Functional gastrointestinal disorders and mood disorders in patients with inactive inflammatory bowel disease: Prevalence and impact on health
Open accessAbstract
BACKGROUND: Symptoms of functional gastrointestinal disorders (FGID) associated with mood disorders (MD), such as depression and anxiety, occur in some patients with quiescent inflammatory bowel disease (IBD) and could be caused by changes in gut motility, visceral hypersensitivity, or psychological dysfunction. We assessed the prevalence of FGID symptoms and mood disorders in ambulatory patients with quiescent IBD and examined their impact on health-related quality of life (HRQOL) and use of health resources. METHODS: Consecutive ambulatory patients with IBD completed a survey of Rome II criteria for FGID, the Hospital Anxiety and Depression Survey, HRQOL indices, and health resource utilization. Logistic and linear regression analyses tested for predictors of FGID and HRQOL. RESULTS: Of 361 patients surveyed, 149 (44 ulcerative colitis [UC] and 105 Crohn's disease [CD]) had inactive IBD during the previous 12 months. Symptoms of at least 1 FGID occurred in 81.9%. Functional anorectal disorders were the most prevalent (53.7%) followed by functional bowel disorders (51.7%), and both were of greater prevalence than in the Canadian population (41.6% and 22.6%, respectively). Irritable bowel syndrome symptoms were more common in inactive CD than in UC (26% versus 9.1%, P = .01) and functional constipation was more common in inactive UC than in CD (26.2% versus 5.8%, P < .01). MD occurred in 27.3% of UC and 31.3% of CD patients. Age > or =40 years and anxiety independently predicted an FGID. Both FGID symptoms and MD were associated with impaired HRQOL and increased use of health services. CONCLUSIONS: Many patients with inactive IBD have symptoms compatible with FGID. Both FGID-like symptoms and MD are associated with impaired HRQOL and increased health resource utilization. Recognition and treatment of FGID and MD could potentially improve daily functioning of IBD patients.
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The pooled mean rate of anxiety in inactive IBD across studies reporting percentages was 28.2% (95% CI ±2.7).
“The pooled mean rate for all the studies reporting percentages (study n=8; total n=1,069) was 28.2% (± 2.7, 95% CI) (18, 27-29, 32, 33, 36, 39).”
From Controversies Revisited: A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases (2016) · cites this paper as [33]
The pooled mean rate of depressive symptoms for inactive IBD was 19.9% (95% CI ±2.05).
“The pooled mean rate of depressive symptoms for those with inactive IBD was 19.9% (± 2.05, 95% CI) (study n=10; total n=1,132) (18, 27-29, 32, 33, 36, 39, 40, 48).”
From Controversies Revisited: A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases (2016) · cites this paper as [33]
In the four largest studies providing data on rates, 22% (95% CI ±2.8) of IBD patients with inactive IBD had clinically elevated anxiety.
“In the four largest studies (n=839) which provided data on rates, 22% (± 2.8, 95% CI) of IBD patients with inactive IBD had clinically elevated anxiety (28, 29, 33, 39).”
From Controversies Revisited: A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases (2016) · cites this paper as [33]
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- Authors
- Farrokhyar, F., Marshall, J. K., Easterbrook, B., & Irvine, J. E.
- Affiliations
- University of Toronto (CA)
- Venue
- Inflammatory Bowel Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-01
- Volume
- 12
- Issue
- 1
- Pages
- 38-46
- ISSN
- 1078-0998 (ISSN-L)
- OpenAlex
- W2033582886
- Cited by
- 310
- References
- 7
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 16 · 2023: 14 · 2022: 14 · 2021: 15 · 2020: 23 · 2019: 16 · 2018: 15 · 2017: 17 · 2016: 17 · 2015: 17 · 2014: 20 · 2013: 14 · 2012: 12
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- Locations
- Inflammatory Bowel Diseases (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- functional gastrointestinal disorders, mood disorders
- MeSH terms
- Adult, Female, Gastrointestinal Diseases, Health Services, Humans, Male, Middle Aged, Prospective Studies, Quality of Life, Regression Analysis, Risk Factors, Inflammatory Bowel Diseases, Prevalence, Logistic Models, Mood Disorders
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