The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation
Abstract
Insulin receptor substrates (IRS) serine phosphorylation is a time-controlled physiological feedback mechanism in insulin signaling that is hijacked by metabolic and inflammatory stresses to promote insulin resistance. Kinases, including IKKbeta, JNK, ERK, mTOR, and S6K, activated by the inducers of insulin resistance induce uncontrolled IRS serine phosphorylation. Studies with genetically modified mice reveal that these kinases integrate signals from metabolic and inflammatory stresses in adipose tissue, liver, and hypothalamus leading to peripheral and central insulin resistance. Moreover, IKKbeta/NF-kappaB and JNK1 pathways in myeloid cells represent a core mechanism involved in inflammation linked to obesity. These kinases are thus potential drug targets against insulin resistance and the targeting of the IKKbeta/NF-kappaB or the JNK pathway may evolve into future diabetes medication.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Increased stress kinase activity also has been implicated in contribute to the serine phosphorylation of IRS-1 and subsequent impairment tyrosine phosphorylation [177, 178].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [177]
Citations
Cites
1 retracted
Herschkovitz, A., Liu, Y., Ilan, E., Ronen, D., Boura‐Halfon, S., & Zick, Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610949200 · Cited by 98
RetractedInflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359
Molecular mechanisms of mTOR-mediated translational control
Ma, X. M., & Blenis, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2672 · Cited by 2,558
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245
Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884
Obesity, Inflammation, and Insulin Resistance
Shoelson, S. E., Herrero, L., & Naaz, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.059 · Cited by 1,806
IKK-β links inflammation to obesity-induced insulin resistance
Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z.-W., Long, J. M., Wynshaw-Boris, A., Poli, G., Olefsky, J., & Karin, M. (2005) · Nature Medicine · doi:10.1038/nm1185 · Cited by 1,773
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
Um, S. H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., Fumagalli, S., Allegrini, P. R., Kozma, S. C., Auwerx, J., et al. (2004) · Nature · doi:10.1038/nature02866 · Cited by 1,677
The IKK NF-κB system: a treasure trove for drug development
Karin, M., Yamamoto, Y., & Wang, Q. M. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1279 · Cited by 1,364
Cited by
Sorted by citations
Items 101–200 of 431
Tsai, C., Liu, K., Lin, Y., & Kuo, W. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300356 · Cited by 63
Rozengurt, E. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00357 · Cited by 67
Jager, J., Grémeaux, T., Gonzalez, T., Bonnafous, S., Debard, C., Laville, M., Vidal, H., Tran, A., Gual, P., MARCHAND‐BRUSTEL, Y. L., et al. (2009) · Diabetes · doi:10.2337/db09-0470 · Cited by 62
Self-citationMetabolic syndrome and hidradenitis suppurativa: epidemiological, molecular, and therapeutic aspects
Mintoff, D., Benhadou, F., Pace, N. P., & Frew, J. W. (2021) · International Journal of Dermatology · doi:10.1111/ijd.15910 · Cited by 61
Inflammation, Oxidative Stress and Metabolic Syndrome: Dietary Modulation
Fernández‐García, J. C., Cardona, F., & Tinahones, F. J. (2014) · Current Vascular Pharmacology · doi:10.2174/15701611113116660175 · Cited by 63
Diacerhein Improves Glucose Tolerance and Insulin Sensitivity in Mice on a High-Fat Diet
