Clinical status, psychosocial impairments, medical treatment and health care costs for patients with inflammatory bowel disease (IBD) in Germany: an online IBD registry

Bokemeyer, B.; Hardt, J.; Hüppe, D.; Prenzler, A.; Conrad, S.; Düffelmeyer, M.; Hartmann, P.; Hoffstadt, M.; Klugmann, T.; Schmidt, C.; Weismüller, J.; Mittendorf, T.; Raspe, H.

doi:10.1016/j.crohns.2012.02.014

Cited by 87Inflammatory Bowel DiseaseOcular Diseases and Behçet’s SyndromePregnancy and Medication Impact

Clinical status, psychosocial impairments, medical treatment and health care costs for patients with inflammatory bowel disease (IBD) in Germany: an online IBD registry

Bokemeyer, B., Hardt, J., Hüppe, D., Prenzler, A., Conrad, S., Düffelmeyer, M., Hartmann, P., Hoffstadt, M. +5 more·2013·Journal of Crohn s and Colitis

DOI 10.1016/j.crohns.2012.02.014

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Abstract

BACKGROUND: The aim of this cross-sectional study was to establish an online inflammatory bowel disease (IBD) registry for a first picture of the situation of IBD outpatients' treatment in Germany. METHODS: Between March 2006 and July 2007 IBD outpatients from 24 gastroenterological specialist practices and two hospitals in Germany were enrolled in an Internet-based registry to evaluate the outpatients' clinical status, psychological impairments, provided health care, as well as medical treatment and medication costs. RESULTS: 1032 IBD patients (ulcerative colitis/UC: 519; Crohn's disease/CD: 511; indeterminate colitis: 2) were enrolled in the study (age: 43 ± 14 years/M ± SD). Disease duration of all patients averaged 10 ± 8.5 years. In 519 UC-patients (49% male; 33% pancolitis), 66% were in remission as were 55% of CD patients (37 % male; 41 % active smokers). Associated with higher rates of disease activity (CDAI ≥ 150; CAI>4) were corticosteroids (CD, UC), topical medication (UC), relevant reported depressive symptoms (15%; 6-31%) and impairments in sexuality (21%; 9-42%). Relevant medication groups prescribed were oral aminosalicylates (UC: 70%; CD: 47%); immunosuppressive therapy - mostly azathioprine/6 MP (CD: 47%; UC: 26%), and Infliximab (CD: 8%; UC: 3%). Strongly associated with their clinical disease activity in UC as well as CD patients, 15% (6-31%) reported relevant depressive symptoms and 21% (9-42%) relevant impairments in sexuality. CONCLUSIONS: The registry constitutes a large complemental database for the patient population in Germany. About one third of the IBD patients were not in clinical remission (CDAI ≥150/CAI >4) (CD: 45%; UC: 27%), although high rates of immunosuppressive drugs (CD: 47%; UC 26%) were administered. This study shows a large burden of active disease associated with an unexpectedly high (co)morbidity and high psychosocial impairments, indicating a reduced health state in IBD patients.

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A German cross-sectional study including 1,032 IBD patients revealed that relevant reported depressive symptoms correlate with increased rates of disease activity.
“In contrast, a German cross-sectional study including 1,032 IBD patients, revealed that relevant reported depressive symptoms correlate with increased rates of disease activity (91).”
From Stress triggers flare of inflammatory bowel disease in children and adults (2019) · cites this paper as [91]

