Alzheimer-Like Changes in Rat Models of Spontaneous Diabetes

Li, Z.-G., Zhang, W., & Sima, A. A. F. (2007) · Diabetes · doi:10.2337/db07-0171 · Cited by 265 · see citing works

Experimental diabetes in rats causes hippocampal dendritic and synaptic reorganization and increased glucocorticoid reactivity to stress

Magariños, A. M., & McEwen, B. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.20.11056 · Cited by 262 · see citing works

Neuronal changes in normal human aging and Alzheimer's disease.

Uylings, H., & de Brabander, J. D. (2002) · Brain and Cognition · doi:10.1006/brcg.2001.1500 · Cited by 260 · see citing works

Influence of an Early-Onset Age of Type 1 Diabetes on Cerebral Structure and Cognitive Function

Ferguson, S. C., Blane, A., Wardlaw, J. M., Frier, B. M., Perros, P., McCrimmon, R. J., & Deary, I. J. (2005) · Diabetes Care · doi:10.2337/diacare.28.6.1431 · Cited by 253 · see citing works

Usefulness of visceral obesity (waist/hip ratio) in predicting vascular endothelial function in healthy overweight adults

Brook, R. D., Bard, R. L., Rubenfire, M., Ridker, P. M., & Rajagopalan, S. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)02088-4 · Cited by 244 · see citing works

Glucose enhancement of performance of memory tests in young and aged humans

Hall, J. L., Gonder-Frederick, L. A., Chewning, W. W., da Silveira, J. C. C., & Gold, P. E. (1989) · Neuropsychologia · doi:10.1016/0028-3932(89)90096-1 · Cited by 241 · see citing works

Insulin Dysfunction InducesIn VivoTau Hyperphosphorylation through Distinct Mechanisms

Planel, E., Tatebayashi, Y., Miyasaka, T., Liu, L., Wang, L., Herman, M., Yu, W. H., Luchsinger, J. A., Wadzinski, B. E., Duff, K., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3949-07.2007 · Cited by 238 · see citing works

Effects of prior hypoglycemia and hyperglycemia on cognition in children with type 1 diabetes mellitus

Perantie, D. C., Lim, A., Wu, J., Weaver, P., Warren, S. L., Sadler, M., White, N. H., & Hershey, T. (2008) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2007.00274.x · Cited by 237 · see citing works

Vascular Basis of Alzheimer's Pathogenesis

de la Torre, J. C. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04817.x · Cited by 236 · see citing works

Learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: interaction of diabetes and ageing

Kamal, A., Biessels, G. J., Duis, S., & Gispen, W. H. (2000) · Diabetologia · doi:10.1007/s001250051335 · Cited by 223 · see citing works

Relation of education to brain size in normal aging

Coffey, C. E., Saxton, J. A., Ratcliff, G., Bryan, R. N., & Lucke, J. F. (1999) · Neurology · doi:10.1212/wnl.53.1.189 · Cited by 220 · see citing works

Hypercortisolemic depression is associated with the metabolic syndrome in late-life

Vogelzangs, N., Suthers, K., Ferrucci, L., Simonsick, E. M., Blè, A., Schrager, M. A., Bandinelli, S., Lauretani, F., Giannelli, S. V., & Penninx, B. W. J. H. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.11.009 · Cited by 218 · see citing works

The Effect of Borderline Diabetes on the Risk of Dementia and Alzheimer’s Disease

Xu, W., Qiu, C., Winblad, B. G., & Fratiglioni, L. (2006) · Diabetes · doi:10.2337/db06-0879 · Cited by 218 · see citing works

Regional Brain Volume Differences Associated With Hyperglycemia and Severe Hypoglycemia in Youth With Type 1 Diabetes

Perantie, D. C., Wu, J., Koller, J. M., Lim, A., Warren, S. L., BLACK, K. J., Sadler, M., White, N. H., & Hershey, T. G. (2007) · Diabetes Care · doi:10.2337/dc07-0351 · Cited by 214 · see citing works

Adaptation in brain glucose uptake following recurrent hypoglycemia.

Boyle, P. J., Nagy, R. J., O'Connor, A. M., Kempers, S. F., Yeo, R. A., & Qualls, C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.20.9352 · Cited by 208 · see citing works

Fluctuations in Brain Glucose Concentration during Behavioral Testing: Dissociations between Brain Areas and between Brain and Blood

McNay, E. C., McCarty, R. C., & Gold, P. E. (2001) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2000.3976 · Cited by 200 · see citing works

Abnormal Cortisol Metabolism and Tissue Sensitivity to Cortisol in Patients with Glucose Intolerance

Andrews, R. C., Herlihy, O., Livingstone, D. E. W., Andrew, R., & Walker, B. R. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020048 · Cited by 199 · see citing works

Links between cognitive impairment in insulin resistance: An explanatory model

Convit, A. J. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.018 · Cited by 198 · see citing works

Metabolic and vascular determinants of impaired cognitive performance and abnormalities on brain magnetic resonance imaging in patients with type 2 diabetes

Manschot, S., Biessels, G. J., de Valk, H. W., Algra, A., Rutten, G. E. H. M., van der Grond, J., Kappelle, L. J., & on behalf of the Utrecht Diabetic Encephalopathy Study Group (2007) · Diabetologia · doi:10.1007/s00125-007-0792-z · Cited by 198 · see citing works

Hippocampal formation size in normal human aging: a correlate of delayed secondary memory performance.Preprint

Golomb, J. B., Kluger, A., de Leon, M. J., Ferris, S. H., Convit, A. J., Mittelman, M. S., Cohen, J., Rusinek, H., Santi, S. D., & GEORGE, A. E. (1994) · Learning & Memory · doi:10.1101/lm.1.1.45 · Cited by 198 · see citing works

Is Mild Cognitive Impairment Prodromal for Vascular Dementia Like Alzheimer’s Disease?

Meyer, J. S., Xu, G., Thornby, J. A., Chowdhury, M. H., & Quach, M. (2002) · Stroke · doi:10.1161/01.str.0000024432.34557.10 · Cited by 195 · see citing works

Cognitive performance is associated with glucose regulation in healthy elderly persons and can be enhanced with glucose and dietary carbohydrates

Kaplan, R. J., Greenwood, C. E., Winocur, G., & Wolever, T. M. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.3.825 · Cited by 193 · see citing works

Brain Aging in Very Old Men With Type 2 Diabetes

Korf, E. S. C., White, L. R., Scheltens, P., & Launer, L. J. (2006) · Diabetes Care · doi:10.2337/dc06-0243 · Cited by 190 · see citing works

Hippocampal synaptic plasticity in streptozotocin-diabetic rats: impairment of long-term potentiation and facilitation of long-term depression

Kamal, A., Biessels, G. J., Urban, I. J. A., & Gispen, W. H. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00485-0 · Cited by 189 · see citing works

Type 2 Diabetes Is Negatively Associated With Alzheimer's Disease Neuropathology

Beeri, M. S., Silverman, J. M., Davis, K. L., Marin, D. B., Grossman, H. T., Schmeidler, J., Purohit, D. P., Perl, D. P., Davidson, M. H., Mohs, R. C., et al. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.4.471 · Cited by 187 · see citing works

Tau Is Hyperphosphorylated at Multiple Sites in Mouse Brain In Vivo After Streptozotocin-Induced Insulin Deficiency

