Cited by 440Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsRegulation of Appetite and Obesity

Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents

Li, X.-L, Aou, S, Oomura, Y, Hori, N, Fukunaga, K, Hori, T·2002·Neuroscience

Abstract

Leptin is well known to be involved in the control of feeding, reproduction and neuroendocrine functions through its action on the hypothalamus. However, leptin receptors are found in brain regions other than the hypothalamus (including the hippocampus and cerebral cortex) suggesting extrahypothalamic functions. We investigated hippocampal long-term potentiation (LTP) and long-term depression (LTD), and the spatial-memory function in two leptin receptor-deficient rodents (Zucker rats and db/db mice). In brain slices, the CA1 hippocampal region of both strains showed impairments of LTP and LTD; leptin (10(-12) M) did not improve these impairments in either strain. These strains also showed lower basal levels of Ca(2+)/calmodulin-dependent protein kinase II activity in the CA1 region than the respective controls, and the levels did not respond to tetanic stimulation. These strains also showed impaired spatial memory in the Morris water-maze test (i.e. longer swim-path lengths during training sessions and less frequent crossings of the platform's original location in the probe test. From these results we suggest that the leptin receptor-deficient animals show impaired LTP in CA1 and poor spatial memory due, at least in part, to a deficiency in leptin receptors in the hippocampus.

Integrity signals

Registry

Crossref · 10.1016/s0306-4522(02)00162-8

Cites

71 of 71 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Neural activity in brain areas involved in cognitive processing of food representations, such as the amygdala and hippocampal complex, is modulated by leptin and ghrelin.

    “Furthermore, neural activity in brain areas thought to be involved in cognitive processing of representations of food such as the amygdala and hippocampal complex is modulated by leptin ([78](#B78), [79](#B79), [105](#B105)) and ghrelin ([27](#B27), [50](#B50), [92](#B92), [109](#B109), [147](#B147), [189](#B189)).”

    From Food reward, hyperphagia, and obesity (2011) · cites this paper as [105]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Li, X.-L., Aou, S., Oomura, Y., Hori, N., Fukunaga, K., & Hori, T.
Affiliations
  • Kyushu University (JP)
  • New York State Department of Health (US)
  • Kumamoto University (JP)
Corresponding author
Aou, S
Venue
Neuroscience
Publisher
Elsevier BV
Published
2002-09
Volume
113
Issue
3
Pages
607-615
ISSN
0306-4522 (ISSN-L)
OpenAlex
W1987248538
Cited by
440
References
71
Citations by year
2026: 2 · 2025: 14 · 2024: 14 · 2023: 10 · 2022: 12 · 2021: 21 · 2020: 14 · 2019: 27 · 2018: 29 · 2017: 29 · 2016: 21 · 2015: 35 · 2014: 29 · 2013: 30 · 2012: 21
FWCI
2.79
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministry of Education, Culture, Sports, Science and Technology
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
leptin, leptin receptor deficiency, long-term potentiation, long-term depression, spatial memory, hippocampus, CA1, CaMKII, db/db mice, Zucker rats, tetanic stimulation
MeSH terms
Animals, Electrophysiology, Hippocampus, Memory, Mice, Inbred C57BL, Receptors, Cell Surface, Spatial Behavior, Water, Long-Term Potentiation, Mice, Knockout, Maze Learning, Long-Term Synaptic Depression, Mice, Rats, Receptors, Leptin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review