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Aktualisierte S3-Leitlinie „Diagnostik und Therapie des Morbus Crohn“ der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) (Version 4.1) – living guideline
Sturm, A., Atreya, R. N., Bettenworth, D., Bokemeyer, B., Dignass, A. U., Ehehalt, R., Germer, C.-T., Grunert, P., Helwig, U., Horisberger, K., et al. (2024) · Zeitschrift für Gastroenterologie · doi:10.1055/a-2309-6123 · Cited by 33 · see citing works
Association between inflammatory bowel disease and subsequent depression or anxiety disorders - A retrospective cohort study of 31,728 outpatients.
Roderburg, C., Yaqubi, K., Konrad, M., May, P., Luedde, T., Kostev, K., & Loosen, S. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.11.026 · Cited by 29 · see citing works
Sexual satisfaction and inflammatory bowel diseases: an interdisciplinary clinical challenge
Sanders, J. N., Gawron, L. M., & Friedman, S. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.01.188 · Cited by 29 · see citing works
Sexual Function and Body Image are Similar after Laparoscopy‐Assisted and Open Ileal Pouch–Anal Anastomosis
Kjær, M. D., Laursen, S. B., Qvist, N., Kjeldsen, J., & Poornoroozy, P. H. (2014) · World Journal of Surgery · doi:10.1007/s00268-014-2557-4 · Cited by 28 · see citing works
“Age (years) 39 [18–70] 38 [16–61] 0.”
BackgroundInfluential
Tu1993 Sexual Dysfunction in Women With Inflammatory Bowel Disease: A New IBD-Specific Scale
de Silva, P. S., O’Toole, A., Carrellas, M., Collins, E., Korzenik, J. R., Nguyen, D. D., Ananthakrishnan, A. N., & Friedman, S. (2016) · Gastroenterology · doi:10.1016/s0016-5085(16)33386-8 · Cited by 28 · see citing works
Promoting psycho-social wellbeing for engaging inflammatory bowel disease patients in their care: an Italian consensus statement
Graffigna, G., Bosio, C., Pagnini, F., Volpato, E., Previtali, E., Leone, S., D’Amico, F., Armuzzi, A., & Danese, S. (2021) · BMC Psychology · doi:10.1186/s40359-021-00692-6 · Cited by 28 · see citing works
Specific neurophysiological mechanisms underlie cognitive inflexibility in inflammatory bowel disease
Petruo, V. A., Zeißig, S., Schmelz, R., Hampe, J., & Beste, C. (2017) · Scientific Reports · doi:10.1038/s41598-017-14345-5 · Cited by 26 · see citing works
Inviting Patients with Inflammatory Bowel Disease to Active Involvement in Their Own Care
Hueppe, A., Langbrandtner, J., & Raspe, H. H. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000044 · Cited by 24 · see citing works
“The IMET has already been used in German IBD research.(3,4,36) IBD-induced restrictions in 9 different areas of life within the past 3 months (self-care, daily duties and responsibilities at and outside home, recreation, social activities, personal relations, sexuality, nutrition) were assessed by numerical rating sca…”
Method
Real-world biologic treatment and associated cost in patients with inflammatory bowel disease
Brandes, A., Groth, A., Gottschalk, F., Wilke, T., Ratsch, B. A., Orzechowski, H., Fuchs, A., Deiters, B., & Bokemeyer, B. (2019) · Zeitschrift für Gastroenterologie · doi:10.1055/a-0903-2938 · Cited by 24 · see citing works
Sex- and gender-related differences in inflammatory bowel diseases
Blumenstein, I., & Sonnenberg, E. (2023) · Frontiers in Gastroenterology · doi:10.3389/fgstr.2023.1199687 · Cited by 22 · see citing works
Management of Crohn's disease – are guidelines transferred to clinical practice?
Klag, T., Stange, E. F., & Wehkamp, J. (2015) · United European Gastroenterology Journal · doi:10.1177/2050640615580228 · Cited by 22 · see citing works
“This is in line with other observations in Germany, showing that about 41% of CD patients are smokers.(14) Hence there is a need for guideline implementation strategies regarding cessation of smoking in CD.”
Result
Hospital Anxiety and Depression Scale (HADS): Validation in Mexican patients with inflammatory bowel disease
Yamamoto-Furusho, J. K., Sarmiento-Aguilar, A., García-Alanis, M., Gómez-García, L. E., Toledo-Mauriño, J., Olivares-Guzmán, L., & Fresán, A. (2018) · Gastroenterología y Hepatología (English Edition) · doi:10.1016/j.gastre.2018.08.009 · Cited by 23 · see citing works
Development, validation and clinical assessment of a short questionnaire to assess disease-related knowledge in inflammatory bowel disease patients
Keegan, D., McDermott, E., Byrne, K. R., Moloney, D., Doherty, G. A., & Mulcahy, H. E. (2012) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2012.744090 · Cited by 20 · see citing works
“The increasing use of IBD registries and databases has placed emphasis on collating large volumes of biological, psychological and socioeconomic data from patients [22,23] and such projects require validated and concise questionnaires to acquire reliable results.”
