SIRT1 signaling as potential modulator of skeletal muscle diseases

Missing Pieces in the NF-κB Puzzle

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Fiber Types in Mammalian Skeletal Muscles

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Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

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Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

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The muscular dystrophies

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Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α

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PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription

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Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

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Aberrant repair and fibrosis development in skeletal muscle

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Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

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Sir2 Regulates Skeletal Muscle Differentiation as a Potential Sensor of the Redox State

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Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy

Villalta, S. A., Nguyen, H. X., Deng, B., Gotoh, T., & Tidball, J. G. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn376 · Cited by 512 · see citing works

Sirtuins, Aging, and Medicine

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Regulation of Hypoxia-Inducible Factor 2α Signaling by the Stress-Responsive Deacetylase Sirtuin 1

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Interplay of IKK/NF-κB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy

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SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity

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Macrophage α1 AMP-activated Protein Kinase (α1AMPK) Antagonizes Fatty Acid-induced Inflammation through SIRT1

Yang, Z., Kahn, B. B., Shi, H., & Xue, B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.123620 · Cited by 413 · see citing works

The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy

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The emerging biology of satellite cells and their therapeutic potential

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Myeloid Deletion of SIRT1 Induces Inflammatory Signaling in Response to Environmental Stress

Schug, T. T., Xu, Q., Gao, H., Peres-da-Silva, A., Draper, D. W., Fessler, M. B., Purushotham, A., & Li, X. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00657-10 · Cited by 324 · see citing works

Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration

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TNF-α regulates myogenesis and muscle regeneration by activating p38 MAPK

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SirT1 Regulates Adipose Tissue Inflammation

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Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis

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The Sirtuin family: therapeutic targets to treat diseases of aging

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Disruption of either the Nfkb1 or the Bcl3 gene inhibits skeletal muscle atrophy

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SIRT1 Controls the Transcription of the Peroxisome Proliferator-activated Receptor-γ Co-activator-1α (PGC-1α) Gene in Skeletal Muscle through the PGC-1α Autoregulatory Loop and Interaction with MyoD

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Sirtuin 1 (SIRT1) Deacetylase Activity Is Not Required for Mitochondrial Biogenesis or Peroxisome Proliferator-activated Receptor-γ Coactivator-1α (PGC-1α) Deacetylation following Endurance Exercise

Philp, A., Chen, A., Lan, D., Meyer, G. A., Murphy, A. N., Knapp, A. E., Olfert, I. M., McCurdy, C. E., Marcotte, G. R., Hogan, M. C., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.261685 · Cited by 184 · see citing works

Resistance training in the oldest old: consequences for muscle strength, fiber types, fiber size, and MHC isoforms

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Resveratrol Ameliorates Muscular Pathology in the Dystrophic mdx Mouse, a Model for Duchenne Muscular Dystrophy

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IFN-γ Promotes Muscle Damage in the <i>mdx</i> Mouse Model of Duchenne Muscular Dystrophy by Suppressing M2 Macrophage Activation and Inhibiting Muscle Cell Proliferation

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Regulation of muscle atrophy in aging and disease

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PGC-1α regulates a HIF2α-dependent switch in skeletal muscle fiber types

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NF-κB Signaling in the Aging Process

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mIGF‐1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart

Vinciguerra, M., Santini, M. P., Martínez, C., Pazienza, V., Claycomb, W. C., Giuliani, A., & Rosenthal, N. A. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00766.x · Cited by 122 · see citing works

NF-κB Signaling in Skeletal Muscle Health and Disease

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Sirt1 increases skeletal muscle precursor cell proliferation

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Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity

Vinciguerra, M., Santini, M. P., Claycomb, W. C., Ladurner, A. G., & Rosenthal, N. A. (2009) · Aging · doi:10.18632/aging.100107 · Cited by 110 · see citing works

The physiological roles of Sirt1 in skeletal muscle

Pardo, P. S., & Boriek, A. M. (2011) · Aging · doi:10.18632/aging.100312 · Cited by 99 · see citing works

Interferon gamma (IFN-γ) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription

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Increased nuclear proteins in muscle satellite cells in aged animals as compared to young growing animals

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Alterations in the mitochondrial regulatory pathways constituted by the nuclear co-factors PGC-1α or PGC-1β and mitofusin 2 in skeletal muscle in type 2 diabetes

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SirT1 in muscle physiology and disease: lessons from mouse models

