Cognitive effects of insulin in the central nervous system

Signals That Regulate Food Intake and Energy Homeostasis

Woods, S. C., Seeley, R. J., Porte, D., & Schwartz, M. W. (1998) · Science · doi:10.1126/science.280.5368.1378 · Cited by 1,169 · see citing works

Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice

Grant, S. G. N., O’Dell, T. J., Karl, K. A., Stein, P. L., Soriano, P. M., & Kandel, E. R. (1992) · Science · doi:10.1126/science.1361685 · Cited by 1,154 · see citing works

Insulin receptors are widely distributed in the central nervous system of the rat

Havránková, J., Roth, J., & Brownstein, M. (1978) · Nature · doi:10.1038/272827a0 · Cited by 1,116 · see citing works

Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia

Saykin, A. J. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950020048005 · Cited by 1,086 · see citing works

Schizophrenics Show Spatial Working Memory Deficits

Park, S. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820120063009 · Cited by 946 · see citing works

Hunger: Basic mechanisms and clinical implications

(1976) · Neuroscience · doi:10.1016/0306-4522(76)90139-1 · Cited by 917 · see citing works

The hippocampus—what does it do?

Eichenbaum, H., Otto, T., & Cohen, N. J. (1992) · Behavioral and Neural Biology · doi:10.1016/0163-1047(92)90724-i · Cited by 867 · see citing works

Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation

Qiu, W. Q., Walsh, D. M., Ye, Z., Vekrellis, K., Zhang, J., Podlisny, M. B., Rosner, M. R., Safavi, A., Hersh, L. B., & Selkoe, D. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32730 · Cited by 812 · see citing works

Insulin in the Brain: A Hormonal Regulator of Energy Balance*

Schwartz, M. W., Figlewicz, D. P., Baskin, D. G., Woods, S. C., & Porte, D. (1992) · Endocrine Reviews · doi:10.1210/edrv-13-3-387 · Cited by 808 · see citing works

Feast and Famine: Critical Role of Glucocorticoids with Insulin in Daily Energy Flow

Dallman, M. F., Strack, A. M., Akana, S. F., Bradbury, M. J., Hanson, E. S., Scribner, K. A., & Smith, M. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1010 · Cited by 796 · see citing works

Cognition and synaptic plasticity in diabetes mellitus

Gispen, W. H., & Biessels, G. J. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01656-8 · Cited by 772 · see citing works

Brain insulin and insulin receptors in aging and sporadic Alzheimer’s disease

Frölich, L., Blum-Degen, D., Bernstein, H.-G., Engelsberger, S., Humrich, J., Laufer, S., Muschner, D., Thalheimer, A., Türk, A., Hoyer, S., et al. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050068 · Cited by 748 · see citing works

The neurotrophin hypothesis for synaptic plasticity

Schinder, A. F. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01672-6 · Cited by 729 · see citing works

Biological actions of cholecystokinin

Crawley, J. N., & Corwin, R. L. (1994) · Peptides · doi:10.1016/0196-9781(94)90104-x · Cited by 713 · see citing works

Diabetes mellitus : a fundamental and clinical text

LeRoith, D., Taylor, S. I., & Olefsky, J. M. (2004) · Cited by 699 · see citing works

Regulation of AMPA Receptor–Mediated Synaptic Transmission by Clathrin-Dependent Receptor Internalization

Man, H., Lin, J., Ju, W. H., Ahmadian, G., Liu, L., Becker, L. E., Sheng, M., & Wang, Y. T. (2000) · Neuron · doi:10.1016/s0896-6273(00)81067-3 · Cited by 698 · see citing works

Activation of ERK/MAP Kinase in the Amygdala Is Required for Memory Consolidation of Pavlovian Fear Conditioning

Schafe, G. E., Atkins, C. M., Swank, M. W., Bauer, E. P., Sweatt, J. D., & LeDoux, J. E. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08177.2000 · Cited by 674 · see citing works

Regulation of NMDA receptors by tyrosine kinases and phosphatases

Wang, Y. T., & Salter, M. W. (1994) · Nature · doi:10.1038/369233a0 · Cited by 666 · see citing works

Acetylcholine: a neurotransmitter for learning and memory?

Blokland, A. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(95)00016-x · Cited by 613 · see citing works

Identification of insulin in rat brain.

Havránková, J., Schmechel, D. E., Roth, J., & Brownstein, M. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.11.5737 · Cited by 607 · see citing works

Type 2 diabetes mellitus, cognitive impairment and dementia

Stewart, R., & Liolitsa, D. (1999) · Diabetic Medicine · doi:10.1046/j.1464-5491.1999.00027.x · Cited by 562 · see citing works

Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: Relationship to severity of dementia and apolipoprotein E genotype

Craft, S., Peskind, E., Schwartz, M. W., Schellenberg, G. D., Raskind, M., & Porte, D. (1998) · Neurology · doi:10.1212/wnl.50.1.164 · Cited by 560 · see citing works

Postsynaptic protein phosphorylation and LTP

Soderling, T. R., & Derkach, V. A. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01490-3 · Cited by 551 · see citing works

Regulation of gene expression by insulin

O’Brien, R. M., & Granner, D. K. (1996) · Physiological Reviews · doi:10.1152/physrev.1996.76.4.1109 · Cited by 547 · see citing works

Memory improvement following induced hyperinsulinemia in Alzheimer’s disease

Craft, S., Newcomer, J., Kanne, S., Dagogo-Jack, S., Cryer, P., Sheline, Y., Luby, J., Dagogo-Jack, A., & Alderson, A. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(95)02002-0 · Cited by 538 · see citing works

Recruitment of functional GABAA receptors to postsynaptic domains by insulin

Wan, Q., Xiong, Z., Man, H., Ackerley, C., Braunton, J., Lu, W. Y., Becker, L. E., MacDonald, J. F., & Wang, Y. T. (1997) · Nature · doi:10.1038/41792 · Cited by 537 · see citing works

Brain Insulin Receptors and Spatial Memory

Zhao, W., Chen, H., Xu, H., Moore, E., Meiri, N., Quon, M. J., & Alkon, D. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.34893 · Cited by 535 · see citing works

The role of neuronal growth factors in neurodegenerative disorders of the human brain

Connor, B. J., & Dragunow, M. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00004-6 · Cited by 534 · see citing works

Is Type II Diabetes Associated With an Increased Risk of Cognitive Dysfunction?: A critical review of published studies

Strachan, M. W. J., Deary, I. J., Ewing, F. M. E., & Frier, B. M. (1997) · Diabetes Care · doi:10.2337/diacare.20.3.438 · Cited by 529 · see citing works

Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats.

Lannert, H., & Hoyer, S. (1998) · Behavioral Neuroscience · doi:10.1037/0735-7044.112.5.1199 · Cited by 525 · see citing works

A Mitogen-Activated Protein Kinase Cascade in the CA1/CA2 Subfield of the Dorsal Hippocampus Is Essential for Long-Term Spatial Memory

Blum, S., Moore, A. N., Adams, F., & Dash, P. K. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-09-03535.1999 · Cited by 522 · see citing works

Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats

Spanswick, D., Smith, M. A., Mirshamsi, S., Routh, V. H., & Ashford, M. L. J. (2000) · Nature Neuroscience · doi:10.1038/77660 · Cited by 495 · see citing works

Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain.

Baura, G. D., Foster, D. M., Porte, D., Kahn, S. E., Bergman, R. N., Cobelli, C., & Schwartz, M. W. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116773 · Cited by 489 · see citing works

Energetics in the pathogenesis of neurodegenerative diseases

Beal, M. F. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01584-8 · Cited by 472 · see citing works

The Molecular Mechanism of Insulin Action

Kahn, C. R. (1985) · Annual Review of Medicine · doi:10.1146/annurev.me.36.020185.002241 · Cited by 432 · see citing works

Place Learning and Hippocampal Synaptic Plasticity in Streptozotocin-Induced Diabetic Rats

Biessels, G. J., Kamal, A., Ramakers, G. M. J., Urban, I. J. A., Spruijt, B. M., Erkelens, D. W., & Gispen, W. H. (1996) · Diabetes · doi:10.2337/diab.45.9.1259 · Cited by 413 · see citing works

The effect of aging on carbohydrate metabolism: a review of the English literature and a practical approach to the diagnosis of diabetes mellitus in the elderly

Davidson, M. B. (1979) · Metabolism · doi:10.1016/0026-0495(79)90024-6 · Cited by 411 · see citing works

Insulin receptors in the central nervous system: Localization, signalling mechanisms and functional aspects

UNGER, J., Livingston, J. H., & Moss, A. (1991) · Progress in Neurobiology · doi:10.1016/0301-0082(91)90015-s · Cited by 403 · see citing works

Alzheimer's β‐amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

Kurochkin, I. V., & Goto, S. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00387-4 · Cited by 401 · see citing works

HORMONAL REGULATION OF MAMMALIAN GLUCOSE TRANSPORT

Simpson, I. A., & Cushman, S. W. (1986) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.55.070186.005211 · Cited by 398 · see citing works

LTP mechanisms: from silence to four-lane traffic.