Background
The Stressometer: A Simple, Valid, and Responsive Measure of Psychological Stress in Inflammatory Bowel Disease Patients
Keegan, D., Byrne, K., Cullen, G., Doherty, G. A., Dooley, B., & Mulcahy, H. E. (2015) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjv120 · Cited by 19 · see citing works
Quality of care in inflammatory bowel disease: results of a prospective controlled cohort study in Germany (NETIBD)
Langbrandtner, J., Hüppe, A., Jessen, P., Büning, J., Nikolaus, S., Raspe, H. H., & Bokemeyer, B. (2017) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s135346 · Cited by 17 · see citing works
“Our sample with 66% patients in actual remission is, however, well comparable with other German samples of IBD outpatients treated in gastroenterological practices (e.g., Blumenstein et al 51 reported 67% and Bokemeyer et al 52 reported 61% patients in remission).”
Identifying training and informational components to develop a psoriasis self- management application
Safdari, R., Firooz, A., & Masoorian, H. (2017) · Medical Journal of the Islamic Republic of Iran · doi:10.14196/mjiri.31.67 · Cited by 16 · see citing works
“The historical study of the diseases in the last century shows a trend away from infectious and noncommunicable towards chronic and non-infectious diseases (1).”
Background
Assessment of sexual dysfunction in patients with inflammatory bowel disease
Szydlarska, D., Jakubowska, A., & Rydzewska, G. M. (2019) · Gastroenterology Review · doi:10.5114/pg.2019.85893 · Cited by 17 · see citing works
“Other quality-of-life measures such as the McMaster Inflammatory Bowel Disease Questionnaire also have incorporated questions on sexual activity or satisfaction, acknowledging the interference of this factor with physical and psychosocial wellbeing [2].”
Method
Perceived distress, personality characteristics, coping strategies and psychosocial impairments in a national German multicenter cohort of patients with Crohn’s disease and ulcerative colitis: Psychosocial impairments in IBD: Data from a national German multicenter cohort
Petruo, V., Krauss, E., Kleist, A., Hardt, J., Hake, K., Peirano, J., Krause, T., Ehehalt, R., von Arnauld de la Perriére, P., Büning, J., et al. (2019) · Zeitschrift für Gastroenterologie · doi:10.1055/a-0838-6371 · Cited by 16 · see citing works
Management of inflammatory bowel disease in France: A nationwide survey among private gastroenterologists
Duchesne, C., Fauré, P., Kohler, F., Pingannaud, M.-P., Bonnaud, G., Devulder, F., Abramowitz, L., Boustière, C., & Peyrin‐Biroulet, L. (2014) · Digestive and Liver Disease · doi:10.1016/j.dld.2014.04.004 · Cited by 15 · see citing works
Pathogenesis of Ulcerative Colitis and Crohn's Disease: Similarities, Differences and a Lot of Things We Do Not Know Yet
Annaházi, A., & Molnár, T. (2014) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000253 · Cited by 19 · see citing works
“Several studies have concluded that anxiety and depression are common in IBD patients, and their severity parallels the disease activity [167-170].”
Background
Sexuality, Fertility, and Pregnancy in Crohn's Disease
Gaidos, J. K. J., & Kane, S. V. (2017) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2017.05.007 · Cited by 14 · see citing works
Impact of BMGIM Music Therapy on Emotional State in Patients with Inflammatory Bowel Disease: A Randomized Controlled Trial
March-Luján, V. A., Prado‐Gascó, V., Huguet, J. M., Cortés, X., Arquiola, J. M. P., Capilla-Igual, M., Josefa-Rodríguez-Morales, M., Monzó, A., Armero, J. L. P., & Ortí, J. E. D. L. R. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081591 · Cited by 14 · see citing works
“recurrent clinical course [1] that impacts on mental health [2].”
Background
IBD and Motherhood: A Journey through Conception, Pregnancy and Beyond
Caballero-Mateos, A. M., Quesada-Caballero, M., la Fuente, G. A. C., Caballero-Vázquez, A., & Contreras‐Chova, F. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12196192 · Cited by 13 · see citing works
“However, active disease has been observed to decrease fertility in both genders [12].”
Background
Pregnancy in Patients with Inflammatory Bowel Diseases—A Literature Review
Grigorescu, R. R., Husar-Sburlan, I. A., Rosulescu, G., Bobirca, A. V., Cerban, R., BOBIRCA, F. T., & Florescu, M. M. (2023) · Life · doi:10.3390/life13020475 · Cited by 12 · see citing works
“3% with UC) report sexuality impairment [13]; this problem is often not addressed by medical personnel [14], although over half of the patients expect to discuss this topic with a physician [15].”
Background
Addressing unmet needs in inflammatory bowel disease
Bokemeyer, B. (2015) · Drug Discovery Today · doi:10.1016/j.drudis.2015.07.005 · Cited by 12 · see citing works
