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Exploration of natural flavones’ bioactivity and bioavailability in chronic inflammation induced-type-2 diabetes mellitus

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A systematic analysis of natural α-glucosidase inhibitors from flavonoids of Radix scutellariae using ultrafiltration UPLC-TripleTOF-MS/MS and network pharmacology

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Links between oral microbiome and insulin resistance: Involvement of MAP kinase signaling pathway

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Unlocking the secrets: Adipose tissue dysfunction and atherosclerosis-mechanisms and innovative therapeutic approaches

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Regulation of insulin resistance and glucose metabolism by interaction of PIM kinases and insulin receptor substrates

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Phospholipase C: underrated players in microbial infections

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Both ERK1 and ERK2 Are Required for Enterovirus 71 (EV71) Efficient Replication

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Conditioned medium of adipose derived Mesenchymal Stem Cells reverse insulin resistance through downregulation of stress induced serine kinases

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Insulin down-regulates specific activity of ATP-binding cassette transporter A1 for high density lipoprotein biogenesis through its specific phosphorylation

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Macrophage-Mediated Effects of Airborne Fine Particulate Matter (PM2.5) on Hepatocyte Insulin Resistance in Vitro

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Alleviating VLDL overproduction is an important mechanism for Laminaria japonica polysaccharide to inhibit atherosclerosis in LDLr−/− mice with diet‐induced insulin resistance

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Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases

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Increased Circulation and Adipose Tissue Levels of DNAJC27/RBJ in Obesity and Type 2-Diabetes

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The Stress-Responsive microRNA-34a Alters Insulin Signaling and Actions in Adipocytes through Induction of the Tyrosine Phosphatase PTP1B

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Large-scale network models of IL-1 and IL-6signalling and their hepatocellular specification

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Prenatal Stress Enhances Excitatory Synaptic Transmission and Impairs Long-Term Potentiation in the Frontal Cortex of Adult Offspring Rats

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Involvement of protein tyrosine phosphatases and inflammation in hypothalamic insulin resistance associated with ageing: Effect of caloric restriction

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Physical activity is associated with retained muscle metabolism in human myotubes challenged with palmitate

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Diabetic Kinome Inhibitors—A New Opportunity for β-Cells Restoration

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Cafeteria diet intake for fourteen weeks can cause obesity and insulin resistance in Wistar rats

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Impairment of insulin receptor substrate 1 signaling by insulin resistance inhibits neurite outgrowth and aggravates neuronal cell death

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Phyllodulcin, a natural functional sweetener, improves diabetic metabolic changes by regulating hepatic lipogenesis, inflammation, oxidative stress, fibrosis, and gluconeogenesis in db/db mice

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Curcumin and docosahexaenoic acid block insulin-induced colon carcinoma cell proliferation

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Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development

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Synergistic effects of β-amyloid and ceramide-induced insulin resistance on mitochondrial metabolism in neuronal cells

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Paradoxical effect of rapamycin on inflammatory stress-induced insulin resistance in vitro and in vivo

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Gut-liver axis in diabetes: Mechanisms and therapeutic opportunities

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Implication of the Tpl2 Kinase in Inflammatory Changes and Insulin Resistance Induced by the Interaction Between Adipocytes and Macrophages

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Hyperinsulinemia alters insulin receptor presentation and internalization in brain microvascular endothelial cells

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Crosstalk Between Insulin and Toll-like Receptor Signaling Pathways in the Central Nervous system

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Disorders of the Endocrine System

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Mechanisms of action of ginger in nuclear factor-kappaB signaling pathways in diabetes

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Blood transcriptome profiling as potential biomarkers of suboptimal health status: potential utility of novel biomarkers for predictive, preventive, and personalized medicine strategy

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MAP3K8 (TPL2/COT) Affects Obesity-Induced Adipose Tissue Inflammation without Systemic Effects in Humans and in Mice

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A model integration approach linking signalling and gene-regulatory logic with kinetic metabolic models

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5′-AMP-activated protein kinase increases glucose uptake independent of GLUT4 translocation in cardiac myocytes

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Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes

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Altered expression of IRS2 and GRB2 in demyelination of peripheral neurons: Implications in diabetic neuropathy

Manu, M. S., Rachana, K. S., & Advirao, G. M. (2016) · Neuropeptides · doi:10.1016/j.npep.2016.12.004 · Cited by 20

Combination of mulberry leaf and oat bran possessed greater hypoglycemic effect on diabetic mice than mulberry leaf or oat bran alone

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Troglitazone induces cytotoxicity in part by promoting the degradation of peroxisome proliferator‐activated receptor γ co‐activator‐1α protein

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The role of ERK1/2 signaling in diabetes: pathogenic and therapeutic implications

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NF-κB-Inducing Kinase Provokes Insulin Resistance in Skeletal Muscle of Obese Mice

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Plasma 25-Hydroxyvitamin D Is Related to Protein Signaling Involved in Glucose Homeostasis in a Tissue-Specific Manner