Clodfelder‐Miller, B., Zmijewska, A. A., Johnson, G. V. W., & Jope, R. S. (2006) · Diabetes · doi:10.2337/db06-0485 · Cited by 185 · see citing works

Leptin regulation of neuronal excitability and cognitive function

Harvey, J. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.10.006 · Cited by 184 · see citing works

Leptin promotes rapid dynamic changes in hippocampal dendritic morphology

O’Malley, D., MacDonald, N., Mizielinska, S., Connolly, C. N., Irving, A. J., & Harvey, J. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.05.001 · Cited by 178 · see citing works

Signatures of hippocampal oxidative stress in aged spatial learning-impaired rodents

Nicolle, M. M., Gonzalez, J., Sugaya, K., Baskerville, K. A., Bryan, D., Lund, K. C., Gallagher, M., & McKinney, M. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00374-8 · Cited by 177 · see citing works

Diabetics do not have increased Alzheimer-type pathology compared with age-matched control subjects

Heitner, J., & Dickson, D. (1997) · Neurology · doi:10.1212/wnl.49.5.1306 · Cited by 173 · see citing works

Intranasal Insulin to Improve Memory Function in Humans

Benedict, C., Hallschmid, M., Schultes, B., Jan Born, A., & Kern, W. (2007) · Neuroendocrinology · doi:10.1159/000106378 · Cited by 171 · see citing works

Diabetes and cardiovascular disease: The Framingham study

Kannel, W. B. (1975) · The American Journal of Cardiology · doi:10.1016/0002-9149(75)90692-x · Cited by 169 · see citing works

Cognitive Performance, Psychological Well-Being, and Brain Magnetic Resonance Imaging in Older Patients With Type 1 Diabetes

Brands, A. M. A., Kessels, R. P. C., Hoogma, R. P. L. M., Henselmans, J. M. L., Boter, J. W. V. D. B., Kappelle, L. J., de Haan, E. H. F., & Biessels, G. J. (2006) · Diabetes · doi:10.2337/db05-1226 · Cited by 167 · see citing works

Obese men respond to cognitive but not to catabolic brain insulin signaling

Hallschmid, M., Benedict, C., Schultes, B., Born, J., & Kern, W. (2008) · International Journal of Obesity · doi:10.1038/sj.ijo.0803722 · Cited by 165 · see citing works

Frequency and Timing of Severe Hypoglycemia Affects Spatial Memory in Children With Type 1 Diabetes

Hershey, T. G., Perantie, D. C., Warren, S. L., Zimmerman, E. C., Sadler, M., & White, N. H. (2005) · Diabetes Care · doi:10.2337/diacare.28.10.2372 · Cited by 157 · see citing works

Type 2 Diabetes Mellitus and Cognitive Decline in Two Large Cohorts of Community‐Dwelling Older Adults

Okereke, O. I., Kang, J. H., Cook, N. R., Gaziano, J. M., Manson, J. E., Buring, J. E., & Grodstein, F. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.01686.x · Cited by 155 · see citing works

White matter lesions are prevalent but differentially related with cognition in aging and early Alzheimer disease

Burns, J. M., Church, J. A., Johnson, D. K., Xiong, C., Marcus, D., Fotenos, A. F., Snyder, A. Z., Morris, J. C., & Buckner, R. L. (2005) · Archives of Neurology · doi:10.1001/archneur.62.12.1870 · Cited by 155 · see citing works

Regional responses in antioxidant system to exercise training and dietary Vitamin E in aging rat brain

Devi, S. A., & Kiran, T. R. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00112-x · Cited by 154 · see citing works

The many lives of leptin

Banks, W. A. (2004) · Peptides · doi:10.1016/j.peptides.2004.02.014 · Cited by 153 · see citing works

Corticosterone Impairs Insulin-Stimulated Translocation of GLUT4 in the Rat Hippocampus

Piroli, G. G., Grillo, C. A., Reznikov, L. R., Adams, S., McEwen, B. S., Charron, M. J., & Reagan, L. P. (2007) · Neuroendocrinology · doi:10.1159/000101694 · Cited by 146 · see citing works

Brain Abnormalities Demonstrated by Magnetic Resonance Imaging in Adult IDDM Patients With and Without a History of Recurrent Severe Hypoglycemia

Perros, P., Deary, I. J., Sellar, R. J., Best, J. J. K., & Frier, B. M. (1997) · Diabetes Care · doi:10.2337/diacare.20.6.1013 · Cited by 143 · see citing works

Distribution and levels of [125I]IGF-I, [125I]IGF-II and [125I]insulin receptor binding sites in the hippocampus of aged memory-unimpaired and -impaired rats

Doré, S., Kar, S., Rowe, W. B., & Quirion, R. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00154-1 · Cited by 128 · see citing works

Cognitive Associations of Subcortical White Matter Lesions in Older People

O'Brien, J. T., Wiseman, R., Burton, E. J., Barber, B., Wesnes, K. A., Saxby, B. K., & Ford, G. A. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04849.x · Cited by 127 · see citing works

Central nervous system complications of diabetes mellitus — a perspective from the blood–brain barrier

Mooradian, A. D. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00003-9 · Cited by 124 · see citing works

Increased astrocyte reactivity in the hippocampus of murine models of type 1 diabetes: the nonobese diabetic (NOD) and streptozotocin-treated mice

Saravia, F., Revsin, Y., Deniselle, M. C. G., González, S. L., Roig, P., Lima, A. E., Homo‐Delarche, F., & Nicola, A. F. D. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03675-2 · Cited by 124 · see citing works

An investigation into signal transduction mechanisms involved in insulin‐induced long‐term depression in the CA1 region of the hippocampus

Huang, C., Lee, C., & Hsu, K. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2003.02307.x · Cited by 120 · see citing works

Insulin signaling effects on memory and mood

Reagan, L. P. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.10.012 · Cited by 118 · see citing works

Association Between Acute-Phase Reactants and Advanced Glycation End Products in Type 2 Diabetes

Tan, K. C. B., Chow, W.-S., Tam, S., Bucala, R., & Betteridge, J. D. (2004) · Diabetes Care · doi:10.2337/diacare.27.1.223 · Cited by 118 · see citing works

Diabetic and non-diabetic subjects with ischemic stroke: Differences, subtype distribution and outcome

Tuttolomondo, A., Pinto, A. V., Salemi, G., Raimondo, D. D., Sciacca, R. D., Fernández, P., Ragonese, P., Savettieri, G., & Licata, G. (2007) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.02.003 · Cited by 115 · see citing works

Effects of Posttraining Administration of Glucose on Retention of a Habituation Response in Mice: Participation of a Central Cholinergic Mechanism

Kopf, S. R., & Baratti, C. M. (1996) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.0030 · Cited by 115 · see citing works

Hippocampal volume and cognitive performance in long‐standing Type 1 diabetic patients without macrovascular complications

Lobnig, B. M., Krömeke, O., Optenhostert‐Porst, C., & Wolf, O. T. (2005) · Diabetic Medicine · doi:10.1111/j.1464-5491.2005.01716.x · Cited by 112 · see citing works

The As and Ds of stress: Metabolic, morphological and behavioral consequences

Reagan, L. P., Grillo, C. A., & Piroli, G. G. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.02.050 · Cited by 111 · see citing works

Immunocytochemical analysis of synaptic proteins provides new insights into diabetes-mediated plasticity in the rat hippocampus

Grillo, C. A., Piroli, G. G., Wood, G. E., Reznikov, L. R., McEwen, B. S., & Reagan, L. P. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.019 · Cited by 106 · see citing works