Fermented Soymilk with Probiotic Lactobacilli and Bifidobacterium Strains Ameliorates Dextran-Sulfate-Sodium-Induced Colitis in Rats
Zahrani, A. J. A., Shori, A. B., & Al-Judaibi, E. A. (2024) · Nutrients · doi:10.3390/nu16203478 · Cited by 11 · see citing works
“This disease not only affects their health, but has a major impact on their economic situation, psychological state, and work activities [1].”
Background
Inflammatory Bowel Diseases
Choi, Y., & Kim, N. (2022) · Springer eBooks · doi:10.1007/978-981-19-0120-1_19 · Cited by 11 · see citing works
Documento de posicionamiento. Recomendaciones del Grupo Español de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa sobre sexualidad y enfermedad inflamatoria intestinal
Calvo, M., Gismero, F. M., Ferrer, C. S., Hernández-Camba, A., Carlón, D. V., Benasach, F. G., Aguas, M., Oliva, F. J. D., González‐Lama, Y., Scheiding, M. M., et al. (2024) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2023.12.013 · Cited by 10 · see citing works
Pulmonary Pathology in Patients with Ulcerative Colitis Treated with Mesalazine—A Challenging and Complex Diagnostic Problem. Case Series and Literature Review
Kacprzak, A., Siemion-Szcześniak, I., Szturmowicz, M., Bestry, I., Langfort, R., & Kuś, J. (2014) · Advances in respiratory medicine · doi:10.5603/piap.2014.0047 · Cited by 10 · see citing works
“In the German registry [39] 70% of patients with UC were treated with those medications.”
Background
Inflammatory Bowel Disease Registry and Monitoring: Feasibility Study and Application (Isfahan Inflammatory Bowel Disease Surveillance Project)
Baghaei, A., Emami, M. H., Adibi, P., Tavakkoli, H., Daghaghzadeh, H., Tamizifar, B., Akbarpour, M., & Hojjatpour, B. (2019) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_316_17 · Cited by 9 · see citing works
Prevalence of Anxiety and Depression in Inflammatory Bowel Disease: Systematic Review and Meta-AnalysisPreprint
Barberio, B., Zamani, M., Black, C. J., Savarino, E. V., & Ford, A. C. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3746277 · Cited by 9 · see citing works
Systematic review: treatment pattern and clinical effectiveness and safety of pharmaceutical therapies for Crohn’s disease in Europe
Lelli, F., Nuhoho, S., Lee, X. Y., & Xu, W. (2016) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s109696 · Cited by 8 · see citing works
“5-ASA The usage of 5-ASA is reported in three publications.(15,17,18) The percentage of patients using 5-ASA lies between 14% and 46.”
Influential
Enhancing Ulcerative Colitis Diagnosis: A Multi-Level Classification Approach with Deep Learning
Alyamani, H. J. (2024) · Computer Modeling in Engineering & Sciences · doi:10.32604/cmes.2024.047756 · Cited by 7 · see citing works
“Researchers in Germany found a high emotional cost associated with UC in a study of patients [2].”
Measuring Mood and Anxiety Disorders by Patient Reported Outcomes in Inflammatory Bowel Disease: A Literature Review Update
Spagnuolo, R., Basile, A., Corea, A., Iaquinta, F. S., Milić, N., Doldo, P., Luzza, F., & Abenavoli, L. (2022) · Reviews on Recent Clinical Trials · doi:10.2174/1574887117666220628151256 · Cited by 7 · see citing works
A Mendelian randomization study on causal effects of inflammatory bowel disease on the risk of erectile dysfunction
Chen, D., Zhou, C., Luo, Q., Chen, C., & Liu, G. (2024) · Scientific Reports · doi:10.1038/s41598-024-52712-1 · Cited by 7 · see citing works
“Within a 10-year observation period, the cumulative surgery rate was 20–50% in patients diagnosed with CD and 10% in those diagnosed with UC 26 .”
Background
Rising Rate of Obesity in Patients Admitted for Crohn’s Disease Increases Costs But Not Mortality
Lipcsey, M. S., Stein, D. J., DeVore, Z., & Feuerstein, J. D. (2020) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001421 · Cited by 6 · see citing works
Mapping from SIBDQ to EQ-5D-5L for patients with inflammatory bowel disease
Steiner, I. M., Bokemeyer, B., & Stargardt, T. (2023) · The European Journal of Health Economics · doi:10.1007/s10198-023-01603-9 · Cited by 5 · see citing works
“The mean age was 40.97 years and 52.42% of all IBD patients were female, which is comparable to other studies in Germany [43, 44].”
ResultInfluential
Measuring structural model invariance across internet-recruited and hospital-recruited IBD patients: Experiential avoidance’s effect on psychopathological symptoms
Trindade, I. A., Keefer, L., Portela, F., Ferreira, C., & Pinto‐Gouveia, J. (2019) · Current Psychology · doi:10.1007/s12144-019-00281-2 · Cited by 5 · see citing works
Sex and age differences in inflammatory bowel disease patients; a nationwide study based on Iranian Registry of Crohn’s and Colitis (IRCC)