Tobar, N., Oliveira, A. G., Guadagnini, D., Bagarolli, R. A., Rocha, G. Z., Araújo, T. G., Santos-Silva, J. C., Zollner, R. D. L., Boechat, L. H. B., Carvalheira, J. B. C., et al. (2011) · Endocrinology · doi:10.1210/en.2011-0249 · Cited by 59
Cheng, H., Kuo, C.-Y., Liao, Y., & Lin, C.-C. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.05.033 · Cited by 59
Signaling crosstalk between the mTOR complexes
Xie, J., & Proud, C. G. (2014) · Translation · doi:10.4161/trla.28174 · Cited by 60
Insulin Induces REDD1 Expression through Hypoxia-inducible Factor 1 Activation in Adipocytes
Regazzetti, C., Bost, F., MARCHAND‐BRUSTEL, Y. L., Tanti, J., & Giorgetti‐Peraldi, S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.047688 · Cited by 67
Self-citationBesse‐Patin, A., & Estall, J. L. (2014) · International Journal of Cell Biology · doi:10.1155/2014/519153 · Cited by 63
Dandona, P., Ghanim, H., Green, K., Sia, C. L., Abuaysheh, S., Kuhadiya, N. D., Batra, M., Dhindsa, S., & Chaudhuri, A. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00566.2012 · Cited by 58
Jia, K., Zheng, Y.-J., Zhang, Y., Liu, J.-H., Jiao, R., Pan, Y., & Kong, L. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.08.004 · Cited by 59
Phosphoinositide 3-kinase (PI3K) classes: From cell signaling to endocytic recycling and autophagy
Safaroghli‐Azar, A., Sanaei, M., Pourbagheri‐Sigaroodi, A., & Bashash, D. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175827 · Cited by 60
Patel, T. P., Rawal, K., Soni, S., & Gupta, S. S. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.07.028 · Cited by 59
Chiu, T. T., Sun, Y., Koshkina, A., & Klip, A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.467647 · Cited by 56
Kwak, S.-J., Kim, C.-S., Choi, M., Park, T., Sung, M., Yun, J. W., Yoo, H., Mine, Y., & Yu, R. (2016) · Journal of Medicinal Food · doi:10.1089/jmf.2016.3685 · Cited by 56
Translational approaches: from fatty liver to non-alcoholic steatohepatitis.
Rosso, N., Chávez-Tapia, N. C., Tiribelli, C., & Bellentani, S. (2014) · PubMed Central · doi:10.3748/wjg.v20.i27.9038 · Cited by 57
PPARβ/δ and lipid metabolism in the heart
Palomer, X., Barroso, E., Zarei, M., Botteri, G., & Vázquez‐Carrera, M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.01.019 · Cited by 58
Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing
Bettedi, L., & Foukas, L. C. (2017) · Biogerontology · doi:10.1007/s10522-017-9724-6 · Cited by 55
Fusco, S., Maulucci, G., & Pani, G. (2012) · Cell Cycle · doi:10.4161/cc.22074 · Cited by 54
Basta‐Kaim, A., Szczęsny-Małysiak, E., Głombik, K., Stachowicz, K., Ślusarczyk, J., Nalepa, I., Zelek-Molik, A., Rafa–Zabłocka, K., Budziszewska, B., Kubera, M., et al. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.07.002 · Cited by 53
Inflammatory markers in children and adolescents with type 2 diabetes mellitus
Reinehr, T. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.07.006 · Cited by 53
Ali, D.-E.-S., Shah, M., Ali, A., Malik, M. O., Rehman, F., Badshah, H., Ehtesham, E., & Vitale, S. G. (2019) · Hormone and Metabolic Research · doi:10.1055/a-1018-9606 · Cited by 53
Pillon, N. J., Arane, K., Bilan, P. J., Chiu, T. T., & Klip, A. (2012) · Cell Communication and Signaling · doi:10.1186/1478-811x-10-30 · Cited by 53
Maurya, C. K., Singh, R. M., Jaiswal, N., Venkateswarlu, K., Narender, T., & Tamrakar, A. K. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.07.018 · Cited by 52
Reinehr, T., Karges, B., Meissner, T., Wiegand, S., Stoffel-Wagner, B., Holl, R. W., & Woelfle, J. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.02.055 · Cited by 51
Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015–2021)
Olekšák, P., Nepovimová, E., Chrienová, Ž., Musílek, K., Patočka, J., & Kuča, K. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114498 · Cited by 53
Kim, J., Park, Y., Jang, Y., & Kwon, Y. H. (2011) · Brain Research · doi:10.1016/j.brainres.2011.08.059 · Cited by 51
Karandrea, S., Yin, H., Liang, X., Slitt, A. L., & Heart, E. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185374 · Cited by 51
Mitochondrial fat oxidation is essential for lipid-induced inflammation in skeletal muscle in mice
Warfel, J. D., Bermudez, E. M., Mendoza, T. M., Ghosh, S., Zhang, J., Elks, C. M., Mynatt, R., & Vandanmagsar, B. (2016) · Scientific Reports · doi:10.1038/srep37941 · Cited by 50
Current Studies on Molecular Mechanisms of Insulin Resistance
Pei, J., Wang, B., & Wang, D. (2022) · Journal of Diabetes Research · doi:10.1155/2022/1863429 · Cited by 58
Hirata, B. K. S., Banin, R. M., Dornellas, A. P. S., de Andrade, I. S., Zemdegs, J. C. S., Caperuto, L. C., Oyama, L. M., Ribeiro, E. B., & Telles, M. M. (2015) · Mediators of Inflammation · doi:10.1155/2015/419106 · Cited by 50
Feng, M., Liang, T., Gan, L., Liu, Z., & Sun, C. (2014) · Biology of the Cell · doi:10.1111/boc.201400004 · Cited by 49
mTORC1 and the regulation of skeletal muscle anabolism and mass
Adegoke, O. A. J., Abdullahi, A., & Tavajohi‐Fini, P. (2012) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h2012-009 · Cited by 55
Hypothalamic Dysfunction in Obesity and Metabolic Disorders
Carmo‐Silva, S., & Cavadas, C. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-63260-5_4 · Cited by 53
Regazzetti, C., Dumas, K., MARCHAND‐BRUSTEL, Y. L., Peraldi, P., Tanti, J., & Giorgetti‐Peraldi, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052154 · Cited by 47
Self-citationFructose-induced ROS generation impairs glucose utilization in L6 skeletal muscle cells
Jaiswal, N., Maurya, C. K., Pandey, J., Rai, A. K., & Tamrakar, A. K. (2015) · Free Radical Research · doi:10.3109/10715762.2015.1031662 · Cited by 49
Rai, U., Kosuru, R., Prakash, S., Singh, S. P., Birla, H., Tiwari, V. K., & Singh, S. K. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116836 · Cited by 46
de Farias, J., Maggi, R. M., Tromm, C. B., da Silva, L. A., Luciano, T. F., Marques, S. M. S., Lira, F. S., de Souza, C., & Pinho, R. A. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-134 · Cited by 45
Hepatic Gi signaling regulates whole-body glucose homeostasis
Rossi, M., Zhu, L., McMillin, S. M., Pydi, S. P., Jain, S., Wang, L., Cui, Y., Lee, R. J., Cohen, A. H., Kaneto, H., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci94505 · Cited by 46
The relationship between pancreatic cancer and type 2 diabetes: cause and consequence
Li, Y., Bian, X., Wei, S., He, M., & Yang, Y. (2019) · Cancer Management and Research · doi:10.2147/cmar.s211972 · Cited by 49
Ciaraldi, T. P., Aroda, V. R., Mudaliar, S. R. D., & Henry, R. R. (2013) · Metabolism · doi:10.1016/j.metabol.2013.07.004 · Cited by 45
Meng, R., Zhu, D., Bi, Y., Yang, D., & Wang, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053557 · Cited by 44
Yang, S., Pascual-Guiral, S., Landete, R. P., Giménez‐Llort, L., Baltrons, M. A., Arancio, O., Palacio, J. R., Clos, M. V., Yuste, V. J., & Bayascas, J. R. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00435 · Cited by 46
Khan, S., Bjij, I., Betz, R. M., & Soliman, M. E. S. (2018) · Future Medicinal Chemistry · doi:10.4155/fmc-2017-0275 · Cited by 44
Egawa, T., Tsuda, S., Ma, X., Hamada, T., & Hayashi, T. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00249.2011 · Cited by 46