Diabetes Increases Atrophy and Vascular Lesions on Brain MRI in Patients With Symptomatic Arterial Disease

Tiehuis, A. M., van der Graaf, Y., Visseren, F. L. J., Vincken, K. L., Biessels, G. J., Appelman, A. P. A., Kappelle, L. J., & Mali, W. P. T. M. (2008) · Stroke · doi:10.1161/strokeaha.107.506089 · Cited by 105 · see citing works

Cognitive Functioning and Brain MRI in Patients with Type 1 and Type 2 Diabetes Mellitus: A Comparative Study

Brands, A. M. A., Biessels, G. J., Kappelle, L. J., de Haan, E. H. F., de Valk, H. W., Algra, A., & Kessels, R. P. C. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000100980 · Cited by 103 · see citing works

Molecular Indices of Neuronal and Glial Plasticity in the Hippocampal Formation in a Rodent Model of Age-Induced Spatial Learning Impairment

Sugaya, K., Chouinard, M. L., Greene, R., Robbins, M., Personett, D. A., Kent, C., Gallagher, M., & McKinney, M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03427.1996 · Cited by 102 · see citing works

Minireview: Mechanisms by Which the Metabolic Syndrome and Diabetes Impair Memory

Meena Kumari, B., Brunner, E. J., & Fuhrer, R. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.5.b228 · Cited by 102 · see citing works

Diabetes mellitus concomitantly facilitates the induction of long‐term depression and inhibits that of long‐term potentiation in hippocampus

Artola, A., Kamal, A., Ramakers, G. M. J., Biessels, G. J., & Gispen, W. H. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04205.x · Cited by 99 · see citing works

Glucose Treatment Reduces Memory Deficits in Young Adult Rats Fed High-Fat Diets

Greenwood, C. E., & Winocur, G. (2001) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2000.3964 · Cited by 97 · see citing works

Glucose and age-related changes in memory

Gold, P. E. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.002 · Cited by 96 · see citing works

Impact of improved glycaemic control on rates of hypoglycaemia in insulin dependent diabetes mellitus

Davis, E. A., Keating, B., Byrne, G. C., Russell, M. T., & Jones, T. W. (1998) · Archives of Disease in Childhood · doi:10.1136/adc.78.2.111 · Cited by 95 · see citing works

Cognitive and Neural Hippocampal Effects of Long-Term Moderate Recurrent Hypoglycemia

McNay, E. C., Williamson, A., McCrimmon, R. J., & Sherwin, R. S. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-1314 · Cited by 95 · see citing works

Alzheimer's Disease

Yaari, R., & Corey‐Bloom, J. (2007) · Seminars in Neurology · doi:10.1055/s-2006-956753 · Cited by 95 · see citing works

Impaired long-term potentiation in obese zucker rats: possible involvement of presynaptic mechanism

Gerges, N. Z., Aleisa, A. M., & Alkadhi, K. A. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00297-5 · Cited by 86 · see citing works

Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons

Brodbeck, J., Balestra, M. E., Saunders, A. M., Roses, A. D., Mahley, R. W., & Huang, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709906104 · Cited by 86 · see citing works

Repetitive Hypoglycemia in Young Rats Impairs Hippocampal Long-Term Potentiation

Yamada, K. A., Rensing, N. R., Izumi, Y., de Erausquin, G. A., Gazit, V. A., Dorsey, D. A., & Herrera, D. G. (2003) · Pediatric Research · doi:10.1203/01.pdr.0000110523.07240.c1 · Cited by 86 · see citing works

Low Circulating Endogenous Secretory Receptor for AGEs Predicts Cardiovascular Mortality in Patients With End-Stage Renal Disease

Koyama, H., Shoji, T., Fukumoto, S., Shinohara, K., Shoji, T., Emoto, M., Mori, K., Tahara, H., Ishimura, E., Kakiya, R., et al. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000251502.88818.4b · Cited by 86 · see citing works

The effects of type 1 diabetes on cerebral white matter

Weinger, K., Jacobson, A. M., Musen, G., Lyoo, I. K., Ryan, C. M., Jimerson, D. C., & Renshaw, P. F. (2007) · Diabetologia · doi:10.1007/s00125-007-0904-9 · Cited by 85 · see citing works

The effect of retrograde and anterograde glucose administration on memory performance in healthy young adults

Sünram‐Lea, S. I., Foster, J. K., Durlach, P. J., & Pérez, C. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00086-4 · Cited by 83 · see citing works

Differential modulation of plasma β-amyloid by insulin in patients with Alzheimer disease

Kulstad, J. J., Green, P. S., Cook, D. G., Watson, G. S., Reger, M. A., Baker, L. D., Plymate, S. R., Asthana, S., Rhoads, K., Mehta, P. D., et al. (2006) · Neurology · doi:10.1212/01.wnl.0000216274.58185.09 · Cited by 82 · see citing works

Synaptic transmission changes in the pyramidal cells of the hippocampus in streptozotocin-induced diabetes mellitus in rats

Kamal, A., Biessels, G. J., Gispen, W. H., & Ramakers, G. M. J. (2006) · Brain Research · doi:10.1016/j.brainres.2005.12.070 · Cited by 81 · see citing works

Enhanced glycemic responsiveness to epinephrine in insulin-dependent diabetes mellitus is the result of the inability to secrete insulin. Augmented insulin secretion normally limits the glycemic, but not the lipolytic or ketogenic, response to epinephrine in humans.

Berk, M. A., Clutter, W. E., Skor, D. A., SHAH, S. D., Gingerich, R. L., Parvin, C. A., & Cryer, P. E. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111898 · Cited by 80 · see citing works

Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?

Kappelle, L. J., & Biessels, G. J. (2005) · Biochemical Society Transactions · doi:10.1042/bst20051041 · Cited by 79 · see citing works

Cognitive impairment and oxidative stress in the elderly: Results of epidemiological studies

Berr, C. (2000) · BioFactors · doi:10.1002/biof.5520130132 · Cited by 78 · see citing works

Cognitive Function in Younger Type II Diabetes

Dey, J., Misra, A., Desai, N. G., Mahapatra, A. K., & Padma, M. V. (1997) · Diabetes Care · doi:10.2337/diacare.20.1.32 · Cited by 75 · see citing works

Adiposity and Alzheimers Disease

Luchsinger, J. A., & Mayeux, R. P. (2007) · Current Alzheimer Research · doi:10.2174/156720507780362100 · Cited by 70 · see citing works

Effects of Posttraining Administration of Insulin on Retention of a Habituation Response in Mice: Participation of a Central Cholinergic Mechanism

Kopf, S. R., & Baratti, C. M. (1999) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1998.3831 · Cited by 63 · see citing works

Enhanced binding of advanced glycation endproducts (AGE) by the ApoE4 isoform links the mechanism of plaque deposition in Alzheimer's disease

Li, Y. M., & Dickson, D. W. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00266-8 · Cited by 62 · see citing works

Stereological quantification of GAD‐67–immunoreactive neurons and boutons in the hippocampus of middle‐aged and old Fischer 344 × Brown Norway rats

Shi, L., Argenta, A. E., Winseck, A. K., & Brunso‐Bechtold, J. K. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20303 · Cited by 62 · see citing works

Albumin, haemoglobin, BMI and cognitive performance in older adults

Ng, T. P., Feng, L., Niti, M., & Yap, K. B. (2008) · Age and Ageing · doi:10.1093/ageing/afn102 · Cited by 58 · see citing works