Malinow, R., Mainen, Z., & Hayashi, Y. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00099-4 · Cited by 397 · see citing works

Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment

Biessels, G. J., Kamal, A., Urban, I. J. A., Spruijt, B. M., Erkelens, D. W., & Gispen, W. H. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00510-1 · Cited by 379 · see citing works

The role of NMDA receptors in learning and memory

Collingridge, G. L. (1987) · Nature · doi:10.1038/330604a0 · Cited by 373 · see citing works

Insulin signal transduction through protein kinase cascades

Avruch, J. (1998) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006823109415 · Cited by 364 · see citing works

Blood-brain barrier transcytosis of insulin in developing rabbits

Duffy, K. R., & Pardridge, W. M. (1987) · Brain Research · doi:10.1016/0006-8993(87)90236-8 · Cited by 358 · see citing works

Intracerebroventricular insulin enhances memory in a passive-avoidance task

Park, C. R., Seeley, R. J., Craft, S., & WOODS, S. (2000) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00220-6 · Cited by 343 · see citing works

Cellular and Molecular Mechanisms Underlying Perturbed Energy Metabolism and Neuronal Degeneration in Alzheimer's and Parkinson's Diseases

Mattson, M. P., Pedersen, W. A., Duan, W., Culmsee, C., & Camandola, S. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07824.x · Cited by 343 · see citing works

Cerebral function in diabetes mellitus

Biessels, G. J., Kappelle, A. C., Bravenboer, B., Erkelens, D. W., & Gispen, W. H. (1994) · Diabetologia · doi:10.1007/bf00417687 · Cited by 341 · see citing works

Differential Permeability of the Blood–Brain Barrier to Two Pancreatic Peptides: Insulin and Amylin

Banks, W. A., & Kastin, A. J. (1998) · Peptides · doi:10.1016/s0196-9781(98)00018-7 · Cited by 340 · see citing works

An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses.

Barnes, C. A., & McNaughton, B. L. (1985) · Behavioral Neuroscience · doi:10.1037//0735-7044.99.6.1040 · Cited by 337 · see citing works

The eating paradox: How we tolerate food.

Woods, S. C. (1991) · Psychological Review · doi:10.1037/0033-295x.98.4.488 · Cited by 337 · see citing works

Insulin gene expression and insulin synthesis in mammalian neuronal cells.

Devaskar, S. U., Giddings, S. J., Rajakumar, P. A., Carnaghi, L. R., Menon, R. K., & Zahm, D. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37214-9 · Cited by 333 · see citing works

Insulin and insulin-like growth factors in the CNS

Baskin, D. G., Wilcox, B. J., Figlewicz, D. P., & Dorsa, D. M. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90155-5 · Cited by 330 · see citing works

Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs.

Kaiyala, K., Prigeon, R., Kahn, S., Woods, S. C., & Schwartz, M. (2000) · Diabetes · doi:10.2337/diabetes.49.9.1525 · Cited by 330 · see citing works

The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses

Abbott, M.-A., Wells, D. G., & Fallon, J. R. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-17-07300.1999 · Cited by 327 · see citing works

Concentrations of Insulin and of Insulin Receptors in the Brain are Independent of Peripheral Insulin Levels

Havránková, J., Roth, J., & Brownstein, M. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109504 · Cited by 325 · see citing works

Direct demonstration of insulin-like growth factor-I-induced nitric oxide production by endothelial cells

Tsukahara, H., Gordienko, D. V., Tönshoff, B., Gelato, M. C., & Goligorsky, M. S. (1994) · Kidney International · doi:10.1038/ki.1994.78 · Cited by 322 · see citing works

Hippocampal acetylcholine release during memory testing in rats: augmentation by glucose.

Ragozzino, M. E., Unick, K., & Gold, P. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4693 · Cited by 318 · see citing works

Transport of Insulin Across the Blood-Brain Barrier: Saturability at Euglycemic Doses of Insulin

Banks, W. A., Jaspan, J. B., Huang, W., & Kastin, A. J. (1997) · Peptides · doi:10.1016/s0196-9781(97)00231-3 · Cited by 318 · see citing works

Enhancement of Memory in Alzheimer Disease With Insulin and Somatostatin, but Not Glucose

Craft, S., Asthana, S., Newcomer, J. W., Wilkinson, C. W., Matos, I. T., Baker, L. D., Cherrier, M., Lofgreen, C., Latendresse, S., Petrova, A., et al. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.12.1135 · Cited by 312 · see citing works

Increased Susceptibility to Induction of Long-Term Depression and Long-Term Potentiation Reversal during Aging

Norris, C. M., Korol, D. L., & Foster, T. C. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-17-05382.1996 · Cited by 295 · see citing works

Distribution of insulin receptor-like immunoreactivity in the rat forebrain

Unger, J. W., McNeill, T. H., Moxley, R. T., White, M. F., Moss, A., & Livingston, J. N. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90036-5 · Cited by 294 · see citing works

Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: Progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone

Morley, J. E., Kaiser, F. E., Raum, W. J., Perry, H. M., Flood, J. F., Jensen, J., Silver, A. J., & Roberts, E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7537 · Cited by 289 · see citing works

An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses.

Barnes, C. A., & McNaughton, B. L. (1985) · Behavioral Neuroscience · doi:10.1037/0735-7044.99.6.1040 · Cited by 286 · see citing works

The nature of learning and memory impairments in schizophrenia

Paulsen, J. S., Heaton, R. K., Sadek, J. R., Perry, W., Delis, D. C., Braff, D., Kuck, J., Zisook, S., & Jeste, D. V. (1995) · Journal of the International Neuropsychological Society · doi:10.1017/s135561770000014x · Cited by 284 · see citing works

Effects of insulin upon ion transport

Moore, R. D. (1983) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(83)90013-8 · Cited by 276 · see citing works

Insulin-like growth factor-1 ameliorates age-related behavioral deficits

Markowska, A. L., Mooney, M., & Sonntag, W. E. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00143-2 · Cited by 270 · see citing works

Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis

Hoyer, S. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050067 · Cited by 265 · see citing works

The Relationship Between Diabetes Mellitus and Parkinson'S Disease

Sandyk, R. (1993) · International Journal of Neuroscience · doi:10.3109/00207459309003322 · Cited by 244 · see citing works

Glucose enhancement of performance of memory tests in young and aged humans

Hall, J. L., Gonder-Frederick, L. A., Chewning, W. W., da Silveira, J. C. C., & Gold, P. E. (1989) · Neuropsychologia · doi:10.1016/0028-3932(89)90096-1 · Cited by 241 · see citing works

Degradation of Soluble Amyloid β-Peptides 1–40, 1–42, and the Dutch Variant 1–40Q by Insulin Degrading Enzyme from Alzheimer Disease and Control Brains

Pérez, A., Morelli, L., Cresto, J. C., & Castaño, E. M. (2000) · Neurochemical Research · doi:10.1023/a:1007527721160 · Cited by 240 · see citing works

Glucose regulation and cognitive functions: relation to Alzheimer's disease and diabetes

Messier, C., & Gagnon, M. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00153-0 · Cited by 237 · see citing works

Decreased autophosphorylation of the insulin receptor-kinase in streptozotocin-diabetic rats.

Kadowaki, T., Kasuga, M., Akanuma, Y., Ezaki, O., & Takaku, F. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89879-9 · Cited by 232 · see citing works

Learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: interaction of diabetes and ageing

Kamal, A., Biessels, G. J., Duis, S., & Gispen, W. H. (2000) · Diabetologia · doi:10.1007/s001250051335 · Cited by 223 · see citing works

The New Elements of Insulin Signaling: Insulin Receptor Substrate-1 and Proteins With SH2 Domains

Myers, M. G., & White, M. F. (1993) · Diabetes · doi:10.2337/diab.42.5.643 · Cited by 220 · see citing works

Selective, Physiological Transport of Insulin Across the Blood-Brain Barrier: Novel Demonstration by Species-Specific Radioimmunoassays

Banks, W. A., Jaspan, J. B., & Kastin, A. J. (1997) · Peptides · doi:10.1016/s0196-9781(97)00198-8 · Cited by 219 · see citing works

Role of glucose in regulating the brain and cognition

Gold, P. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.4.987s · Cited by 215 · see citing works

Modulation of Hippocampal Acetylcholine Release and Spontaneous Alternation Scores by Intrahippocampal Glucose Injections

Ragozzino, M. E., Pal, S. N., Unick, K., Stefani, M. R., & Gold, P. E. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-04-01595.1998 · Cited by 214 · see citing works

Regional Concentrations of Insulin in the Rat Brain*

Baskin, D. G., Porte, D., GUEST, K., & Dorsa, D. M. (1983) · Endocrinology · doi:10.1210/endo-112-3-898 · Cited by 212 · see citing works

Insulin and insulin-like growth factor receptors in the nervous system

Adamo, M. L., Raizada, M. K., & LeRoith, D. (1989) · Molecular Neurobiology · doi:10.1007/bf02935589 · Cited by 212 · see citing works

Diabetes Mellitus: A Fundamental and Clinical Text

Matthews, D. R. (2000) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2000.01136.x · Cited by 202 · see citing works

Insulin receptors and insulin modulation of norepinephrine uptake in neuronal cultures from rat brain.