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miR‐375 induces adipogenesis through targeting Erk1 in pancreatic duct cells under the influence of sodium palmitate

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The intestine and the microbiota in maternal glucose homeostasis during pregnancy

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Exopolysaccharides of Bacillus amyloliquefaciens Amy-1 Mitigate Inflammation by Inhibiting ERK1/2 and NF-κB Pathways and Activating p38/Nrf2 Pathway

Sung, W., Lin, Y.-Y., Huang, S.-D., & Cheng, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810237 · Cited by 18

Smilax china L. Polyphenols Improves Insulin Resistance and Obesity in High-fat Diet-induced Mice Through IRS/AKT-AMPK and NF-κB Signaling Pathways

Xu, M. J., Xue, H., Kong, L., Lin, L., & Zheng, G. (2023) · Plant Foods for Human Nutrition · doi:10.1007/s11130-023-01052-y · Cited by 18

Review article Insulin resistance and its consequences in chronic hepatitis C

Kukla, M., Piotrowski, D., Waluga, M., & Hartleb, M. (2015) · Clinical and Experimental Hepatology · doi:10.5114/ceh.2015.51375 · Cited by 18

Permethrin decreased insulin-stimulated AKT phosphorylation dependent on extracellular signal-regulated kinase-1 (ERK), but not AMP-activated protein kinase α (AMPKα), in C2C12 myotubes

Sun, Q., Peng, Y., Qi, W., Kim, Y., Clark, J. M., Kim, D., & Park, Y. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.08.046 · Cited by 18

Hepatitis C Virus Clearance with Glucose Improvement and Factors Affecting the Glucose Control in Chronic Hepatitis C Patients

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Short‐Term Lenalidomide (Revlimid) Administration Ameliorates Cardiomyocyte Contractile Dysfunction in ob/ob Obese Mice

Li, L., Hua, Y., Dong, M., Li, Q., Smith, D. T., Yuan, M., Jones, K. R., & Ren, J. T. (2012) · Obesity · doi:10.1038/oby.2012.106 · Cited by 18

Involvement of Activation of Mitogen-Activated Protein Kinase (MAPK)/Extracellular Signal-Regulated Kinase (ERK) Signaling Pathway in Proliferation of Urethral Plate Fibroblasts in Finasteride-Induced Rat Hypospadias

An, N., Peng, J., He, G., Fan, X., Li, F. R., & Chen, H. (2018) · Medical Science Monitor · doi:10.12659/msm.911271 · Cited by 18

GPR21 Inhibition Increases Glucose-Uptake in HepG2 Cells

Kinsella, G. K., Cannito, S., Bordano, V., Stephens, J. C., Rosa, A. C., Miglio, G., Guaschino, V., Iannaccone, V., Findlay, J. B. C., & Benetti, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910784 · Cited by 17

Insulin Resistance May Contribute to Upregulation of Adhesion Molecules on Endothelial Cells in Psoriatic Plaques

Schlüter, K., Diehl, S., Lang, V., Kaufmann, R., Boehncke, W., & Bürger, C. (2015) · Acta Dermato Venereologica · doi:10.2340/00015555-2227 · Cited by 17

Vascular smooth muscle insulin resistance, but not hypertrophic signaling, is independent of angiotensin II-induced IRS-1 phosphorylation by JNK

Hitomi, H., Mehta, P. K., Taniyama, Y., Lassegue, B. P., Seidel-Rogol, B. L., Martín, A. S., & Griendling, K. K. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00017.2011 · Cited by 17

Maternal selenium status is profoundly involved in metabolic fetal programming by modulating insulin resistance, oxidative balance and energy homeostasis

Ojeda, M. L., Nogales, F., Membrilla, A., & Carreras, O. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1861-4 · Cited by 17

Bitter Melon Extract Yields Multiple Effects on Intestinal Epithelial Cells and Likely Contributes to Anti-diabetic Functions

Chang, C., Cheng, S., Nurlatifah, A. O., Sung, W., Tu, J.-H., Lee, L.-L., & Cheng, H. (2021) · International Journal of Medical Sciences · doi:10.7150/ijms.55866 · Cited by 17

MiRNA and mRNA Profiling in Systemic Lupus Reveals a Novel Set of Cytokine - Related miRNAs and their Target Genes in Cases With and Without Renal Involvement

Ghods, F. J., Sarıkaya, A. T., Arda, N., & Hamuryudan, V. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000485987 · Cited by 16

Investigating the role of P38, JNK and ERK in LPS induced hippocampal insulin resistance and spatial memory impairment

Iloun, P., Abbasnejad, Z., Janahmadi, M., Ahmadiani, A., & Ghasemi, R. (2018) · EXCLI journal · doi:10.17179/excli2018-1387 · Cited by 16

Heat treatment reduced the expression of miR-7-5p to facilitate insulin-stimulated lactate secretion by targeting IRS2 in boar Sertoli cells