Glucose, stress, and hippocampal neuronal vulnerability

Reagan, L. P. (2002) · International review of neurobiology · doi:10.1016/s0074-7742(02)51009-6 · Cited by 55 · see citing works

A prospective study of severe hypoglycemia and long-term spatial memory in children with type 1 diabetes

Hershey, T. G., Lillie, R., Sadler, M., & White, N. H. (2004) · Pediatric Diabetes · doi:10.1111/j.1399-543x.2004.00045.x · Cited by 55 · see citing works

Hilar neuropeptide Y interneuron loss in the aged rat hippocampal formation

Cadiacio, C. L., Milner, T. A., Gallagher, M., & Pierce, J. P. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00126-2 · Cited by 54 · see citing works

Regional Rat Brain Distribution of Heme Oxygenase-1 and Manganese Superoxide Dismutase mRNA: Relevance of Redox Homeostasis in the Aging Processes

Colombrita, C., Calabrese, V., Stella, A. M. G., Mattei, F., Alkon, D. L., & Scapagnini, G. (2003) · Experimental Biology and Medicine · doi:10.1177/15353702-0322805-16 · Cited by 53 · see citing works

Glucose Metabolism in Identical Twins Discordant for Obesity. The Critical Role of Visceral Fat

Rönnemaa, T., Koskenvuo, M., Marniemi, J., Koivunen, T., Sajantila, A., Rissanen, A., Kaitsaari, M., Bouchard, C., & Kaprio, J. A. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.2.3763 · Cited by 52 · see citing works

The natural course of MRI white matter hyperintensities

Schmidt, R., Schmidt, H., Kapeller, P., Enzinger, C., Ropele, S., Saurugg, R., & Fazekas, F. (2002) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(02)00300-3 · Cited by 51 · see citing works

Neuropsychological functioning in older people with Type 2 diabetes: the effect of controlling for confounding factors

Asimakopoulou, K. G., Hampson, S. E., & Morrish, N. J. (2002) · Diabetic Medicine · doi:10.1046/j.1464-5491.2002.00680.x · Cited by 50 · see citing works

GABAA receptor-associated phosphoinositide 3-kinase is required for insulin-induced recruitment of postsynaptic GABAA receptors

Vetiska, S., Ahmadian, G., Ju, W., Liu, L., Wymann, M. P., & Wang, Y. T. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.06.023 · Cited by 50 · see citing works

Structural brain imaging in diabetes: A methodological perspective

Jongen, C., & Biessels, G. J. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.085 · Cited by 50 · see citing works

Increased Glucose Levels Are Associated With Episodic Memory in Nondiabetic Women

Rolandsson, O., Backeström, A., Eriksson, S., Hallmans, G., & Nilsson, L. (2007) · Diabetes · doi:10.2337/db07-1215 · Cited by 48 · see citing works

Peritoneal implantation of macroencapsulated porcine pancreatic islets in diabetic rats ameliorates severe hyperglycemia and prevents retraction and simplification of hippocampal dendrites

Magariños, A. M., Jain, K., Blount, E. D., Reagan, L. P., Smith, B. H., & McEwen, B. S. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02400-3 · Cited by 43 · see citing works

Diagnostic utility of serum or cerebrospinal fluid levels of toxic advanced glycation end-products (TAGE) in early detection of Alzheimer’s disease

Takeuchi, M., Sato, T., Takino, J.-I., Kobayashi, Y., Furuno, S., Kikuchi, S., & Yamagishi, S. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2006.12.017 · Cited by 42 · see citing works

Insulin induces a novel form of postsynaptic mossy fiber long-term depression in the hippocampus

Huang, C., You, J.-L., Lee, C.-C., & Hsu, K. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00238-0 · Cited by 39 · see citing works

Hyperglycemia Inhibits Retinoic Acid–Induced Activation of Rac1, Prevents Differentiation of Cortical Neurons, and Causes Oxidative Stress in a Rat Model of Diabetic Pregnancy

Guleria, R. S., Pan, J., DiPette, D., & Singh, U. S. (2006) · Diabetes · doi:10.2337/db06-0169 · Cited by 39 · see citing works

Diabetes, sugar-coated but harmful to the brain

Starr, V., & Convit, A. J. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.10.007 · Cited by 33 · see citing works

A simple deep breathing test reveals altered cerebral autoregulation in type 2 diabetic patients

Brown, C., Marthol, H., Zikeli, U., Ziegler, D., & Hilz, M. J. (2008) · Diabetologia · doi:10.1007/s00125-008-0958-3 · Cited by 29 · see citing works

Role of Insulin Metabolism Disturbances in the Development of Alzheimer Disease: Mini Review

Sabayan, B., Foroughinia, F., Mowla, A., & Borhani‐Haghighi, A. (2008) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317507312623 · Cited by 25 · see citing works

Assessment of cerebral perfusion and cerebrovascular reserve in insulin-dependent diabetic patients without central neurological symptoms by means of 99mTc-HMPAO SPET with acetazolamide

Jiménez-Bonilla, J. F., Quirce, R., Hernández, A. L., Vallina, N. K., GUEDE, C., Banzo, I., Amado, J., & CARRIL, J. M. (2001) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s002590100595 · Cited by 24 · see citing works

Effect of amyloid precursor protein 17mer peptide on microtubule structure and tau protein hyperphosphorylation in hippocampal neurons of experimental diabetic mice

Zhao, Y., Pei, J.-J., Ji, Z., Zhao, Z., Qian, Y.-Y., & Sheng, S. (2003) · Neuroreport · doi:10.1097/00001756-200301200-00012 · Cited by 22 · see citing works

Effects of glycemic control on target organ responses to epinephrine in type 1 diabetes

Guy, D. L. A., Sandoval, D. A., Richardson, M. A., Tate, D. B., & Davis, S. N. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00311.2004 · Cited by 13 · see citing works

Effects of the AMPA receptor modulator S 18986 on measures of cognition and oxidative stress in aged rats

Kelly, S. J., Bernard, K., Muñoz, C., Lawrence, R. C., Thacker, J. S., Grillo, C. A., Piroli, G. G., & Reagan, L. P. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1301-x · Cited by 12 · see citing works

Erratum to “Hilar neuropeptide Y interneuron loss in the aged rat hippocampal formation” [Exp. Neurol. 183 (2003) 147–158]

Cadacio, C. L., Milner, T. A., Gallagher, M., & Pierce, J. P. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.03.001 · Cited by 4 · see citing works

Untitled work

(2000) · doi:10.1002/1520-7560(2000)9999:9999

Hippocampal insulin resistance and cognitive dysfunction

Biessels, G. J., & Reagan, L. P. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn4019 · Cited by 536 · see citing works

Insulin in the Brain: Its Pathophysiological Implications for States Related with Central Insulin Resistance, Type 2 Diabetes and Alzheimer’s Disease

Blázquez, E., Velázquez, E., Hurtado-Carneiro, V., & Ruiz-Albusac, J. M. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00161 · Cited by 502 · see citing works

A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives

Reed, J., Bain, S., & Kanamarlapudi, V. (2021) · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · doi:10.2147/dmso.s319895 · Cited by 441 · see citing works

Type 2 diabetes mellitus and Alzheimer’s disease

Barbagallo, M. (2014) · World Journal of Diabetes · doi:10.4239/wjd.v5.i6.889 · Cited by 313 · see citing works

Metformin: Is it a drug for all reasons and diseases?