Boyd, F. T., Clarke, D. W., Muther, T. F., & Raizada, M. K. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36340-8 · Cited by 194 · see citing works

GLUT4 glucose transporter expression in rodent brain: effect of diabetes

Vannucci, S. J., Koehler-Stec, E. M., Li, K., Reynolds, T., Clark, R. R., & Simpson, I. A. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00103-6 · Cited by 193 · see citing works

Predominant abnormality in cerebral glucose utilization in late-onset dementia of the Alzheimer type: A cross-sectional comparison against advanced late-onset and incipient early-onset cases

Hoyer, S., Nitsch, R. M., & Oesterreich, K. (1991) · Journal of Neural Transmission - Parkinsons Disease and Dementia Section · doi:10.1007/bf02251132 · Cited by 193 · see citing works

Kinetics and specificity of insulin uptake from plasma into cerebrospinal fluid.

Schwartz, M. W., Sipols, A. J., Kahn, S. E., Lattemann, D. F., Taborsky, G. J., Bergman, R. N., Woods, S. C., & Porte, D. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.259.3.e378 · Cited by 191 · see citing works

Effects of hyperglycemia on memory and hormone levels in dementia of the Alzheimer type: A longitudinal study.

Craft, S., Dagogo-Jack, S. E., Wiethop, B. V., Murphy, C., Nevins, R. T., Fleischman, S., Rice, V., Newcomer, J. W., & Cryer, P. E. (1993) · Behavioral Neuroscience · doi:10.1037//0735-7044.107.6.926 · Cited by 191 · see citing works

Effects of hyperglycemia on memory and hormone levels in dementia of the Alzheimer type: A longitudinal study.

Craft, S., Dagogo-Jack, S. E., Wiethop, B. V., Murphy, C., Nevins, R. T., Fleischman, S., Rice, V., Newcomer, J. W., & Cryer, P. E. (1993) · Behavioral Neuroscience · doi:10.1037/0735-7044.107.6.926 · Cited by 191 · see citing works

Hippocampal synaptic plasticity in streptozotocin-diabetic rats: impairment of long-term potentiation and facilitation of long-term depression

Kamal, A., Biessels, G. J., Urban, I. J. A., & Gispen, W. H. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00485-0 · Cited by 189 · see citing works

Effect of insulin on central catecholamines

Sauter, A., Goldstein, M., Engel, J., & Ueta, K. (1983) · Brain Research · doi:10.1016/0006-8993(83)90691-1 · Cited by 181 · see citing works

Effect of Age and Diet on Insulin Secretion and Insulin Action in the Rat

REAVEN, E. P., Wright, D. W., Mondon, C. E., Solomon, R., Ho, H., & Reaven, G. M. (1983) · Diabetes · doi:10.2337/diab.32.2.175 · Cited by 178 · see citing works

Action of the diabetogenic drug streptozotocin on glycolytic and glycogenolytic metabolism in adult rat brain cortex and hippocampus

Plaschke, K., & Hoyer, S. (1993) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(93)90021-5 · Cited by 178 · see citing works

Topography of Cross-sectional and Longitudinal Glucose Metabolic Deficits in Alzheimer's Disease: Pathophysiologic Implications

Smith, G. S. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530350056020 · Cited by 178 · see citing works

Localization of binding sites for insulin-like growth factor-I (IGF-I) in the rat brain by quantitative autoradiography

Bohannon, N. J. V., Wilcox, B. J., Figlewicz, D. P., Dorsa, D. M., & Baskin, D. G. (1988) · Brain Research · doi:10.1016/0006-8993(88)90931-6 · Cited by 177 · see citing works

Insulin-Like Growth Factor-I and Central Nervous System Development

Anlar, B., Sullivan, K., & Feldman, E. (1999) · Hormone and Metabolic Research · doi:10.1055/s-2007-978708 · Cited by 175 · see citing works

Characteristics of Learning and Memory in Streptozocin-Induced Diabetic Mice

Flood, J. F., Mooradian, A. D., & Morley, J. E. (1990) · Diabetes · doi:10.2337/diab.39.11.1391 · Cited by 175 · see citing works

Insulin inhibits pyramidal neurons in hippocampal slices

Palovcik, R. A., Phillips, M. I., Kappy, M. S., & Raizada, M. K. (1984) · Brain Research · doi:10.1016/0006-8993(84)91028-x · Cited by 174 · see citing works

Glucocorticoid regulation of insulin receptor and substrate IRS-1 tyrosine phosphorylation in rat skeletal muscle in vivo.

Giorgino, F., Almahfouz, A., Goodyear, L. J., & Smith, R. J. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116424 · Cited by 173 · see citing works

Central insulin enhances sensitivity to cholecystokinin

RIEDY, C., Chavez, M., Figlewicz, D. P., & WOODS, S. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(95)00108-u · Cited by 172 · see citing works

Localization of 125I-insulin binding sites in the rat hypothalamus by quantitative autoradiography

Woods, S. C., Porte, D., Dorsa, D. M., Figlewicz, D. P., & Baskin, D. G. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90430-1 · Cited by 168 · see citing works

Brain Insulin Receptor Causes Activity-Dependent Current Suppression in the Olfactory Bulb Through Multiple Phosphorylation of Kv1.3

Fadool, D. A., Tucker, K. R., Phillips, J. J., & Simmen, J. A. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.4.2332 · Cited by 161 · see citing works

Serial Changes of Cerebral Glucose Metabolism and Caudate Size in Persons at Risk for Huntington's Disease

Grafton, S. T., Mazziotta, J. C., Pahl, J. J., George-Hyslop, P. S., Haines, J. L., Gusella, J., Hoffman, J. M., Baxter, L. R., & Phelps, M. E. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530350075022 · Cited by 157 · see citing works

A direct action of insulin on the hypothalamic satiety center

Debons, A. F., KRIMSKY, I., & From, A. (1970) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1970.219.4.938 · Cited by 156 · see citing works

Insulin metabolism in Alzheimer’s disease differs according to apolipoprotein E genotype and gender

Craft, S., Asthana, S., Schellenberg, G., Cherrier, M., Baker, L. D., Newcomer, J., Plymate, S., Latendresse, S., Petrova, A., Raskind, M., et al. (1999) · Neuroendocrinology · doi:10.1159/000054469 · Cited by 154 · see citing works

Glucose effects on memory: Behavioral and pharmacological characteristics

Gold, P. E., Vogt, J., & Hall, J. L. (1986) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(86)90626-6 · Cited by 152 · see citing works

Insulin-like growth factor-1 (somatomedin-C) receptors in the rat brain: distribution and interaction with the hippocampal cholinergic system

Araujo, D. M., Lapchak, P. A., Collier, B., Chabot, J., & Quirion, R. (1989) · Brain Research · doi:10.1016/0006-8993(89)90355-7 · Cited by 150 · see citing works

Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease

Moroo, I., Yamada, T., Makino, H., Tooyama, I., McGeer, P., Mcgeer, E., & Hirayama, K. (1994) · Acta Neuropathologica · doi:10.1007/bf00313602 · Cited by 149 · see citing works

The Insulin Receptor: A Multifunctional Protein

Olefsky, J. M. (1990) · Diabetes · doi:10.2337/diab.39.9.1009 · Cited by 148 · see citing works

Periventricular hypothalamic cells in the rat brain contain insulin mRNA

Young, W. S. (1986) · Neuropeptides · doi:10.1016/0143-4179(86)90035-1 · Cited by 147 · see citing works

Regulation of the Na+/K+-ATPase by insulin: Why and how?