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Aging-Dependent Regulation of Antioxidant Enzymes and Redox Status in Chronically Loaded Rat Dorsiflexor Muscles

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Acute exercise reverses aged-induced impairments in insulin signaling in rodent skeletal muscle

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Inhibition of the IKK/NF-κB pathway by AAV gene transfer improves muscle regeneration in older mdx mice

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Transforming Growth Factor-β-activated Kinase 1 Is an Essential Regulator of Myogenic Differentiation

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Genetic Defects in Muscular Dystrophy

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Mechanisms for fiber-type specificity of skeletal muscle atrophy

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Muscle wasting in end-stage renal disease promulgates premature death: established, emerging and potential novel treatment strategies

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Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults

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SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens

Kim, H.-D., Hesterman, J., Call, T., Magazu, S., Keeley, E., Armenta, K., Kronman, H., Neve, R. L., Nestler, E. J., & Ferguson, D. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0212-16.2016 · Cited by 158 · see citing works

The Role of Metabolic Remodeling in Macrophage Polarization and Its Effect on Skeletal Muscle Regeneration

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A Twist2-dependent progenitor cell contributes to adult skeletal muscle

Liu, N., Garry, G. A., Li, S., Bezprozvannaya, S., Sanchez‐Ortiz, E., Chen, B., Shelton, J. M., Jaichander, P., Bassel‐Duby, R., & Olson, E. N. (2017) · Nature Cell Biology · doi:10.1038/ncb3477 · Cited by 144 · see citing works

Role and possible mechanisms of Sirt1 in depression

Lu, G., Li, J., Zhang, H., Zhao, X., Yan, L.-J., & Yang, X. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8596903 · Cited by 106 · see citing works

FGF19 protects skeletal muscle against obesity‐induced muscle atrophy, metabolic derangement and abnormal irisin levels via the AMPK/SIRT‐1/PGC‐α pathway

Guo, A., Li, K., Tian, H., Fan, Z., Chen, Q., Yang, Y., Yu, J., Wu, Y., & Xiao, Q. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16448 · Cited by 112 · see citing works

GLP-1RA Liraglutide and Semaglutide Improves Obesity-Induced Muscle Atrophy via SIRT1 Pathway

Xiang, J., Qin, L., Zhong, J., Xia, N., & Liang, Y. (2023) · Diabetes, Metabolic Syndrome and Obesity · doi:10.2147/dmso.s425642 · Cited by 100 · see citing works

Exercise training augments Sirt1-signaling and attenuates cardiac inflammation in D-galactose induced-aging rats

Chen, W.-K., Tsai, Y., Shibu, M. A., Shen, C.-Y., Chang-Lee, S. N., Chen, R., Yao, C., Ban, B., Kuo, W., & Huang, C. (2018) · Aging · doi:10.18632/aging.101714 · Cited by 86 · see citing works

Dysregulation of SIRT-1 in aging mice increases skeletal muscle fatigue by a PARP-1-dependent mechanism

Mohamed, J. S., Wilson, J. C., Myers, M. J., Sisson, K. J., & Alway, S. E. (2014) · Aging · doi:10.18632/aging.100696 · Cited by 81 · see citing works

The impact of resveratrol and hydrogen peroxide on muscle cell plasticity shows a dose-dependent interaction

Bosutti, A., & Degens, H. (2015) · Scientific Reports · doi:10.1038/srep08093 · Cited by 81 · see citing works

An extensive review regarding the adipokines in the pathogenesis and progression of osteoarthritis.

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Effects of Ginsenoside Rg3 on fatigue resistance and SIRT1 in aged rats.

Yang, Q.-Y., Lai, X., Ouyang, J., & Yang, J.-D. (2018) · Toxicology · doi:10.1016/j.tox.2018.08.010 · Cited by 68 · see citing works

Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice

Shiota, A., Shimabukuro, M., Fukuda, D., Soeki, T., Sato, H., Uematsu, E., Hirata, Y., Kurobe, H., Maeda, N., Sakaue, H., et al. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-139 · Cited by 64 · see citing works

Impact of Selected Glucagon-like Peptide-1 Receptor Agonists on Serum Lipids, Adipose Tissue, and Muscle Metabolism—A Narrative Review

Szekeres, Z., Nagy, A., Jahner, K., & Szabados, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158214 · Cited by 66 · see citing works