Triggle, C. R., Mohammed, I., Bshesh, K., Marei, I., Ye, K., Ding, H., MacDonald, R. S., Hollenberg, M. D., & Hill, M. A. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155223 · Cited by 282 · see citing works

Cognitive dysfunction in older adults with diabetes: what a clinician needs to know

Munshi, M. N. (2017) · Diabetes Care · doi:10.2337/dc16-1229 · Cited by 255 · see citing works

Pathophysiology of RAGE in inflammatory diseases

Dong, H., Zhang, Y., Huang, Y., & Deng, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.931473 · Cited by 245 · see citing works

Brain insulin signaling: A key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes

McNay, E. C., & Recknagel, A. K. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.08.005 · Cited by 229 · see citing works

Bone marrow-derived mesenchymal stem cells improve diabetes-induced cognitive impairment by exosome transfer into damaged neurons and astrocytes

Nakano, M. H., Nagaishi, K., Konari, N., Saito, Y., Chikenji, T., Mizue, Y., & Fujimiya, M. (2016) · Scientific Reports · doi:10.1038/srep24805 · Cited by 211 · see citing works

Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes

Bhutada, P., Mundhada, Y. R., Bansod, K. U., Tawari, S., Patil, S., Dixit, P. V., Umathe, S. N., & Mundhada, D. R. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.01.022 · Cited by 205 · see citing works

Cerebral ischemic damage in diabetes: an inflammatory perspective

Shukla, V., Shakya, A. K., Pérez‐Pinzón, M. A., & Dave, K. R. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0774-5 · Cited by 201 · see citing works

Inside the Diabetic Brain: Role of Different Players Involved in Cognitive Decline

Gaspar, J. M., Baptista, F. I., Macedo, M. P., & Ambrósio, A. F. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00240 · Cited by 179 · see citing works

Crosstalk between obesity, diabetes, and alzheimer’s disease: Introducing quercetin as an effective triple herbal medicine

Ebrahimpour, S., Zakeri, M., & Esmaeili, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101095 · Cited by 158 · see citing works

Type 1 diabetes‐associated cognitive decline: A meta‐analysis and update of the current literature 1型糖尿病相关的认知能力下降：一项对最新文献的meta分析

Tonoli, C., Heyman, E., Roelands, B., Pattyn, N., Buyse, L., Piacentini, M. F., Berthoin, S., & Meeusen, R. (2014) · Journal of Diabetes · doi:10.1111/1753-0407.12193 · Cited by 148 · see citing works

Ameliorative effect of quercetin on memory dysfunction in streptozotocin-induced diabetic rats

Bhutada, P., Mundhada, Y. R., Bansod, K. U., Bhutada, C., Tawari, S., Dixit, P. V., & Mundhada, D. R. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.06.008 · Cited by 152 · see citing works

Neuronal damage and cognitive impairment associated with hypoglycemia: An integrated view

Languren, G., Montiel, T., Julio-Amilpas, A., & Massieu, L. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.06.018 · Cited by 135 · see citing works

Diabetes and cognitive function: An evidence-based current perspective

Sebastian, M. J., Khan, S. K. A., Pappachan, J. M., & Jeeyavudeen, M. S. (2023) · World Journal of Diabetes · doi:10.4239/wjd.v14.i2.92 · Cited by 111 · see citing works

Diabetes as a chronic metabolic stressor: Causes, consequences and clinical complications

Reagan, L. P. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.02.004 · Cited by 101 · see citing works

Ginsenoside Re attenuates diabetes-associated cognitive deficits in rats

Liu, Y., Xia Shuang, Z. H. U., Li, W., Lü, Q., Wang, J., Wei, Y., & Yin, X. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.12.003 · Cited by 97 · see citing works

Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance

Cardoso, S., Santos, R. X., Correia, S. C., Carvalho, C., Santos, M. S., Baldeiras, I., Oliveira, C. R., & Moreira, P. I. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.08.008 · Cited by 94 · see citing works

Chronic epigallocatechin-3-gallate ameliorates learning and memory deficits in diabetic rats via modulation of nitric oxide and oxidative stress

Baluchnejadmojarad, T., & Roghani, M. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.06.007 · Cited by 92 · see citing works

Type 2 Diabetes Mellitus Increases the Risk of Late-Onset Alzheimer’s Disease: Ultrastructural Remodeling of the Neurovascular Unit and Diabetic Gliopathy

Hayden, M. R. (2019) · Brain Sciences · doi:10.3390/brainsci9100262 · Cited by 90 · see citing works

A high calorie diet causes memory loss, metabolic syndrome and oxidative stress into hippocampus and temporal cortex of rats

Treviño, S., Aguilar‐Alonso, P., Hernández, J. A. F., Brambila, E., Guevara, J., Flores, G., López‐López, G., Muñoz‐Arenas, G., Morales‐Medina, J. C., Toxqui, V., et al. (2015) · Synapse · doi:10.1002/syn.21832 · Cited by 87 · see citing works

Irisin Exerts Neuroprotective Effects on Cultured Neurons by Regulating Astrocytes

Wang, K., Li, H., Wang, H., Wang, J., Song, F., & Sun, Y. S. (2018) · Mediators of Inflammation · doi:10.1155/2018/9070341 · Cited by 86 · see citing works

The Feasibility of Detecting Neuropsychologic and Neuroanatomic Effects of Type 1 Diabetes in Young Children

Aye, T., Reiss, A. L., Kesler, S. R., Hoang, S., Drobny, J., Park, Y., Schleifer, K., Baumgartner, H. A., Wilson, D. M., & Buckingham, B. A. (2011) · Diabetes Care · doi:10.2337/dc10-2164 · Cited by 86 · see citing works

Huperzine A Ameliorates Cognitive Deficits in Streptozotocin-Induced Diabetic Rats

Mao, X., Cao, D., Li, X., Yin, J., Wang, Z., Zhang, Y., Mao, C., Zhou, H., & Liu, Z. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15057667 · Cited by 85 · see citing works

Insulin Resistance, Diabetes Mellitus, and Brain Structure in Bipolar Disorders

Hájek, T., Calkin, C. V., Blagdon, R. A., Slaney, C., Uher, R., & Alda, M. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.148 · Cited by 83 · see citing works

Brain volume abnormalities and neurocognitive deficits in diabetes mellitus: Points of pathophysiological commonality with mood disorders?

McIntyre, R. S., Kenna, H. A., Nguyen, H. T., Law, C. W. Y., Sultan, F., Woldeyohannes, H. O., Alsuwaidan, M. T., Soczynska, J. K., Adams, A. K., Cheng, J. S. H., et al. (2010) · Advances in Therapy · doi:10.1007/s12325-010-0011-z · Cited by 83 · see citing works

Cortical and hippocampal mitochondria bioenergetics and oxidative status during hyperglycemia and/or insulin-induced hypoglycemia

Cardoso, S., Santos, M. S., Seiça, R. M. F., & Moreira, P. I. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.07.001 · Cited by 79 · see citing works

Insulin resistance in the brain: An old-age or new-age problem?