Sweeney, G., & Klip, A. (1998) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006805510749 · Cited by 146 · see citing works

Effect of Diabetes Mellitus on the Permeability of the Blood–Brain Barrier to Insulin

Banks, W. A., Jaspan, J. B., & Kastin, A. J. (1997) · Peptides · doi:10.1016/s0196-9781(97)00238-6 · Cited by 145 · see citing works

Cerebral Glucose Metabolism in Parkinson's Disease With and Without Dementia

Peppard, R. F., Martin, W. R. W., Carr, G., Grochowski, E. C., Schulzer, M., Guttman, M., McGeer, P. L., Phillips, A. G., Tsui, J. K. C., & Calne, D. B. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530360060019 · Cited by 143 · see citing works

Patterns of cerebral glucose utilization in Parkinson's disease and Huntington's disease

Kuhl, D. E., Metter, E. J., Riege, W. H., & Markham, C. H. (1984) · Annals of Neurology · doi:10.1002/ana.410150723 · Cited by 142 · see citing works

Memory improvement by glucose, fructose, and two glucose analogs: A possible effect on peripheral glucose transport

Messier, C., & White, N. M. (1987) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(87)90634-0 · Cited by 141 · see citing works

Insulin Through the Ages: Phylogeny of a Growth Promoting and Metabolic Regulatory Hormone1

Chan, S. J., & Steiner, D. F. (2000) · American Zoologist · doi:10.1668/0003-1569(2000)040[0213:ittapo]2.0.co;2 · Cited by 141 · see citing works

Insulin II gene expression in rat central nervous system

Devaskar, S. U., Singh, B. S., Carnaghi, L. R., Rajakumar, P. A., & Giddings, S. J. (1993) · Regulatory Peptides · doi:10.1016/0167-0115(93)90335-6 · Cited by 137 · see citing works

The evaluation of insulin as a metabolic signal influencing behavior via the brain

Woods, S. C., Chavez, M., Park, C. R., Riedy, C. A., Kaiyala, K. J., Richardson, R. D., Figlewicz, D. P., Schwartz, M. W., Porte, D., & Seeley, R. J. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00044-f · Cited by 135 · see citing works

Insulin: new roles for an ancient hormone

Ferrannini, Galvan, Gastaldelli, Camastra, Sironi, Toschi, Baldi, Frascerra, Monzani, Antonelli, et al. (1999) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1999.00536.x · Cited by 133 · see citing works

CELLULAR AND MOLECULAR BIOLOGY OF ALZHEIMER'S DISEASE AND ANIMAL MODELS

Price, D. L., & Sisodia, S. S. (1994) · Annual Review of Medicine · doi:10.1146/annurev.med.45.1.435 · Cited by 132 · see citing works

Insulin receptor mRNA in the substantia nigra in Parkinson's disease.

Takahashi, M., Yamada, T., Tooyama, I., Moroo, I., Kimura, H., Yamamoto, T., & Okada, H. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12357-0 · Cited by 131 · see citing works

Towards Understanding the Role of Insulin in the Brain: Lessons from Insulin-related Signaling Systems in the Invertebrate Brain

Smit, A. B. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00063-4 · Cited by 129 · see citing works

Place learning and hippocampal synaptic plasticity in streptozotocin-induced diabetic rats

Biessels, G. J., Kamal, A., Ramakers, G. M., et al. (1996) · Diabetes · doi:10.2337/diabetes.45.9.1259 · Cited by 128 · see citing works

Hippocampal and prefrontal cortex contributions to learning and memory: Analysis of lesion and aging effects on maze learning in rats.

Winocur, G., & Moscovitch, M. (1990) · Behavioral Neuroscience · doi:10.1037//0735-7044.104.4.544 · Cited by 127 · see citing works

Protein Tyrosine Kinase‐Mediated Potentiation of Currents from Cloned NMDA Receptors

Chen, S.-J., & Leonard, J. P. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67010194.x · Cited by 125 · see citing works

Insulin-like growth factor 1 (IGF-1) receptors in the human brain: quantitative autoradiographic localization

Adem, A., Jossan, S. S., d'Argy, R., Gillberg, P., Nordberg, A. K., Winblad, B. G., & Sara, V. R. (1989) · Brain Research · doi:10.1016/0006-8993(89)91678-8 · Cited by 122 · see citing works

Immunocytochemical Detection of Insulin in Rat Hypothalamus and Its Possible Uptake from Cerebrospinal Fluid*

Baskin, D. G., Woods, S. C., West, D. B., van Houten, M., Posner, B. I., Dorsa, D. M., & Porte, D. (1983) · Endocrinology · doi:10.1210/endo-113-5-1818 · Cited by 122 · see citing works

Insulin potentiates N-methyl-d-aspartate receptor activity in Xenopus oocytes and rat hippocampus

Liu, L., Brown, J. C., Webster, W. W., Morrisett, R. A., & Monaghan, D. T. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11593-l · Cited by 122 · see citing works

Insulin reduces norepinephrine transporter mRNA in vivo in rat locus coeruleus

Figlewicz, D. P., Szot, P., Israel, P. A., Payne, C., & Dorsa, D. M. (1993) · Brain Research · doi:10.1016/0006-8993(93)90258-o · Cited by 121 · see citing works

Regulation by insulin of a unique neuronal Ca2+ pool and of neuropeptide secretion

Jonas, E. A., Knox, R. J., Smith, T. C. M., Wayne, N. L., Connor, J. A., & Kaczmarek, L. K. (1997) · Nature · doi:10.1038/385343a0 · Cited by 120 · see citing works

Insulin Transport From Plasma Into the Central Nervous System Is Inhibited by Dexamethasone in Dogs

Baura, G., Foster, D. M., Kaiyala, K. J., Porte, D., Kahn, S. E., & Schwartz, M. W. (1996) · Diabetes · doi:10.2337/diab.45.1.86 · Cited by 119 · see citing works

Cognitive decline associated with normal aging in rats: a neuropsychological approach.Preprint

Zyzak, D. R., Otto, T., Eichenbaum, H., & Gallagher, M. (1995) · Learning & Memory · doi:10.1101/lm.2.1.1 · Cited by 116 · see citing works

Insulin-Like Growth Factors as Mediators of Functional Plasticity in the Adult Brain

Torres‐Alemán, I. (1999) · Hormone and Metabolic Research · doi:10.1055/s-2007-978707 · Cited by 115 · see citing works

Hippocampal and prefrontal cortex contributions to learning and memory: Analysis of lesion and aging effects on maze learning in rats.

Winocur, G., & Moscovitch, M. (1990) · Behavioral Neuroscience · doi:10.1037/0735-7044.104.4.544 · Cited by 113 · see citing works

Intraventricular insulin and the level of maintained body weight in rats.

Chavez, M., Kaiyala, K. J., Madden, L. J., Schwartz, M. W., & Woods, S. C. (1995) · Behavioral Neuroscience · doi:10.1037//0735-7044.109.3.528 · Cited by 111 · see citing works

Insulin Causes a Transient Tyrosine Phosphorylation of NR2A and NR2B NMDA Receptor Subunits in Rat Hippocampus

Christie, J. M., Wenthold, R. J., & Monaghan, D. T. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.721523.x · Cited by 109 · see citing works

Impaired modulation of AMPA receptors by calcium-dependent processes in streptozotocin-induced diabetic rats.

Chabot, C., Massicotte, G., Milot, M., Trudeau, F., & Gagné, J. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00648-3 · Cited by 109 · see citing works

The psychobiology of meals

Woods, S. C., & STRUBBE, J. H. (1994) · Psychonomic Bulletin & Review · doi:10.3758/bf03200770 · Cited by 106 · see citing works

NMDA receptor subunits are modified transcriptionally and post-translationally in the brain of streptozotocin-diabetic rats

Luca, M. D., Ruts, L., Gardoni, F., Cattabeni, F., Biessels, G. J., & Gispen, W. H. (1999) · Diabetologia · doi:10.1007/s001250051217 · Cited by 106 · see citing works

Nitric oxide and hippocampal synaptic plasticity.

Zorumski, C., & Izumi, Y. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90484-e · Cited by 102 · see citing works

Minireview: Mechanisms by Which the Metabolic Syndrome and Diabetes Impair Memory

Meena Kumari, B., Brunner, E. J., & Fuhrer, R. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.5.b228 · Cited by 102 · see citing works

Insulin-degrading enzyme in the Alzheimer's disease brain: prominent localization in neurons and senile plaques

Bernstein, H., Ansorge, S., Riederer, P. F., Reiser, M., Frölich, L., & Bogerts, B. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00135-4 · Cited by 101 · see citing works

Intraventricular insulin and the level of maintained body weight in rats.

Chavez, M., Kaiyala, K. J., Madden, L. J., et al. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.3.528 · Cited by 96 · see citing works

Insulin Synthesis by Isolated Rabbit Neurons*

Schechter, R., Holtzclaw, L. A., Sadiq, F. H., Kahn, A. J., & Devaskar, S. U. (1988) · Endocrinology · doi:10.1210/endo-123-1-505 · Cited by 93 · see citing works

Insulin-like growth factors-I and -II differentially regulate endogenous acetylcholine release from the rat hippocampal formation

Kar, S., Seto, D., Doré, S., Hanisch, U., & Quirion, R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.14054 · Cited by 93 · see citing works

Memory enhancement with posttraining intraventricular glucose injections in rats.

Lee, M. K., Graham, S. N., & Gold, P. E. (1988) · Behavioral Neuroscience · doi:10.1037//0735-7044.102.4.591 · Cited by 91 · see citing works

Abnormal Glucose Tolerance and Arginine Tolerance Tests in Huntington’s Disease

Podolsky, S., & Leopold, N. A. (2009) · Gerontology · doi:10.1159/000212174 · Cited by 90 · see citing works

Intrahypothalamic injection of insulin decreases firing rate of sympathetic nerves.