Gan, L., Huang, S., Hu, Y., Zhang, J., & Wang, X. (2021) · Theriogenology · doi:10.1016/j.theriogenology.2021.12.029 · Cited by 16

Time-course study of high fat diet induced alterations in spatial memory, hippocampal JNK, P38, ERK and Akt activity

Abbasnejad, Z., Nasseri, B., Zardooz, H., & Ghasemi, R. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0369-1 · Cited by 16

Garlic ( Allium sativum L. ) in diabetes and its complications: Recent advances in mechanisms of action

Jiang, Y., Yue, R., Liu, G., Liu, J., Peng, B., Yang, M., Zhao, L., & Li, Z. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2153793 · Cited by 21

Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways

Li, D., Fan, J., Du, L., & Ren, G. (2024) · Archives of Pharmacal Research · doi:10.1007/s12272-024-01485-2 · Cited by 15

The Role of Calpain in Diabetes-Associated Platelet Hyperactivation

Randriamboavonjy, V., & Fleming, I. (2010) · Advances in pharmacology · doi:10.1016/s1054-3589(10)59008-2 · Cited by 15

2,4-Thiazolidinediones as PTP 1B Inhibitors: A Mini Review (2012-2018)

Verma, S. K., Yadav, Y. S., & Thareja, S. (2019) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557518666181026092029 · Cited by 15

Dendrobium mixture improves gestational diabetes mellitus through regulating Nrf2/HO1 signaling pathway

Wang, H., Chen, X., Miao, X., Lu, K., He, M., & Wu, X. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113656 · Cited by 14

The neuropeptide substance P/neurokinin‐1 receptor system and diabetes: From mechanism to therapy

Kokabi, F., Ebrahimi, S., Mirzavi, F., Nooghabi, N. G., Hashemi, S. F., & Hashemy, S. I. (2023) · BioFactors · doi:10.1002/biof.1935 · Cited by 14

Inflammation in human adipose tissues–Shades of gray, rather than white and brown

Rakotoarivelo, V., Variya, B. C., Ilangumaran, S., Langlois, M., & Ramanathan, S. (2018) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2018.10.001 · Cited by 14

Smoothelin-Like Protein 1 Regulates Development and Metabolic Transformation of Skeletal Muscle in Hyperthyroidism

Major, E., Győry, F., Horváth, D., Keller, I., Tamás, I., Uray, K., Fülöp, P., & Lontay, B. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.751488 · Cited by 14

Prediction of functional phosphorylation sites by incorporating evolutionary information

Niu, S., Wang, Z., Ge, D., Zhang, G., & Li, Y. (2012) · Protein & Cell · doi:10.1007/s13238-012-2048-z · Cited by 13

Extracellular vesicles regulate the transmission of insulin resistance and redefine noncommunicable diseases

Li, B., Wan, L., Liu, T., & Zha, L. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1024786 · Cited by 15

Free fatty acid induced impairment of insulin signaling is prevented by the diastereomeric mixture of calophyllic acid and isocalophyllic acid in skeletal muscle cells

Jaiswal, N., Naresh, G., Maurya, C. K., Narender, T., & Tamrakar, A. K. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.10.049 · Cited by 13

Amyloid β oligomer-induced ERK1/2-dependent serine 636/639 phosphorylation of insulin receptor substrate-1 impairs insulin signaling and glycogen storage in human astrocytes

Zhang, Q., Guo, S., Zhang, X., Tang, S. H., Wang, L., Xiaojuan, H., Shao, W., Cong, L., & Du, Y. (2015) · Gene · doi:10.1016/j.gene.2015.02.011 · Cited by 13

Improved insulin sensitivity with calorie restriction does not require reduced JNK1/2, p38, or ERK1/2 phosphorylation in skeletal muscle of 9-month-old rats

Sharma, N., Bhat, A. D., Kassa, A. D., Xiao, Y., Arias, E. B., & Cartee, G. D. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00372.2011 · Cited by 13

Fructose exposure during gestation and lactation altered hepatic selenoprotein expression, oxidative balance and metabolic profile in female rat pups

Ojeda, M. L., Carreras, O., del Valle, P. M., Murillo, M. L. O., & Nogales, F. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.01.026 · Cited by 12

Human cytomegalovirus attenuates AKT activity by destabilizing insulin receptor substrate proteins

Domma, A. J., Henderson, L. A., Goodrum, F. D., Moorman, N. J., & Kamil, J. P. (2023) · Journal of Virology · doi:10.1128/jvi.00563-23 · Cited by 12

Ingestion of a natural mineral-rich water in an animal model of metabolic syndrome: effects in insulin signalling and endoplasmic reticulum stress

Pereira, C., Passos, E., Severo, M., Vitó, I., Wen, X., Carneiro, F., Gomes, P., Monteiro, R., & Martins, M. J. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0033 · Cited by 12

Methionine sulfoxide reductase B1 deficiency does not increase high-fat diet-induced insulin resistance in mice

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