Luo, Z., Xu, W., Yuan, T., Chen, S., Jin, T., Chong, Y., Ji, J., Lin, L., Xu, J., Zhang, Y., et al. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154595 · Cited by 43
Gerrits, A. J., Gitz, E., Koekman, A. C., Visseren, F. L. J., van Haeften, T. W., & Akkerman, J. N. (2012) · Haematologica · doi:10.3324/haematol.2011.054916 · Cited by 43
Parker, L., Stepto, N. K., Shaw, C. S., Serpiello, F. R., Anderson, M. J., Hare, D. L., & Levinger, I. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00411 · Cited by 42
Type 3 diabetes and metabolic reprogramming of brain neurons: causes and therapeutic strategies
Meng, X., Zhang, H., Zhao, Z., Li, S., Zhang, X., Guo, R., Li, H., Yuan, Y., Li, W., Song, Q., et al. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01101-z · Cited by 47
Copps, K. D., Hançer, N. J., Qiu, W., & White, M. F. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.714915 · Cited by 41
Chang, C., Tseng, H.-I., Liao, Y., Yen, C.-H., Chen, T.-M., Lin, C.-C., & Cheng, H. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.09.043 · Cited by 41
Batrakoulis, A., Jamurtas, A. Z., Draganidis, D., Georgakouli, K., Tsimeas, P. D., Poulios, A., Syrou, N. F., Deli, C. K., Παπανικολάου, Κ., Tournis, S., et al. (2021) · Antioxidants · doi:10.3390/antiox10101601 · Cited by 41
The role of interleukin 1β in the anti-adipogenic action of macrophages on human preadipocytes
Gagnon, A., Foster, C. E., Landry, A., & Sorisky, A. (2013) · Journal of Endocrinology · doi:10.1530/joe-12-0565 · Cited by 46
Anusree, S. S., Sindhu, G., Rani, M. R. P., & Raghu, K. G. (2017) · Biochimie · doi:10.1016/j.biochi.2017.11.014 · Cited by 40
Xu, W., Tang, M., Wang, J., & Wang, L. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05816-6 · Cited by 40
Passos, E., Ascensão, A. A. M. R., Martins, M. J., & Magalhães, J. (2015) · Metabolism · doi:10.1016/j.metabol.2015.02.003 · Cited by 40
Parelman, M. A., Storms, D. H., Kirschke, C. P., Huang, L., & Zunino, S. J. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512000037 · Cited by 40
Insulin Receptor Substrate 2 Is Required for Testicular Development
Griffeth, R. J., Carretero, J., & Burks, D. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062103 · Cited by 39
Cellular Senescence in Obesity and Associated Complications: a New Therapeutic Target
Narasimhan, A., Flores, R. R., Camell, C. D., Bernlohr, D., Robbins, P. D., & Niedernhofer, L. J. (2022) · Current Diabetes Reports · doi:10.1007/s11892-022-01493-w · Cited by 40
Li, P., Ding, L., Cao, S., Feng, X., Zhang, Q., Chen, Y., Zhang, N., & Qiu, F. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113015 · Cited by 38
Computational modelling of the regulation of Insulin signalling by oxidative stress
Smith, G. R., & Shanley, D. P. (2013) · BMC Systems Biology · doi:10.1186/1752-0509-7-41 · Cited by 40
Karagiannides, I., Bakirtzi, K., Kokkotou, E. G., Stavrakis, D. G., Margolis, K. G., Thomou, T., Giorgadze, N., Kirkland, J. L., & Pothoulakis, C. (2011) · Endocrinology · doi:10.1210/en.2011-1170 · Cited by 38
mTOR pathway and DNA damage response: A therapeutic strategy in cancer therapy
Pazhooh, R. D., Farnood, P. R., Asemi, Z., Mirsafaei, L., Yousefi, B., & Mirzaei, H. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103142 · Cited by 36
Insulin resistance in glomerular podocytes: Potential mechanisms of induction
Rogacka, D. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.109005 · Cited by 38
Siddiqa, A., Cirillo, E., Tareen, S. H. K., Ali, A., Kutmon, M., Eijssen, L., Ahmad, J., Evelo, C. T., & Coort, S. L. (2017) · Genomics · doi:10.1016/j.ygeno.2017.06.006 · Cited by 37