Williamson, R., McNeilly, A. D., & Sutherland, C. D. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.05.007 · Cited by 77 · see citing works

Suppression of methylglyoxal hyperactivity by mangiferin can prevent diabetes-associated cognitive decline in rats

Liu, Y., Zhu, X., Yang, Q., Lü, Q., Wang, J., Li, H.-P., Wei, Y., Yin, J., & Yin, X. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3061-5 · Cited by 77 · see citing works

True or false? Alzheimer’s disease is type 3 diabetes: Evidences from bench to bedside

Peng, Y., Yao, S.-Y., Chen, Q., Jin, H., Du, M., Xue, Y.-H., & Liu, S. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102383 · Cited by 76 · see citing works

Pioglitazone ameliorates memory deficits in streptozotocin-induced diabetic mice by reducing brain β-amyloid through PPARγ activation

Liu, L., Yan, T., Jiang, L., Hu, W. M., Hu, M., Wang, C., Zhang, Q., Long, Y., Wang, J.-Q., Li, Y., et al. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.11 · Cited by 71 · see citing works

Effect of quercetin-conjugated superparamagnetic iron oxide nanoparticles on diabetes-induced learning and memory impairment in rats

Ebrahimpour, S., Esmaeili, A., & Beheshti, S. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s177871 · Cited by 69 · see citing works

Hippocampal neurovascular and hypothalamic–pituitary–adrenal axis alterations in spontaneously type 2 diabetic GK rats

Beauquis, J., Homo‐Delarche, F., Giroix, M.-H., Ehses, J. A., Coulaud, J., Roig, P., Portha, B., Nicola, A. F. D., & Saravia, F. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2009.12.022 · Cited by 64 · see citing works

The effects of the Chinese medicine ZiBu PiYin recipe on the hippocampus in a rat model of diabetes-associated cognitive decline: a proteomic analysis

Shi, X., Lu, X., Zhan, L., Qi, X., Liang, L., Hu, S. Y., Yan, Y., Zhao, S. Y., Sui, H. X., & Zhang, F. L. (2011) · Diabetologia · doi:10.1007/s00125-011-2147-z · Cited by 65 · see citing works

Total saponins from Rhizoma Anemarrhenae ameliorate diabetes-associated cognitive decline in rats: Involvement of amyloid-beta decrease in brain

Liu, Y., Zhu, X., Lü, Q., Wang, J., Li, W., Wei, Y., & Yin, X. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.11.004 · Cited by 65 · see citing works

Stem cell-derived exosomes: a novel vector for tissue repair and diabetic therapy

Newton, W. C., Kim, J. W., Luo, J. Z. Q., & Luo, L. (2017) · Journal of Molecular Endocrinology · doi:10.1530/jme-17-0080 · Cited by 65 · see citing works

Melatonin exerts neuroprotective effects by inhibiting neuronal pyroptosis and autophagy in STZ‐induced diabetic mice

Che, H., Li, H., Li, Y., Wang, Y., Yang, Z., Wang, R., & Wang, L. (2020) · The FASEB Journal · doi:10.1096/fj.202001328r · Cited by 63 · see citing works

Food for thought: The role of appetitive peptides in age-related cognitive decline

Fadel, J. R., Jolivalt, C. G., & Reagan, L. P. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.01.009 · Cited by 62 · see citing works

Diabetes exacerbates amyloid and neurovascular pathology in aging‐accelerated mice

Currais, A. J. M., Prior, M., Lo, D., Jolivalt, C. G., Schubert, D. A., & Maher, P. A. (2012) · Aging Cell · doi:10.1111/acel.12002 · Cited by 61 · see citing works

Role of Insulin Signaling in the Interaction Between Alzheimer Disease and Diabetes Mellitus: A Missing Link to Therapeutic Potential

Sato, N., Takeda, S., Uchio‐Yamada, K., Ueda, H., Fujisawa, T., Rakugi, H., & Morishita, R. (2011) · Current Aging Science · doi:10.2174/1874609811104020118 · Cited by 61 · see citing works

Central nervous system: a conductor orchestrating metabolic regulations harmed by both hyperglycaemia and hypoglycaemia

Scheen, A. J. (2010) · Diabetes & Metabolism · doi:10.1016/s1262-3636(10)70464-x · Cited by 60 · see citing works

Stop signs in hippocampal insulin signaling: the role of insulin resistance in structural, functional and behavioral deficits

Fadel, J. R., & Reagan, L. P. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.12.004 · Cited by 57 · see citing works

Type 2 Diabetes Mellitus: A Potentially Modifiable Risk Factor for Neurochemical Brain Changes in Bipolar Disorders

Hájek, T., Calkin, C. V., Blagdon, R. A., Slaney, C., & Alda, M. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.11.007 · Cited by 54 · see citing works

Danshensu ameliorates the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammation

Wang, T., Fu, F., Han, B., Zhang, L., & Zhang, X. (2012) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2012.02.008 · Cited by 54 · see citing works

Diabetes Status and Susceptibility to the Effects of PM2.5 Exposure on Cardiovascular Mortality in a National Canadian Cohort

Pinault, L. L., Brauer, M. D., Crouse, D. L., Weichenthal, S., Erickson, A. C., van Donkelaar, A., Martin, R. V., Charbonneau, S., Hystad, P., Brook, J. R., et al. (2018) · Epidemiology · doi:10.1097/ede.0000000000000908 · Cited by 52 · see citing works

Vernonia Amygdalina Del. stimulated glucose uptake in brain tissues enhances antioxidative activities; and modulates functional chemistry and dysregulated metabolic pathways

Erukainure, O. L., Oyebode, O. A., Ibeji, C. U., Koorbanally, N. A., & Islam, M. S. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-018-0363-7 · Cited by 50 · see citing works

Central nervous system endoplasmic reticulum stress in a murine model of type 2 diabetes

Sims‐Robinson, C., Zhao, S., Hur, J., & Feldman, E. L. (2012) · Diabetologia · doi:10.1007/s00125-012-2573-6 · Cited by 48 · see citing works

Chronic Cyanidin‐3‐glucoside Administration Improves Short‐term Spatial Recognition Memory but not Passive Avoidance Learning and Memory in Streptozotocin‐diabetic Rats

Nasri, S., Roghani, M., Baluchnejadmojarad, T., Balvardi, M., & Rabani, T. (2012) · Phytotherapy Research · doi:10.1002/ptr.3702 · Cited by 47 · see citing works

Neurotrophins and cognitive functions in T1D compared with healthy controls: effects of a high-intensity exercise

Tonoli, C., Heyman, E., Buyse, L., Roelands, B., Piacentini, M. F., Bailey, S. P., Pattyn, N., Berthoin, S., & MEEUSEN, R. R. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2014-0098 · Cited by 46 · see citing works

Effects of quercetin-conjugated with superparamagnetic iron oxide nanoparticles on learning and memory improvement through targeting microRNAs/NF-κB pathway

Ebrahimpour, S., Esmaeili, A., Dehghanian, F., & Beheshti, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-71678-4 · Cited by 45 · see citing works

Baicalin alleviates diabetes-associated cognitive deficits via modulation of mitogen-activated protein kinase signaling, brain-derived neurotrophic factor and apoptosis

Ma, P., Mao, X., Li, X., Ma, Y., QIAO, Y.-D., Liu, Z., Zhou, H., & Cao, Y. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4219 · Cited by 45 · see citing works

The antioxidant gallic acid induces anxiolytic-, but not antidepressant-like effect, in streptozotocin-induced diabetes

Pereira, M. M., Morais, H., Silva, E. D. S., Corso, C. R., Adami, E. R., Carlos, R. M., Acco, A., & Zanoveli, J. M. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0264-9 · Cited by 45 · see citing works

Type 2 diabetes induced oxidative brain injury involves altered cerebellar neuronal integrity and elemental distribution, and exacerbated Nrf2 expression: therapeutic potential of raffia palm (Raphia hookeri) wine

