Cited by 88Seaweed-derived Bioactive CompoundsPharmacology and Obesity TreatmentObesity, Physical Activity, Diet

Effects of Spirulina supplementation on obesity: A systematic review and meta-analysis of randomized clinical trials

Moradi, Sajjad, Ziaei, Rahele, Foshati, Sahar, Mohammadi, Hamed, Nachvak, Seyed Mostafa, Rouhani, Mohammad Hossein·2019·Complementary Therapies in Medicine

Abstract

Objective Evidence has suggested that Spirulina supplementation may affect anthropometric indices. Therefore, a systematic review and meta-analysis was performed to summarize published randomized clinical trials which assess the effect of Spirulina supplementation on obesity.Setting Pertinent studies were identified using Embase, Scopus, ISI Web of Science, PubMed and Cochrane library databases up to May 2019. Mean Differences (MD) were pooled using a random-effects model. Heterogeneity, sensitivity analysis and publication bias were reported using standard methods.Results Results of 5 studies (7 treatment arms) showed a significant reduction in weight (MD: -1.56 Kg, 95% CI: -1.98 to -1.14) after Spirulina supplementation. Subgroup analysis based on health status revealed that weight change in obese subjects (MD: -2.06 Kg, 95% CI: -2.45 to -1.68) was greater than overweight participants (MD: -1.28 Kg, 95% CI: -1.62 to -0.93) following Spirulina supplementation. Also, pooled analysis showed that Spirulina supplementation led to a significant reduction in body fat percent (MD: -1.02, 95% CI: -1.49 to -0.54) and waist circumference (MD: -1.40, 95% CI: -1.40 to -1.39), but not in body mass index and waist to hip ratio.Conclusion Spirulina supplementation significantly reduces body weight, especially in obese individuals.

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Crossref · 10.1016/j.ctim.2019.102211

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  • Clinical trials involving Spirulina/Limnospira supplementation reported modest but consistent improvements in appetite regulation, reductions in triglyceride levels, and small decreases in body weight and BMI over 8 to 12 weeks, particularly at doses around 2 g/day.

    “Clinical trials involving Spirulina/Limnospira supplementation have reported modest but consistent improvements in appetite regulation, reductions in triglyceride levels, and small decreases in body weight and BMI over intervention periods ranging from 8 to 12 weeks, particularly at doses around 2 g/day [159–161].”

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Authors
Moradi, S., Ziaei, R., Foshati, S., Mohammadi, H., Nachvak, S. M., & Rouhani, M. H.
Affiliations
  • Kermanshah University of Medical Sciences (IR)
  • Isfahan University of Medical Sciences (IR)
Corresponding author
Rouhani, Mohammad Hossein
Venue
Complementary Therapies in Medicine
Publisher
Elsevier BV
Published
2019-12
Volume
47
Pages
102211
ISSN
0965-2299 (ISSN-L)
OpenAlex
W2980804088
Cited by
88
References
50
Citations by year
2026: 9 · 2025: 14 · 2024: 16 · 2023: 12 · 2022: 13 · 2021: 13 · 2020: 11
FWCI
0.92
Type
journal article
Language
en
Open access
closed
Locations
  • Complementary Therapies in Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords
Spirulina, obesity, weight loss, body fat percentage, waist circumference, overweight, dietary supplementation, anthropometric indices
MeSH terms
Anthropometry, Humans, Obesity, Weight Loss, Randomized Controlled Trials as Topic, Dietary Supplements, Spirulina

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