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Cited by 65Probiotics and Fermented FoodsThyroid Disorders and TreatmentsGut microbiota and health

The effects of synbiotic supplementation on thyroid function and inflammation in hypothyroid patients: a randomized, double-blind, placebo-controlled trial

Talebi, Sepide, Karimifar, Mozhgan, Heidari, Zahra, Mohammadi, Hamed, Askari, Gholamreza·2020·Complementary Therapies in Medicine
DOI 10.1016/j.ctim.2019.102234
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Abstract

Background There is a positive link between thyroid homeostasis and the composition of gut microbiota. A limited number of studies have suggested the efficacy of probiotic products on levothyroxine metabolism and thyroid hormone activity. Therefore, the purpose of this study was to investigate the effect of synbiotic supplementation on thyroid function, inflammation markers, and blood pressure in subjects with hypothyroidism. Methods This study was conducted as a randomized, double-blind, placebo-controlled trial involving 60 patients with hypothyroidism. Participants were randomly recruited into two groups to receive either 500 mg/day of synbiotic (n = 30) or a placebo (n = 30) for 8 weeks. Results Thyroid-stimulating hormone concentration, levothyroxine dose, and fatigue severity scale score were significantly decreased after the 8-week intervention in the synbiotic group (P 3 at the end of intervention was significantly higher (P = 0.001) in both groups, although these changes were not significant between the two groups (P = 0.259). Synbiotic supplements led to a significant elevation in serum CRP (P = 0.006), but this increase was not significant between groups (P = 0.699). Moreover, no statistical significance was observed within or between groups in terms of anti-thyroid peroxidase, systolic blood pressure and diastolic blood pressure (P > 0.05). Conclusion Synbiotic supplementation among hypothyroid patients for 8 weeks may have beneficial effects on thyroid function.…

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  • In hypothyroid patients who continue to show symptoms despite optimal levothyroxine therapy, probiotic use improves fatigue levels.

    “For example, use of probiotics leads to reduced levels of TSH, lower the required dose of levothyroxine, and improve hypothyroid patients’ fatigue levels who continue to show symptoms even after optimum levothyroxine therapy (Talebi et al., 2020).”

    From Thyroid disorders and gastrointestinal dysmotility: an old association (2024) · cites this paper as Talebi et al., 2020

  • In hypothyroid patients, probiotic use lowers the required dose of levothyroxine.

    “For example, use of probiotics leads to reduced levels of TSH, lower the required dose of levothyroxine, and improve hypothyroid patients’ fatigue levels who continue to show symptoms even after optimum levothyroxine therapy (Talebi et al., 2020).”

    From Thyroid disorders and gastrointestinal dysmotility: an old association (2024) · cites this paper as Talebi et al., 2020

  • In hypothyroid patients, probiotic use reduces TSH levels.

    “For example, use of probiotics leads to reduced levels of TSH, lower the required dose of levothyroxine, and improve hypothyroid patients’ fatigue levels who continue to show symptoms even after optimum levothyroxine therapy (Talebi et al., 2020).”

    From Thyroid disorders and gastrointestinal dysmotility: an old association (2024) · cites this paper as Talebi et al., 2020

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Authors
Talebi, S., Karimifar, M., Heidari, Z., Mohammadi, H., & Askari, G.
Affiliations
Isfahan University of Medical Sciences (IR)
Corresponding author
Askari, Gholamreza
ORCID
Venue
Complementary Therapies in Medicine
Publisher
Elsevier BV
Published
2020-01
Volume
48
Pages
102234
ISSN
0965-2299 (ISSN-L)
DOI
10.1016/j.ctim.2019.102234
OpenAlex
W2983955950
Cited by
64
References
41
Citations by year
2026: 8 · 2025: 7 · 2024: 10 · 2023: 17 · 2022: 12 · 2021: 5 · 2020: 5
FWCI
4.24
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Complementary Therapies in Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
Food Security Research Center, School of Nutrition & Food Sciences, Isfahan University of Medical Sciences (297074)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
synbiotic supplementation, hypothyroidism, thyroid function, inflammation, C-reactive protein, thyroid peroxidase antibodies, blood pressure, gut microbiota
MeSH terms
Adult, Blood Pressure, C-Reactive Protein, Double-Blind Method, Female, Humans, Hypothyroidism, Inflammation, Male, Surveys and Questionnaires, Thyroid Gland, Thyroid Hormones, Synbiotics

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