Sammons, R. M., Perry, N. A., Li, Y., Cho, E. J., Piserchio, A., Zamora‐Olivares, D., Ghose, R., Kaoud, T. S., Debevec, G., Bartholomeusz, C., et al. (2019) · ACS Chemical Biology · doi:10.1021/acschembio.9b00093 · Cited by 36
Bitar, M. S., & Al‐Mulla, F. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.007872 · Cited by 36
NOD1: An Interface Between Innate Immunity and Insulin Resistance
RIVERS, S. L., Klip, A., & Giacca, A. (2019) · Endocrinology · doi:10.1210/en.2018-01061 · Cited by 36
Ahuja, S., Uniyal, A., Akhtar, A., & Sah, S. P. (2019) · Pharmacological Reports · doi:10.1016/j.pharep.2019.02.016 · Cited by 34
Arab, L., Sadeghi, R., Walker, D. G., Lue, L.-F., & Sabbagh, M. N. (2011) · Current Neuropharmacology · doi:10.2174/157015911798376334 · Cited by 35
Insulin signalling in hypothalamic neurones
Belsham, D. D., & Dalvi, P. S. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12919 · Cited by 35
Chang, C., Hsu, C.-M., Li, T.-S., Huang, S.-D., Lin, C.-C., Yen, C., Chou, C., & Cheng, H. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.06.017 · Cited by 33
de Lemos, L., Junyent, F., Camins, A., Castro-Torres, R. D., Folch, J., Olloquequi, J., Beas‐Zárate, C., Verdaguer, E., & Auladell, C. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0669-1 · Cited by 32
Vitamin C deficiency aggravates tumor necrosis factor α-induced insulin resistance
Zhou, Q., Wu, X., Wu, X., & Zou, C. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.03.044 · Cited by 31
Activation of c-Jun N-Terminal Kinase, a Potential Therapeutic Target in Autoimmune Arthritis
Lai, B., Wu, C., & Lai, J. (2020) · Cells · doi:10.3390/cells9112466 · Cited by 32
Chuang, W.-T., Yen, C., Huang, C., Chen, H., & Lii, C. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c06269 · Cited by 33
Targeting Insulin for Alzheimer’s Disease: Mechanisms, Status and Potential Directions
Lee, J. H., Jahrling, J. B., Denner, L. A., & Dineley, K. T. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179923 · Cited by 36
Dual-Specific Protein and Lipid Phosphatase PTEN and Its Biological FunctionsPreprint
Tu, T., Chen, J., Chen, L., & Stiles, B. L. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a036301 · Cited by 34
Karagiannides, I., Golovatscka, V., Bakirtzi, K., Sideri, A., Salas, M. C., Stavrakis, D. G., Polytarchou, C., Iliopoulos, D., Pothoulakis, C., & Bradesi, S. (2014) · Physiological Reports · doi:10.14814/phy2.284 · Cited by 33
Ding, Y., Liu, Y., Fei, F., Yang, L., Mao, G., Zhao, T. K., Zhang, Z., Yan, M., Feng, W., & Wu, X. (2019) · Toxicology · doi:10.1016/j.tox.2019.05.011 · Cited by 31
The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions
Sorriento, D., Rusciano, M. R., Visco, V., Fiordelisi, A., Cerasuolo, F. A., Poggio, P., Ciccarelli, M., & Iaccarino, G. (2021) · Cells · doi:10.3390/cells10010167 · Cited by 31
Hyperglycemia and Loss of Redox Homeostasis in COVID-19 Patients
Soto, M. E., Guarner‐Lans, V., Díaz‐Díaz, E., Manzano-Pech, L., Chavarría, A. P., Valdez‐Vázquez, R. R., Aisa-Álvarez, A., Saucedo‐Orozco, H., & Pérez-Torres, I. (2022) · Cells · doi:10.3390/cells11060932 · Cited by 31
Replacing SNAP-25b with SNAP-25a expression results in metabolic disease
Valladolid‐Acebes, I., Daraio, T., Brismar, K., Harkany, T., Ögren, S. O., Hökfelt, T. G. M., & Bark, C. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1511951112 · Cited by 31
Insulin resistance, steatosis and hepatitis C virus
Mangia, A., & Ripoli, M. C. (2013) · Hepatology International · doi:10.1007/s12072-013-9460-1 · Cited by 30
Treatment of Nonalcoholic Steatohepatitis in Adults: Present and Future