Erukainure, O. L., Ijomone, O. M., Sanni, O., Aschner, M., & Islam, M. S. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-019-00444-x · Cited by 44 · see citing works

Exogenous Hydrogen Sulfide Ameliorates Diabetes-Associated Cognitive Decline by Regulating the Mitochondria-Mediated Apoptotic Pathway and IL-23/IL-17 Expression in db/db Mice

Ma, S., Zhong, D., Ma, P., Li, G., Hua, W., Sun, Y., Liu, N., Zhang, L., & Zhang, W. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000471932 · Cited by 41 · see citing works

Raffia palm (Raphia hookeri G. Mann & H. Wendl) wine modulates glucose homeostasis by enhancing insulin secretion and inhibiting redox imbalance in a rat model of diabetes induced by high fructose diet and streptozotocin

Erukainure, O. L., Oyebode, O. A., Ijomone, O. M., Chukwuma, C. I., Koorbanally, N. A., & Islam, M. S. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.03.039 · Cited by 41 · see citing works

Enhancement of glyoxalase 1, a polyfunctional defense enzyme, by quercetin in the brain in streptozotocin-induced diabetic rats

Xia Shuang, Z. H. U., Cheng, Y., Lü, Q., Du, L., Yin, X., & Liu, Y. (2018) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-018-1543-z · Cited by 39 · see citing works

Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer’s Disease

Shetty, A. K., Upadhya, R., Madhu, L. N., & Kodali, M. (2019) · Aging and Disease · doi:10.14336/ad.2019.0330 · Cited by 39 · see citing works

Long-term exposure to high glucose induces changes in the content and distribution of some exocytotic proteins in cultured hippocampal neurons

Gaspar, J. M., Castilho, Á., Baptista, F. I., Liberal, J. M. T., & Ambrósio, A. F. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.10.019 · Cited by 37 · see citing works

The Role of Mesenchymal Stromal Cells-Derived Small Extracellular Vesicles in Diabetes and Its Chronic Complications

Li, F., Lin, X., Xu, F., Shan, S., Guo, B., Lei, L.-M., Zheng, M.-H., Wang, Y., Xu, Q.-S., & Yuan, L. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.780974 · Cited by 36 · see citing works

Cognitive complaints in age-related chronic conditions: A systematic review

Hill, N. L., Bhargava, S., Brown, M. J., Kim, H., Bhang, I., Mullin, K. T., Phillips, K., & Mogle, J. A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0253795 · Cited by 35 · see citing works

The unfolded protein response to endoplasmic reticulum stress in cultured astrocytes and rat brain during experimental diabetes

Lind, K. R., Ball, K. K., Cruz, N. F., & Dienel, G. A. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.02.009 · Cited by 35 · see citing works

Scope of new formulation approaches in the repurposing of pioglitazone for the management of Alzheimer’s disease

Jojo, G. M., & Kuppusamy, G. (2019) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.12808 · Cited by 34 · see citing works

Neurocognitive Outcomes in Pediatric Diabetes: a Developmental Perspective

Schwartz, D. D., Wasserman, R. M., Powell, P. W., & Axelrad, M. E. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0533-x · Cited by 32 · see citing works

Glycemic control is related to cognitive dysfunction in Chinese children with type 1 diabetes mellitus

He, J., Li, S., Liu, F., Zheng, H. X., Yan, X., Xie, Y., Li, X., Zhou, Z., & Zhu, X. (2018) · Journal of Diabetes · doi:10.1111/1753-0407.12775 · Cited by 32 · see citing works

Hyperglycemia induces RAGE-dependent hippocampal spatial memory impairments

Momeni, Z., NEAPETUNG, J. T., Pacholko, A. G., Kiir, T. A. B., Yamamoto, Y., Bekar, L. K., & Campanucci, V. A. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113287 · Cited by 31 · see citing works

Sex differences and left–right asymmetries in expression of insulin and insulin-like growth factor-1 receptors in developing rat hippocampus

Hami, J., Sadr‐Nabavi, A., Sankian, M., & Haghir, H. (2011) · Brain Structure and Function · doi:10.1007/s00429-011-0358-1 · Cited by 32 · see citing works

Metformin: From diabetes to cancer to prolongation of life

Sirtori, C. R., Castiglione, S., & Pavanello, C. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107367 · Cited by 33 · see citing works

Detecting subtle fingertip sensory and motor dysfunction in adults with type II diabetes

Gorniak, S. L., Khan, A., Ochoa, N., Sharma, M. D., & Phan, C. L. (2014) · Experimental Brain Research · doi:10.1007/s00221-014-3844-x · Cited by 31 · see citing works

Ginsenoside Rb1 Improves Cognitive Impairment Induced by Insulin Resistance through Cdk5/p35‐NMDAR‐IDE Pathway

Yang, R., Jiang, X. X., He, X., Liang, D., Sun, S., & Zhou, G. (2020) · BioMed Research International · doi:10.1155/2020/3905719 · Cited by 31 · see citing works

Hyperglycemia-induced oxidative brain injury: Therapeutic effects of Cola nitida infusion against redox imbalance, cerebellar neuronal insults, and upregulated Nrf2 expression in type 2 diabetic rats

Erukainure, O. L., Ijomone, O. M., Oyebode, O. A., Chukwuma, C. I., Aschner, M., & Islam, M. S. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.03.044 · Cited by 30 · see citing works

Effect of Streptozotocin on Plasma Insulin Levels of Rats and Mice: A Meta-analysis Study

Köksal, B. (2015) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2015.093 · Cited by 30 · see citing works

Dacryodes edulis (G. Don) H.J. Lam modulates glucose metabolism, cholinergic activities and Nrf2 expression, while suppressing oxidative stress and dyslipidemia in diabetic rats

Erukainure, O. L., Ijomone, O. M., Chukwuma, C. I., Xiao, X., Salau, V. F., & Islam, M. S. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112744 · Cited by 29 · see citing works

Type 2 Diabetes Leads to Axon Initial Segment Shortening in db/db Mice

Yermakov, L. M., Drouet, D. E., Griggs, R. B., Elased, K. M., & Susuki, K. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00146 · Cited by 29 · see citing works

Ceramide profiles in the brain of rats with diabetes induced by streptozotocin

Car, H., Żendzian‐Piotrowska, M., Prokopiuk, S., Fiedorowicz, A., Sadowska, A. J., Kurek, K., & Sawicka, D. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08575.x · Cited by 28 · see citing works

Hyperglycemia, Hypoglycemia and Dementia: Role of Mitochondria and Uncoupling Proteins

Cardoso, S., Correia, S. C., Santos, R. X., Carvalho, C., Candeias, E., Duarte, A. I., Plácido, A. I., Santos, M. S., & Moreira, P. I. (2013) · Current Molecular Medicine · doi:10.2174/1566524011313040010 · Cited by 30 · see citing works

Dynamic associations between glucose and ecological momentary cognition in Type 1 Diabetes

Hawks, Z., Beck, E. D., Jung, L., Fonseca, L. M., Sliwinski, M. J., Weinstock, R. S., Grinspoon, E. A., Xu, I., Strong, R. W., Singh, S. M., et al. (2024) · npj Digital Medicine · doi:10.1038/s41746-024-01036-5 · Cited by 27 · see citing works

High Glucose Induces Reactive Oxygen Species-Dependent Matrix Metalloproteinase-9 Expression and Cell Migration in Brain Astrocytes

Hsieh, H., Lin, C., Hsiao, L., & Yang, C. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8442-6 · Cited by 27 · see citing works

Swimming exercise attenuates anxiety-like behavior by reducing brain oxidative stress in type 2 diabetic mice

Matinfar, P., Peeri, M., & Azarbayjani, M. A. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113449 · Cited by 28 · see citing works

1-Methylnicotinamide (MNA) in prevention of diabetes-associated brain disorders

Kuchmerovska, T. M., Shymanskyi, I., Chłopicki, S., & Klimenko, A. P. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.10.004 · Cited by 27 · see citing works

Posttraumatic stress disorder-type behaviors in streptozotocin-induced diabetic rats can be prevented by prolonged treatment with vitamin E

de Souza, C. P., Gambeta, E., Stern, C. A. J., & Zanoveli, J. M. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.09.008 · Cited by 27 · see citing works

Does physical activity reduce risk for Alzheimer's disease through interaction with the stress neuroendocrine system?