Khanmohammadi, S., Sheidaei, A., Alatab, S., Tabatabaei‐Malazy, O., Vahedi, H., Mansour‐Ghanaei, F., Fakheri, H. T., Sheikhesmaeili, F., Sadeghı, A., Sima, A. R., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0304792 · Cited by 4 · see citing works
Induction and maintenance of mucosal healing in Crohn’s disease with ustekinumab in clinical practice across all care levels in Germany (MUCUS)
Baumgart, D. C., Stallmach, A., Grunert, P., Schubert, S., Howaldt, S. M., von Arnim, U., Ochsenkühn, T., Stein, J. M., Lügering, A., Schmidt, D. N., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-70241-9 · Cited by 4 · see citing works
Long-term cost and complications of surgery in patients with ulcerative colitis: a claims data analysis
Ghiani, M., Naessens, D., Takács, P., Myers, D., Bokemeyer, B., & Wilke, T. (2021) · International Journal of Colorectal Disease · doi:10.1007/s00384-021-03876-z · Cited by 4 · see citing works
Real-world evidence on medication patterns in inflammatory bowel disease the first decade after diagnosis
Christensen, H. S., Larsen, L., Lees, C. W., Bøgsted, M., & Jess, T. (2026) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjag025 · Cited by 3 · see citing works
Colorectal Diseases and Gut Microbiome
Kim, N. (2024) · Springer eBooks · doi:10.1007/978-981-97-0130-8_6 · Cited by 1 · see citing works
Psychosomatik
Häuser, W. (2020) · Springer eBooks · doi:10.1007/978-3-662-59104-8_36 · Cited by 1 · see citing works
A Framework for Multi-Grade Classification of Ulcerative-Colitis Using Deep Neural Networks
Noor, M. N., Nazir, M., Dillshad, V., & Haneef, F. (2023) · International Multi-Topic Conference · doi:10.1109/inmic60434.2023.10465806 · Cited by 1 · see citing works
“In a study of UC patients in Germany, researchers discovered a significant emotional cost linked with the condition [3].”
Background
Morning Salivary Cortisol Has a Positive Correlation with GAD-7 Scores in Patients with Ulcerative Colitis
Castro, C. M., Mithal, A., Deyhim, T., Rabinowitz, L. G., Olagoke, O. C., Freedman, S. D., Cheifetz, A. S., Ballou, S., & Papamichael, K. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13226707 · Cited by 2 · see citing works
“The clinical manifestations and treatment modalities of IBD can have a lasting impact on patients’ mental health and quality of life, with some studies reporting a 15% prevalence of depressive symptoms [2–5].”
Geschlechtsspezifische Unterschiede bei chronisch-entzündlichen Darmerkrankungen
Blumenstein, I., Siegmund, B., & Sonnenberg, E. (2019) · Die Gastroenterologie · doi:10.1007/s11377-019-0323-8
“Etwas überraschend ist der hoheAnteil anRaucherinnenunterdenPatientinnen mit Morbus Crohn, der deutlich höher ist als beiMännern (42,8%vs. 35,8%, p= 0,025).”
BackgroundInfluential
Reply to Comment on “Inflammatory Bowel Diseases Were Associated With Risk of Sexual Dysfunction in Both Sexes: A Meta-analysis” by Li Y and Liu X
Zhao, S., Xie, Q., & Zhao, Z. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz028
Italian Consensus Statement for Promoting Psycho-Social Wellbeing and Engagement in the Care of Inflammatory Bowel Disease PatientsPreprint
Graffigna, G., Bosio, C., Pagnini, F., Volpato, E., Previtali, E., Leone, S., D’Amico, F., Armuzzi, A., & Danese, S. (2021) · Research Square · doi:10.21203/rs.3.rs-587615/v1
Description of the inflammatory bowel disease natural history in Tehran province, Iran: Mixed panel approaches.
Olfatifar, M., Aghdaei, H. A., Pourhoseingholi, M. A., Balaii, H., Nazari, S. S. H., Shahrokh, S., Sabour, S., Іванчук, М. А., Іванчук, П. Р., Khodakarim, S., et al. (2021) · Gastroenterology and hepatology from bed to bench. · doi:10.22037/ghfbb.vi.2354
Psoriasis: From Gene to Clinic
Cash, N. J. (2018) · EMJ Dermatology · doi:10.33590/emjdermatol/10314512
Gender-Medizin bei chronisch entzündlicher Darmerkrankung
Sonnenberg, E., & Kubesch, A. (2023) · Die Gastroenterologie · doi:10.1007/s11377-023-00738-8
Position statement of the Spanish Working Group on Crohn’s Disease and Ulcerative Colitis on sexuality and inflammatory bowel disease
Calvo, M., Gismero, F. M., Ferrer, C. S., Hernández-Camba, A., Carlón, D. V., Benasach, F. G., Aguas, M., Oliva, F. J. D., González‐Lama, Y., Scheiding, M. M., et al. (2024) · Gastroenterología y Hepatología (English Edition) · doi:10.1016/j.gastre.2024.04.059
Successful Pregnancy Outcome in a Patient With Crohn’s Disease and Prior Intestinal Surgery: A Case Report
Xydias, E. M., Koutsia, V., Toulios, G., Kotoula, Z., Tsartsalis, I., Zachos, K., Kariotaki, A., Kotoula, I., Ziogas, A. C., & Thanasas, I. (2026) · Cureus · doi:10.7759/cureus.106444
“%) with CD report sexual dysfunction, which can be particularly severe during disease flares [19].”

