Cited by 32Lung Cancer Diagnosis and TreatmentLung Cancer Treatments and MutationsLung Cancer Research Studies

What can platinum offer yet in the treatment of PS2 NSCLC patients? A systematic review and meta-analysis

Bronte, Giuseppe, Rolfo, Christian, Passiglia, Francesco, Rizzo, Sergio, Gil-Bazo, Ignacio, Fiorentino, Eugenio, Cajozzo, Massimo, Van Meerbeeck, Jan P. +4 more·2015·Critical Reviews in Oncology/Hematology

Abstract

Background Randomized phase III trials showed interesting, but conflicting results, regarding the treatment of NSCLC, PS2 population. This meta-analysis aims to review all randomized trials comparing platinum-based doublets and single-agents in NSCLC PS2 patients.Materials and methods Data from all published randomized trials, comparing efficacy and safety of platinum-based doublets to single agents in untreated NSCLC, PS2 patients, were collected. Pooled ORs were calculated for the 1-year Survival-Rate (1y-SR), Overall Response Rate (ORR), and grade 3-4 (G3-4) hematologic toxicities.Results Six eligible trials (741 patients) were selected. Pooled analysis showed a significant improvement in ORR (OR: 3.243; 95% CI: 1.883-5.583) and 1y-SR (OR: 1.743; 95% CI: 1.203-2.525) in favor of platinum-based doublets. G3-4 hematological toxicities were also more frequent in this group.Conclusion This meta-analysis suggests that platinum-combination regimens are superior to singleagent both in terms of ORR and survival-rate with increase of severe hematological toxicities.

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Crossref · 10.1016/j.critrevonc.2015.03.010

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  • A meta-analysis of randomised trials comparing platinum-based doublets versus single-agent regimens in first-line therapy of PS 2 patients revealed platinum-based regimens to be superior in terms of response rate and survival (74% higher probability of being alive after 1 year) despite an increase in toxicities (mainly haematological).

    “A recently published meta-analysis of randomised trials comparing the efficacy and safety of platinum-based doublets versus single-agent regimens in the first-line therapy of PS 2 patients revealed platinum-based regimens to be superior in terms of RR and survival (74% higher probability of being alive after 1 year) despite an increase in toxicities (mainly haematological) [65].”

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Authors
Bronte, G., Rolfo, C., Passiglia, F., Rizzo, S., Gil-Bazo, I., Fiorentino, E., Cajozzo, M., Van Meerbeeck, J. P., Lequaglie, C., Santini, D., Pauwels, P., & Russo, A.
Affiliations
  • University of Palermo (IT)
  • Antwerp University Hospital (BE)
  • Centro di Riferimento Oncologico della Basilicata (IT)
  • Università Campus Bio-Medico (IT)
Corresponding author
Rolfo, Christian
Venue
Critical Reviews in Oncology/Hematology
Publisher
Elsevier BV
Published
2015-09
Volume
95
Issue
3
Pages
306-317
ISSN
1040-8428 (ISSN-L)
OpenAlex
W2048703619
Cited by
32
References
39
Citations by year
2025: 1 · 2024: 1 · 2023: 6 · 2022: 1 · 2021: 1 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 5 · 2015: 2
FWCI
0.77
Type
journal article
Language
en
Open access
closed
Locations
  • Critical Reviews in Oncology/Hematology (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
  • Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
  • Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
  • Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
  • Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
Keywords
platinum-based doublets, non-small cell lung cancer, performance status 2, combination chemotherapy, overall response rate, one-year survival, hematologic toxicity, treatment efficacy and safety
MeSH terms
Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Non-Small-Cell Lung, Humans, Lung Neoplasms, Platinum, Survival Rate, Randomized Controlled Trials as Topic

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