Tortosa‐Martínez, J., & Clow, A. (2012) · Stress · doi:10.3109/10253890.2011.629323 · Cited by 26 · see citing works

Potential Biochemical Mechanisms of Brain Injury in Diabetes Mellitus

Ma, W.-X., Tang, J., Lei, Z.-W., Li, C.-Y., Zhao, L.-Q., Lin, C., Sun, T., Li, Z.-Y., Jiang, Y.-H., Jia, J.-T., et al. (2020) · Aging and Disease · doi:10.14336/ad.2019.0910 · Cited by 26 · see citing works

RU486 (mifepristone) ameliorates cognitive dysfunction and reverses the down-regulation of astrocytic N-myc downstream-regulated gene 2 in streptozotocin-induced type-1 diabetic rats

Zuo, Z.-F., Wang, W., Niu, L., Kou, Z., Zhu, C., Wang, W., Zhao, X., Luo, D., Zhang, T., Zhang, F.-X., et al. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.06.025 · Cited by 26 · see citing works

Simvastatin ameliorates memory impairment and neurotoxicity in streptozotocin-induced diabetic mice

Fang, S., Xie, H., Fang, C., Hu, M. Y., Long, Y., Sun, H., Kong, L., Hong, H., & Tang, S. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.05.001 · Cited by 26 · see citing works

Acute glycaemic load breakfast manipulations do not attenuate cognitive impairments in adults with type 2 diabetes

Lamport, D. J., Dye, L., Mansfield, M. W., & Lawton, C. L. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.07.008 · Cited by 26 · see citing works

Reprint of: ‘Brain insulin signaling: A key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes’

McNay, E. C., & Recknagel, A. K. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.11.001 · Cited by 25 · see citing works

The Anti-diabetic Drug Gliquidone Modulates Lipopolysaccharide-Mediated Microglial Neuroinflammatory Responses by Inhibiting the NLRP3 Inflammasome

Kim, J., Park, J.-H., Shah, K., Mitchell, S. J., Cho, K., & Hoe, H. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.754123 · Cited by 24 · see citing works

Brain accumulation of amyloid β protein visualized by positron emission tomography and BF‐227 in Alzheimer's disease patients with or without diabetes mellitus

Tomita, N., Furukawa, K., Okamura, N., Tashiro, M., Une, K., Furumoto, S., Iwata, R., Yanai, K., Kudo, Y., & Arai, H. (2012) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2012.00880.x · Cited by 24 · see citing works

Diabetes, Insulin and Alzheimer's Disease

Craft, S., & Christen, Y. (2010) · Research and perspectives in Alzheimer's disease · doi:10.1007/978-3-642-04300-0 · Cited by 24 · see citing works

Ultrastructural Remodeling of the Neurovascular Unit in the Female Diabetic db/db Model—Part I: Astrocyte

Hayden, M. R., Grant, D. G., Aroor, A. R., & DeMarco, V. G. (2018) · Neuroglia · doi:10.3390/neuroglia1010015 · Cited by 23 · see citing works

Increased Serum Trimethylamine N-Oxide Level in Type 2 Diabetic Patients with Mild Cognitive Impairment

Xu, N., Wan, J., Wang, C., Liu, J., Qian, C., & Tan, H. (2022) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s370206 · Cited by 22 · see citing works

Bio-psycho-social factors’ associations with brain age: a large-scale UK Biobank diffusion study of 35,749 participants

Korbmacher, M., Gurholt, T. P., de Lange, A. G., van der Meer, D., Beck, D., Eikefjord, E., Lundervold, A., Andreassen, O. A., Westlye, L. T., & Maximov, I. I. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1117732 · Cited by 22 · see citing works

RAGE signaling is required for AMPA receptor dysfunction in the hippocampus of hyperglycemic mice

Momeni, Z., Bautista, M., NEAPETUNG, J. T., Urban, R., Yamamoto, Y., Krishnan, A., & Campanucci, V. A. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113255 · Cited by 22 · see citing works

UCP2 and ANT differently modulate proton-leak in brain mitochondria of long-term hyperglycemic and recurrent hypoglycemic rats

Cardoso, S., Santos, M. S., Moreno, A. J., & Moreira, P. I. (2013) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-013-9503-2 · Cited by 21 · see citing works

Cognitive impairment in type 2 diabetes and its impact on daily living and self-care: A case - Control study in Kanpur, North India

Verma, S., Agarwal, S., Tashok, S., Verma, A., & Giri, R. (2021) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2021.05.020 · Cited by 20 · see citing works

Insulin Resistance and Impaired Branched-Chain Amino Acid Metabolism in Alzheimer’s Disease

Liu, R., Zhang, L., & You, H. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221147 · Cited by 20 · see citing works

An evaluation of aversive memory and hippocampal oxidative status in streptozotocin-induced diabetic rats treated with resveratrol

Bagatini, P. B., Xavier, L. L., Bertoldi, K., Moysés, F. D. S., Lovatel, G. A., Neves, L. T., Barbosa, S., Saur, L., de Senna, P. N., Souto, A. A., et al. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.10.059 · Cited by 18 · see citing works

Are neurocognitive speed and inconsistency similarly affected in type 2 diabetes?

Whitehead, B. P., Dixon, R. A., Hultsch, D. F., & MacDonald, S. W. S. (2011) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2010.547845 · Cited by 18 · see citing works

Atomoxetine and Methylphenidate Treatment in ADHD

Šnircová, E., Hrtánek, I., Kulhan, T., Nosál'ová, G., & Ondrejka, I. (2015) · Acta Medica Martiniana · doi:10.1515/acm-2015-0003 · Cited by 1 · see citing works

Ageing and diabetes: implications for brain function

Biessels, G. J., van der Heide, L. P., Kamal, A., Bleys, R. L. A. W., & Gispen, W. H. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01486-3 · Cited by 458 · see citing works

A metabolic and functional overview of brain aging linked to neurological disorders

Baquer, N. Z., Taha, A., Kumar, P., McLean, P., Cowsik, S. M., Kale, R. K., Singh, R., & Sharma, D. (2009) · Biogerontology · doi:10.1007/s10522-009-9226-2 · Cited by 87 · see citing works

Accelerated aging processes in type I streptozotocin-induced diabetes mellitus in rats.

Kamal, A. (2020)

Diabetes and brain aging: Epidemiologic evidence

Launer, L. J. (2005) · Current Diabetes Reports · doi:10.1007/s11892-005-0069-1 · Cited by 85 · see citing works