Health care and cost of medication for inflammatory bowel disease in the Rhein-Main region, Germany: A multicenter, prospective, internet-based study
Blumenstein, I., Bock, H., Weber, C. I. K., Rambow, A., Tacke, W., Kihn, R., Pfaff, R., Orlemann, S., Schaeffer, R., Schröder, O., et al. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20257 · Cited by 22 · see citing works
P358 Factors associated with disability in inflammatory bowel disease (IBD): A cross-sectional study in outpatients
Costa, J. M. S. S. D., Matos, D., Costa, R. S., Arroja, B., Gonçalves, R., & Soares, J. (2018) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjx180.485
Development of an internet-based cohort of patients with inflammatory bowel diseases (CCFA Partners): Methodology and initial results
Long, M. D., Kappelman, M. D., Martin, C. F., Lewis, J. D., Mayer, L., Kinneer, P., & Sandler, R. S. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22895 · Cited by 109 · see citing works
N03 Disease burden of patients with inflammatory bowel disease from the viewpoint of QOL and depression
Takahashi, M., Aoyama, N., & Nunotani, M. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjz203.987 · Cited by 1 · see citing works
Registry of patients with inflammatory bowel diseases: clinical, demographic and pharmacoepidemiological aspects
Сергеевна, М. А., Eliseeva, E. V., Чеснокова, О. В., & Валерьевна, П. О. (2026) · Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice · doi:10.37489/2588-0519-gcp-0016