Gitto, S., Vitale, G., Villa, E., & Andreoné, P. (2015) · Gastroenterology Research and Practice · doi:10.1155/2015/732870 · Cited by 30
Small intestine remodeling in male Goto–Kakizaki rats
Pereira, J. N. B., Murata, G. M., Sato, F. T., Marosti, A. R., Carvalho, C. R. D. O., & Curi, R. (2021) · Physiological Reports · doi:10.14814/phy2.14755 · Cited by 30
Passos, E., Pereira, C., Gonçalves, I. O., Rocha‐Rodrigues, S., Silva, N., Guimarães, J. T., Neves, D., Ascensão, A. A. M. R., Magalhães, J., & Martins, M. J. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.12.013 · Cited by 31
Ding, Y., Gao, K., Liu, Y., Mao, G., Chen, K., Qiu, X., Zhao, T., Yang, L., Feng, W., & Wu, X. (2019) · Archives of Toxicology · doi:10.1007/s00204-019-02590-8 · Cited by 31
Recent advances in development of hetero-bivalent kinase inhibitors
Lee, S., Kim, J., Jo, J., Chang, J. W., Sim, J., & Yun, H. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113318 · Cited by 30
Fatty acids role on obesity induced hypothalamus inflammation: From problem to solution – A review
Salsinha, A. S., Rodríguez-Alcalá, L. M., Relvas, J. B., & Pintado, M. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.03.042 · Cited by 29
Zhang, H., Ge, Z., Tang, S., Meng, R., Bi, Y., & Zhu, D. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6810 · Cited by 29
Ghasemi, R., Moosavi, M., Zarifkar, A., Rastegar, K., & Maghsoudi, N. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0622-6 · Cited by 28
Vázquez‐Meza, H., de Piña, M., Pardo, J. P., Riveros‐Rosas, H., Villalobos‐Molina, R., & Piña, E. (2013) · BMC Biochemistry · doi:10.1186/1471-2091-14-13 · Cited by 28
Proteomic and bioinformatic analysis of membrane proteome in type 2 diabetic mouse liver
Kim, G., Park, E. C., Yun, S., Hong, Y., Lee, D. G., Shin, E., Jung, J., Kim, Y. H., Lee, K., Jang, I., et al. (2013) · PROTEOMICS · doi:10.1002/pmic.201200210 · Cited by 28
Xin, Y., Zhang, D., Fu, Y., Wang, C., Li, Q., Tian, C., Suhe, Z., & Lyu, X. (2017) · Endocrine Journal · doi:10.1507/endocrj.ej17-0128 · Cited by 28
Zhao, X., Feng, X., Zhao, X., Jiang, Y., Li, X., Niu, J., Meng, X., Wu, J., Xu, G., Hou, L., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.659268 · Cited by 28
Lee, H., & Lee, J. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13993 · Cited by 28
Butterfield, D. A., Favia, M., Spera, I., Campanella, A., Lanza, M., & Castegna, A. (2022) · Molecules · doi:10.3390/molecules27030951 · Cited by 29
Metadata
- Authors
- Tanti, J.-F., & Jager, J.
- Affiliations
- Inserm (FR)
- Corresponding author
- Tanti, Jean-François
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 9
- Issue
- 6
- Pages
- 753-762
- ISSN
- 1471-4892 (ISSN-L)
- OpenAlex
- W2001649002
- Cited by
- 430
- References
- 74
- Citations by year
- 2026: 19 · 2025: 14 · 2024: 8 · 2023: 17 · 2022: 29 · 2021: 24 · 2020: 17 · 2019: 20 · 2018: 23 · 2017: 28 · 2016: 32 · 2015: 36 · 2014: 41 · 2013: 41 · 2012: 38
- FWCI
- 18.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- insulin resistance, insulin receptor substrate, serine phosphorylation, insulin signaling, IKKβ, NF-κB, JNK, ERK, mTOR, S6K, inflammation, obesity, adipose tissue, liver, hypothalamus, myeloid cells
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Humans, Inflammation, Insulin Resistance, Models, Biological, Phosphorylation, Signal Transduction, NF-kappa B, Drug Delivery Systems, Protein Serine-Threonine Kinases, Mice, Knockout, Intracellular Signaling Peptides and Proteins, Mice, I-kappa B Kinase, Insulin Receptor Substrate Proteins, TOR Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review