Cited by 17Medicinal Plants and Bioactive CompoundsMuscle Physiology and DisordersAdipose Tissue and Metabolism

The Treatment of Rhodiola Mimics Exercise to Resist High-Fat Diet-Induced Muscle Dysfunction via Sirtuin1-Dependent Mechanisms

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You, Baiyang, Dun, Yaoshan, Fu, Siqian, Qi, Dake, Zhang, Wenliang, Liu, Yuan, Qiu, Ling, Xie, Murong +1 more·2021·Frontiers in Pharmacology

Abstract

Muscle dysfunction is a complication of high-fat diet (HFD)-induced obesity that could be prevented by exercise, but patients did not get enough therapeutic efficacy from exercise due to multiple reasons. To explore alternative or supplementary approaches to prevent or treat muscle dysfunction in individuals with obesity, we investigated the effects of Rhodiola on muscle dysfunction as exercise pills. SIRT1 might suppress atrogenes expression and improve mitochondrial quality control, which could be a therapeutic target stimulated by exercise and Rhodiola, but further mechanisms remain unclear. We verified the lipid metabolism disorders and skeletal muscle dysfunction in HFD feeding mice. Moreover, exercise and Rhodiola were used to intervene mice with a HFD. Our results showed that exercise and Rhodiola prevented muscle atrophy and dysfunction in obese mice and activating the SIRT1 pathway, while atrogenes were suppressed and mitochondrial quality control was improved. EX-527, SIRT1 inhibitor, was used to validate the essential role of SIRT1 in salidroside benefit. Results of cell culture experiment showed that salidroside alleviated high palmitate-induced atrophy and mitochondrial quality control impairments, but these improvements of salidroside were inhibited by EX-527 in C2C12 myotubes. Overall, Rhodiola mimics exercise that activates SIRT1 signaling leading to improvement of HFD-induced muscle dysfunction.

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Authors
You, B., Dun, Y., Fu, S., Qi, D., Zhang, W., Liu, Y., Qiu, L., Xie, M., & Liu, S.
Affiliations
  • Central South University (CN)
  • Mayo Clinic (US)
  • University of Manitoba (CA)
Corresponding author
  • Dun, Yaoshan
  • Liu, Suixin
Venue
Frontiers in Pharmacology
Published
2021-04-15
Volume
12
Pages
646489-646489
ISSN
1663-9812 (ISSN-L)
OpenAlex
W3153958357
Cited by
17
References
38
Citations by year
2026: 1 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 6
FWCI
0.94
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Pharmacology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (81702241, 82002403, 81672262)
  • National Development and Reform Commission
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Medicinal Plants and Bioactive Compounds
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
Rhodiola, salidroside, SIRT1, high-fat diet, obesity, skeletal muscle dysfunction, muscle atrophy, atrogenes, mitochondrial quality control, exercise mimetics, palmitate, EX527, lipid metabolism

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