Sakaguchi, T., & Bray, G. A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.7.2012 · Cited by 89 · see citing works

Insulin and the paraventricular hypothalamus: modulation of energy balance

Menéndez, J., & Atrens, D. M. (1991) · Brain Research · doi:10.1016/0006-8993(91)90342-s · Cited by 89 · see citing works

Insulin receptor substrate-1 (IRS-1) expression in rat brain

Baskin, D. G., Schwartz, M. W., Sipols, A. J., D’Alessio, D. A., Goldstein, B. J., & White, M. F. (1994) · Endocrinology · doi:10.1210/endo.134.4.7511094 · Cited by 86 · see citing works

Analysis of tyrosine hydroxylase and insulin transcripts in human neuroendocrine tissues

Coker, G. T., Studelska, D. R., Harmon, S., Burke, W. J., & O’Malley, K. L. (1990) · Molecular Brain Research · doi:10.1016/0169-328x(90)90052-f · Cited by 85 · see citing works

Reduced Effect of Experimental Peripheral Hyperinsulinemia to Elevate Cerebrospinal Fluid Insulin Concentrations of Obese Zucker Rats*

Stein, L. J., Dorsa, D. M., Baskin, D. G., Figlewicz, D. P., Porte, D., & Woods, S. C. (1987) · Endocrinology · doi:10.1210/endo-121-5-1611 · Cited by 84 · see citing works

Memory enhancement with posttraining intraventricular glucose injections in rats.

Lee, M. K., Graham, S. N., & Gold, P. E. (1988) · Behavioral Neuroscience · doi:10.1037/0735-7044.102.4.591 · Cited by 84 · see citing works

The Subcortical Dementia of Huntington's Disease

Zakzanis, K. K. (1998) · Journal of Clinical and Experimental Neuropsychology · doi:10.1076/jcen.20.4.565.1468 · Cited by 82 · see citing works

Object Recognition in Mice: Improvement of Memory by Glucose

Messier, C. (1997) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.3755 · Cited by 82 · see citing works

Penetration of peripheral glucose and insulin into cerebrospinal fluid in rats

Steffens, A. B., Scheurink, A. J. W., Porte, D., & Woods, S. C. (1988) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1988.255.2.r200 · Cited by 80 · see citing works

Alterations in Glucose Metabolism in Patients with Alzheimer's Disease

Meneilly, G. S., & Hill, A. (1993) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1993.tb07458.x · Cited by 79 · see citing works

Effect of diet restriction on glucose metabolism and insulin responsiveness in aging rats

Kalant, N., Stewart, J., & Kaplan, R. B. (1988) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(88)90117-0 · Cited by 77 · see citing works

Long-term potentiation is lost in aged rats but preserved by calorie restriction

Hori, N., Hirotsu, I., Davis, P. J., & Carpenter, D. O. (1992) · Neuroreport · doi:10.1097/00001756-199212000-00013 · Cited by 76 · see citing works

Cognitive function in diabetes mellitus

Richardson, J. T. E. (1990) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80060-0 · Cited by 75 · see citing works

Brain Glucose Metabolism Is Controlled by Amplification and Desensitization of the Neuronal Insulin Receptora

Hoyer, S., Henneberg, N., KNAPP, S., Lannert, H., & MARTIN, E. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb34448.x · Cited by 73 · see citing works

Learning of the conditioned eye-blink response is impaired by an antisense insulin-like growth factor I oligonucleotide.

Castro‐Alamancos, M. A., & Torres‐Alemán, I. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.10203 · Cited by 71 · see citing works

Insulin‐like Growth Factor Receptors: Implications for Nervous System Function

LeRoith, D., Werner, H., Faria, T. N., Kato, H., Adamo, M. L., & Roberts, C. T. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb26202.x · Cited by 70 · see citing works

Evaluation of rat insulin messenger RNA in pancreatic and extrapancreatic tissues

Giddings, S. J., Chirgwin, J. M., & Permutt, M. A. (1985) · Diabetologia · doi:10.1007/bf00283141 · Cited by 69 · see citing works

Intracisternal insulin alters sensitivity to CCK-induced meal suppression in baboons

Figlewicz, D. P., Stein, L. J., West, D., Porte, D., & Woods, S. C. (1986) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1986.250.5.r856 · Cited by 69 · see citing works

Glucose Transporter Isoform Expression in Huntington's Disease Brain

Gamberino, W. C., & Brennan, W. A. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63041392.x · Cited by 65 · see citing works

Transgenic animals relevant to Alzheimer’s disease

Seabrook, G. R., & Rosahl, T. W. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(98)00170-1 · Cited by 63 · see citing works

Immunocytochemical detection of insulin receptor substrate-1 (IRS-1) in rat brain: colocalization with phosphotyrosine

Baskin, D. G., Sipols, A. J., Schwartz, M. W., & White, M. F. (1993) · Regulatory Peptides · doi:10.1016/0167-0115(93)90355-c · Cited by 63 · see citing works

Characteristics of learning and memory in streptozocin-induced diabetic mice

Flood, J. F., Mooradian, A. D., & Morley, J. E. (1990) · Diabetes · doi:10.2337/diabetes.39.11.1391 · Cited by 60 · see citing works

Adrenalectomy Increases Sensitivity to Central Insulin

Chavez, M. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00188-1 · Cited by 57 · see citing works

A re-assessment of the regulation of adiposity and appetite by the brain insulin system.

Woods, S. C., Lattemann, D. F., Schwartz, M. W., & Porte, D. (1990) · PubMed · Cited by 57 · see citing works

Effect of age and diet on insulin secretion and insulin action in the rat

REAVEN, E. P., Wright, D. W., Mondon, C. E., et al. (1983) · Diabetes · doi:10.2337/diabetes.32.2.175 · Cited by 57 · see citing works

Insulin in Brain and Other Extrapancreatic Tissues of Vertebrates and Nonvertebrates

Roith, D. L., HENDRICKS, S. A., Lesniak, M. A., Rishi, S., Becker, K. L., Havránková, J., Rosenzweig, J. L., Brownstein, M., & Roth, J. (1983) · Advances in metabolic disorders · doi:10.1016/b978-0-12-027310-2.50017-7 · Cited by 56 · see citing works

Short-term or long-term intracerebroventricular (i.c.v.) infusion of insulin exhibits a discrete anabolic effect on cerebral energy metabolism in the rat

Henneberg, N., & Hoyer, S. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)91102-9 · Cited by 55 · see citing works

Glucose-insulin metabolism in chronic schizophrenia.

Brambilla, F., Guastalla, A., Guerrini, A., Riggi, F., Rovere, C., Zanoboni, A., & Zanoboni-Muciaccia, W. (1976) · PubMed · Cited by 54 · see citing works

Inhibitory action of insulin on suprachiasmatic nucleus neurons in rat hypothalamic slice preparations

Shibata, S., Liou, S. Y., Ueki, S., & Oomura, Y. (1986) · Physiology & Behavior · doi:10.1016/0031-9384(86)90077-6 · Cited by 52 · see citing works

The insulin receptor. A multifunctional protein

Olefsky, J. M. (1990) · Diabetes · doi:10.2337/diabetes.39.9.1009 · Cited by 52 · see citing works

Age- and dose-dependent glucose-induced increases in memory and attention in schizophrenia

Fucetola, R. P., Newcomer, J. W., Craft, S., & Melson, A. K. (1999) · Psychiatry Research · doi:10.1016/s0165-1781(99)00063-3 · Cited by 51 · see citing works

Apolipoprotein E: a review of its roles in lipoprotein metabolism, neuronal growth and repair and as a risk factor for Alzheimer's disease

Rubinsztein, D. C. (1995) · Psychological Medicine · doi:10.1017/s0033291700036138 · Cited by 51 · see citing works

Insulin and insulin mRNA are detected in neuronal cell cultures maintained in an insulin-free/serum-free medium.

