The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation
Abstract
Insulin receptor substrates (IRS) serine phosphorylation is a time-controlled physiological feedback mechanism in insulin signaling that is hijacked by metabolic and inflammatory stresses to promote insulin resistance. Kinases, including IKKbeta, JNK, ERK, mTOR, and S6K, activated by the inducers of insulin resistance induce uncontrolled IRS serine phosphorylation. Studies with genetically modified mice reveal that these kinases integrate signals from metabolic and inflammatory stresses in adipose tissue, liver, and hypothalamus leading to peripheral and central insulin resistance. Moreover, IKKbeta/NF-kappaB and JNK1 pathways in myeloid cells represent a core mechanism involved in inflammation linked to obesity. These kinases are thus potential drug targets against insulin resistance and the targeting of the IKKbeta/NF-kappaB or the JNK pathway may evolve into future diabetes medication.
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“Increased stress kinase activity also has been implicated in contribute to the serine phosphorylation of IRS-1 and subsequent impairment tyrosine phosphorylation [177, 178].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [177]
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1 retracted
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RetractedInflammation and metabolic disorders
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A central role for JNK in obesity and insulin resistance
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Molecular mechanisms of mTOR-mediated translational control
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Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245
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Obesity, Inflammation, and Insulin Resistance
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IKK-β links inflammation to obesity-induced insulin resistance
Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z.-W., Long, J. M., Wynshaw-Boris, A., Poli, G., Olefsky, J., & Karin, M. (2005) · Nature Medicine · doi:10.1038/nm1185 · Cited by 1,773
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
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Items 401–431 of 431
Role de l’axe endothéline-1 et des map kinases dans la physiologie des leiomyomes utérins de rates
Oyeniran, C. (2011) · theses.fr (ABES) · doi:10.70675/3fd6b30dz83a2z4e57zb7a7z8679ee073766
Étude du rôle de la production hépatique de glucose dans le développement du diabète et de l’obésité
Abdul-Wahed, A. (2012) · theses.fr (ABES) · doi:10.70675/61924053za287z4f04zb650zc51c1916ee64
Vella, R. (2013) · theses.fr (ABES) · doi:10.70675/5d6d7be0z4be0z4763z94a7z7426da9a6eb3
Inflammation du tissu adipeux au cours de l'obésité humaine : implication des lymphocytes Th17
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Étude de la sensibilité à l’insuline du tissu adipeux en absence de production hépatique de glucose
Casteras, S. (2012) · theses.fr (ABES) · doi:10.70675/7b0400e0z9e49z4df6za2c1z0c19ce63d0ca
Marziou, A. (2021) · theses.fr (ABES) · doi:10.70675/5ac5d7aez174dz4164z86fbze535a2a8522a
Lipid rewiring by adipose tissue macrophages during diet-induced inflammation and insulin resistance
Dahik, V. D. (2023) · theses.fr (ABES) · doi:10.70675/8f4f001ez6ebez4d7az934bz039a1f4d4116
Hu, X., Yang, X., Zhu, Z., Yang, Z., Wang, P., Wu, M., & Zhang, N. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1768784
Molecular interplay of insulin resistance and cancer: advances in monoclonal antibody therapeutics
Moni, S. S., Ayish, F., Musawi, S., Salawi, A., Elmobark, M. E., Jabeen, A., Mohammed, M. A. A., Aqdi, M. J., Aziabi, M. Y., Harbi, R. H., et al. (2026) · Cancer Biology & Therapy · doi:10.1080/15384047.2026.2708386
Xu, X.-Z., Dong, M.-S., Dai, J.-Y., Wang, Q.-Y., Dong, X.-C., & Jin, Y. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1865281
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Heart and Brain: Linking Obesity-Related Inflammation, Cardiovascular Disease and Cognitive Function
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Brain insulin resistance and microglial immunometabolic dysregulation in neurodegenerative diseases
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BindingDB (2023) · UC San Diego · doi:10.7270/q2zg6xb2
BindingDB Entry 50015607: Recent advances in development of hetero-bivalent kinase inhibitors.
BindingDB (2023) · UC San Diego · doi:10.7270/q25q5115
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Metadata
- Authors
- Tanti, J.-F., & Jager, J.
- Affiliations
- Inserm (FR)
- Corresponding author
- Tanti, Jean-François
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 9
- Issue
- 6
- Pages
- 753-762
- ISSN
- 1471-4892 (ISSN-L)
- OpenAlex
- W2001649002
- Cited by
- 430
- References
- 74
- Citations by year
- 2026: 19 · 2025: 14 · 2024: 8 · 2023: 17 · 2022: 29 · 2021: 24 · 2020: 17 · 2019: 20 · 2018: 23 · 2017: 28 · 2016: 32 · 2015: 36 · 2014: 41 · 2013: 41 · 2012: 38
- FWCI
- 18.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- insulin resistance, insulin receptor substrate, serine phosphorylation, insulin signaling, IKKβ, NF-κB, JNK, ERK, mTOR, S6K, inflammation, obesity, adipose tissue, liver, hypothalamus, myeloid cells
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Humans, Inflammation, Insulin Resistance, Models, Biological, Phosphorylation, Signal Transduction, NF-kappa B, Drug Delivery Systems, Protein Serine-Threonine Kinases, Mice, Knockout, Intracellular Signaling Peptides and Proteins, Mice, I-kappa B Kinase, Insulin Receptor Substrate Proteins, TOR Serine-Threonine Kinases
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