COPD elicits remodeling of the diaphragm and vastus lateralis muscles in humans

Levine, S., Bashir, M. H., Clanton, T. L., Powers, S. K., & Singhal, S. K. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01121.2012 · Cited by 61 · see citing works

Control of MicroRNA Expression as a New Way for Resveratrol To Deliver Its Beneficial Effects

Lançon, A., Kaminski, J., Tili, E., Michaille, J., & Latruffe, N. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf301479v · Cited by 58 · see citing works

Celastrol attenuates inflammatory responses in adipose tissues and improves skeletal muscle mitochondrial functions in high fat diet-induced obese rats via upregulation of AMPK/SIRT1 signaling pathways

Abu Bakar, M. H., Shariff, K. A., Tan, J. S., & Lee, L. K. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173371 · Cited by 51 · see citing works

Biomarkers of frailty

Assar, M. E., Rodríguez-Sánchez, I., Álvarez‐Bustos, A., & Rodríguez‐Mañas, L. (2024) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2024.101271 · Cited by 50 · see citing works

Perturbations of NAD+salvage systems impact mitochondrial function and energy homeostasis in mouse myoblasts and intact skeletal muscle

Agerholm, M., Dall, M., Jensen, B. A. H., Prats, C., Madsen, S., Basse, A. L., Graae, A.-S., Risis, S., Goldenbaum, J., Quistorff, B., et al. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00213.2017 · Cited by 43 · see citing works

Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice.

Xu, C., Bai, B., Fan, P., Cai, Y., Huang, B., Law, I. K. M., Liu, L., Xu, A., Tung, C., Li, X., et al. (2013) · Europe PMC (PubMed Central) · Cited by 42 · see citing works

Regulation of stem cell aging by SIRT1 – Linking metabolic signaling to epigenetic modifications

An, Y., & Dang, W. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.03.031 · Cited by 32 · see citing works

Boosting the peripheral immune response in the skeletal muscles improved motor function in ALS transgenic mice

Trolese, M. C., Scarpa, C., Melfi, V., Fabbrizio, P., Sironi, F. M., Rossi, M., Bendotti, C., & Nardo, G. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.04.018 · Cited by 29 · see citing works

SIRT1: A Novel Target for the Treatment of Muscular Dystrophies

Kuno, A., & Horio, Y. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/6714686 · Cited by 29 · see citing works

A novel dipeptide from potato protein hydrolysate augments the effects of exercise training against high-fat diet-induced damages in senescence-accelerated mouse-prone 8 by boosting pAMPK / SIRT1/ PGC-1α/ pFOXO3 pathway

Shibu, M. A., Wang, T., Wang, M.-F., & Lin, W. (2020) · Aging · doi:10.18632/aging.103081 · Cited by 28 · see citing works

Cardioprotective mIGF-1/SIRT1 signaling induces hypertension, leukocytosis and fear response in mice

Bolasco, G., Calogero, R., Carrara, M., Banchaabouchi, M. A., Bilbao, D., Mazzoccoli, G., & Vinciguerra, M. (2012) · Aging · doi:10.18632/aging.100464 · Cited by 26 · see citing works

SIRT1 Coordinates Transcriptional Regulation of Neural Activity and Modulates Depression-Like Behaviors in the Nucleus Accumbens

Kim, H., Wei, J., Call, T., Ma, X., Quintus, N. T., Summers, A. J., Carotenuto, S., Johnson, R., Nguyen, A., Cui, Y., et al. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.03.017 · Cited by 21 · see citing works

Epitranscriptomics as a New Layer of Regulation of Gene Expression in Skeletal Muscle: Known Functions and Future Perspectives

Imbriano, C., Moresi, V., Belluti, S., Renzini, A., Cavioli, G., Maretti, E., & Molinari, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015161 · Cited by 20 · see citing works

Metabolomic analysis of longissimus from underperforming piglets relative to piglets with normal preweaning growth

Ramsay, T. G., Stoll, M. J., Shannon, A. E., & Blomberg, L. A. (2018) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-018-0251-3 · Cited by 18 · see citing works

The Treatment of Rhodiola Mimics Exercise to Resist High-Fat Diet-Induced Muscle Dysfunction via Sirtuin1-Dependent Mechanisms

You, B., Dun, Y., Fu, S., Qi, D., Zhang, W., Liu, Y., Qiu, L., Xie, M., & Liu, S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.646489 · Cited by 17 · see citing works