Schechter, R., Sadiq, H. F., & Devaskar, S. U. (1990) · Journal of Histochemistry & Cytochemistry · doi:10.1177/38.6.2186089 · Cited by 50 · see citing works

The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains

Myers, M. G., & White, M. F. (1993) · Diabetes · doi:10.2337/diabetes.42.5.643 · Cited by 48 · see citing works

The effect of insulin and glucose on the plasma concentration of Alzheimer's amyloid precursor protein

Boyt, A., Taddei, K., Hallmayer, J. F., Helmerhorst, E., Gandy, S., Craft, S., & Martins, R. N. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00458-3 · Cited by 46 · see citing works

Insulin Modulation of Cloned Mouse NMDA Receptor Currents in Xenopus Oocytes

Liao, G., & Leonard, J. P. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731510.x · Cited by 46 · see citing works

Effect of Combinations of Insulin, Glucose and Scopolamine on Radial Arm Maze Performance

Blanchard, J. G., & Duncan, P. M. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00064-6 · Cited by 42 · see citing works

Effects of feeding and insulin on extracellular acetylcholine in the amygdala of freely moving rats

Hajnal, A., Pothos, E. N., Lénárd, L., & Hoebel, B. G. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01291-2 · Cited by 39 · see citing works

Insulin receptors in the brain cortex of aging mice

Zaia, A., & PIANTANELLI, L. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(99)00118-9 · Cited by 38 · see citing works

Glucose-insulin metabolism in chronic schizophrenia

Brambilla, F., Guastalla, A., Guerrini, A., Riggi, F., Rovere, C., Zanoboni, A., & Zanoboni-Muciaccia, W. (1975) · Progress in brain research · doi:10.1016/s0079-6123(08)63700-0 · Cited by 37 · see citing works

C-peptide immunoreactive neurons in human brain

Dorn, A., Rinne, A., Hahn, H.-J., Bernstein, H., & ZIEGLER, M. (1982) · Acta Histochemica · doi:10.1016/s0065-1281(82)80080-9 · Cited by 37 · see citing works

Modulation of ATP-Sensitive K+Channel by Insulin in Rat Skeletal Muscle Fibers

Tricarico, D., Mallamaci, R., Barbieri, M., & Camerino, D. C. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6320 · Cited by 36 · see citing works

Complex maze performance in young and aged rats: Response to glucose treatment and relationship to blood insulin and glucose

LONG, J., DAVIS, B., Garofalo, P., Spangler, E. L., & INGRAM, D. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90159-y · Cited by 36 · see citing works

The Impairment of Retention Induced by Insulin in Mice May Be Mediated by a Reduction in Central Cholinergic Activity

Kopf, S. R., & Baratti, C. M. (1995) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1995.1026 · Cited by 34 · see citing works

Insulin transport from plasma into the central nervous system is inhibited by dexamethasone in dogs

Baura, G. D., Foster, D. M., Kaiyala, K. J., et al. (1996) · Diabetes · doi:10.2337/diabetes.45.1.86 · Cited by 34 · see citing works

Memory Modulation by Post-training Glucose or Insulin Remains Evident at Long Retention Intervals

Kopf, S. R., & Baratti, C. M. (1996) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.0020 · Cited by 33 · see citing works

Insulin increases energy expenditure and respiratory quotient in the rat

Menéndez, J., & Atrens, D. M. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90272-4 · Cited by 32 · see citing works

Intracerebroventricular administration of insulin attenuates retrieval of a passive avoidance response in rats

Schwarzberg, H., Bernstein, H., Reiser, M., & Günther, O. (1989) · Neuropeptides · doi:10.1016/0143-4179(89)90002-4 · Cited by 32 · see citing works

Insulin attenuates scopolamine-induced memory deficits

Messier, C., & Destrade, C. (1994) · Psychobiology · doi:10.3758/bf03327075 · Cited by 31 · see citing works

Schizophrenia is a diabetic brain state: An elucidation of impaired neurometabolism

Holden, R. J., & Mooney, P. A. (1994) · Medical Hypotheses · doi:10.1016/0306-9877(94)90020-5 · Cited by 31 · see citing works

Homeostatic disruption and memory: effect of insulin administration in rats

Santucci, A. C., Schroeder, H., & Riccio, D. C. (1990) · Behavioral and Neural Biology · doi:10.1016/0163-1047(90)90184-8 · Cited by 30 · see citing works

Insulin and Insulin-Like Growth Factor-I Inhibit the L-Type Calcium Channel Current in Rat Pinealocytes1

Chik, C. L., Li, B., Karpinski, E., & Ho, A. K. (1997) · Endocrinology · doi:10.1210/endo.138.5.5129 · Cited by 29 · see citing works

Effect of intracerebroventricularly administered insulin on brain monoamines and acetylcholine in euglycaemic and alloxan-induced hyperglycaemic rats.

Bhattacharya, S. K., & Saraswati, M. (1991) · PubMed · Cited by 29 · see citing works

Insulin stimulates membrane phospholipid metabolism by enhancing endogenousα1-adrenergic activity in the rat hippocampus

Figlewicz, D. P., & Szot, P. (1991) · Brain Research · doi:10.1016/0006-8993(91)90410-w · Cited by 28 · see citing works

Differential Effects of Insulin on Choline Acetyltransferase and Glutamic Acid Decarboxylase Activities in Neuron‐Rich Striatal Cultures

Brass, B. J., Nonner, D., & Barrett, J. N. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09387.x · Cited by 27 · see citing works

Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers

Reitz, C., & Mayeux, R. P. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.024 · Cited by 1,180 · see citing works

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

Belfiore, A., Frasca, F., Pandini, G., Sciacca, L., & Vigneri, R. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0047 · Cited by 1,035 · see citing works

Aggregation of vascular risk factors and risk of incident Alzheimer disease

Luchsinger, J. A., Reitz, C., Honig, L. S., Tang, M. X., Shea, S., & Mayeux, R. (2005) · Neurology · doi:10.1212/01.wnl.0000172914.08967.dc · Cited by 790 · see citing works

Hyperinsulinemia and risk of Alzheimer disease

Luchsinger, J. A., Tang, M.-X., Shea, S., & Mayeux, R. (2004) · Neurology · doi:10.1212/01.wnl.0000140292.04932.87 · Cited by 683 · see citing works

Is Alzheimer’s disease a type 3 diabetes? A critical appraisal

Kandimalla, R., Thirumala, V., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.08.018 · Cited by 621 · see citing works

Amyloid beta oligomers induce impairment of neuronal insulin receptors

Zhao, W., De Felice, F. G., Fernandez, S., Chen, H., Lambert, M. P., Quon, M. J., Krafft, G. A., & Klein, W. L. (2008) · The FASEB Journal · doi:10.1096/fj.06-7703com · Cited by 587 · see citing works

Estrogen: A master regulator of bioenergetic systems in the brain and body

Rettberg, J. R., Yao, J., & Brinton, R. D. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.08.001 · Cited by 534 · see citing works

A systematic review of the effect of breakfast on the cognitive performance of children and adolescents

Hoyland, A., Dye, L., & Lawton, C. L. (2009) · Nutrition Research Reviews · doi:10.1017/s0954422409990175 · Cited by 510 · see citing works

Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice

Hwang, L., Wang, C., Li, T., Chang, S., Lin, L., Chen, C., Chen, C., Liang, K., Ho, I., Yang, W., et al. (2010) · Obesity · doi:10.1038/oby.2009.273 · Cited by 395 · see citing works

Glucose transporter expression in the central nervous system: relationship to synaptic function

McEwen, B. S., & Reagan, L. P. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.041 · Cited by 378 · see citing works

Insulin in Central Nervous System: More than Just a Peripheral Hormone

Duarte, A. I., Moreira, P. I., & Oliveira, C. R. (2012) · Journal of Aging Research · doi:10.1155/2012/384017 · Cited by 324 · see citing works

Does insulin dysfunction play a role in Alzheimer's disease?

Gasparini, L. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02037-0 · Cited by 314 · see citing works

Hippocampal Insulin Resistance Impairs Spatial Learning and Synaptic Plasticity

Grillo, C. A., Piroli, G. G., Lawrence, R. C., Wrighten, S. A., Green, A. J., Wilson, S. P., Sakai, R. R., Kelly, S. J., Wilson, M. A., Mott, D. D., et al. (2015) · Diabetes · doi:10.2337/db15-0596 · Cited by 308 · see citing works

Insulin in the Brain: Sources, Localization and Functions

Ghasemi, R., Haeri, A., Dargahi, L., Mohamed, Z., & Ahmadiani, A. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8339-9 · Cited by 291 · see citing works

Improving Metabolic Control Leads to Better Working Memory in Adults With Type 2 Diabetes

Ryan, C. M., Freed, M. I., Rood, J. A., Cobitz, A. R., Waterhouse, B. R., & Strachan, M. W. J. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1626 · Cited by 289 · see citing works

Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial

Luchsinger, J. A., Perez, T., Chang, H., Mehta, P., Steffener, J., Pradabhan, G., Ichise, M., Manly, J., Devanand, D. P., & Bagiella, E. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-150493 · Cited by 285 · see citing works

Memory impairment in obese Zucker rats: An investigation of cognitive function in an animal model of insulin resistance and obesity.

Winocur, G., Greenwood, C. E., Piroli, G. G., Grillo, C. A., Reznikov, L. R., Reagan, L. P., & McEwen, B. S. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.5.1389 · Cited by 281 · see citing works

Effect of the treatment of Type 2 diabetes mellitus on the development of cognitive impairment and dementia

Sastre, A. A., Vernooij, R. W. M., Harmand, M. G., & Martínez, G. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003804.pub2 · Cited by 271 · see citing works

Cognitive and physiological effects of an ?energy drink?: an evaluation of the whole drink and of glucose, caffeine and herbal flavouring fractions

Scholey, A. B., & Kennedy, D. O. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1935-2 · Cited by 254 · see citing works

Cardiovascular risk factors and Alzheimer’s disease

Luchsinger, J. A., & Mayeux, R. P. (2004) · Current Atherosclerosis Reports · doi:10.1007/s11883-004-0056-z · Cited by 238 · see citing works

Brain Insulin: Regulation, Mechanisms of Action and Functions

Gerozissis, K. (2003) · Cellular and Molecular Neurobiology · doi:10.1023/a:1022598900246 · Cited by 235 · see citing works

‘Adipaging’: ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue

Pérez, L. M., Pareja‐Galeano, H., Sanchis‐Gomar, F., Emanuele, E., Lucia, A., & Gálvez, B. G. (2016) · The Journal of Physiology · doi:10.1113/jp271691 · Cited by 215 · see citing works

Insulin-resistant brain state: The culprit in sporadic Alzheimer's disease?

