What can platinum offer yet in the treatment of PS2 NSCLC patients? A systematic review and meta-analysis
Abstract
Background Randomized phase III trials showed interesting, but conflicting results, regarding the treatment of NSCLC, PS2 population. This meta-analysis aims to review all randomized trials comparing platinum-based doublets and single-agents in NSCLC PS2 patients.Materials and methods Data from all published randomized trials, comparing efficacy and safety of platinum-based doublets to single agents in untreated NSCLC, PS2 patients, were collected. Pooled ORs were calculated for the 1-year Survival-Rate (1y-SR), Overall Response Rate (ORR), and grade 3-4 (G3-4) hematologic toxicities.Results Six eligible trials (741 patients) were selected. Pooled analysis showed a significant improvement in ORR (OR: 3.243; 95% CI: 1.883-5.583) and 1y-SR (OR: 1.743; 95% CI: 1.203-2.525) in favor of platinum-based doublets. G3-4 hematological toxicities were also more frequent in this group.Conclusion This meta-analysis suggests that platinum-combination regimens are superior to singleagent both in terms of ORR and survival-rate with increase of severe hematological toxicities.
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A meta-analysis of randomised trials comparing platinum-based doublets versus single-agent regimens in first-line therapy of PS 2 patients revealed platinum-based regimens to be superior in terms of response rate and survival (74% higher probability of being alive after 1 year) despite an increase in toxicities (mainly haematological).
“A recently published meta-analysis of randomised trials comparing the efficacy and safety of platinum-based doublets versus single-agent regimens in the first-line therapy of PS 2 patients revealed platinum-based regimens to be superior in terms of RR and survival (74% higher probability of being alive after 1 year) despite an increase in toxicities (mainly haematological) [65].”
From Metastatic non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (2016) · cites this paper as [65]
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- Authors
- Bronte, G., Rolfo, C., Passiglia, F., Rizzo, S., Gil-Bazo, I., Fiorentino, E., Cajozzo, M., Van Meerbeeck, J. P., Lequaglie, C., Santini, D., Pauwels, P., & Russo, A.
- Affiliations
- University of Palermo (IT)
- Antwerp University Hospital (BE)
- Centro di Riferimento Oncologico della Basilicata (IT)
- Università Campus Bio-Medico (IT)
- Corresponding author
- Rolfo, Christian
- ORCID
- Venue
- Critical Reviews in Oncology/Hematology
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 95
- Issue
- 3
- Pages
- 306-317
- ISSN
- 1040-8428 (ISSN-L)
- OpenAlex
- W2048703619
- Cited by
- 32
- References
- 39
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 6 · 2022: 1 · 2021: 1 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 5 · 2015: 2
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Oncology/Hematology (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
- Keywords
- platinum-based doublets, non-small cell lung cancer, performance status 2, combination chemotherapy, overall response rate, one-year survival, hematologic toxicity, treatment efficacy and safety
- MeSH terms
- Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Non-Small-Cell Lung, Humans, Lung Neoplasms, Platinum, Survival Rate, Randomized Controlled Trials as Topic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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