Human centenarian–associated SIRT6 mutants modulate hepatocyte metabolism and collagen deposition in multilineage hepatic 3D spheroids

Fröhlich, J., Raffaele, M., Skálová, H., Leire, E., Pata, I., Pata, P., Gorbunova, V. A., & Vinciguerra, M. (2022) · GeroScience · doi:10.1007/s11357-022-00713-1 · Cited by 16 · see citing works

Juzentaihoto Suppresses Muscle Atrophy and Decreased Motor Function in SAMP8 Mice

Morita, Y., Ishida, T., Morisawa, S., Jobu, K., Ou, Y., Fujita, H. M., Hanazaki, K., & Miyamura, M. (2020) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b20-00555 · Cited by 15 · see citing works

Epigenetics of Skeletal Muscle Atrophy

Du, J., Wu, Q., & Bae, E. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158362 · Cited by 15 · see citing works

The TRPA1 channel is a cardiac target of mIGF-1/SIRT1 signaling

Pazienza, V., Pomara, C., Cappello, F., Calogero, R., Carrara, M., Mazzoccoli, G., & Vinciguerra, M. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00150.2014 · Cited by 15 · see citing works

SIRT1 Synchs Satellite Cell Metabolism with Stem Cell Fate

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Targeting mitochondrial quality control in muscle aging: Natural dietary products as potential interventions

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Additional file 5 of Epigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant

Fröhlich, J., Liorni, N., Mangoni, M., Lochmanová, G., Pírek, P., Kaštánková, N., Pata, P., Kucera, J., Chaldakov, G. N., Tonchev, A. B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26752207

Additional file 3 of Epigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant

Fröhlich, J., Liorni, N., Mangoni, M., Lochmanová, G., Pírek, P., Kaštánková, N., Pata, P., Kucera, J., Chaldakov, G. N., Tonchev, A. B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26752201

Additional file 1 of Epigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant

Fröhlich, J., Liorni, N., Mangoni, M., Lochmanová, G., Pírek, P., Kaštánková, N., Pata, P., Kučera, J., Chaldakov, G. N., Tonchev, A. B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26752195

Additional file 8 of Epigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant

Fröhlich, J., Liorni, N., Mangoni, M., Lochmanová, G., Pírek, P., Kaštánková, N., Pata, P., Kučera, J., Chaldakov, G. N., Tonchev, A. B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26752216

Additional file 10 of Epigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant

Fröhlich, J., Liorni, N., Mangoni, M., Lochmanová, G., Pírek, P., Kaštánková, N., Pata, P., Kucera, J., Chaldakov, G. N., Tonchev, A. B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26752222

Additional file 7 of Epigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant

Fröhlich, J., Liorni, N., Mangoni, M., Lochmanová, G., Pírek, P., Kaštánková, N., Pata, P., Kucera, J., Chaldakov, G. N., Tonchev, A. B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26752213

Additional file 6 of Epigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant

Fröhlich, J., Liorni, N., Mangoni, M., Lochmanová, G., Pírek, P., Kaštánková, N., Pata, P., Kučera, J., Chaldakov, G. N., Tonchev, A. B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26752210

Additional file 2 of Epigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant

Fröhlich, J., Liorni, N., Mangoni, M., Lochmanová, G., Pírek, P., Kaštánková, N., Pata, P., Kucera, J., Chaldakov, G. N., Tonchev, A. B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26752198

Additional file 4 of Epigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant

Fröhlich, J., Liorni, N., Mangoni, M., Lochmanová, G., Pírek, P., Kaštánková, N., Pata, P., Kucera, J., Chaldakov, G. N., Tonchev, A. B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26752204

Additional file 11 of Epigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant

Fröhlich, J., Liorni, N., Mangoni, M., Lochmanová, G., Pírek, P., Kaštánková, N., Pata, P., Kucera, J., Chaldakov, G. N., Tonchev, A. B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26752225

Additional file 9 of Epigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant

Fröhlich, J., Liorni, N., Mangoni, M., Lochmanová, G., Pírek, P., Kaštánková, N., Pata, P., Kucera, J., Chaldakov, G. N., Tonchev, A. B., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26752219

microRNA–SIRT‐1 interactions: key regulators of adult skeletal muscle homeostasis?

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