Correia, S. C., Santos, R. X., Perry, G., Zhu, X., Moreira, P. I., & Smith, M. A. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.01.001 · Cited by 212 · see citing works

Long-term effects of a very low-carbohydrate diet and a low-fat diet on mood and cognitive function

Brinkworth, G. D. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.329 · Cited by 205 · see citing works

A biochemical and functional characterization of diet‐induced brain insulin resistance

Mielke, J. G., Taghibiglou, C., Liu, L., Zhang, Y., Jia, Z., Adeli, K., & Wang, Y. T. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03155.x · Cited by 205 · see citing works

A summary risk score for the prediction of Alzheimer disease in elderly persons

Reitz, C., Tang, M.-X., Schupf, N., Manly, J. J., Mayeux, R., & Luchsinger, J. A. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.136 · Cited by 199 · see citing works

Type 2 Diabetes and Cognitive Impairment: Linking Mechanisms

Luchsinger, J. A. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111433 · Cited by 196 · see citing works

Insulin and the CNS: effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans

Stockhorst, U., de Fries, D., Steingrüber, H.-J., & Scherbaum, W. A. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.07.022 · Cited by 191 · see citing works

Memory-specific temporal profiles of gene expression in the hippocampus

Cavallaro, S., D’Agata, V., Manickam, P., Dufour, F., & Alkon, D. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242597199 · Cited by 191 · see citing works

The delivery rate of dietary carbohydrates affects cognitive performance in both rats and humans

Benton, D., Ruffin, M.-P., Lassel, T. S., Nabb, S., Messaoudi, M., Vinoy, S., Desor, D., & Lang, V. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1334-5 · Cited by 187 · see citing works

How Does Exercise Reduce the Rate of Age-Associated Cognitive Decline? A Review of Potential Mechanisms

Kennedy, G., Hardman, R. J., Macpherson, H., Scholey, A. B., & Pipingas, A. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160665 · Cited by 187 · see citing works

Insulin expressing cells from differentiated embryonic stem cells are not beta cells

Sipione, S., Eshpeter, A., Lyon, J. G., Korbutt, G. S., & Bleackley, R. C. (2004) · Diabetologia · doi:10.1007/s00125-004-1349-z · Cited by 176 · see citing works

International Encyclopedia of Rehabilitation

Tower, K. (2010) · Cited by 173 · see citing works

Intraventricular Insulin and Leptin Reverse Place Preference Conditioned With High-Fat Diet in Rats.

Figlewicz, D. P., Bennett, J. L., Evans, S. B., Kaiyala, K. J., Sipols, A. J., & Benoit, S. C. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.3.479 · Cited by 172 · see citing works

Obese men respond to cognitive but not to catabolic brain insulin signaling

Hallschmid, M., Benedict, C., Schultes, B., Born, J., & Kern, W. (2008) · International Journal of Obesity · doi:10.1038/sj.ijo.0803722 · Cited by 165 · see citing works

The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review

Hoyer, S. (2002) · Journal of Neural Transmission · doi:10.1007/s007020200082 · Cited by 161 · see citing works

Insulin-mediated synaptic plasticity in the CNS: Anatomical, functional and temporal contexts

Ferrario, C. R., & Reagan, L. P. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.001 · Cited by 160 · see citing works

A high fructose diet impairs spatial memory in male rats

Ross, A. P., Bartness, T. J., Mielke, J. G., & Parent, M. B. (2009) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2009.05.007 · Cited by 154 · see citing works

Cerebral dysfunction in type 1 diabetes: effects of insulin, vascular risk factors and blood-glucose levels

Brands, A. M. A., Kessels, R. P. C., de Haan, E. H. F., Kappelle, L. J., & Biessels, G. J. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.053 · Cited by 150 · see citing works

Type 1 diabetes‐associated cognitive decline: A meta‐analysis and update of the current literature 1型糖尿病相关的认知能力下降：一项对最新文献的meta分析

Tonoli, C., Heyman, E., Roelands, B., Pattyn, N., Buyse, L., Piacentini, M. F., Berthoin, S., & Meeusen, R. (2014) · Journal of Diabetes · doi:10.1111/1753-0407.12193 · Cited by 148 · see citing works

Crosstalk between diabetes and brain: Glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration

Duarte, A. I., Candeias, E., Correia, S. C., Santos, R. X., Carvalho, C., Cardoso, S., Plácido, A. I., Santos, M. S., Oliveira, C. R., & Moreira, P. I. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.01.008 · Cited by 142 · see citing works

Neuronal LRP1 Regulates Glucose Metabolism and Insulin Signaling in the Brain

Liu, C., Hu, J., Tsai, C., Yue, M., Melrose, H. L., Kanekiyo, T., & Bu, G. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.5180-14.2015 · Cited by 140 · see citing works

Type 2 Diabetes and Late-Onset Alzheimer’s Disease

Cheng, D., Noble, J. M., Tang, M. ‐., Schupf, N., Mayeux, R. P., & Luchsinger, J. A. (2011) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000324134 · Cited by 134 · see citing works

Effect of donepezil and lercanidipine on memory impairment induced by intracerebroventricular streptozotocin in rats

Sonkusare, S. K., Srinivasan, K. K., Kaul, C., & Ramarao, P. (2005) · Life Sciences · doi:10.1016/j.lfs.2004.10.036 · Cited by 134 · see citing works

Acute effects of macronutrient manipulations on cognitive test performance in healthy young adults: A systematic research review

Hoyland, A., Lawton, C. L., & Dye, L. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.05.006 · Cited by 131 · see citing works

Insulin signaling effects on memory and mood

Reagan, L. P. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.10.012 · Cited by 118 · see citing works

Considerations for Using Sucrose to Reduce Procedural Pain in Preterm Infants

Holsti, L., & GRUNAU, R. E. (2010) · PEDIATRICS · doi:10.1542/peds.2009-2445 · Cited by 114 · see citing works

The As and Ds of stress: Metabolic, morphological and behavioral consequences

Reagan, L. P., Grillo, C. A., & Piroli, G. G. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.02.050 · Cited by 111 · see citing works

Brain insulin and feeding: a bi-directional communication

Gerozissis, K. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.044 · Cited by 108 · see citing works

Muscular and Aerobic Fitness, Working Memory, and Academic Achievement in Children

Kao, S., Westfall, D. R., Parks, A. C., Pontifex, M. B., & Hillman, C. H. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001132 · Cited by 105 · see citing works

Food for Thought: Fluctuations in Brain Extracellular Glucose Provide Insight into the Mechanisms of Memory Modulation

McNay, E. C., & Gold, P. E. (2002) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582302238337 · Cited by 103 · see citing works

Integrated transcriptome and metabolome analysis to investigate the mechanism of intranasal insulin treatment in a rat model of vascular dementia

Tang, L., Wang, Y., Gong, X., Xiang, J., Zhang, Y., Qin, X., & Li, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1182803 · Cited by 100 · see citing works

Cytoprotective effects of hesperetin and hesperidin against amyloid β‐induced impairment of glucose transport through downregulation of neuronal autophagy

Huang, S., Tsai, S.-Y., Lin, J., Wu, C., & Yen, G. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100682 · Cited by 100 · see citing works

Glucose and age-related changes in memory

Gold, P. E. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.002 · Cited by 96 · see citing works

Better cognitive performance following a low-glycaemic-index compared with a high-glycaemic-index carbohydrate meal in adults with type 2 diabetes

Papanikolaou, Y., Palmer, H., Binns, M. A., Jenkins, D. J. A., & Greenwood, C. E. (2006) · Diabetologia · doi:10.1007/s00125-006-0183-x · Cited by 94 · see citing works

Type 2 diabetes, related conditions, in relation and dementia: An opportunity for prevention?