Authors: Bokemeyer, B., Hardt, J., Hüppe, D., Prenzler, A., Conrad, S., Düffelmeyer, M., Hartmann, P., Hoffstadt, M., Klugmann, T., Schmidt, C., Weismüller, J., Mittendorf, T., & Raspe, H.
Affiliations: University Hospital Schleswig-Holstein (DE)
University of Wuppertal (DE)
Leibniz University Hannover (DE)
National Association of Statutory Health Insurance Physicians (DE)
University of Lübeck (DE)
ORCID: Bokemeyer, B.
Düffelmeyer, M.
Hartmann, P.
Schmidt, C.
Weismüller, J.
Raspe, H.
Venue: Journal of Crohn s and Colitis
Publisher: Oxford University Press (OUP)
Published: 2013-06
Volume: 7
Issue: 5
Pages: 355-368
ISSN: 1873-9946 (ISSN-L)
DOI: 10.1016/j.crohns.2012.02.014
OpenAlex: W2113319332
Cited by: 87
References: 33
Citations by year: 2026: 2 · 2024: 10 · 2023: 8 · 2022: 4 · 2021: 11 · 2020: 4 · 2019: 10 · 2018: 7 · 2017: 7 · 2016: 7 · 2015: 4 · 2014: 9 · 2013: 3 · 2012: 1
FWCI: 3.28
Type: journal article
Language: en
Open access: closed
Locations: Journal of Crohn s and Colitis (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
Keywords: inflammatory bowel disease, ulcerative colitis
MeSH terms: Infliximab, Adrenal Cortex Hormones, Adult, Age Factors, Anti-Inflammatory Agents, Non-Steroidal, Antibodies, Monoclonal, C-Reactive Protein, Colitis, Ulcerative, Crohn Disease, Cross-Sectional Studies, Depression, Female, Germany, Humans, Immunosuppressive Agents, Male, Middle Aged, Obesity, Surveys and Questionnaires, Registries, Severity of Illness Index, Sexual Behavior, Sex Factors, Smoking, Time Factors, Drug Costs, Internet

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Clinical status, psychosocial impairments, medical treatment and health care costs for patients with inflammatory bowel disease (IBD) in Germany: an online IBD registry

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