Luchsinger, J. A. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091687 · Cited by 91 · see citing works

Agmatine Improves Cognitive Dysfunction and Prevents Cell Death in a Streptozotocin-Induced Alzheimer Rat Model

Song, J., Hur, B. E., Bokara, K. K., Yang, W., Cho, H. J., Park, K. A., Lee, W. T., Lee, K. M., & Lee, J. E. (2014) · Yonsei Medical Journal · doi:10.3349/ymj.2014.55.3.689 · Cited by 89 · see citing works

Branched-Chain Amino Acids Enhance the Cognitive Recovery of Patients With Severe Traumatic Brain Injury

Aquilani, R., Iadarola, P., Contardi, A., Boselli, M., Verri, M., Pastoris, O., Boschi, F., Arcidiaco, P., & Viglio, S. (2005) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2005.03.022 · Cited by 88 · see citing works

Effect of the treatment of Type II diabetes mellitus on the development of cognitive impairment and dementia

Evans, J. G., & Sastre, A. A. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003804 · Cited by 87 · see citing works

Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: role in learning and memory

Beck, B., & Pourié, G. (2013) · Nutrition Reviews · doi:10.1111/nure.12045 · Cited by 86 · see citing works

Antidepressant effects of insulin in streptozotocin induced diabetic mice: Modulation of brain serotonin system

Gupta, D., Kurhe, Y., & Radhakrishnan, M. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.02.036 · Cited by 86 · see citing works

Exercise increases insulin signaling in the hippocampus: Physiological effects and pharmacological impact of intracerebroventricular insulin administration in mice

Muller, A. P., Gnoatto, J. A., Moreira, J. D., Zimmer, E. R., Haas, C. B., Lulhier, F., Perry, M. L. S., Souza, D. O., Torres‐Alemán, I., & Portela, L. V. (2010) · Hippocampus · doi:10.1002/hipo.20822 · Cited by 85 · see citing works

The influence of breakfast and a snack on psychological functioning

Benton, D., Slater, O., & Fothergill, R. T. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00601-1 · Cited by 84 · see citing works

Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural Nootropic

Suliman, N. A., Taib, C. N. M., Moklas, M. A. M., Adenan, M. I., Baharuldin, M. T. H., & Basir, R. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/4391375 · Cited by 85 · see citing works

Sweet but Bitter: Focus on Fructose Impact on Brain Function in Rodent Models

Spagnuolo, M. S., Iossa, S., & Cigliano, L. (2020) · Nutrients · doi:10.3390/nu13010001 · Cited by 83 · see citing works

Association of cognitive dysfunction with hippocampal atrophy in elderly Japanese people with type 2 diabetes

Hayashi, K., Kurioka, S., Yamaguchi, T., Morita, M., Kanazawa, I., Takase, H., Wada, A., Kitagaki, H., Nagai, A., Bokura, H., et al. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2011.07.002 · Cited by 81 · see citing works

Motherhood Induces and Maintains Behavioral and Neural Plasticity across the Lifespan in the Rat

Kinsley, C. H., Bardi, M., Karelina, K., Rima, B., Christon, L., Friedenberg, J. M., & Griffin, G. R. (2007) · Archives of Sexual Behavior · doi:10.1007/s10508-007-9277-x · Cited by 80 · see citing works

Branched-Chain Amino Acids May Improve Recovery From a Vegetative or Minimally Conscious State in Patients With Traumatic Brain Injury: A Pilot Study

Aquilani, R., Boselli, M., Boschi, F., Viglio, S., Iadarola, P., Dossena, M., Pastoris, O., & Verri, M. (2008) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2008.02.023 · Cited by 80 · see citing works

Role of the blood–brain barrier in the evolution of feeding and cognition

Banks, W. A. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06568.x · Cited by 79 · see citing works

A Physiological Increase of Insulin in the Olfactory Bulb Decreases Detection of a Learned Aversive Odor and Abolishes Food Odor-Induced Sniffing Behavior in Rats

Aimé, P., Hegoburu, C., Jaillard, T., Dégletagne, C., Garcia, S., Messaoudi, B., Thévenet, M., Lorsignol, A., Duchamp, C., Mouly, A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051227 · Cited by 82 · see citing works

Intrahippocampal insulin improves memory in a passive-avoidance task in male wistar rats

Babri, S., Pourbadie, H. G., Khamenei, S., & Seydlar, M. O. (2007) · Brain and Cognition · doi:10.1016/j.bandc.2007.01.002 · Cited by 79 · see citing works

The influence on cognition of the interaction between the macro-nutrient content of breakfast and glucose tolerance

Nabb, S., & Benton, D. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.034 · Cited by 74 · see citing works

Potential role of insulin on the pathogenesis of depression

Zou, X.-H., Sun, L.-H., Yang, W., Li, B.-J., & Cui, R.-J. (2020) · Cell Proliferation · doi:10.1111/cpr.12806 · Cited by 66 · see citing works

Why the Maternal Brain?

Kinsley, C. H., & Amory, E. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02194.x · Cited by 69 · see citing works

Cinnamon Counteracts the Negative Effects of a High Fat/High Fructose Diet on Behavior, Brain Insulin Signaling and Alzheimer-Associated Changes

Anderson, R. A., Qin, B., Canini, F., Poulet, L., & Roussel, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083243 · Cited by 71 · see citing works

The influence of carbohydrate on cognitive performance: a critical evaluation from the perspective of glycaemic load

Gilsenan, M. B., de Bruin, E. A., & Dye, L. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114508199019 · Cited by 67 · see citing works

The role of insulin receptor signaling in synaptic plasticity and cognitive function.

Huang, C. C., Lee, C. C., & Hsu, K. (2010) · PubMed · Cited by 66 · see citing works

Insulin inhibits AMPA-induced neuronal damage via stimulation of protein kinase B (Akt)

Kim, S.-J., & Han, Y. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0163-6 · Cited by 60 · see citing works

Long-term abnormalities in brain glucose/energy metabolism after inhibition of the neuronal insulin receptor: implication of tau-protein

Hoyer, S., & Lannert, H. (2007) · Springer eBooks · doi:10.1007/978-3-211-73574-9_25 · Cited by 59 · see citing works

Insulin reverses anxiety-like behavior evoked by streptozotocin-induced diabetes in mice

Gupta, D., Radhakrishnan, M., & Kurhe, Y. (2014) · Metabolic Brain Disease · doi:10.1007/s11011-014-9540-5 · Cited by 59 · see citing works

Glucose administration prior to a divided attention task improves tracking performance but not word recognition: evidence against differential memory enhancement?

Scholey, A. B., Sünram‐Lea, S. I., Greer, J. M. H., Elliott, J. M., & Kennedy, D. O. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1387-1 · Cited by 59 · see citing works

Pathogenesis of Alzheimer's Disease: Role of Amyloid-beta and Hyperphosphorylated Tau Protein

Sajjad, R., Arif, R., Shah, A. A., Manzoor, I., & Mustafa, G. (2018) · Indian Journal of Pharmaceutical Sciences · doi:10.4172/pharmaceutical-sciences.1000397 · Cited by 57 · see citing works

Neuronal insulin signal transduction mechanisms in diabetes phenotypes

Reagan, L. P. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.001 · Cited by 56 · see citing works

Insulin receptor substrate 2 is a negative regulator of memory formationPreprint

Irvine, E. E., Drinkwater, L., Radwańska, K., Al‐Qassab, H., Smith, M. A., O’Brien, M. S., Kielar, C., Choudhury, A. I., Krauss, S. J. K., Cooper, J. D., et al. (2011) · Learning & Memory · doi:10.1101/lm.2111311 · Cited by 56 · see citing works

Loss of temporal lobe beta power in young adults with type 1 diabetes mellitus

Brismar, T., Hyllienmark, L., Ekberg, K., & Johansson, B. (2002) · Neuroreport · doi:10.1097/00001756-200212200-00019 · Cited by 52 · see citing works

Biphasic effects of stress upon GLUT8 glucose transporter expression and trafficking in the diabetic rat hippocampus

Piroli, G. G., Grillo, C. A., Charron, M. J., McEwen, B. S., & Reagan, L. P. (2004) · Brain Research · doi:10.1016/j.brainres.2004.01.044 · Cited by 49 · see citing works

Metabolic Syndrome and Cognitive Decline Among the Oldest Old in Okinawa: In Search of a Mechanism. The KOCOA Project

Katsumata, Y., Todoriki, H., Higashiuesato, Y., Yasura, S., Willcox, D. C., Ohya, Y., Willcox, B. J., & Dodge, H. H. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr189 · Cited by 50 · see citing works

Molecular and biochemical trajectories from diabetes to Alzheimer’s disease: A critical appraisal

Sandhir, R., & Gupta, S. N. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i12.1223 · Cited by 47 · see citing works

Effect of insulin and melatonin on acetylcholinesterase activity in the brain of amnesic mice

Agrawal, R., Tyagi, E., Shukla, R., & Nath, C. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.01.015 · Cited by 48 · see citing works

Systematic Review and Meta‐Analysis on Neuropsychological Effects of Long‐Term Use of Opioids in Patients With Chronic Noncancer Pain

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Davari, S., & Reisi, P. (2013) · DOAJ (DOAJ: Directory of Open Access Journals)

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Rotte, M., Baerecke, C., Pottag, G., Klose, S., Kanneberg, E., Heinze, H., & Lehnert, H. (2005) · Neuroendocrinology · doi:10.1159/000084874 · Cited by 48 · see citing works

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